RU2434640C2 - Лечение метастатического рака молочной железы - Google Patents

Лечение метастатического рака молочной железы Download PDF

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Publication number
RU2434640C2
RU2434640C2 RU2008130963/15A RU2008130963A RU2434640C2 RU 2434640 C2 RU2434640 C2 RU 2434640C2 RU 2008130963/15 A RU2008130963/15 A RU 2008130963/15A RU 2008130963 A RU2008130963 A RU 2008130963A RU 2434640 C2 RU2434640 C2 RU 2434640C2
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Russia
Prior art keywords
epcam
administered
dose
antibody
breast cancer
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RU2008130963/15A
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English (en)
Russian (ru)
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RU2008130963A (ru
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Карстен РАЙНХАРДТ (DE)
Карстен РАЙНХАРДТ
Роберт САЛЛЕР (DE)
Роберт САЛЛЕР
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Микромет Аг
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Publication of RU2008130963A publication Critical patent/RU2008130963A/ru
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
RU2008130963/15A 2006-02-09 2007-02-09 Лечение метастатического рака молочной железы RU2434640C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US77242106P 2006-02-09 2006-02-09
EP06002680 2006-02-09
US60/772,421 2006-02-09
EP06002680.4 2006-02-09

Publications (2)

Publication Number Publication Date
RU2008130963A RU2008130963A (ru) 2010-03-20
RU2434640C2 true RU2434640C2 (ru) 2011-11-27

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU2008130963/15A RU2434640C2 (ru) 2006-02-09 2007-02-09 Лечение метастатического рака молочной железы

Country Status (9)

Country Link
US (3) US7976842B2 (https=)
EP (1) EP1981539B1 (https=)
JP (2) JP2009526770A (https=)
KR (1) KR101296264B1 (https=)
AU (1) AU2007213920B2 (https=)
CA (1) CA2638040A1 (https=)
IL (1) IL192944A0 (https=)
RU (1) RU2434640C2 (https=)
WO (1) WO2007090670A1 (https=)

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DE10254601A1 (de) 2002-11-22 2004-06-03 Ganymed Pharmaceuticals Ag Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
AU2007213920B2 (en) * 2006-02-09 2013-08-29 Amgen Research (Munich) Gmbh Treatment of metastatic breast cancer
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
EP2589668A1 (en) 2006-06-14 2013-05-08 Verinata Health, Inc Rare cell analysis using sample splitting and DNA tags
EP2029779A4 (en) 2006-06-14 2010-01-20 Living Microsystems Inc HIGHLY PARALLEL SNP GENOTYPING UTILIZATION FOR FETAL DIAGNOSIS
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
DE102006035617A1 (de) * 2006-07-31 2008-02-21 Siemens Ag Automatische Bestimmung von Tumorlast
US9604931B2 (en) 2007-01-22 2017-03-28 Gtx, Inc. Nuclear receptor binding agents
US9623021B2 (en) * 2007-01-22 2017-04-18 Gtx, Inc. Nuclear receptor binding agents
EA026578B1 (ru) * 2007-01-22 2017-04-28 ДЖиТиЭкс, ИНК. Вещества, связывающие ядерные рецепторы
JP5130999B2 (ja) * 2008-03-31 2013-01-30 住友ベークライト株式会社 抗癌剤の有効性予測方法
CA3069082C (en) 2008-09-20 2022-03-22 The Board Of Trustees Of The Leland Stanford Junior University Noninvasive diagnosis of fetal aneuploidy by sequencing
WO2011091154A2 (en) * 2010-01-21 2011-07-28 The Regents Of The University Of California Use of human erythrocytes for prevention and treatment of cancer dissemination and growth
AU2011339929B2 (en) * 2010-12-06 2017-05-11 Tom C. Tsang Methods of metabolic targeting cancer cells using chemo- and immunotherapy for treating cancer
WO2012158818A2 (en) * 2011-05-16 2012-11-22 Fabion Pharmaceuticals, Inc. Multi-specific fab fusion proteins and methods of use
FR2977674B1 (fr) * 2011-07-06 2015-08-14 Cisbio Bioassays Methode amelioree de detection et/ou de quantification d'un analyte present a la surface d'une cellule
CA2843158A1 (en) 2011-08-26 2013-03-07 Merrimack Pharmaceuticals, Inc. Tandem fc bispecific antibodies
US20130179184A1 (en) * 2012-01-06 2013-07-11 Katherine L. Hurst Individualized Dosing Technique With Multiple Variables
WO2013142390A1 (en) * 2012-03-21 2013-09-26 Gtx, Inc. Aldo-keto reductase subfamily 1c3 (akr1c3) inhibitors
JP6499079B2 (ja) 2012-11-13 2019-04-10 バイオエヌテック アーゲーＢｉｏＮＴｅｃｈ ＡＧ クローディンを発現するガン疾患を処置するための剤
HK1220465A1 (zh) 2013-03-06 2017-05-05 Merrimack Pharmaceuticals, Inc. 抗c-met串联fc双特异性抗体
WO2014146672A1 (en) 2013-03-18 2014-09-25 Ganymed Pharmaceuticals Ag Therapy involving antibodies against claudin 18.2 for treatment of cancer
WO2015065505A1 (en) * 2013-10-29 2015-05-07 Duke University Use of cyp27a1 inhibitors, statin, or lxr antagonists alone or in combination with conventional therapy for the treatment of breast cancer
US10975164B2 (en) 2018-02-26 2021-04-13 Emory University Antibodies useful for detection of human carcinoma antigen
EP3847196A4 (en) 2018-09-07 2023-01-04 ITabMed (HK) Limited BISPECIFIC ANTIGEN BINDING PROTEINS AND USES THEREOF
WO2020132810A1 (en) 2018-12-24 2020-07-02 Generon (Shanghai) Corporation Ltd. Multispecific antigen binding proteins capable of binding cd19 and cd3, and use thereof

Citations (3)

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RU2188025C2 (ru) * 2000-07-19 2002-08-27 Ростовский научно-исследовательский онкологический институт Способ лечения рака молочной железы
RU2195312C2 (ru) * 1996-05-31 2002-12-27 Дзе Скриппс Рисерч Инститьют СПОСОБЫ И КОМПОЗИЦИИ, ИСПОЛЬЗУЕМЫЕ ДЛЯ ИНГИБИРОВАНИЯ αvβ5-ОПОСРЕДОВАННОГО АНГИОГЕНЕЗА
WO2005080428A2 (en) * 2004-02-13 2005-09-01 Micromet Ag Anti-epcam immunoglobulins

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US20050009097A1 (en) * 2003-03-31 2005-01-13 Better Marc D. Human engineered antibodies to Ep-CAM
AU2007213920B2 (en) * 2006-02-09 2013-08-29 Amgen Research (Munich) Gmbh Treatment of metastatic breast cancer
RU2769948C2 (ru) * 2007-04-03 2022-04-11 Эмджен Рисерч (Мьюник) Гмбх CD3-Эпсилон-связывающий домен с межвидовой специфичностью

Patent Citations (3)

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RU2195312C2 (ru) * 1996-05-31 2002-12-27 Дзе Скриппс Рисерч Инститьют СПОСОБЫ И КОМПОЗИЦИИ, ИСПОЛЬЗУЕМЫЕ ДЛЯ ИНГИБИРОВАНИЯ αvβ5-ОПОСРЕДОВАННОГО АНГИОГЕНЕЗА
RU2188025C2 (ru) * 2000-07-19 2002-08-27 Ростовский научно-исследовательский онкологический институт Способ лечения рака молочной железы
WO2005080428A2 (en) * 2004-02-13 2005-09-01 Micromet Ag Anti-epcam immunoglobulins

Non-Patent Citations (2)

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Title
BRAUN S et al. Monoclonal antibody therapy with edrecolomab in breast cancer patients: monitoring of elimination of disseminated cytokeratin-positive tumor cells in bone marrow // Clin Cancer Res. 1999 Dec; 5(12):3999-4004 он-лайн [найдено в Интернет на (http://clincancerres.aacrjournals.org/content/5/12/3999.full.pdf+html]. *
PRANG N et al. Cellular and complement-dependent cytotoxicity of Ep-CAM-specific monoclonal antibody MT201 against breast cancer cell lines // Br J Cancer. 2005 Jan 31; 92(2):342-9. реферат, он лайн [Найдено в Интернет на www.pubmed.com 10.09.2010], PMID: 15655555 [PubMed - indexed for MEDLINE]. MAKOWER D et al. A pilot study of edrecolomab (Panorex, 17-1A antibody) and capecitabine in patients with advanced or metastatic adenocarcinoma // Cancer Invest. 2003 Apr; 21(2): 177-84 реферат, он лайн [Найдено в Интернет на www.pubmed.com 10.09.2010], PMID: 12743982 [PubMed - indexed for MEDLINE]. *

Also Published As

Publication number Publication date
KR101296264B1 (ko) 2013-08-14
JP2009526770A (ja) 2009-07-23
RU2008130963A (ru) 2010-03-20
EP1981539A1 (en) 2008-10-22
CA2638040A1 (en) 2007-08-16
IL192944A0 (en) 2009-02-11
WO2007090670A1 (en) 2007-08-16
US20090304716A1 (en) 2009-12-10
US8658172B2 (en) 2014-02-25
US20130177578A1 (en) 2013-07-11
US8337843B2 (en) 2012-12-25
EP1981539B1 (en) 2014-07-23
AU2007213920A1 (en) 2007-08-16
US20120009204A1 (en) 2012-01-12
KR20080091817A (ko) 2008-10-14
US7976842B2 (en) 2011-07-12
JP2013067645A (ja) 2013-04-18
AU2007213920B2 (en) 2013-08-29

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PC43 Official registration of the transfer of the exclusive right without contract for inventions

Effective date: 20131127

PD4A Correction of name of patent owner
MM4A The patent is invalid due to non-payment of fees

Effective date: 20160210