RU2430162C2 - Варианты эритропоэтина - Google Patents
Варианты эритропоэтина Download PDFInfo
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- RU2430162C2 RU2430162C2 RU2007146455/10A RU2007146455A RU2430162C2 RU 2430162 C2 RU2430162 C2 RU 2430162C2 RU 2007146455/10 A RU2007146455/10 A RU 2007146455/10A RU 2007146455 A RU2007146455 A RU 2007146455A RU 2430162 C2 RU2430162 C2 RU 2430162C2
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05010473.6 | 2005-05-13 | ||
| EP05010473A EP1736481A1 (en) | 2005-05-13 | 2005-05-13 | Erythropoietin variants |
Publications (2)
| Publication Number | Publication Date |
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| RU2007146455A RU2007146455A (ru) | 2009-06-20 |
| RU2430162C2 true RU2430162C2 (ru) | 2011-09-27 |
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| RU2007146455/10A RU2430162C2 (ru) | 2005-05-13 | 2006-05-15 | Варианты эритропоэтина |
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|---|---|
| EP (2) | EP1736481A1 (https=) |
| JP (1) | JP5231214B2 (https=) |
| KR (1) | KR101468737B1 (https=) |
| CN (1) | CN101175768B (https=) |
| AU (1) | AU2006245916B2 (https=) |
| BR (1) | BRPI0608769A2 (https=) |
| CA (1) | CA2608379C (https=) |
| DK (1) | DK1885747T3 (https=) |
| ES (1) | ES2457398T3 (https=) |
| RU (1) | RU2430162C2 (https=) |
| WO (1) | WO2006120030A1 (https=) |
| ZA (1) | ZA200709091B (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| SI2540309T1 (en) | 2005-08-05 | 2018-04-30 | Araim Pharmaceuticals, Inc. | Tissue protective peptides and their uses |
| WO2008137636A2 (en) * | 2007-05-02 | 2008-11-13 | University Of Utah Research Foundation | Compositions and methods for identifying and treating subjects at risk of developing type 2 diabetes |
| DE102007031708A1 (de) * | 2007-07-06 | 2009-01-08 | Dade Behring Marburg Gmbh | Bestimmung der von Willebrand Faktor-Aktivität in Abwesenheit von Ristocetin |
| KR20200075044A (ko) | 2008-01-22 | 2020-06-25 | 아라임 파마슈티칼즈, 인크. | 조직 손상 관련 질환 및 장애를 예방 및 치료하기 위한 조직 보호 펩티드 및 펩티드 유사체 |
| KR101931403B1 (ko) | 2011-09-23 | 2018-12-21 | 블루버드 바이오, 인코포레이티드. | 개선된 유전자 치료 방법 |
| KR101148191B1 (ko) * | 2011-09-27 | 2012-05-23 | 김후정 | 에리스로포이에틴-유래 펩타이드 및 그 용도 |
| DK2928921T3 (da) | 2012-12-05 | 2021-04-19 | Novartis Ag | Sammensætninger og fremgangsmåder til antistoffer målrettet epo |
| EP2953473B1 (en) | 2013-02-06 | 2018-11-28 | Nc Medical Research Inc. | Method of producing a heterogeneous subpopulation of bone marrow cells suitable for the treatement of neurodegeneration cased by ischemic stroke |
| CN107922975B (zh) | 2015-08-12 | 2022-06-28 | 诺华股份有限公司 | 治疗眼科病症的方法 |
| CA2995733A1 (en) * | 2015-08-31 | 2017-03-09 | The Trustees Of The University Of Pennsylvania | Aav-epo for treating companion animals |
| CN110475786A (zh) * | 2017-02-27 | 2019-11-19 | 大邱庆北科学技术院 | 红细胞生成素衍生肽通过其对预防细胞损伤的作用的用途 |
| CN107880109B (zh) * | 2017-11-01 | 2019-08-30 | 复旦大学附属中山医院 | 一种促红细胞生成素来源肽及其制备方法和用途 |
| AR113091A1 (es) | 2018-09-27 | 2020-01-22 | Univ Nacional Del Litoral | Eritropoyetina humana modificada |
| EP3916008A1 (en) * | 2020-05-26 | 2021-12-01 | Sylus Co., Ltd. | New peptide and use thereof for treatment of disease of brain and nervous system |
| CN113376186B (zh) * | 2021-05-12 | 2022-12-23 | 无锡科金生物科技有限公司 | 一种精准度高的智能红细胞叶酸检测仪及其检测方法 |
| CN117940451A (zh) * | 2021-06-15 | 2024-04-26 | 安德烈马肯有限公司 | Epo变体和调节剂 |
Citations (1)
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|---|---|---|---|---|
| RU2003131695A (ru) * | 1996-03-05 | 2005-04-10 | Риджентс Оф Дзе Юниверсити Оф Калифорния (Us) | Способ воздействия на нейродегенеративное нарушение или нарушение миелинизации |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4558006A (en) * | 1983-02-04 | 1985-12-10 | Kirin-Amgen, Inc. | A.T.C.C. HB8209 and its monoclonal antibody to erythropoietin |
| DE3924746A1 (de) * | 1989-07-26 | 1991-01-31 | Behringwerke Ag | Erythropoietin (epo)-peptide und dagegen gerichtete antikoerper |
| CN1057534C (zh) | 1993-08-17 | 2000-10-18 | 柯瑞英-艾格公司 | 促红细胞生成素类似物 |
| DE19857609A1 (de) | 1998-12-14 | 2000-06-15 | Hannelore Ehrenreich | Verwendung von Erythropoietin zur Behandlung von cerebralen Ischämien des Menschen |
| US7259146B2 (en) | 2000-05-26 | 2007-08-21 | Ortho-Mcneil Pharmaceutical, Inc. | Neuroprotective peptides |
| DE10043457A1 (de) | 2000-09-04 | 2002-03-28 | Hannelore Ehrenreich | Verfahren zur Behandlung von Schizophrenie und verwandten Psychosen sowie Verwendung von Erythropoietin oder Erythropoietinderivaten zur Behandlung von Schizophrenien und verwandten Psychosen |
| US6531121B2 (en) | 2000-12-29 | 2003-03-11 | The Kenneth S. Warren Institute, Inc. | Protection and enhancement of erythropoietin-responsive cells, tissues and organs |
| EP1552298A4 (en) * | 2002-07-01 | 2006-11-08 | Kenneth S Warren Inst Inc | RECOMBINANT TISSUE-PROOFING CYTOKINS AND NUCLEIC ACIDS COORDINATING THEREOF FOR THE PROTECTION, RECOVERY AND IMPROVEMENT OF CELLS, TISSUE AND ORGANS THEREOF |
| WO2005025606A1 (en) | 2003-09-09 | 2005-03-24 | Warren Pharmaceuticals, Inc. | Long acting erythropoietins that maintain tissue protective activity of endogenous erythropoietin |
| US20040091961A1 (en) * | 2002-11-08 | 2004-05-13 | Evans Glen A. | Enhanced variants of erythropoietin and methods of use |
| CA2563874A1 (en) * | 2004-04-23 | 2005-11-03 | Cambridge Antibody Technology Limited | Erythropoietin protein variants |
-
2005
- 2005-05-13 EP EP05010473A patent/EP1736481A1/en not_active Withdrawn
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- 2006-05-15 RU RU2007146455/10A patent/RU2430162C2/ru not_active IP Right Cessation
- 2006-05-15 EP EP06753630.0A patent/EP1885747B1/en not_active Not-in-force
- 2006-05-15 CN CN2006800165436A patent/CN101175768B/zh not_active Expired - Fee Related
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2003131695A (ru) * | 1996-03-05 | 2005-04-10 | Риджентс Оф Дзе Юниверсити Оф Калифорния (Us) | Способ воздействия на нейродегенеративное нарушение или нарушение миелинизации |
Non-Patent Citations (1)
| Title |
|---|
| LEIST M. et al. Science, v.305, no.5681, 239-242, 2004. CAMPANA et al. Int. J.Mol.Med., 1(1), 235-241, 1998. * |
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| CA2608379A1 (en) | 2006-11-16 |
| AU2006245916A1 (en) | 2006-11-16 |
| CN101175768B (zh) | 2013-09-11 |
| EP1885747A1 (en) | 2008-02-13 |
| JP5231214B2 (ja) | 2013-07-10 |
| KR20080021595A (ko) | 2008-03-07 |
| EP1885747B1 (en) | 2013-11-20 |
| CN101175768A (zh) | 2008-05-07 |
| BRPI0608769A2 (pt) | 2010-01-26 |
| CA2608379C (en) | 2014-12-16 |
| AU2006245916B2 (en) | 2012-03-15 |
| ZA200709091B (en) | 2009-08-26 |
| WO2006120030A1 (en) | 2006-11-16 |
| EP1736481A1 (en) | 2006-12-27 |
| ES2457398T3 (es) | 2014-04-25 |
| DK1885747T3 (en) | 2014-02-24 |
| JP2008539745A (ja) | 2008-11-20 |
| WO2006120030A8 (en) | 2006-12-28 |
| KR101468737B1 (ko) | 2014-12-09 |
| RU2007146455A (ru) | 2009-06-20 |
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