RU2423360C2 - Производные индола как ингибиторы н3-рецептора гистамина для лечения когнитивных расстройств и нарушений сна, ожирения и других расстройств центральной нервной системы - Google Patents
Производные индола как ингибиторы н3-рецептора гистамина для лечения когнитивных расстройств и нарушений сна, ожирения и других расстройств центральной нервной системы Download PDFInfo
- Publication number
- RU2423360C2 RU2423360C2 RU2008118904/04A RU2008118904A RU2423360C2 RU 2423360 C2 RU2423360 C2 RU 2423360C2 RU 2008118904/04 A RU2008118904/04 A RU 2008118904/04A RU 2008118904 A RU2008118904 A RU 2008118904A RU 2423360 C2 RU2423360 C2 RU 2423360C2
- Authority
- RU
- Russia
- Prior art keywords
- phenyl
- indole
- pyrrolidin
- ylpropoxy
- propoxy
- Prior art date
Links
- ZVIPNNXDWVBYCP-UHFFFAOYSA-N CCOC(c1cc2ccccc2[n]1-c(cc1)ccc1OCCCN1CCCC1)=O Chemical compound CCOC(c1cc2ccccc2[n]1-c(cc1)ccc1OCCCN1CCCC1)=O ZVIPNNXDWVBYCP-UHFFFAOYSA-N 0.000 description 1
- MGMASIAGBNSABM-UHFFFAOYSA-N COCc1cc2cc(F)ccc2[n]1-c(cc1)ccc1OCCCN1CCCC1 Chemical compound COCc1cc2cc(F)ccc2[n]1-c(cc1)ccc1OCCCN1CCCC1 MGMASIAGBNSABM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72679305P | 2005-10-14 | 2005-10-14 | |
| US60/726,793 | 2005-10-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2008118904A RU2008118904A (ru) | 2009-11-20 |
| RU2423360C2 true RU2423360C2 (ru) | 2011-07-10 |
Family
ID=37962842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008118904/04A RU2423360C2 (ru) | 2005-10-14 | 2006-10-16 | Производные индола как ингибиторы н3-рецептора гистамина для лечения когнитивных расстройств и нарушений сна, ожирения и других расстройств центральной нервной системы |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US7528262B2 (ja) |
| EP (1) | EP1945206B1 (ja) |
| JP (1) | JP5250420B2 (ja) |
| AR (1) | AR056690A1 (ja) |
| AU (1) | AU2006304584B2 (ja) |
| CA (1) | CA2626028C (ja) |
| DK (1) | DK1945206T3 (ja) |
| ES (1) | ES2429940T3 (ja) |
| HK (1) | HK1122497A1 (ja) |
| IL (1) | IL190783A (ja) |
| RU (1) | RU2423360C2 (ja) |
| TW (1) | TWI378097B (ja) |
| WO (1) | WO2007047775A1 (ja) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0619233A2 (pt) * | 2005-11-30 | 2011-09-20 | Hoffmann La Roche | compostos, processo para a sua manufatura, método para o tratamento e/ou prevenção de enfermidades que estão associadas com a modulação de receptores de h3, uso dos compostos e método para o tratamento ou prevenção de obesidade e de diabetes do tipo ii em um ser humano ou animal |
| SI2276732T1 (sl) | 2008-04-16 | 2015-09-30 | Karo Bio Ab | Novi ligandi estrogenskega receptorja |
| GB201113538D0 (en) | 2011-08-04 | 2011-09-21 | Karobio Ab | Novel estrogen receptor ligands |
| WO2016090094A1 (en) * | 2014-12-03 | 2016-06-09 | Wisconsin Alumni Research Foundation | Synthesis of cyclopropyl indoles and cyclohepta[b]indoles, pharmeceutical compositions containing them, and methods and using them |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3799943A (en) * | 1971-06-23 | 1974-03-26 | Sterling Drug Inc | 1,2-diphenylindoles |
| TW229140B (ja) | 1992-06-05 | 1994-09-01 | Shell Internat Res Schappej B V | |
| US5399599A (en) * | 1993-04-06 | 1995-03-21 | Thiokol Corporation | Thermoplastic elastomeric internal insulation for rocket motors for low temperature applications |
| EP0738713B1 (en) * | 1995-04-21 | 2000-02-09 | Rhone-Poulenc Agrochimie | Process for the preparation of pesticidal 1-(chloroaryl)heterocyclic compounds |
| US6630496B1 (en) * | 1996-08-26 | 2003-10-07 | Genetics Institute Llc | Inhibitors of phospholipase enzymes |
| KR20010041346A (ko) | 1998-02-25 | 2001-05-15 | 브루스 엠. 에이센, 토마스 제이 데스로저 | 포스포리파제 ａ2 억제제 |
| EP1268421B1 (en) * | 2000-03-31 | 2009-05-06 | Ortho-McNeil Pharmaceutical, Inc. | Phenyl-substituted indoles as histamine h3-receptor antagonists |
| AU2001249679A1 (en) * | 2000-03-31 | 2001-10-15 | Ortho-Mcneil Pharmaceutical, Inc. | Phenyl-substituted imidazopyridines |
| US6353007B1 (en) * | 2000-07-13 | 2002-03-05 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted 1-(4-aminophenyl)indoles and their use as anti-inflammatory agents |
| CN100396668C (zh) * | 2000-08-08 | 2008-06-25 | 奥索-麦克尼尔药品公司 | 非-咪唑芳氧基哌啶 |
| ES2201907B1 (es) * | 2002-05-29 | 2005-06-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de indolilpiperidina como potentes agentes antihistaminicos y antialergicos. |
| GB0224557D0 (en) * | 2002-10-22 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
| MXPA05011539A (es) | 2003-04-30 | 2006-01-23 | Inst For Pharm Discovery Inc | Acidos carboxilicos sustituidos con heterociclo como inhibidores de la proteina tirosina-fosfatasa-1b. |
| CN101006053A (zh) * | 2004-06-18 | 2007-07-25 | 比奥里波克斯公司 | 用于治疗炎症的吲哚 |
-
2006
- 2006-10-11 AR ARP060104464A patent/AR056690A1/es unknown
- 2006-10-12 TW TW095137574A patent/TWI378097B/zh not_active IP Right Cessation
- 2006-10-16 ES ES06826203T patent/ES2429940T3/es active Active
- 2006-10-16 AU AU2006304584A patent/AU2006304584B2/en not_active Ceased
- 2006-10-16 JP JP2008535801A patent/JP5250420B2/ja not_active Expired - Fee Related
- 2006-10-16 RU RU2008118904/04A patent/RU2423360C2/ru not_active IP Right Cessation
- 2006-10-16 CA CA2626028A patent/CA2626028C/en not_active Expired - Fee Related
- 2006-10-16 DK DK06826203.9T patent/DK1945206T3/da active
- 2006-10-16 WO PCT/US2006/040744 patent/WO2007047775A1/en active Application Filing
- 2006-10-16 US US11/581,631 patent/US7528262B2/en not_active Expired - Fee Related
- 2006-10-16 EP EP06826203.9A patent/EP1945206B1/en not_active Not-in-force
-
2008
- 2008-04-10 IL IL190783A patent/IL190783A/en not_active IP Right Cessation
- 2008-09-23 US US12/284,574 patent/US7855224B2/en not_active Expired - Fee Related
-
2009
- 2009-01-14 HK HK09100386.3A patent/HK1122497A1/xx not_active IP Right Cessation
-
2010
- 2010-11-10 US US12/943,659 patent/US8129424B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007047775A1 (en) | 2007-04-26 |
| IL190783A0 (en) | 2008-11-03 |
| EP1945206A1 (en) | 2008-07-23 |
| CA2626028C (en) | 2014-06-17 |
| US7528262B2 (en) | 2009-05-05 |
| CA2626028A1 (en) | 2007-04-26 |
| AU2006304584A1 (en) | 2007-04-26 |
| RU2008118904A (ru) | 2009-11-20 |
| EP1945206A4 (en) | 2011-05-04 |
| AU2006304584B2 (en) | 2011-11-24 |
| DK1945206T3 (da) | 2013-07-29 |
| JP5250420B2 (ja) | 2013-07-31 |
| AR056690A1 (es) | 2007-10-17 |
| US20070161676A1 (en) | 2007-07-12 |
| IL190783A (en) | 2014-07-31 |
| US8129424B2 (en) | 2012-03-06 |
| US20090036446A1 (en) | 2009-02-05 |
| TW200745091A (en) | 2007-12-16 |
| JP2009511605A (ja) | 2009-03-19 |
| HK1122497A1 (en) | 2009-05-22 |
| ES2429940T3 (es) | 2013-11-18 |
| US20110059966A1 (en) | 2011-03-10 |
| TWI378097B (en) | 2012-12-01 |
| EP1945206B1 (en) | 2013-04-24 |
| US7855224B2 (en) | 2010-12-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20151017 |