RU2421467C2 - Композиции частично деацетилированных производных хитина - Google Patents

Композиции частично деацетилированных производных хитина Download PDF

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Publication number
RU2421467C2
RU2421467C2 RU2008101385/05A RU2008101385A RU2421467C2 RU 2421467 C2 RU2421467 C2 RU 2421467C2 RU 2008101385/05 A RU2008101385/05 A RU 2008101385/05A RU 2008101385 A RU2008101385 A RU 2008101385A RU 2421467 C2 RU2421467 C2 RU 2421467C2
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Russia
Prior art keywords
chitin
partially deacetylated
deacetylated chitin
bone
deacetylation
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RU2008101385/05A
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English (en)
Russian (ru)
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RU2008101385A (ru
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Йоханнес ДЖИСЛЕЙЗОН (IS)
Йоханнес ДЖИСЛЕЙЗОН
Йон М. АЙНАРССОН (IS)
Йон М. АЙНАРССОН
ХАУ Нг ЧУЕН (IS)
ХАУ Нг ЧУЕН
Свен БАРКЕ (DE)
Свен БАРКЕ
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Дженис Эхф.
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028—Polypeptides; Proteins; Degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0066—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/009—Materials resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polymers & Plastics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Surgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Sustainable Development (AREA)
  • Immunology (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
RU2008101385/05A 2005-06-14 2006-06-14 Композиции частично деацетилированных производных хитина RU2421467C2 (ru)

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Application Number Priority Date Filing Date Title
IS7895 2005-06-14
IS7895 2005-06-14

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RU2008101385A RU2008101385A (ru) 2009-07-20
RU2421467C2 true RU2421467C2 (ru) 2011-06-20

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US (3) US9078949B2 (enExample)
EP (1) EP1917218B1 (enExample)
JP (2) JP5632125B2 (enExample)
KR (1) KR101569751B1 (enExample)
CN (1) CN101248019B (enExample)
AU (1) AU2006257177A1 (enExample)
BR (1) BRPI0612034A2 (enExample)
CA (1) CA2611453C (enExample)
DK (1) DK1917218T3 (enExample)
HU (1) HUE035956T2 (enExample)
LT (1) LT1917218T (enExample)
MX (2) MX336736B (enExample)
NO (2) NO344086B1 (enExample)
NZ (1) NZ565022A (enExample)
RU (1) RU2421467C2 (enExample)
SI (1) SI1917218T1 (enExample)
WO (1) WO2006134614A1 (enExample)

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IS6085A (is) * 2001-09-26 2003-03-27 Genis Ehf. Lyfjablanda með kítósan óligómerum
US9034348B2 (en) 2006-12-11 2015-05-19 Chi2Gel Ltd. Injectable chitosan mixtures forming hydrogels
US10201490B2 (en) 2007-02-14 2019-02-12 Polichem Sa Use of chitosans for the treatment of nail inflammatory diseases
EP1958639A1 (en) 2007-02-14 2008-08-20 Polichem S.A. Use of chitosans for the treatment of nail inflammatory diseases
AU2009258885A1 (en) * 2008-06-11 2009-12-17 Chi2Gel Ltd. Injectable hydrogel forming chitosan mixtures
CA2731201C (en) * 2008-07-18 2018-10-16 Genis Ehf. Composition for treating autoimmune disorders
CN102417550B (zh) * 2010-09-28 2014-04-30 扬州鸿信生物制品有限公司 一种甲壳素生产设备
WO2012145626A1 (en) * 2011-04-22 2012-10-26 Ancora Pharmaceuticals Inc. Synthetic oligosaccharides for staphylococcus vaccine
US10130654B2 (en) * 2011-05-24 2018-11-20 Hangli Biosciences Co., Ltd. Method of inducing osteogensis and promoting osseointegration around an implant
GB201205174D0 (en) * 2012-03-23 2012-05-09 Medtrade Products Ltd Process for producing low endotoxin chitosan
CN104470550A (zh) * 2012-04-23 2015-03-25 杰尼斯公共有限公司 作为骨移植替代物的含有部分脱乙酰壳多糖的自硬化生物活性接合剂组合物
FI2968427T3 (fi) 2013-03-12 2023-03-01 Konjugaatti sienisoluseinämän polysakkarideihin kohdentuvien vasta-aineiden indusoimiseksi
GB201309606D0 (en) * 2013-05-29 2013-07-10 Medtrade Products Ltd Process for producing low endotoxin chitosan
GB201309607D0 (en) * 2013-05-29 2013-07-10 Medtrade Products Ltd Process for producing low endotoxin chitosan
GB2514592A (en) 2013-05-30 2014-12-03 Medtrade Products Ltd Degradable haemostat composition
FR3016882A1 (fr) 2014-01-30 2015-07-31 Sofradim Production Procede de preparation de chitosane a haut degre d’acetylation
JP6512630B2 (ja) * 2015-02-26 2019-05-15 オルガノ株式会社 セレン及び／またはヒ素の濃縮方法及び分析方法並びに装置
CN108114321A (zh) * 2017-12-29 2018-06-05 广州军区广州总医院 一种抗骨巨细胞瘤壳聚糖-纳米羟基磷灰石支架、其制备方法及应用
CN109529105A (zh) * 2018-10-04 2019-03-29 南京航空航天大学溧水仿生产业研究院有限公司 仿生人工骨材料的制备方法
WO2020186021A1 (en) * 2019-03-13 2020-09-17 Virginia Commonwealth University Method for forming flexible and biodegradable structures from low molecular weight chitin biopolymers
US20230285442A1 (en) * 2020-03-26 2023-09-14 Subhra Mohapatra Use of oligochitosans and derivatives thereof for neutralizing viral agents
JP7602224B2 (ja) * 2020-05-15 2024-12-18 京都府公立大学法人 非晶性キチンを含む創傷治癒材
CN111803714B (zh) * 2020-07-29 2021-12-21 陕西科技大学 一种综合酸-碱溶剂体系的壳聚糖骨修复支架及其制备方法
CN112341551A (zh) * 2020-11-05 2021-02-09 广东广纳安疗科技有限公司 一种具有超低内毒素的壳聚糖类物质及其制备方法
CN112724273B (zh) * 2021-01-26 2022-02-22 焦点生物医药有限公司 一种高分子量银耳多糖的提取及制备方法
EP4122961A1 (en) * 2021-07-20 2023-01-25 Westfälische Wilhelms-Universität Münster Chitosan oligomers and uses thereof
AU2022417673A1 (en) * 2021-12-20 2024-08-01 Genis Hf. Implants with bioactive coating comprising partially deacetylated chitosan
CN114533967B (zh) * 2022-03-30 2023-01-03 江苏益通生物科技有限公司 一种脱乙酰壳聚糖神经导管及其制备方法
CA3263004A1 (en) * 2022-08-11 2024-02-15 Genis Hf. 3D PRINTED BIOACTIVE SCAFFOLDING

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US5077052A (en) * 1988-11-30 1991-12-31 Rhone-Poulenc Sante Chitosan derivatives useful in compositions for coating feedstuff additives intended for ruminants
RU2065447C1 (ru) * 1992-11-30 1996-08-20 Владимир Петрович Голицин Способ получения хитозана
CN1554267A (zh) * 2003-12-23 2004-12-15 孝感学院 一种制备水溶性壳聚糖的方法

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IS6085A (is) * 2001-09-26 2003-03-27 Genis Ehf. Lyfjablanda með kítósan óligómerum
JP3755004B2 (ja) * 2003-07-01 2006-03-15 独立行政法人物質・材料研究機構 キチン誘導体−リン酸カルシウム複合体繊維とその製造方法
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Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2795579A (en) * 1953-10-09 1957-06-11 Warner Lambert Pharmaceutical Process for purification of chitosan by means of the salicylic acid salt thereof
US5077052A (en) * 1988-11-30 1991-12-31 Rhone-Poulenc Sante Chitosan derivatives useful in compositions for coating feedstuff additives intended for ruminants
RU2065447C1 (ru) * 1992-11-30 1996-08-20 Владимир Петрович Голицин Способ получения хитозана
CN1554267A (zh) * 2003-12-23 2004-12-15 孝感学院 一种制备水溶性壳聚糖的方法

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US9078949B2 (en) 2015-07-14
US20180186899A1 (en) 2018-07-05
NZ565022A (en) 2011-04-29
BRPI0612034A2 (pt) 2012-08-28
KR20080036580A (ko) 2008-04-28
LT1917218T (lt) 2017-11-27
CA2611453A1 (en) 2006-12-21
US20160002360A1 (en) 2016-01-07
MX375577B (es) 2025-03-06
CA2611453C (en) 2015-10-06
SI1917218T1 (sl) 2017-12-29
NO344086B1 (no) 2019-09-02
US20090281058A1 (en) 2009-11-12
MX336736B (es) 2016-01-29
KR101569751B1 (ko) 2015-11-19
EP1917218B1 (en) 2017-05-17
CN101248019A (zh) 2008-08-20
JP2008544014A (ja) 2008-12-04
AU2006257177A1 (en) 2006-12-21
NO20080240L (no) 2008-03-06
JP6293005B2 (ja) 2018-03-14
DK1917218T3 (en) 2017-09-11
EP1917218A1 (en) 2008-05-07
JP5632125B2 (ja) 2014-11-26
NO20190933A1 (no) 2008-03-06
WO2006134614A1 (en) 2006-12-21
CN101248019B (zh) 2012-12-26
JP2014221905A (ja) 2014-11-27
RU2008101385A (ru) 2009-07-20
HUE035956T2 (en) 2018-05-28

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