CN101248019B - 部分脱乙酰化壳多糖衍生物的组合物 - Google Patents

部分脱乙酰化壳多糖衍生物的组合物 Download PDF

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Publication number
CN101248019B
CN101248019B CN2006800285048A CN200680028504A CN101248019B CN 101248019 B CN101248019 B CN 101248019B CN 2006800285048 A CN2006800285048 A CN 2006800285048A CN 200680028504 A CN200680028504 A CN 200680028504A CN 101248019 B CN101248019 B CN 101248019B
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chitin
bone
chos
partially deacetylated
shell
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CN101248019A (zh
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约翰内斯·吉斯拉松
乔恩·M·埃纳尔松
Ng·泉·豪
斯文·巴尔克
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Genis ehf
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Genis ehf
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028—Polypeptides; Proteins; Degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0066—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/009—Materials resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polymers & Plastics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Surgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Sustainable Development (AREA)
  • Immunology (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
CN2006800285048A 2005-06-14 2006-06-14 部分脱乙酰化壳多糖衍生物的组合物 Expired - Lifetime CN101248019B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IS7895 2005-06-14
IS7895 2005-06-14
PCT/IS2006/000013 WO2006134614A1 (en) 2005-06-14 2006-06-14 Compositions of partially deacetylated chitin derivatives

Publications (2)

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CN101248019A CN101248019A (zh) 2008-08-20
CN101248019B true CN101248019B (zh) 2012-12-26

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US (3) US9078949B2 (enExample)
EP (1) EP1917218B1 (enExample)
JP (2) JP5632125B2 (enExample)
KR (1) KR101569751B1 (enExample)
CN (1) CN101248019B (enExample)
AU (1) AU2006257177A1 (enExample)
BR (1) BRPI0612034A2 (enExample)
CA (1) CA2611453C (enExample)
DK (1) DK1917218T3 (enExample)
HU (1) HUE035956T2 (enExample)
LT (1) LT1917218T (enExample)
MX (2) MX336736B (enExample)
NO (2) NO344086B1 (enExample)
NZ (1) NZ565022A (enExample)
RU (1) RU2421467C2 (enExample)
SI (1) SI1917218T1 (enExample)
WO (1) WO2006134614A1 (enExample)

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FI2968427T3 (fi) 2013-03-12 2023-03-01 Konjugaatti sienisoluseinämän polysakkarideihin kohdentuvien vasta-aineiden indusoimiseksi
GB201309606D0 (en) * 2013-05-29 2013-07-10 Medtrade Products Ltd Process for producing low endotoxin chitosan
GB201309607D0 (en) * 2013-05-29 2013-07-10 Medtrade Products Ltd Process for producing low endotoxin chitosan
GB2514592A (en) 2013-05-30 2014-12-03 Medtrade Products Ltd Degradable haemostat composition
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JP6512630B2 (ja) * 2015-02-26 2019-05-15 オルガノ株式会社 セレン及び／またはヒ素の濃縮方法及び分析方法並びに装置
CN108114321A (zh) * 2017-12-29 2018-06-05 广州军区广州总医院 一种抗骨巨细胞瘤壳聚糖-纳米羟基磷灰石支架、其制备方法及应用
CN109529105A (zh) * 2018-10-04 2019-03-29 南京航空航天大学溧水仿生产业研究院有限公司 仿生人工骨材料的制备方法
WO2020186021A1 (en) * 2019-03-13 2020-09-17 Virginia Commonwealth University Method for forming flexible and biodegradable structures from low molecular weight chitin biopolymers
US20230285442A1 (en) * 2020-03-26 2023-09-14 Subhra Mohapatra Use of oligochitosans and derivatives thereof for neutralizing viral agents
JP7602224B2 (ja) * 2020-05-15 2024-12-18 京都府公立大学法人 非晶性キチンを含む創傷治癒材
CN111803714B (zh) * 2020-07-29 2021-12-21 陕西科技大学 一种综合酸-碱溶剂体系的壳聚糖骨修复支架及其制备方法
CN112341551A (zh) * 2020-11-05 2021-02-09 广东广纳安疗科技有限公司 一种具有超低内毒素的壳聚糖类物质及其制备方法
CN112724273B (zh) * 2021-01-26 2022-02-22 焦点生物医药有限公司 一种高分子量银耳多糖的提取及制备方法
EP4122961A1 (en) * 2021-07-20 2023-01-25 Westfälische Wilhelms-Universität Münster Chitosan oligomers and uses thereof
AU2022417673A1 (en) * 2021-12-20 2024-08-01 Genis Hf. Implants with bioactive coating comprising partially deacetylated chitosan
CN114533967B (zh) * 2022-03-30 2023-01-03 江苏益通生物科技有限公司 一种脱乙酰壳聚糖神经导管及其制备方法
CA3263004A1 (en) * 2022-08-11 2024-02-15 Genis Hf. 3D PRINTED BIOACTIVE SCAFFOLDING

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Publication number Priority date Publication date Assignee Title
US2795579A (en) * 1953-10-09 1957-06-11 Warner Lambert Pharmaceutical Process for purification of chitosan by means of the salicylic acid salt thereof
US5077052A (en) * 1988-11-30 1991-12-31 Rhone-Poulenc Sante Chitosan derivatives useful in compositions for coating feedstuff additives intended for ruminants
CN1554267A (zh) * 2003-12-23 2004-12-15 孝感学院 一种制备水溶性壳聚糖的方法

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US9078949B2 (en) 2015-07-14
US20180186899A1 (en) 2018-07-05
NZ565022A (en) 2011-04-29
BRPI0612034A2 (pt) 2012-08-28
KR20080036580A (ko) 2008-04-28
RU2421467C2 (ru) 2011-06-20
LT1917218T (lt) 2017-11-27
CA2611453A1 (en) 2006-12-21
US20160002360A1 (en) 2016-01-07
MX375577B (es) 2025-03-06
CA2611453C (en) 2015-10-06
SI1917218T1 (sl) 2017-12-29
NO344086B1 (no) 2019-09-02
US20090281058A1 (en) 2009-11-12
MX336736B (es) 2016-01-29
KR101569751B1 (ko) 2015-11-19
EP1917218B1 (en) 2017-05-17
CN101248019A (zh) 2008-08-20
JP2008544014A (ja) 2008-12-04
AU2006257177A1 (en) 2006-12-21
NO20080240L (no) 2008-03-06
JP6293005B2 (ja) 2018-03-14
DK1917218T3 (en) 2017-09-11
EP1917218A1 (en) 2008-05-07
JP5632125B2 (ja) 2014-11-26
NO20190933A1 (no) 2008-03-06
WO2006134614A1 (en) 2006-12-21
JP2014221905A (ja) 2014-11-27
RU2008101385A (ru) 2009-07-20
HUE035956T2 (en) 2018-05-28

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