RU2412944C2 - Иммуногены для вакцин против менингита а - Google Patents

Иммуногены для вакцин против менингита а Download PDF

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Publication number
RU2412944C2
RU2412944C2 RU2007145219/05A RU2007145219A RU2412944C2 RU 2412944 C2 RU2412944 C2 RU 2412944C2 RU 2007145219/05 A RU2007145219/05 A RU 2007145219/05A RU 2007145219 A RU2007145219 A RU 2007145219A RU 2412944 C2 RU2412944 C2 RU 2412944C2
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Russia
Prior art keywords
oligosaccharide
mannose
unit
mannose unit
protein
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RU2007145219/05A
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English (en)
Russian (ru)
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RU2007145219A (ru
Inventor
Стефан ОСКАРСОН (SE)
Стефан ОСКАРСОН
Питер ТЕОДОРОВИЧ (SE)
Питер ТЕОДОРОВИЧ
Паоло КОНСТАНТИНО (IT)
Паоло КОНСТАНТИНО
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Новартис Вэксинз Энд Дайагностикс Срл
Стефан ОСКАРСОН
Питер ТЕОДОРОВИЧ
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Application filed by Новартис Вэксинз Энд Дайагностикс Срл, Стефан ОСКАРСОН, Питер ТЕОДОРОВИЧ filed Critical Новартис Вэксинз Энд Дайагностикс Срл
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C07H11/04—Phosphates; Phosphites; Polyphosphates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
RU2007145219/05A 2005-05-06 2006-05-08 Иммуногены для вакцин против менингита а RU2412944C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67828905P 2005-05-06 2005-05-06
US60/678,289 2005-05-06

Publications (2)

Publication Number Publication Date
RU2007145219A RU2007145219A (ru) 2009-06-20
RU2412944C2 true RU2412944C2 (ru) 2011-02-27

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ID=36942242

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RU2007145219/05A RU2412944C2 (ru) 2005-05-06 2006-05-08 Иммуногены для вакцин против менингита а

Country Status (15)

Country Link
US (1) US8062641B2 (https=)
EP (1) EP1885734B1 (https=)
JP (2) JP2008540398A (https=)
CN (1) CN101282984B (https=)
AU (1) AU2006245440B2 (https=)
BR (1) BRPI0611447A2 (https=)
CA (1) CA2606890C (https=)
ES (1) ES2533248T3 (https=)
MX (1) MX2007013881A (https=)
NZ (1) NZ563940A (https=)
PL (1) PL1885734T3 (https=)
PT (1) PT1885734E (https=)
RU (1) RU2412944C2 (https=)
WO (1) WO2006120576A2 (https=)
ZA (1) ZA200710558B (https=)

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PE20110072A1 (es) * 2005-06-27 2011-02-04 Glaxosmithkline Biolog Sa Composicion inmunogenica
AR064642A1 (es) 2006-12-22 2009-04-15 Wyeth Corp Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi
AU2014200640B2 (en) * 2007-01-11 2016-06-16 Glaxosmithkline Biologicals Sa Modified saccharides
GB0700562D0 (en) * 2007-01-11 2007-02-21 Novartis Vaccines & Diagnostic Modified Saccharides
KR101646960B1 (ko) 2007-10-16 2016-08-09 프로젠 피지500 시리즈 피티와이 리미티드 신규한 황산화된 올리고사카라이드 유도체
CN107913396B (zh) 2010-08-23 2022-03-08 惠氏有限责任公司 脑膜炎萘瑟氏菌rLP2086抗原的稳定制剂
EP2612148B1 (en) 2010-09-04 2019-06-12 GlaxoSmithKline Biologicals SA Bactericidal antibody assays to assess immunogenicity and potency of meningococcal capsular saccharide vaccines
AU2011300409B2 (en) 2010-09-10 2015-03-26 Wyeth Llc Non-lipidated variants of Neisseria meningitidis ORF2086 antigens
CN102417521B (zh) * 2010-09-28 2014-05-07 中国医学科学院医药生物技术研究所 一种非环核苷类抗病毒药物磷酸单酯化合物的制备方法
WO2012103444A2 (en) * 2011-01-28 2012-08-02 Purdue Research Foundation Immunogenic compositions and reagents for preparing
RU2476444C1 (ru) * 2011-07-15 2013-02-27 Российская Федерация, от имени которой выступает Министерство промышленности и торговли Российской Федерации (Минпромторг России) СПОСОБ ПОЛУЧЕНИЯ КОНЪЮГАТА НОНА-β-(1→3)-ГЛЮКОЗИДА С БЫЧЬИМ СЫВОРОТОЧНЫМ АЛЬБУМИНОМ СКВАРАТНЫМ МЕТОДОМ
SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
MY198910A (en) 2012-03-09 2023-10-02 Pfizer Neisseria meningitidis compositions and methods thereof
WO2014130613A2 (en) * 2013-02-22 2014-08-28 Amgen Inc. Carbohydrate phosphonate derivatives as modulators of glycosylation
WO2014136064A2 (en) 2013-03-08 2014-09-12 Pfizer Inc. Immunogenic fusion polypeptides
MX2016000099A (es) * 2013-07-07 2016-07-07 Max Planck Ges Zur Förderung Der Wissenschaften E V Vacunas sinteticas contra streptococcus pneumoniae tipo 1.
RU2662968C2 (ru) 2013-09-08 2018-07-31 Пфайзер Инк. Иммуногенная композиция против neisseria meningitidis (варианты)
CN106061986B (zh) * 2014-02-25 2020-07-07 默沙东和惠康基金会合资的希勒曼实验室私人有限公司 脑膜炎奈瑟菌血清组x的新的合成寡聚体及其制备方法
EA201700177A1 (ru) * 2014-10-09 2017-07-31 Мсд Уэлком Траст Хиллеман Лабораторис Пвт. Лтд. Улучшенный способ конъюгирования и полученные с помощью него новые синтетические конъюгаты олигосахарида с белком
WO2016132294A1 (en) 2015-02-19 2016-08-25 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
BR112019003992A2 (pt) 2016-09-02 2019-05-28 Sanofi Pasteur Inc vacina contra neisseria meningitidis
AU2018215585B2 (en) 2017-01-31 2022-03-17 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
WO2018173068A1 (en) * 2017-03-21 2018-09-27 Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd. A novel synthetic neisseria meningitidis serogroup a oligomer and process for synthesizing thereof
CA3120451A1 (en) 2018-11-22 2020-05-28 Idorsia Pharmaceuticals Ltd Stable vaccine against clostridium difficile with modifications to the ps-ii saccharide
WO2021059181A1 (en) 2019-09-27 2021-04-01 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
CN118178643B (zh) * 2024-04-28 2024-11-29 亚培烯科技(上海)有限公司 饱和α烯烃低聚物作为佐剂在动物疫苗中的应用

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RU2250113C2 (ru) * 2003-06-04 2005-04-20 Институт биоорганической химии им. академиков М.М.Шемякина и Ю.А.Овчинникова Российской академии наук Способ приготовления бивалентной вакцины для профилактики менингококковой инфекции

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TORRES-SANCHEZ M I ET AL: "Synthesis of the phosphono analogue of the dimeric subunit of Neisseria meningitides type A capsular polysaccharide" SYNLETT 02 MAY 2005 GERMANY, no.7, pages 1147-1151. BERKIN ALI ET AL: "Towards a synthetic glycoconjugate naccine against Neisseria meningitides A" CHEMISTRY (WEINHEIM AN DER BERGSTRASSE GERMANY) 4 ОСТ 2002, vol.8, №19, p.4424-4433. *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013009826A1 (en) * 2011-07-12 2013-01-17 The General Hospital Corporation Conjugating amines
US9616139B2 (en) 2011-07-12 2017-04-11 The General Hospital Corporation Conjugating amines

Also Published As

Publication number Publication date
JP2008540398A (ja) 2008-11-20
AU2006245440A1 (en) 2006-11-16
US20090304734A1 (en) 2009-12-10
EP1885734B1 (en) 2015-01-14
NZ563940A (en) 2010-11-26
WO2006120576A2 (en) 2006-11-16
ZA200710558B (en) 2010-04-28
EP1885734A2 (en) 2008-02-13
CA2606890C (en) 2014-02-04
MX2007013881A (es) 2008-10-22
PL1885734T3 (pl) 2015-08-31
US8062641B2 (en) 2011-11-22
PT1885734E (pt) 2015-03-04
CA2606890A1 (en) 2006-11-16
RU2007145219A (ru) 2009-06-20
AU2006245440B2 (en) 2012-04-19
CN101282984B (zh) 2013-05-08
CN101282984A (zh) 2008-10-08
ES2533248T3 (es) 2015-04-08
BRPI0611447A2 (pt) 2010-09-08
WO2006120576A3 (en) 2007-07-12
JP5699174B2 (ja) 2015-04-08
JP2013136639A (ja) 2013-07-11

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