CN101282984B - A型脑膜炎疫苗的免疫原 - Google Patents

A型脑膜炎疫苗的免疫原 Download PDF

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Publication number
CN101282984B
CN101282984B CN2006800243581A CN200680024358A CN101282984B CN 101282984 B CN101282984 B CN 101282984B CN 2006800243581 A CN2006800243581 A CN 2006800243581A CN 200680024358 A CN200680024358 A CN 200680024358A CN 101282984 B CN101282984 B CN 101282984B
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CN
China
Prior art keywords
oligosaccharides
unit
protein
seminose
seminose unit
Prior art date
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Expired - Fee Related
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CN2006800243581A
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English (en)
Chinese (zh)
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CN101282984A (zh
Inventor
S·奥斯卡松
P·特奥多罗维奇
P·科斯坦蒂诺
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Oscarson Stefan
S Oscar Song
Novartis Vaccines and Diagnostics Inc
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Novartis Vaccines and Diagnostics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C07H11/04—Phosphates; Phosphites; Polyphosphates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
CN2006800243581A 2005-05-06 2006-05-08 A型脑膜炎疫苗的免疫原 Expired - Fee Related CN101282984B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67828905P 2005-05-06 2005-05-06
US60/678,289 2005-05-06
PCT/IB2006/001703 WO2006120576A2 (en) 2005-05-06 2006-05-08 Immunogens for meningitidis-a vaccines

Publications (2)

Publication Number Publication Date
CN101282984A CN101282984A (zh) 2008-10-08
CN101282984B true CN101282984B (zh) 2013-05-08

Family

ID=36942242

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CN2006800243581A Expired - Fee Related CN101282984B (zh) 2005-05-06 2006-05-08 A型脑膜炎疫苗的免疫原

Country Status (15)

Country Link
US (1) US8062641B2 (https=)
EP (1) EP1885734B1 (https=)
JP (2) JP2008540398A (https=)
CN (1) CN101282984B (https=)
AU (1) AU2006245440B2 (https=)
BR (1) BRPI0611447A2 (https=)
CA (1) CA2606890C (https=)
ES (1) ES2533248T3 (https=)
MX (1) MX2007013881A (https=)
NZ (1) NZ563940A (https=)
PL (1) PL1885734T3 (https=)
PT (1) PT1885734E (https=)
RU (1) RU2412944C2 (https=)
WO (1) WO2006120576A2 (https=)
ZA (1) ZA200710558B (https=)

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US8398983B2 (en) 2005-06-27 2013-03-19 Glaxosmithkline Biologicals, S.A. Immunogenic composition
AR064642A1 (es) 2006-12-22 2009-04-15 Wyeth Corp Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi
GB0700562D0 (en) * 2007-01-11 2007-02-21 Novartis Vaccines & Diagnostic Modified Saccharides
AU2014200640B2 (en) * 2007-01-11 2016-06-16 Glaxosmithkline Biologicals Sa Modified saccharides
US8828952B2 (en) 2007-10-16 2014-09-09 Progen Pharmaceuticals Limited Sulfated oligosaccharide derivatives
KR101594228B1 (ko) 2010-08-23 2016-02-15 와이어쓰 엘엘씨 네이세리아 메닌기티디스 ｒＬＰ２０８６ 항원의 안정한 제제
ES2744471T3 (es) 2010-09-04 2020-02-25 Glaxosmithkline Biologicals Sa Ensayos de anticuerpos bactericidas para evaluar la inmunogenia y la potencia de vacunas de sacárido capsular meningocócico
NZ607224A (en) 2010-09-10 2014-11-28 Wyeth Llc Non-lipidated variants of neisseria meningitidis orf2086 antigens
CN102417521B (zh) * 2010-09-28 2014-05-07 中国医学科学院医药生物技术研究所 一种非环核苷类抗病毒药物磷酸单酯化合物的制备方法
WO2012103444A2 (en) * 2011-01-28 2012-08-02 Purdue Research Foundation Immunogenic compositions and reagents for preparing
US9616139B2 (en) 2011-07-12 2017-04-11 The General Hospital Corporation Conjugating amines
RU2476444C1 (ru) * 2011-07-15 2013-02-27 Российская Федерация, от имени которой выступает Министерство промышленности и торговли Российской Федерации (Минпромторг России) СПОСОБ ПОЛУЧЕНИЯ КОНЪЮГАТА НОНА-β-(1→3)-ГЛЮКОЗИДА С БЫЧЬИМ СЫВОРОТОЧНЫМ АЛЬБУМИНОМ СКВАРАТНЫМ МЕТОДОМ
MX359256B (es) 2012-03-09 2018-09-19 Pfizer Composiciones de neisseria meningitidis y metodos de las mismas.
SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
WO2014130613A2 (en) * 2013-02-22 2014-08-28 Amgen Inc. Carbohydrate phosphonate derivatives as modulators of glycosylation
US9802987B2 (en) 2013-03-08 2017-10-31 Pfizer Inc. Immunogenic fusion polypeptides
HK1224300A1 (zh) * 2013-07-07 2017-08-18 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. 合成针对1型肺炎链球菌的疫苗
RU2662968C2 (ru) 2013-09-08 2018-07-31 Пфайзер Инк. Иммуногенная композиция против neisseria meningitidis (варианты)
JP6526692B2 (ja) * 2014-02-25 2019-06-05 エムエスディー ウェルカム トラスト ヒルマン ラボラトリーズ プライベート リミテッドＭｓｄ Ｗｅｌｌｃｏｍｅ Ｔｒｕｓｔ Ｈｉｌｌｅｍａｎ Ｌａｂｏｒａｔｏｒｉｅｓ Ｐｖｔ．Ｌｔｄ． 髄膜炎菌（Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓ）血清型Ｘの新規の合成オリゴマー及びその調製方法
BR112017006447A2 (pt) * 2014-10-09 2017-12-12 Msd Wellcome Trust Hilleman Laboratories Pvt Ltd processo de conjugação e conjugados sintéticos de oligossacarídeo-proteína obtidos dos mesmos
AU2016221318B2 (en) 2015-02-19 2020-06-25 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
KR102906912B1 (ko) 2016-09-02 2026-01-05 사노피 파스퇴르 인크 네이세리아 메닌기티디스 백신
AU2018215585B2 (en) 2017-01-31 2022-03-17 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
WO2018173068A1 (en) * 2017-03-21 2018-09-27 Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd. A novel synthetic neisseria meningitidis serogroup a oligomer and process for synthesizing thereof
CA3120451A1 (en) 2018-11-22 2020-05-28 Idorsia Pharmaceuticals Ltd Stable vaccine against clostridium difficile with modifications to the ps-ii saccharide
EP4034157A1 (en) 2019-09-27 2022-08-03 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
CN118178643B (zh) * 2024-04-28 2024-11-29 亚培烯科技(上海)有限公司 饱和α烯烃低聚物作为佐剂在动物疫苗中的应用

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WO2004067030A2 (en) * 2003-01-30 2004-08-12 Chiron Srl Injectable vaccines against multiple meningococcal serogroups

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US6114309A (en) * 1997-11-21 2000-09-05 Incara Research Laboratories Combinatorial library of moenomycin analogs and methods of producing same
JP4774496B2 (ja) * 2001-06-14 2011-09-14 独立行政法人産業技術総合研究所 α−マンノシダーゼ
PT1777236T (pt) * 2002-03-26 2017-02-13 Glaxosmithkline Biologicals Sa Sacáridos modificados possuindo estabilidade melhorada em água para utilização como um medicamento
GB0220198D0 (en) * 2002-08-30 2002-10-09 Chiron Spa Modified saccharides,conjugates thereof and their manufacture
RU2250113C2 (ru) * 2003-06-04 2005-04-20 Институт биоорганической химии им. академиков М.М.Шемякина и Ю.А.Овчинникова Российской академии наук Способ приготовления бивалентной вакцины для профилактики менингококковой инфекции

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004067030A2 (en) * 2003-01-30 2004-08-12 Chiron Srl Injectable vaccines against multiple meningococcal serogroups

Non-Patent Citations (2)

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Ali Berkin et al.Towards a synthetic glycoconjugate vaccine against neisseria meningitidis A.《chem.Eur.J》.2002,第8卷(第19期),4424-4433. *
M.I.Torres et al.synthesis of the phosphono analogue of the dimeric subunit of neisseria meningitidis type a capsular polysaccharide.《SYNLETT》.2005,(第7期),1147-1151页. *

Also Published As

Publication number Publication date
ES2533248T3 (es) 2015-04-08
EP1885734B1 (en) 2015-01-14
US20090304734A1 (en) 2009-12-10
AU2006245440A1 (en) 2006-11-16
JP5699174B2 (ja) 2015-04-08
JP2008540398A (ja) 2008-11-20
NZ563940A (en) 2010-11-26
CN101282984A (zh) 2008-10-08
RU2007145219A (ru) 2009-06-20
MX2007013881A (es) 2008-10-22
JP2013136639A (ja) 2013-07-11
RU2412944C2 (ru) 2011-02-27
EP1885734A2 (en) 2008-02-13
ZA200710558B (en) 2010-04-28
AU2006245440B2 (en) 2012-04-19
CA2606890A1 (en) 2006-11-16
CA2606890C (en) 2014-02-04
PL1885734T3 (pl) 2015-08-31
WO2006120576A2 (en) 2006-11-16
PT1885734E (pt) 2015-03-04
BRPI0611447A2 (pt) 2010-09-08
WO2006120576A3 (en) 2007-07-12
US8062641B2 (en) 2011-11-22

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C06 Publication
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C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: STEFAN OSCARSON PETER TEODOROVIC

Free format text: FORMER OWNER: STOCKHOLM UNIVERSITY

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20100825

Address after: Siena city of Italy

Applicant after: NOVARTIS VACCINES & DIAGNOSTIC

Co-applicant after: S. Oscar Song

Co-applicant after: Oscarson Stefan

Address before: Siena city of Italy

Applicant before: NOVARTIS VACCINES & DIAGNOSTIC

Co-applicant before: Stockholm University

C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20130508