RU2398567C2 - Трансдермальная терапевтическая система с адгезионным слоем, способ силиконизации слоя основы системы и применение слоя основы - Google Patents

Трансдермальная терапевтическая система с адгезионным слоем, способ силиконизации слоя основы системы и применение слоя основы Download PDF

Info

Publication number
RU2398567C2
RU2398567C2 RU2007113674/15A RU2007113674A RU2398567C2 RU 2398567 C2 RU2398567 C2 RU 2398567C2 RU 2007113674/15 A RU2007113674/15 A RU 2007113674/15A RU 2007113674 A RU2007113674 A RU 2007113674A RU 2398567 C2 RU2398567 C2 RU 2398567C2
Authority
RU
Russia
Prior art keywords
transdermal therapeutic
layer
therapeutic system
base layer
substrate
Prior art date
Application number
RU2007113674/15A
Other languages
English (en)
Russian (ru)
Other versions
RU2007113674A (ru
Inventor
Вальтер МЮЛЛЕР (DE)
Вальтер Мюллер
Йоханнес ЛЕОНХАРД (DE)
Йоханнес ЛЕОНХАРД
Original Assignee
Лтс Ломанн Терапи-Системе Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Лтс Ломанн Терапи-Системе Аг filed Critical Лтс Ломанн Терапи-Системе Аг
Publication of RU2007113674A publication Critical patent/RU2007113674A/ru
Application granted granted Critical
Publication of RU2398567C2 publication Critical patent/RU2398567C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/023—Adhesive bandages or dressings wound covering film layers without a fluid retention layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0246—Adhesive bandages or dressings characterised by the skin-adhering layer
    • A61F13/0253—Adhesive bandages or dressings characterised by the skin-adhering layer characterized by the adhesive material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/34—Silicon-containing compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0246—Adhesive bandages or dressings characterised by the skin-adhering layer

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
RU2007113674/15A 2004-09-13 2005-09-06 Трансдермальная терапевтическая система с адгезионным слоем, способ силиконизации слоя основы системы и применение слоя основы RU2398567C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004044578A DE102004044578A1 (de) 2004-09-13 2004-09-13 Transdermales therapeutisches System mit einer Haftschicht, Verfahren zum Silikonisieren einer Rückschicht des Systems und Verwendung der Rückschicht
DE102004044578.8 2004-09-13

Publications (2)

Publication Number Publication Date
RU2007113674A RU2007113674A (ru) 2008-10-27
RU2398567C2 true RU2398567C2 (ru) 2010-09-10

Family

ID=35911201

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2007113674/15A RU2398567C2 (ru) 2004-09-13 2005-09-06 Трансдермальная терапевтическая система с адгезионным слоем, способ силиконизации слоя основы системы и применение слоя основы

Country Status (25)

Country Link
US (2) US9226903B2 (https=)
EP (2) EP1791533B1 (https=)
JP (1) JP4921371B2 (https=)
KR (1) KR101297903B1 (https=)
CN (2) CN101018545A (https=)
AR (1) AR050621A1 (https=)
AU (1) AU2005284436B2 (https=)
BR (1) BRPI0515270B8 (https=)
CA (1) CA2578534C (https=)
CY (2) CY1113997T1 (https=)
DE (1) DE102004044578A1 (https=)
DK (2) DK2529732T3 (https=)
ES (2) ES2406958T3 (https=)
IL (1) IL181337A (https=)
LT (1) LT2529732T (https=)
MX (1) MX2007002966A (https=)
NZ (1) NZ553485A (https=)
PH (1) PH12012501165A1 (https=)
PL (2) PL1791533T3 (https=)
PT (2) PT1791533E (https=)
RU (1) RU2398567C2 (https=)
SI (2) SI2529732T1 (https=)
TW (1) TWI383811B (https=)
WO (1) WO2006029740A2 (https=)
ZA (1) ZA200701138B (https=)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8252321B2 (en) 2004-09-13 2012-08-28 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like
AU2005284908B2 (en) 2004-09-13 2011-12-08 Morningside Venture Investments Limited Biosynchronous transdermal drug delivery
US8518926B2 (en) * 2006-04-10 2013-08-27 Knopp Neurosciences, Inc. Compositions and methods of using (R)-pramipexole
US20070259930A1 (en) * 2006-04-10 2007-11-08 Knopp Neurosciences, Inc. Compositions and methods of using r(+) pramipexole
ATE537826T1 (de) 2006-05-16 2012-01-15 Knopp Neurosciences Inc Zusammensetzungen aus r(+)- und s(-)-pramipexol sowie verfahren zu ihrer anwendung
US8524695B2 (en) * 2006-12-14 2013-09-03 Knopp Neurosciences, Inc. Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same
JP2010521496A (ja) 2007-03-14 2010-06-24 ノップ ニューロサイエンシーズ、インク． キラル精製置換ベンゾチアゾールジアミンの合成
US20110190356A1 (en) * 2008-08-19 2011-08-04 Knopp Neurosciences Inc. Compositions and Methods of Using (R)- Pramipexole
AU2010262970A1 (en) * 2009-06-19 2012-01-12 Knopp Neurosciences, Inc. Compositions and methods for treating amyotrophic lateral sclerosis
WO2013006643A1 (en) 2011-07-06 2013-01-10 The Parkinson's Institute Compositions and methods for treatment of symptoms in parkinson's disease patients
WO2013096816A1 (en) 2011-12-22 2013-06-27 Biogen Idec Ma Inc. Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
KR101850161B1 (ko) 2012-05-17 2018-04-19 도레이첨단소재 주식회사 경피흡수제에 적합하게 사용될 수 있는 릴리즈 라이너 및 그 제조방법
US9662313B2 (en) 2013-02-28 2017-05-30 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
US9468630B2 (en) 2013-07-12 2016-10-18 Knopp Biosciences Llc Compositions and methods for treating conditions related to increased eosinophils
PL3019167T3 (pl) 2013-07-12 2021-06-14 Knopp Biosciences Llc Leczenie podwyższonych poziomów eozynofili i/lub bazofili
DK3033081T3 (da) 2013-08-13 2021-05-31 Knopp Biosciences Llc Sammensætninger og fremgangsmåder til behandling af kronisk urticaria
EP3038467B1 (en) 2013-08-13 2020-07-29 Knopp Biosciences LLC Compositions and methods for treating plasma cell disorders and b-cell prolymphocytic disorders
EP3049120B1 (fr) * 2013-09-24 2018-10-31 Zodiac Coating Procede de realisation d'un materiau adhesif pour application medicale
EP2921184A1 (de) * 2014-03-19 2015-09-23 LTS LOHMANN Therapie-Systeme AG Überpflaster mit verbesserter Verträglichkeit und einer langen Haftungsdauer und Verfahren zu seiner Herstellung
AU2016211330A1 (en) 2015-01-28 2017-08-03 Chrono Therapeutics Inc. Drug delivery methods and systems
US10679516B2 (en) 2015-03-12 2020-06-09 Morningside Venture Investments Limited Craving input and support system
CA3049529A1 (en) 2017-01-06 2018-07-12 Chrono Therapeutics Inc. Transdermal drug delivery devices and methods
US11596779B2 (en) 2018-05-29 2023-03-07 Morningside Venture Investments Limited Drug delivery methods and systems
US12397141B2 (en) 2018-11-16 2025-08-26 Morningside Venture Investments Limited Thermally regulated transdermal drug delivery system

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2002102869A (ru) * 1999-07-02 2003-10-10 Лтс Ломанн Терапи-Системе Аг Микрорезервуарная система на основе полисилоксанов и амбифильных растворителей
WO2004069286A2 (de) * 2003-02-07 2004-08-19 Lts Lohmann Therapie-Systeme Ag Für die wärmeanwendung zur beschleunigung der permeation von wirkstoffen geeignetes transdermales therapeutisches system und seine verwendung

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3131734A1 (de) * 1981-08-11 1983-02-24 Bayer Ag, 5090 Leverkusen Hitzehaertbare organopolysiloxan-mischungen
US4806341A (en) * 1985-02-25 1989-02-21 Rutgers, The State University Of New Jersey Transdermal absorption dosage unit for narcotic analgesics and antagonists and process for administration
FR2619388A1 (fr) * 1987-08-14 1989-02-17 Rhone Poulenc Chimie Article stratifie souple pour adhesif de transfert
DE19738643C2 (de) * 1997-09-04 2001-10-04 Lohmann Therapie Syst Lts Transdermales therapeutisches System mit dem Wirkstoff Scopolaminbase und Verfahren zu seiner Herstellung
AU733564B2 (en) * 1997-09-16 2001-05-17 Teijin Limited Gel-form pressure-sensitive adhesive, and adhesive material and adhesive medicinal preparation both containing the same
CN1195505C (zh) * 1999-07-02 2005-04-06 Lts勒曼治疗系统股份公司 以聚硅氧烷及亲两性溶剂为基础的微贮存系统
US6261595B1 (en) 2000-02-29 2001-07-17 Zars, Inc. Transdermal drug patch with attached pocket for controlled heating device
DE10015783C2 (de) * 2000-03-30 2003-12-04 Lohmann Therapie Syst Lts Transdermales therapeutisches System zur Abgabe von Lerisetron und seine Verwendung
US6488599B2 (en) * 2000-06-06 2002-12-03 Lifetime Products, Inc. System and method for basketball goal height adjustment
GB0017468D0 (en) * 2000-07-18 2000-08-30 Dow Corning Silicone release coating compositions
DE10060550C1 (de) * 2000-12-06 2002-04-18 Lohmann Therapie Syst Lts Transdermales therapeutisches System mit dem Wirkstoff Oxybutynin und Verfahren zur Herstellung Oxybutynin enthaltender Wirkstoffschichten
US20030224090A1 (en) * 2002-02-11 2003-12-04 Edizone, Lc Snacks of orally soluble edible films
ITRM20020378A1 (it) 2002-07-15 2004-01-15 Euro 3 S R L Dispositivo iniettore ipodermico attivabile.
CN100512806C (zh) * 2003-04-14 2009-07-15 Lts勒曼治疗系统股份公司 具有包含辣椒碱的聚硅氧烷基质的治疗贴剂
US7407709B2 (en) * 2003-12-22 2008-08-05 3M Innovative Properties Company Silicone pressure sensitive adhesive and articles
KR20070004587A (ko) * 2003-12-23 2007-01-09 게에 바이엘 실리콘스 게엠베하 운트 코. 카게 개질된 표면 특성을 갖는 경화성 실록산 조성물
US20050282977A1 (en) * 2004-06-17 2005-12-22 Emil Stempel Cross-linked gel and pressure sensitive adhesive blend, and skin-attachable products using the same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2002102869A (ru) * 1999-07-02 2003-10-10 Лтс Ломанн Терапи-Системе Аг Микрорезервуарная система на основе полисилоксанов и амбифильных растворителей
WO2004069286A2 (de) * 2003-02-07 2004-08-19 Lts Lohmann Therapie-Systeme Ag Für die wärmeanwendung zur beschleunigung der permeation von wirkstoffen geeignetes transdermales therapeutisches system und seine verwendung

Also Published As

Publication number Publication date
US20160074336A1 (en) 2016-03-17
DE102004044578A1 (de) 2006-03-30
PT2529732T (pt) 2017-07-17
CY1120228T1 (el) 2018-12-12
IL181337A (en) 2014-09-30
JP2008512411A (ja) 2008-04-24
US9226903B2 (en) 2016-01-05
PL2529732T3 (pl) 2017-12-29
AU2005284436B2 (en) 2011-02-17
DK1791533T3 (da) 2013-06-10
ES2634439T3 (es) 2017-09-27
CN102755305A (zh) 2012-10-31
KR101297903B1 (ko) 2013-08-22
ZA200701138B (en) 2008-08-27
PL1791533T3 (pl) 2013-08-30
BRPI0515270B1 (pt) 2018-11-06
IL181337A0 (en) 2007-07-04
CA2578534A1 (en) 2006-03-23
KR20070053244A (ko) 2007-05-23
BRPI0515270A (pt) 2008-07-15
PH12012501165A1 (en) 2013-09-02
JP4921371B2 (ja) 2012-04-25
PT1791533E (pt) 2013-05-07
MX2007002966A (es) 2007-04-27
TW200621319A (en) 2006-07-01
EP2529732B1 (de) 2017-06-21
WO2006029740A2 (de) 2006-03-23
US20080026043A1 (en) 2008-01-31
AR050621A1 (es) 2006-11-08
TWI383811B (zh) 2013-02-01
CY1113997T1 (el) 2016-07-27
NZ553485A (en) 2010-06-25
DK2529732T3 (en) 2017-09-18
EP2529732A1 (de) 2012-12-05
US10034841B2 (en) 2018-07-31
CN101018545A (zh) 2007-08-15
AU2005284436A1 (en) 2006-03-23
RU2007113674A (ru) 2008-10-27
EP1791533A2 (de) 2007-06-06
BRPI0515270B8 (pt) 2021-07-27
LT2529732T (lt) 2017-09-11
SI2529732T1 (sl) 2017-10-30
WO2006029740A3 (de) 2006-06-22
SI1791533T1 (sl) 2013-05-31
CA2578534C (en) 2013-03-19
EP1791533B1 (de) 2013-03-06
ES2406958T3 (es) 2013-06-10

Similar Documents

Publication Publication Date Title
RU2398567C2 (ru) Трансдермальная терапевтическая система с адгезионным слоем, способ силиконизации слоя основы системы и применение слоя основы
FI100987B (fi) Puristusherkkä sulatesilikonipohjainen liima-ainekoostumus ja siihen l iittyvät menetelmät ja tuotteet
CA2139992A1 (en) Hot-melt silicone pressure sensitive adhesive with siloxylated polyether waxes as additives
JPH05202349A (ja) アルキルメチルシロキサン・ワックス含有のシリコーン感圧接着剤及び関連の方法及びデバイス
WO2001066095A1 (fr) Timbre extensible
JP2007514011A (ja) シリコーンゲルをプラスチックに接着させるための方法
CN107820432B (zh) 硅胶涂覆的粘附性层结构
JP3576621B2 (ja) シロキシル化アリルオキシプロパンジオールコポリマーを添加剤として含有するホットメルトシリコーン感圧接着剤組成物
KR102741324B1 (ko) 의료용 첩부재
HK1105360A (en) Transdermal therapeutic system comprising an adhesive layer method for siliconizing the back layer of the system and use of said back layer
HK1175110A (zh) 具有粘着层的经皮治疗系统，将该系统的背衬层加以硅氧烷化的方法以及该背衬层的用途
KR100790703B1 (ko) 피부 적용을 위한 의료용 반창고
HK40061153B (zh) 医疗用贴附材料
JPS61136571A (ja) 剥離性処理剤
EP3411023A1 (en) Transdermal drug delivery systems with fluorosilicone release liners