DK2529732T3 - Transdermal therapeutic system with an adhesive layer, method of silicone treatment of a backing layer in the system and application of the backing layer - Google Patents
Transdermal therapeutic system with an adhesive layer, method of silicone treatment of a backing layer in the system and application of the backing layer Download PDFInfo
- Publication number
- DK2529732T3 DK2529732T3 DK12006147.8T DK12006147T DK2529732T3 DK 2529732 T3 DK2529732 T3 DK 2529732T3 DK 12006147 T DK12006147 T DK 12006147T DK 2529732 T3 DK2529732 T3 DK 2529732T3
- Authority
- DK
- Denmark
- Prior art keywords
- layer
- transdermal therapeutic
- backing layer
- therapeutic system
- silicone
- Prior art date
Links
- 239000010410 layer Substances 0.000 title claims description 69
- 229920001296 polysiloxane Polymers 0.000 title claims description 35
- 230000001225 therapeutic effect Effects 0.000 title claims description 19
- 239000012790 adhesive layer Substances 0.000 title claims description 9
- 238000000034 method Methods 0.000 title claims description 5
- 239000000853 adhesive Substances 0.000 claims description 18
- 239000013464 silicone adhesive Substances 0.000 claims description 18
- -1 polyethylene terephthalate Polymers 0.000 claims description 16
- 229920000642 polymer Polymers 0.000 claims description 15
- 239000002904 solvent Substances 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 9
- 239000011241 protective layer Substances 0.000 claims description 8
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 8
- 229920000728 polyester Polymers 0.000 claims description 7
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 229920000139 polyethylene terephthalate Polymers 0.000 claims description 6
- 239000005020 polyethylene terephthalate Substances 0.000 claims description 6
- 239000003054 catalyst Substances 0.000 claims description 5
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims description 5
- 239000004698 Polyethylene Substances 0.000 claims description 4
- 239000004743 Polypropylene Substances 0.000 claims description 4
- 229920001577 copolymer Polymers 0.000 claims description 4
- 239000005038 ethylene vinyl acetate Substances 0.000 claims description 4
- 229920000573 polyethylene Polymers 0.000 claims description 4
- 229920001155 polypropylene Polymers 0.000 claims description 4
- 229920001328 Polyvinylidene chloride Polymers 0.000 claims description 3
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 3
- 229920002635 polyurethane Polymers 0.000 claims description 3
- 239000004814 polyurethane Substances 0.000 claims description 3
- 239000005033 polyvinylidene chloride Substances 0.000 claims description 3
- 229920000298 Cellophane Polymers 0.000 claims description 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims description 2
- 239000001856 Ethyl cellulose Substances 0.000 claims description 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 2
- 239000005977 Ethylene Substances 0.000 claims description 2
- 239000001089 [(2R)-oxolan-2-yl]methanol Substances 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 229920002301 cellulose acetate Polymers 0.000 claims description 2
- SBZXBUIDTXKZTM-UHFFFAOYSA-N diglyme Chemical compound COCCOCCOC SBZXBUIDTXKZTM-UHFFFAOYSA-N 0.000 claims description 2
- 229920001249 ethyl cellulose Polymers 0.000 claims description 2
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 2
- 150000002191 fatty alcohols Chemical class 0.000 claims description 2
- BSYVTEYKTMYBMK-UHFFFAOYSA-N tetrahydrofurfuryl alcohol Chemical compound OCC1CCCO1 BSYVTEYKTMYBMK-UHFFFAOYSA-N 0.000 claims description 2
- 239000013543 active substance Substances 0.000 claims 2
- 239000013047 polymeric layer Substances 0.000 claims 2
- MFZIBZIYFYCONN-UHFFFAOYSA-N 2-(2-butoxyethoxy)ethanol;2-(2-hydroxyethoxy)ethanol Chemical compound OCCOCCO.CCCCOCCOCCO MFZIBZIYFYCONN-UHFFFAOYSA-N 0.000 claims 1
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 claims 1
- 229940075557 diethylene glycol monoethyl ether Drugs 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 239000002985 plastic film Substances 0.000 claims 1
- 229920006255 plastic film Polymers 0.000 claims 1
- 239000011347 resin Substances 0.000 claims 1
- 229920005573 silicon-containing polymer Polymers 0.000 claims 1
- 229920002050 silicone resin Polymers 0.000 claims 1
- 230000001070 adhesive effect Effects 0.000 description 15
- 239000004480 active ingredient Substances 0.000 description 13
- 239000010408 film Substances 0.000 description 8
- 239000011159 matrix material Substances 0.000 description 7
- 230000015572 biosynthetic process Effects 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 4
- 238000000576 coating method Methods 0.000 description 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 4
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 229920003235 aromatic polyamide Polymers 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 229910052697 platinum Inorganic materials 0.000 description 2
- 238000005475 siliconizing Methods 0.000 description 2
- 238000003892 spreading Methods 0.000 description 2
- SBASXUCJHJRPEV-UHFFFAOYSA-N 2-(2-methoxyethoxy)ethanol Chemical compound COCCOCCO SBASXUCJHJRPEV-UHFFFAOYSA-N 0.000 description 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 150000001733 carboxylic acid esters Chemical class 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 229940028356 diethylene glycol monobutyl ether Drugs 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- JCGNDDUYTRNOFT-UHFFFAOYSA-N oxolane-2,4-dione Chemical compound O=C1COC(=O)C1 JCGNDDUYTRNOFT-UHFFFAOYSA-N 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/023—Adhesive bandages or dressings wound covering film layers without a fluid retention layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0246—Adhesive bandages or dressings characterised by the skin-adhering layer
- A61F13/0253—Adhesive bandages or dressings characterised by the skin-adhering layer characterized by the adhesive material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/34—Silicon-containing compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0246—Adhesive bandages or dressings characterised by the skin-adhering layer
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004044578A DE102004044578A1 (de) | 2004-09-13 | 2004-09-13 | Transdermales therapeutisches System mit einer Haftschicht, Verfahren zum Silikonisieren einer Rückschicht des Systems und Verwendung der Rückschicht |
| EP05777179A EP1791533B1 (de) | 2004-09-13 | 2005-09-06 | Transdermales therapeutisches system mit einer haftschicht, verfahren zum silikonisieren einer rückschicht des systems und verwendung der rückschicht |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2529732T3 true DK2529732T3 (en) | 2017-09-18 |
Family
ID=35911201
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12006147.8T DK2529732T3 (en) | 2004-09-13 | 2005-09-06 | Transdermal therapeutic system with an adhesive layer, method of silicone treatment of a backing layer in the system and application of the backing layer |
| DK05777179.2T DK1791533T3 (da) | 2004-09-13 | 2005-09-06 | Transdermalt terapeutisk system med et klæbelag, fremgangsmåde til silikonebehandling af et bagsidelag i systemet samt anvendelse af bagsidelaget |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05777179.2T DK1791533T3 (da) | 2004-09-13 | 2005-09-06 | Transdermalt terapeutisk system med et klæbelag, fremgangsmåde til silikonebehandling af et bagsidelag i systemet samt anvendelse af bagsidelaget |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US9226903B2 (https=) |
| EP (2) | EP1791533B1 (https=) |
| JP (1) | JP4921371B2 (https=) |
| KR (1) | KR101297903B1 (https=) |
| CN (2) | CN101018545A (https=) |
| AR (1) | AR050621A1 (https=) |
| AU (1) | AU2005284436B2 (https=) |
| BR (1) | BRPI0515270B8 (https=) |
| CA (1) | CA2578534C (https=) |
| CY (2) | CY1113997T1 (https=) |
| DE (1) | DE102004044578A1 (https=) |
| DK (2) | DK2529732T3 (https=) |
| ES (2) | ES2634439T3 (https=) |
| IL (1) | IL181337A (https=) |
| LT (1) | LT2529732T (https=) |
| MX (1) | MX2007002966A (https=) |
| NZ (1) | NZ553485A (https=) |
| PH (1) | PH12012501165A1 (https=) |
| PL (2) | PL1791533T3 (https=) |
| PT (2) | PT1791533E (https=) |
| RU (1) | RU2398567C2 (https=) |
| SI (2) | SI2529732T1 (https=) |
| TW (1) | TWI383811B (https=) |
| WO (1) | WO2006029740A2 (https=) |
| ZA (1) | ZA200701138B (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5254616B2 (ja) | 2004-09-13 | 2013-08-07 | クロノ セラピューティクス、インコーポレイテッド | 生物学的同調性（ｂｉｏｓｙｎｃｈｒｏｎｏｕｓ）経皮的薬物送達 |
| US8252321B2 (en) | 2004-09-13 | 2012-08-28 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like |
| WO2007121188A2 (en) * | 2006-04-10 | 2007-10-25 | Knopp Neurosciences, Inc. | Compositions and methods of using r(+) pramipexole |
| US8518926B2 (en) * | 2006-04-10 | 2013-08-27 | Knopp Neurosciences, Inc. | Compositions and methods of using (R)-pramipexole |
| ES2379117T3 (es) | 2006-05-16 | 2012-04-20 | Knopp Neurosciences, Inc. | Composiciones de R(+) y S(-) pramipexol y métodos de utilización de las mismas |
| US8524695B2 (en) * | 2006-12-14 | 2013-09-03 | Knopp Neurosciences, Inc. | Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same |
| CA2681110A1 (en) * | 2007-03-14 | 2008-09-18 | Knopp Neurosciences, Inc. | Synthesis of chirally purified substituted benzothiazole diamines |
| KR20110071064A (ko) * | 2008-08-19 | 2011-06-28 | 크놉 뉴로사이언시스 인코포레이티드 | (ｒ)-프라미펙솔을 사용하는 조성물 및 방법 |
| RU2012101792A (ru) * | 2009-06-19 | 2013-07-27 | Нопп Ньюросайенсиз, Инк. | Композиции и способы для лечения бокового амиотрофического склероза |
| US20130017259A1 (en) | 2011-07-06 | 2013-01-17 | The Parkinson's Institute | Compositions and Methods for Treatment of Symptoms in Parkinson's Disease Patients |
| WO2013096816A1 (en) | 2011-12-22 | 2013-06-27 | Biogen Idec Ma Inc. | Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds |
| KR101850161B1 (ko) | 2012-05-17 | 2018-04-19 | 도레이첨단소재 주식회사 | 경피흡수제에 적합하게 사용될 수 있는 릴리즈 라이너 및 그 제조방법 |
| US9662313B2 (en) | 2013-02-28 | 2017-05-30 | Knopp Biosciences Llc | Compositions and methods for treating amyotrophic lateral sclerosis in responders |
| US9468630B2 (en) | 2013-07-12 | 2016-10-18 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to increased eosinophils |
| EP3838271B1 (en) | 2013-07-12 | 2025-09-03 | Areteia Therapeutics, Inc. | Treating elevated levels of eosinophils and/or basophils |
| ES2813674T3 (es) | 2013-08-13 | 2021-03-24 | Knopp Biosciences Llc | Composiciones y métodos para el tratamiento de trastornos de células plasmáticas y trastornos prolinfocíticos de células b |
| CA2921381A1 (en) | 2013-08-13 | 2015-02-19 | Knopp Biosciences Llc | Compositions and methods for treating chronic urticaria |
| EP3049120B1 (fr) * | 2013-09-24 | 2018-10-31 | Zodiac Coating | Procede de realisation d'un materiau adhesif pour application medicale |
| EP2921184A1 (de) * | 2014-03-19 | 2015-09-23 | LTS LOHMANN Therapie-Systeme AG | Überpflaster mit verbesserter Verträglichkeit und einer langen Haftungsdauer und Verfahren zu seiner Herstellung |
| JP2018511355A (ja) | 2015-01-28 | 2018-04-26 | クロノ セラピューティクス インコーポレイテッドＣｈｒｏｎｏ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． | 薬剤送達方法及びシステム |
| AU2016228779A1 (en) | 2015-03-12 | 2017-09-07 | Chrono Therapeutics Inc. | Craving input and support system |
| EP3565617A1 (en) | 2017-01-06 | 2019-11-13 | Chrono Therapeutics Inc. | Transdermal drug delivery devices and methods |
| EP3801732A4 (en) | 2018-05-29 | 2022-04-27 | Morningside Venture Investments Limited | METHODS AND SYSTEMS FOR DRUG DELIVERY |
| US12397141B2 (en) | 2018-11-16 | 2025-08-26 | Morningside Venture Investments Limited | Thermally regulated transdermal drug delivery system |
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| DE3131734A1 (de) * | 1981-08-11 | 1983-02-24 | Bayer Ag, 5090 Leverkusen | Hitzehaertbare organopolysiloxan-mischungen |
| US4806341A (en) * | 1985-02-25 | 1989-02-21 | Rutgers, The State University Of New Jersey | Transdermal absorption dosage unit for narcotic analgesics and antagonists and process for administration |
| FR2619388A1 (fr) * | 1987-08-14 | 1989-02-17 | Rhone Poulenc Chimie | Article stratifie souple pour adhesif de transfert |
| DE19738643C2 (de) * | 1997-09-04 | 2001-10-04 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit dem Wirkstoff Scopolaminbase und Verfahren zu seiner Herstellung |
| CA2303936A1 (en) * | 1997-09-16 | 1999-03-25 | Teijin Limited | Gel-form pressure-sensitive adhesive, and adhesive material and adhesive medicinal preparation both containing the same |
| ATE234081T1 (de) * | 1999-07-02 | 2003-03-15 | Lohmann Therapie Syst Lts | Mikroreservoirsystem auf basis von polysiloxanen und ambiphilen lösemitteln |
| US6261595B1 (en) | 2000-02-29 | 2001-07-17 | Zars, Inc. | Transdermal drug patch with attached pocket for controlled heating device |
| DE10015783C2 (de) * | 2000-03-30 | 2003-12-04 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System zur Abgabe von Lerisetron und seine Verwendung |
| US6488599B2 (en) | 2000-06-06 | 2002-12-03 | Lifetime Products, Inc. | System and method for basketball goal height adjustment |
| GB0017468D0 (en) * | 2000-07-18 | 2000-08-30 | Dow Corning | Silicone release coating compositions |
| DE10060550C1 (de) * | 2000-12-06 | 2002-04-18 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit dem Wirkstoff Oxybutynin und Verfahren zur Herstellung Oxybutynin enthaltender Wirkstoffschichten |
| US20030224090A1 (en) * | 2002-02-11 | 2003-12-04 | Edizone, Lc | Snacks of orally soluble edible films |
| ITRM20020378A1 (it) | 2002-07-15 | 2004-01-15 | Euro 3 S R L | Dispositivo iniettore ipodermico attivabile. |
| MXPA05008366A (es) * | 2003-02-07 | 2005-11-04 | Lohmann Therapie Syst Lts | Sistema terapeutico transdermico adecuado para la aplicacion de calor para promover la penetracion de sustancias activas y el uso del mismo. |
| RU2349315C9 (ru) * | 2003-04-14 | 2010-02-27 | Лтс Ломанн Терапи-Системе Аг | Терапевтический пластырь с полисилоксановой матрицей, содержащей капсаицин |
| US7407709B2 (en) * | 2003-12-22 | 2008-08-05 | 3M Innovative Properties Company | Silicone pressure sensitive adhesive and articles |
| BRPI0418131A (pt) * | 2003-12-23 | 2007-04-27 | Ge Bayer Silicones Gmbh & Co | composição de siloxano curável com propriedades de superfìcie modificadas |
| US20050282977A1 (en) * | 2004-06-17 | 2005-12-22 | Emil Stempel | Cross-linked gel and pressure sensitive adhesive blend, and skin-attachable products using the same |
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2004
- 2004-09-13 DE DE102004044578A patent/DE102004044578A1/de not_active Ceased
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2005
- 2005-08-30 AR ARP050103629A patent/AR050621A1/es active IP Right Grant
- 2005-09-02 TW TW094130154A patent/TWI383811B/zh not_active IP Right Cessation
- 2005-09-06 PL PL05777179T patent/PL1791533T3/pl unknown
- 2005-09-06 CN CNA2005800305367A patent/CN101018545A/zh active Pending
- 2005-09-06 CN CN2012102639862A patent/CN102755305A/zh active Pending
- 2005-09-06 DK DK12006147.8T patent/DK2529732T3/en active
- 2005-09-06 EP EP05777179A patent/EP1791533B1/de not_active Expired - Lifetime
- 2005-09-06 LT LTEP12006147.8T patent/LT2529732T/lt unknown
- 2005-09-06 JP JP2007530634A patent/JP4921371B2/ja not_active Expired - Lifetime
- 2005-09-06 CA CA2578534A patent/CA2578534C/en not_active Expired - Lifetime
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- 2005-09-06 AU AU2005284436A patent/AU2005284436B2/en not_active Expired
- 2005-09-06 KR KR1020077005735A patent/KR101297903B1/ko not_active Expired - Lifetime
- 2005-09-06 WO PCT/EP2005/009547 patent/WO2006029740A2/de not_active Ceased
- 2005-09-06 PH PH1/2012/501165A patent/PH12012501165A1/en unknown
- 2005-09-06 PT PT57771792T patent/PT1791533E/pt unknown
- 2005-09-06 RU RU2007113674/15A patent/RU2398567C2/ru active
- 2005-09-06 BR BRPI0515270A patent/BRPI0515270B8/pt active IP Right Grant
- 2005-09-06 NZ NZ553485A patent/NZ553485A/en not_active IP Right Cessation
- 2005-09-06 ES ES12006147.8T patent/ES2634439T3/es not_active Expired - Lifetime
- 2005-09-06 SI SI200532168T patent/SI2529732T1/sl unknown
- 2005-09-06 PT PT120061478T patent/PT2529732T/pt unknown
- 2005-09-06 EP EP12006147.8A patent/EP2529732B1/de not_active Expired - Lifetime
- 2005-09-06 MX MX2007002966A patent/MX2007002966A/es active IP Right Grant
- 2005-09-06 PL PL12006147T patent/PL2529732T3/pl unknown
- 2005-09-06 DK DK05777179.2T patent/DK1791533T3/da active
- 2005-09-06 SI SI200531700T patent/SI1791533T1/sl unknown
- 2005-09-06 ES ES05777179T patent/ES2406958T3/es not_active Expired - Lifetime
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2007
- 2007-02-08 ZA ZA200701138A patent/ZA200701138B/xx unknown
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2013
- 2013-05-16 CY CY20131100401T patent/CY1113997T1/el unknown
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2015
- 2015-11-30 US US14/953,789 patent/US10034841B2/en not_active Expired - Lifetime
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2017
- 2017-09-13 CY CY20171100968T patent/CY1120228T1/el unknown
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