RU2382041C2 - Новые сложные эфиры кватернизованного хинуклидина - Google Patents
Новые сложные эфиры кватернизованного хинуклидина Download PDFInfo
- Publication number
- RU2382041C2 RU2382041C2 RU2006136085/04A RU2006136085A RU2382041C2 RU 2382041 C2 RU2382041 C2 RU 2382041C2 RU 2006136085/04 A RU2006136085/04 A RU 2006136085/04A RU 2006136085 A RU2006136085 A RU 2006136085A RU 2382041 C2 RU2382041 C2 RU 2382041C2
- Authority
- RU
- Russia
- Prior art keywords
- hydroxy
- octane
- azoniumbicyclo
- acetoxy
- dithien
- Prior art date
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- 150000002148 esters Chemical class 0.000 title description 3
- SBYHFKPVCBCYGV-UHFFFAOYSA-N quinuclidine Chemical compound C1CC2CCN1CC2 SBYHFKPVCBCYGV-UHFFFAOYSA-N 0.000 title 1
- -1 - O(CO)R1 Chemical group 0.000 claims abstract description 407
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- 238000000034 method Methods 0.000 claims abstract description 96
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- 125000000217 alkyl group Chemical group 0.000 claims abstract description 39
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- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 24
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- 125000005843 halogen group Chemical group 0.000 claims abstract description 9
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- 125000004430 oxygen atom Chemical group O* 0.000 claims abstract 2
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- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 4
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- 239000005557 antagonist Substances 0.000 claims description 2
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- 125000001246 bromo group Chemical group Br* 0.000 description 43
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- 125000003072 pyrazolidinyl group Chemical group 0.000 description 1
- 125000002755 pyrazolinyl group Chemical group 0.000 description 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 description 1
- 125000001422 pyrrolinyl group Chemical group 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 125000004621 quinuclidinyl group Chemical group N12C(CC(CC1)CC2)* 0.000 description 1
- 239000000018 receptor agonist Substances 0.000 description 1
- 229940044601 receptor agonist Drugs 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 125000003548 sec-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 125000005504 styryl group Chemical group 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 230000016978 synaptic transmission, cholinergic Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
- 125000001113 thiadiazolyl group Chemical group 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 125000006168 tricyclic group Chemical group 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- 210000001186 vagus nerve Anatomy 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Otolaryngology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200400638A ES2239546B1 (es) | 2004-03-15 | 2004-03-15 | Nuevos esteres de quinuclidina cuaternizados. |
| ESP200400638 | 2004-03-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2006136085A RU2006136085A (ru) | 2008-04-27 |
| RU2382041C2 true RU2382041C2 (ru) | 2010-02-20 |
Family
ID=34955916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2006136085/04A RU2382041C2 (ru) | 2004-03-15 | 2005-03-10 | Новые сложные эфиры кватернизованного хинуклидина |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US20080214600A1 (enExample) |
| EP (1) | EP1725552B1 (enExample) |
| JP (1) | JP2007529444A (enExample) |
| KR (1) | KR20070003940A (enExample) |
| CN (1) | CN1930158A (enExample) |
| AR (1) | AR048004A1 (enExample) |
| AT (1) | ATE399166T1 (enExample) |
| AU (1) | AU2005223310A1 (enExample) |
| BR (1) | BRPI0508177A (enExample) |
| CA (1) | CA2560157A1 (enExample) |
| CY (1) | CY1108324T1 (enExample) |
| DE (1) | DE602005007714D1 (enExample) |
| DK (1) | DK1725552T3 (enExample) |
| EC (1) | ECSP066770A (enExample) |
| ES (2) | ES2239546B1 (enExample) |
| HR (1) | HRP20080338T3 (enExample) |
| IL (1) | IL177341A0 (enExample) |
| MY (1) | MY142036A (enExample) |
| NO (1) | NO20064659L (enExample) |
| NZ (1) | NZ548583A (enExample) |
| PE (1) | PE20060005A1 (enExample) |
| PL (1) | PL1725552T3 (enExample) |
| PT (1) | PT1725552E (enExample) |
| RS (1) | RS50566B (enExample) |
| RU (1) | RU2382041C2 (enExample) |
| SI (1) | SI1725552T1 (enExample) |
| TW (1) | TW200604196A (enExample) |
| UA (1) | UA88634C2 (enExample) |
| WO (1) | WO2005090342A1 (enExample) |
| ZA (1) | ZA200605931B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2165768B1 (es) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
| GB0424284D0 (en) * | 2004-11-02 | 2004-12-01 | Novartis Ag | Organic compounds |
| ES2298049B1 (es) * | 2006-07-21 | 2009-10-20 | Laboratorios Almirall S.A. | Procedimiento para fabricar bromuro de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo (2.2.2) octano. |
| JP2010519193A (ja) * | 2007-02-15 | 2010-06-03 | アージェンタ ディスカバリー リミテッド | Ｍ３ムスカリン受容体としての複素環式誘導体 |
| KR101517574B1 (ko) | 2007-09-07 | 2015-05-07 | 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 | 무스카린 수용체 길항제로서 유용한 구아니딘을 함유하는 화합물 |
| CA2608561A1 (en) * | 2007-10-29 | 2009-04-29 | Carl Paluszkiewicz | Motorcycle wind deflector accessory support |
| JP2011506477A (ja) | 2007-12-14 | 2011-03-03 | セラヴァンス， インコーポレーテッド | ムスカリン受容体拮抗薬として有用なアミジン含有化合物 |
| EP2100598A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
| EP2100599A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
| US20090326004A1 (en) | 2008-06-03 | 2009-12-31 | Ranbaxy Laboratories Limited | Muscarinic receptor antagonists |
| KR101290893B1 (ko) | 2009-04-09 | 2013-07-29 | 노파르티스 아게 | 피롤리디늄 염의 제조 방법 |
| EP2510928A1 (en) | 2011-04-15 | 2012-10-17 | Almirall, S.A. | Aclidinium for use in improving the quality of sleep in respiratory patients |
| TW201439089A (zh) * | 2012-12-05 | 2014-10-16 | Chiesi Farma Spa | 新穎化合物 |
| CN103755698A (zh) * | 2014-01-06 | 2014-04-30 | 万特制药(海南)有限公司 | 一锅法制备阿地溴铵的工艺 |
| CN103755699A (zh) * | 2014-01-06 | 2014-04-30 | 万特制药(海南)有限公司 | 一种2-羟基-2,2-二噻吩-2-基乙酸-1-氮杂二环[2,2,2]辛-3(r)-基酯制备方法 |
| KR101511090B1 (ko) | 2014-04-24 | 2015-04-10 | 고려대학교 산학협력단 | 염증성 질환의 예방 또는 치료용 약학 조성물 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU97112907A (ru) * | 1994-12-28 | 1999-06-27 | Яманоути Фармасьютикал Ко., Лтд. | Новые производные хинуклидина и медицинские композиции, содержащие их |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1219606A (en) * | 1968-07-15 | 1971-01-20 | Rech S Et D Applic Scient Soge | Quinuclidinol derivatives and preparation thereof |
| US4843074A (en) * | 1988-05-17 | 1989-06-27 | Marion Laboratories, Inc. | 1-azabicyclo[2.2.2]octan-3-yl 2-aryl-3-azacyclo-2-hydroxypropionates and their quaternary salts |
| NO2005012I1 (no) * | 1994-12-28 | 2005-06-06 | Debio Rech Pharma Sa | Triptorelin og farmasoytisk akseptable salter derav |
| ES2165768B1 (es) * | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
| NZ526674A (en) * | 2000-12-28 | 2005-03-24 | Almirall Prodesfarma Ag | Novel quinuclidine derivatives and medicinal compositions containing the same |
| NZ532283A (en) * | 2001-10-17 | 2005-06-24 | Ucb S | Quinuclidine derivatives, processes for preparing them and their uses as m2 and/or m3 muscarinic receptor inhibitors |
| ES2204295B1 (es) * | 2002-07-02 | 2005-08-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de quinuclidina-amida. |
| AR044134A1 (es) * | 2003-05-02 | 2005-08-24 | Novartis Ag | Derivados de quinuclidina, metodo de preparacion y composiciones farmaceuticas. |
-
2004
- 2004-03-15 ES ES200400638A patent/ES2239546B1/es not_active Expired - Fee Related
-
2005
- 2005-03-10 HR HR20080338T patent/HRP20080338T3/xx unknown
- 2005-03-10 AU AU2005223310A patent/AU2005223310A1/en not_active Abandoned
- 2005-03-10 WO PCT/EP2005/002523 patent/WO2005090342A1/en not_active Ceased
- 2005-03-10 CN CNA2005800082369A patent/CN1930158A/zh active Pending
- 2005-03-10 CA CA002560157A patent/CA2560157A1/en not_active Abandoned
- 2005-03-10 DE DE602005007714T patent/DE602005007714D1/de not_active Expired - Lifetime
- 2005-03-10 NZ NZ548583A patent/NZ548583A/en unknown
- 2005-03-10 PL PL05729711T patent/PL1725552T3/pl unknown
- 2005-03-10 US US10/592,787 patent/US20080214600A1/en not_active Abandoned
- 2005-03-10 KR KR1020067018902A patent/KR20070003940A/ko not_active Ceased
- 2005-03-10 JP JP2007503242A patent/JP2007529444A/ja not_active Withdrawn
- 2005-03-10 SI SI200530293T patent/SI1725552T1/sl unknown
- 2005-03-10 PT PT05729711T patent/PT1725552E/pt unknown
- 2005-03-10 ES ES05729711T patent/ES2307168T3/es not_active Expired - Lifetime
- 2005-03-10 DK DK05729711T patent/DK1725552T3/da active
- 2005-03-10 BR BRPI0508177-7A patent/BRPI0508177A/pt not_active IP Right Cessation
- 2005-03-10 RS RSP-2008/0334A patent/RS50566B/sr unknown
- 2005-03-10 PE PE2005000281A patent/PE20060005A1/es not_active Application Discontinuation
- 2005-03-10 RU RU2006136085/04A patent/RU2382041C2/ru not_active IP Right Cessation
- 2005-03-10 EP EP05729711A patent/EP1725552B1/en not_active Expired - Lifetime
- 2005-03-10 AT AT05729711T patent/ATE399166T1/de not_active IP Right Cessation
- 2005-03-11 AR ARP050100934A patent/AR048004A1/es unknown
- 2005-03-15 MY MYPI20051090A patent/MY142036A/en unknown
- 2005-03-15 TW TW094107865A patent/TW200604196A/zh unknown
- 2005-10-03 UA UAA200610595A patent/UA88634C2/ru unknown
-
2006
- 2006-07-18 ZA ZA200605931A patent/ZA200605931B/en unknown
- 2006-08-07 IL IL177341A patent/IL177341A0/en unknown
- 2006-08-14 EC EC2006006770A patent/ECSP066770A/es unknown
- 2006-10-13 NO NO20064659A patent/NO20064659L/no not_active Application Discontinuation
-
2008
- 2008-09-09 CY CY20081100965T patent/CY1108324T1/el unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU97112907A (ru) * | 1994-12-28 | 1999-06-27 | Яманоути Фармасьютикал Ко., Лтд. | Новые производные хинуклидина и медицинские композиции, содержащие их |
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