ES2239546B1 - Nuevos esteres de quinuclidina cuaternizados. - Google Patents

Nuevos esteres de quinuclidina cuaternizados.

Info

Publication number
ES2239546B1
ES2239546B1 ES200400638A ES200400638A ES2239546B1 ES 2239546 B1 ES2239546 B1 ES 2239546B1 ES 200400638 A ES200400638 A ES 200400638A ES 200400638 A ES200400638 A ES 200400638A ES 2239546 B1 ES2239546 B1 ES 2239546B1
Authority
ES
Spain
Prior art keywords
hydroxy
azoniabicyclo
ylacetoxy
octane
dithien
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES200400638A
Other languages
English (en)
Spanish (es)
Other versions
ES2239546A1 (es
Inventor
Maria Dolors Fernandez Forner
Maria Prat Quiñones
Maria Antonia Buil Albero
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Almirall SA
Original Assignee
Almirall Prodesfarma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES200400638A priority Critical patent/ES2239546B1/es
Application filed by Almirall Prodesfarma SA filed Critical Almirall Prodesfarma SA
Priority to DK05729711T priority patent/DK1725552T3/da
Priority to CA002560157A priority patent/CA2560157A1/en
Priority to ES05729711T priority patent/ES2307168T3/es
Priority to DE602005007714T priority patent/DE602005007714D1/de
Priority to NZ548583A priority patent/NZ548583A/en
Priority to US10/592,787 priority patent/US20080214600A1/en
Priority to PL05729711T priority patent/PL1725552T3/pl
Priority to EP05729711A priority patent/EP1725552B1/en
Priority to RSP-2008/0334A priority patent/RS50566B/sr
Priority to RU2006136085/04A priority patent/RU2382041C2/ru
Priority to PT05729711T priority patent/PT1725552E/pt
Priority to PE2005000281A priority patent/PE20060005A1/es
Priority to AT05729711T priority patent/ATE399166T1/de
Priority to KR1020067018902A priority patent/KR20070003940A/ko
Priority to BRPI0508177-7A priority patent/BRPI0508177A/pt
Priority to SI200530293T priority patent/SI1725552T1/sl
Priority to HK07105721.8A priority patent/HK1101855B/en
Priority to JP2007503242A priority patent/JP2007529444A/ja
Priority to HR20080338T priority patent/HRP20080338T3/xx
Priority to CNA2005800082369A priority patent/CN1930158A/zh
Priority to AU2005223310A priority patent/AU2005223310A1/en
Priority to PCT/EP2005/002523 priority patent/WO2005090342A1/en
Priority to ARP050100934A priority patent/AR048004A1/es
Priority to TW094107865A priority patent/TW200604196A/zh
Priority to MYPI20051090A priority patent/MY142036A/en
Publication of ES2239546A1 publication Critical patent/ES2239546A1/es
Priority to UAA200610595A priority patent/UA88634C2/ru
Priority to ZA200605931A priority patent/ZA200605931B/en
Priority to IL177341A priority patent/IL177341A0/en
Priority to EC2006006770A priority patent/ECSP066770A/es
Priority to NO20064659A priority patent/NO20064659L/no
Application granted granted Critical
Publication of ES2239546B1 publication Critical patent/ES2239546B1/es
Priority to CY20081100965T priority patent/CY1108324T1/el
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ES200400638A 2004-03-15 2004-03-15 Nuevos esteres de quinuclidina cuaternizados. Expired - Fee Related ES2239546B1 (es)

Priority Applications (32)

Application Number Priority Date Filing Date Title
ES200400638A ES2239546B1 (es) 2004-03-15 2004-03-15 Nuevos esteres de quinuclidina cuaternizados.
CA002560157A CA2560157A1 (en) 2004-03-15 2005-03-10 New quaternized quinuclidine esters
ES05729711T ES2307168T3 (es) 2004-03-15 2005-03-10 Nuevos esteres de quinuclidina cuaternizados.
DE602005007714T DE602005007714D1 (de) 2004-03-15 2005-03-10 Neue quaternisierte chinuclidinester
NZ548583A NZ548583A (en) 2004-03-15 2005-03-10 New quaternized quinuclidine esters
US10/592,787 US20080214600A1 (en) 2004-03-15 2005-03-10 Quaternized Quinuclidine Esters
PL05729711T PL1725552T3 (pl) 2004-03-15 2005-03-10 Nowe czwartorzędowane estry chinuklidyny
EP05729711A EP1725552B1 (en) 2004-03-15 2005-03-10 New quaternized quinuclidine esters
RSP-2008/0334A RS50566B (sr) 2004-03-15 2005-03-10 Novi kvaternizovani kvinuklidin estri
RU2006136085/04A RU2382041C2 (ru) 2004-03-15 2005-03-10 Новые сложные эфиры кватернизованного хинуклидина
PT05729711T PT1725552E (pt) 2004-03-15 2005-03-10 Novos ésteres de quinuclidina quartenizados
PE2005000281A PE20060005A1 (es) 2004-03-15 2005-03-10 Nuevos esteres de quinuclidina cuaternizados
AT05729711T ATE399166T1 (de) 2004-03-15 2005-03-10 Neue quaternisierte chinuclidinester
KR1020067018902A KR20070003940A (ko) 2004-03-15 2005-03-10 신규한 사차화 퀴뉴클리딘 에스테르
BRPI0508177-7A BRPI0508177A (pt) 2004-03-15 2005-03-10 composto, processo para a produção do composto, composição farmacêutica, uso do composto método para o tratamento de uma doença e produto de combinação
SI200530293T SI1725552T1 (sl) 2004-03-15 2005-03-10 Novi kvaternizirani kinuklidin estri
DK05729711T DK1725552T3 (da) 2004-03-15 2005-03-10 Nye kvaterniserede quinuclidinestere
HK07105721.8A HK1101855B (en) 2004-03-15 2005-03-10 New quaternized quinuclidine esters
JP2007503242A JP2007529444A (ja) 2004-03-15 2005-03-10 新しい四級化キヌクリジンエステル
CNA2005800082369A CN1930158A (zh) 2004-03-15 2005-03-10 新季铵化的奎宁环酯
AU2005223310A AU2005223310A1 (en) 2004-03-15 2005-03-10 New quaternized quinuclidine esters
PCT/EP2005/002523 WO2005090342A1 (en) 2004-03-15 2005-03-10 New quaternized quinuclidine esters
HR20080338T HRP20080338T3 (hr) 2004-03-15 2005-03-10 Novi kvaternizirani kinuklidinski esteri
ARP050100934A AR048004A1 (es) 2004-03-15 2005-03-11 Nuevos esteres de quinuclidina cuaternizados
TW094107865A TW200604196A (en) 2004-03-15 2005-03-15 New quinuclidine derivatives and pharmaceutical compositions comprising them
MYPI20051090A MY142036A (en) 2004-03-15 2005-03-15 New quaternized quinuclidine esters
UAA200610595A UA88634C2 (en) 2004-03-15 2005-10-03 Quaternized quinuclidine esters
ZA200605931A ZA200605931B (en) 2004-03-15 2006-07-18 New quaternized quinuclidine esters
IL177341A IL177341A0 (en) 2004-03-15 2006-08-07 New quaternized quinuclidine esters
EC2006006770A ECSP066770A (es) 2004-03-15 2006-08-14 Nuevos ésteres de quinuclidina cuaternizados
NO20064659A NO20064659L (no) 2004-03-15 2006-10-13 Nye kvarterniserte quinuklidin-estere
CY20081100965T CY1108324T1 (el) 2004-03-15 2008-09-09 Νεοι τεταρτοταγοποιημενοι εστερες κουινουκλιδινης

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200400638A ES2239546B1 (es) 2004-03-15 2004-03-15 Nuevos esteres de quinuclidina cuaternizados.

Publications (2)

Publication Number Publication Date
ES2239546A1 ES2239546A1 (es) 2005-09-16
ES2239546B1 true ES2239546B1 (es) 2006-12-01

Family

ID=34955916

Family Applications (2)

Application Number Title Priority Date Filing Date
ES200400638A Expired - Fee Related ES2239546B1 (es) 2004-03-15 2004-03-15 Nuevos esteres de quinuclidina cuaternizados.
ES05729711T Expired - Lifetime ES2307168T3 (es) 2004-03-15 2005-03-10 Nuevos esteres de quinuclidina cuaternizados.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES05729711T Expired - Lifetime ES2307168T3 (es) 2004-03-15 2005-03-10 Nuevos esteres de quinuclidina cuaternizados.

Country Status (30)

Country Link
US (1) US20080214600A1 (enExample)
EP (1) EP1725552B1 (enExample)
JP (1) JP2007529444A (enExample)
KR (1) KR20070003940A (enExample)
CN (1) CN1930158A (enExample)
AR (1) AR048004A1 (enExample)
AT (1) ATE399166T1 (enExample)
AU (1) AU2005223310A1 (enExample)
BR (1) BRPI0508177A (enExample)
CA (1) CA2560157A1 (enExample)
CY (1) CY1108324T1 (enExample)
DE (1) DE602005007714D1 (enExample)
DK (1) DK1725552T3 (enExample)
EC (1) ECSP066770A (enExample)
ES (2) ES2239546B1 (enExample)
HR (1) HRP20080338T3 (enExample)
IL (1) IL177341A0 (enExample)
MY (1) MY142036A (enExample)
NO (1) NO20064659L (enExample)
NZ (1) NZ548583A (enExample)
PE (1) PE20060005A1 (enExample)
PL (1) PL1725552T3 (enExample)
PT (1) PT1725552E (enExample)
RS (1) RS50566B (enExample)
RU (1) RU2382041C2 (enExample)
SI (1) SI1725552T1 (enExample)
TW (1) TW200604196A (enExample)
UA (1) UA88634C2 (enExample)
WO (1) WO2005090342A1 (enExample)
ZA (1) ZA200605931B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9056100B2 (en) 1999-07-14 2015-06-16 Almirall, S.A. Quinuclidine derivatives and medicinal compositions containing the same
US9254262B2 (en) 2008-03-13 2016-02-09 Almirall, S.A. Dosage and formulation

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0424284D0 (en) * 2004-11-02 2004-12-01 Novartis Ag Organic compounds
ES2298049B1 (es) 2006-07-21 2009-10-20 Laboratorios Almirall S.A. Procedimiento para fabricar bromuro de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo (2.2.2) octano.
MX2009008323A (es) * 2007-02-15 2009-08-13 Argenta Discovery Ltd Derivados heterociclicos como receptores muscarinicos m3.
BRPI0816219B8 (pt) 2007-09-07 2021-05-25 Theravance Biopharma R&D Ip Llc compostos contendo guanidina úteis como antagonistas de receptor muscarínico, composição farmacêutica e uso
CA2608561A1 (en) * 2007-10-29 2009-04-29 Carl Paluszkiewicz Motorcycle wind deflector accessory support
EP2222637A1 (en) 2007-12-14 2010-09-01 Theravance, Inc. Amidine-containing compounds useful as muscarinic receptor antagonists
EP2100599A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
US20090326004A1 (en) 2008-06-03 2009-12-31 Ranbaxy Laboratories Limited Muscarinic receptor antagonists
JP5902612B2 (ja) 2009-04-09 2016-04-13 ノバルティス アーゲー ピロリジニウム塩の調製方法
EP2510928A1 (en) 2011-04-15 2012-10-17 Almirall, S.A. Aclidinium for use in improving the quality of sleep in respiratory patients
HK1212986A1 (zh) * 2012-12-05 2016-06-24 奇斯药制品公司 作为pde4-抑制剂的苯基乙基吡啶衍生物
CN103755698A (zh) * 2014-01-06 2014-04-30 万特制药(海南)有限公司 一锅法制备阿地溴铵的工艺
CN103755699A (zh) * 2014-01-06 2014-04-30 万特制药(海南)有限公司 一种2-羟基-2,2-二噻吩-2-基乙酸-1-氮杂二环[2,2,2]辛-3(r)-基酯制备方法
KR101511090B1 (ko) 2014-04-24 2015-04-10 고려대학교 산학협력단 염증성 질환의 예방 또는 치료용 약학 조성물

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003033495A1 (en) * 2001-10-17 2003-04-24 Ucb, S.A. Quinuclidine derivatives, processes for preparing them and their uses as m2 and/or m3 muscarinic receptor inhibitors
ES2193098T3 (es) * 1999-07-14 2003-11-01 Almirall Prodesfarma Ag Derivados de quinuclidina y su uso comoligandos de los receptores muscarinicos m3.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1219606A (en) * 1968-07-15 1971-01-20 Rech S Et D Applic Scient Soge Quinuclidinol derivatives and preparation thereof
US4843074A (en) * 1988-05-17 1989-06-27 Marion Laboratories, Inc. 1-azabicyclo[2.2.2]octan-3-yl 2-aryl-3-azacyclo-2-hydroxypropionates and their quaternary salts
NO2005012I1 (no) * 1994-12-28 2005-06-06 Debio Rech Pharma Sa Triptorelin og farmasoytisk akseptable salter derav
KR100869721B1 (ko) * 2000-12-28 2008-11-21 알미랄 에이쥐 신규한 퀴누클리딘 유도체 및 그를 함유한 의약 조성물
ES2204295B1 (es) * 2002-07-02 2005-08-01 Almirall Prodesfarma, S.A. Nuevos derivados de quinuclidina-amida.
AR044134A1 (es) * 2003-05-02 2005-08-24 Novartis Ag Derivados de quinuclidina, metodo de preparacion y composiciones farmaceuticas.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2193098T3 (es) * 1999-07-14 2003-11-01 Almirall Prodesfarma Ag Derivados de quinuclidina y su uso comoligandos de los receptores muscarinicos m3.
WO2003033495A1 (en) * 2001-10-17 2003-04-24 Ucb, S.A. Quinuclidine derivatives, processes for preparing them and their uses as m2 and/or m3 muscarinic receptor inhibitors

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9056100B2 (en) 1999-07-14 2015-06-16 Almirall, S.A. Quinuclidine derivatives and medicinal compositions containing the same
US9333195B2 (en) 1999-07-14 2016-05-10 Almirall, S.A. Quinuclidine derivatives and medicinal compositions containing the same
US9254262B2 (en) 2008-03-13 2016-02-09 Almirall, S.A. Dosage and formulation

Also Published As

Publication number Publication date
PE20060005A1 (es) 2006-01-28
DK1725552T3 (da) 2008-10-13
RU2006136085A (ru) 2008-04-27
EP1725552B1 (en) 2008-06-25
ECSP066770A (es) 2006-11-16
TW200604196A (en) 2006-02-01
IL177341A0 (en) 2006-12-10
CA2560157A1 (en) 2005-09-29
ATE399166T1 (de) 2008-07-15
PL1725552T3 (pl) 2008-12-31
RU2382041C2 (ru) 2010-02-20
CN1930158A (zh) 2007-03-14
KR20070003940A (ko) 2007-01-05
ES2239546A1 (es) 2005-09-16
MY142036A (en) 2010-08-16
JP2007529444A (ja) 2007-10-25
HRP20080338T3 (hr) 2008-07-31
CY1108324T1 (el) 2014-02-12
ES2307168T3 (es) 2008-11-16
AR048004A1 (es) 2006-03-15
SI1725552T1 (sl) 2008-10-31
US20080214600A1 (en) 2008-09-04
WO2005090342A1 (en) 2005-09-29
PT1725552E (pt) 2008-09-18
HK1101855A1 (en) 2007-10-26
AU2005223310A1 (en) 2005-09-29
UA88634C2 (en) 2009-11-10
RS50566B (sr) 2010-05-07
NO20064659L (no) 2006-12-13
DE602005007714D1 (de) 2008-08-07
NZ548583A (en) 2010-05-28
ZA200605931B (en) 2007-11-28
EP1725552A1 (en) 2006-11-29
BRPI0508177A (pt) 2007-08-07

Similar Documents

Publication Publication Date Title
ES2204295B1 (es) Nuevos derivados de quinuclidina-amida.
ES2266291T3 (es) Nuevos derivados de quinuclidina y composiciones medicinales que los contienen.
ES2206021B1 (es) Nuevos derivados de pirrolidinio.
ES2239546B1 (es) Nuevos esteres de quinuclidina cuaternizados.
AU2002238471A1 (en) Quinuclidine derivatives and their use as M3 antagonists
HK1101855B (en) New quaternized quinuclidine esters
MXPA06009832A (en) New quaternized quinuclidine esters
KR20050024450A (ko) 신규한 퀴누클리딘 아미드 유도체

Legal Events

Date Code Title Description
EC2A Search report published

Date of ref document: 20050916

Kind code of ref document: A1

FG2A Definitive protection

Ref document number: 2239546B1

Country of ref document: ES

FD2A Announcement of lapse in spain

Effective date: 20180809