RU2381226C2 - Полигетероциклические соединения и их применение в качестве антагонистов метаботропного рецептора глутамата - Google Patents

Полигетероциклические соединения и их применение в качестве антагонистов метаботропного рецептора глутамата Download PDF

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RU2381226C2
RU2381226C2 RU2006127572/04A RU2006127572A RU2381226C2 RU 2381226 C2 RU2381226 C2 RU 2381226C2 RU 2006127572/04 A RU2006127572/04 A RU 2006127572/04A RU 2006127572 A RU2006127572 A RU 2006127572A RU 2381226 C2 RU2381226 C2 RU 2381226C2
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Russia
Prior art keywords
methyl
phenyl
triazol
alkyl
chloro
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RU2006127572/04A
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Russian (ru)
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RU2006127572A (ru
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Джалай АРОРА (CA)
Джалай Арора
Луиза ЭДВАРДС (CA)
Луиза Эдвардс
Метвин АЙЗЕК (CA)
Метвин Айзек
Анника КЕРС (SE)
Анника Керс
Карин СТААФ (SE)
Карин Стааф
Абдельмалик СЛАССИ (CA)
Абдельмалик Сласси
Томислав СТЕФАНАК (CA)
Томислав Стефанак
Давид ВЕНСБО (SE)
Давид Венсбо
Тао КСИН (CA)
Тао Ксин
Бьёрн ХОЛЬМ (SE)
Бьёрн ХОЛЬМ
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Астразенека Аб
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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  • Diabetes (AREA)
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  • Hematology (AREA)
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  • Child & Adolescent Psychology (AREA)
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  • Immunology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RU2006127572/04A 2004-02-18 2005-02-17 Полигетероциклические соединения и их применение в качестве антагонистов метаботропного рецептора глутамата RU2381226C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54529204P 2004-02-18 2004-02-18
US60/545,292 2004-02-18

Publications (2)

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RU2006127572A RU2006127572A (ru) 2008-03-27
RU2381226C2 true RU2381226C2 (ru) 2010-02-10

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RU2006127572/04A RU2381226C2 (ru) 2004-02-18 2005-02-17 Полигетероциклические соединения и их применение в качестве антагонистов метаботропного рецептора глутамата

Country Status (20)

Country Link
US (2) US20070185100A1 (https=)
EP (1) EP1716143A1 (https=)
JP (1) JP2007523181A (https=)
KR (1) KR20070052693A (https=)
CN (1) CN1918154A (https=)
AR (1) AR047966A1 (https=)
AU (1) AU2005214378A1 (https=)
BR (1) BRPI0507481A (https=)
CA (1) CA2555272A1 (https=)
IL (1) IL177058A0 (https=)
MX (1) MXPA06009023A (https=)
NO (1) NO20063469L (https=)
NZ (1) NZ548693A (https=)
RU (1) RU2381226C2 (https=)
SG (1) SG149900A1 (https=)
TW (1) TW200538179A (https=)
UA (1) UA82434C2 (https=)
UY (1) UY28764A1 (https=)
WO (1) WO2005080386A1 (https=)
ZA (1) ZA200606314B (https=)

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BRPI0818448A2 (pt) 2007-10-19 2015-05-12 Astrazeneca Ab Composto, composição farmacêutica, uso de um composto, e, métodos para o tratamento ou prevenção de um distúrbio madiano pelo receptor mglur5.
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WO2009054786A1 (en) * 2007-10-26 2009-04-30 Astrazeneca Ab 1,2,4-triazole aryl n-oxides derivatives as modulators of mglur5
WO2009054789A1 (en) * 2007-10-26 2009-04-30 Astrazeneca Ab 1,2,3-triazole pyrrolidine derivatives as modulators of mglur5
US8546576B2 (en) * 2008-06-06 2013-10-01 Sk Biopharmaceuticals Co., Ltd. 3 or 4-substituted piperidine compounds
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WO2010114971A1 (en) * 2009-04-03 2010-10-07 Sepracor Inc. Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof
EP2421370A4 (en) * 2009-04-23 2012-12-12 Merck Sharp & Dohme 2-alkyl-piperidine-mGluR5 receptor MODULATORS
AR080056A1 (es) 2010-02-01 2012-03-07 Novartis Ag Derivados de ciclohexil-amida como antagonistas de los receptores de crf
JP2013518085A (ja) 2010-02-01 2013-05-20 ノバルティス アーゲー ＣＲＦ−１受容体アンタゴニストとしてのピラゾロ［５，１ｂ］オキサゾール誘導体
JP5748777B2 (ja) 2010-02-02 2015-07-15 ノバルティス アーゲー Ｃｒｆ受容体アンタゴニストとしてのシクロヘキシルアミド誘導体
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RU2664644C2 (ru) * 2013-06-11 2018-08-21 Ф. Хоффманн-Ля Рош Аг Новые производные тетразолона

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