RU2378271C2 - Способы получения ингибиторов триптазы - Google Patents
Способы получения ингибиторов триптазы Download PDFInfo
- Publication number
- RU2378271C2 RU2378271C2 RU2006134623/04A RU2006134623A RU2378271C2 RU 2378271 C2 RU2378271 C2 RU 2378271C2 RU 2006134623/04 A RU2006134623/04 A RU 2006134623/04A RU 2006134623 A RU2006134623 A RU 2006134623A RU 2378271 C2 RU2378271 C2 RU 2378271C2
- Authority
- RU
- Russia
- Prior art keywords
- formula
- salt
- tert
- acid
- pyridyl
- Prior art date
Links
- 0 C[C@]1I(C)(C)C(C)=CC(*)CC1CNIC Chemical compound C[C@]1I(C)(C)C(C)=CC(*)CC1CNIC 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/32—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of salts of sulfonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/53—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/08—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04004799.5 | 2004-03-02 | ||
| EP04004799A EP1571150A1 (en) | 2004-03-02 | 2004-03-02 | Process for the preparation of tryptase inhibitors |
| US58574504P | 2004-07-06 | 2004-07-06 | |
| US60/585,745 | 2004-07-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2006134623A RU2006134623A (ru) | 2008-04-10 |
| RU2378271C2 true RU2378271C2 (ru) | 2010-01-10 |
Family
ID=34745976
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2006134623/04A RU2378271C2 (ru) | 2004-03-02 | 2005-02-18 | Способы получения ингибиторов триптазы |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20130225825A1 (https=) |
| EP (2) | EP1571150A1 (https=) |
| JP (1) | JP4851440B2 (https=) |
| CN (2) | CN1950362B (https=) |
| AT (1) | ATE447567T1 (https=) |
| AU (1) | AU2005229319B2 (https=) |
| BR (1) | BRPI0508430A (https=) |
| CA (1) | CA2557391C (https=) |
| DK (1) | DK1723140T3 (https=) |
| ES (1) | ES2334245T3 (https=) |
| NZ (1) | NZ549224A (https=) |
| PL (1) | PL1723140T3 (https=) |
| PT (1) | PT1723140E (https=) |
| RS (1) | RS51144B (https=) |
| RU (1) | RU2378271C2 (https=) |
| SI (1) | SI1723140T1 (https=) |
| TN (1) | TNSN06260A1 (https=) |
| UA (1) | UA85701C2 (https=) |
| WO (1) | WO2005095385A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200840566A (en) * | 2006-12-22 | 2008-10-16 | Esteve Labor Dr | Heterocyclyl-substituted-ethylamino-phenyl derivatives, their preparation and use as medicaments |
| ES2469824T3 (es) * | 2007-11-21 | 2014-06-20 | Janssen Pharmaceutica N.V. | Espiropiperidinas para su uso como inhibidores de la triptasa |
| CN102149705B (zh) * | 2008-08-22 | 2013-08-07 | 赛诺菲-安万特 | 作为肥大细胞类胰蛋白酶抑制剂的[4-(5-氨基甲基-2-氟苯基)-哌啶-1-基]-[7-氟-1-(2-甲氧基乙基)-4-三氟甲氧基-1h-吲哚-3-基]-甲酮 |
| EP2483243B1 (en) * | 2009-09-24 | 2015-03-18 | Sanofi-Aventis U.S. LLC | Synthesis of (4-fluoro-3-piperidin-4-yl-benzyl)-carbamic acid tert-butyl ester and intermediates thereof |
| AU2010333892A1 (en) * | 2009-12-23 | 2012-07-19 | Sanofi | Treatment for inflammatory bowel disease |
| JP2014520151A (ja) | 2011-06-20 | 2014-08-21 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 蠕虫感染を処置するためのヘテロ環式化合物 |
| TW201326128A (zh) | 2011-11-28 | 2013-07-01 | Du Pont | 磺醯胺驅蟲劑 |
| WO2014099837A1 (en) | 2012-12-18 | 2014-06-26 | E. I. Du Pont De Nemours And Company | Sulfonamide anthelmintics |
| CN111793101B (zh) | 2020-07-17 | 2022-09-30 | 四川大学 | C-核苷化合物的合成方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999018053A1 (en) * | 1997-10-02 | 1999-04-15 | The University Of Western Ontario | Preparation of radiolabelled haloaromatics via polymer-bound intermediates |
| WO2001090101A1 (en) * | 2000-05-22 | 2001-11-29 | Aventis Pharmaceuticals Inc. | Arylmethylamine derivatives for use as tryptase inhibitors |
| RU2183624C2 (ru) * | 1996-11-14 | 2002-06-20 | Акцо Нобель Н.В. | Производные пиперидина и фармацевтический препарат на их основе |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5068371A (en) * | 1989-06-01 | 1991-11-26 | Ciba-Geigy Corporation | Novel nitrogen-containing titanocenes, and the use thereof |
| US5252753A (en) * | 1991-11-01 | 1993-10-12 | Ortho Pharmaceutical Corporation | Process for the preparation of certain substituted biphenyl tetrazoles and compounds thereof |
| US20020045613A1 (en) * | 2000-04-27 | 2002-04-18 | Heinz Pauls | 1-aroyl-piperidinyl benzamidines |
| CA2502358C (en) * | 2002-10-18 | 2012-03-13 | John F. Valliant | Methods for purifying radiolabelled compounds |
| GB0308613D0 (en) * | 2002-12-26 | 2003-05-21 | Aventis Pharma Inc | 4-(3-Aminomethylphenyl) piperidin-1-yl- 5-(2-fluorophenylethynyl) furan-2-yl- methanone as an inhibitor of mast cell tryptase |
-
2004
- 2004-03-02 EP EP04004799A patent/EP1571150A1/en not_active Withdrawn
-
2005
- 2005-02-18 BR BRPI0508430-0A patent/BRPI0508430A/pt not_active IP Right Cessation
- 2005-02-18 ES ES05779890T patent/ES2334245T3/es not_active Expired - Lifetime
- 2005-02-18 SI SI200530896T patent/SI1723140T1/sl unknown
- 2005-02-18 AU AU2005229319A patent/AU2005229319B2/en not_active Ceased
- 2005-02-18 WO PCT/EP2005/001676 patent/WO2005095385A1/en not_active Ceased
- 2005-02-18 CA CA2557391A patent/CA2557391C/en not_active Expired - Fee Related
- 2005-02-18 EP EP05779890A patent/EP1723140B1/en not_active Expired - Lifetime
- 2005-02-18 NZ NZ549224A patent/NZ549224A/en not_active IP Right Cessation
- 2005-02-18 AT AT05779890T patent/ATE447567T1/de active
- 2005-02-18 JP JP2007501151A patent/JP4851440B2/ja not_active Expired - Fee Related
- 2005-02-18 UA UAA200610386A patent/UA85701C2/ru unknown
- 2005-02-18 CN CN2005800140491A patent/CN1950362B/zh not_active Expired - Fee Related
- 2005-02-18 RS RSP-2009/0532A patent/RS51144B/sr unknown
- 2005-02-18 PL PL05779890T patent/PL1723140T3/pl unknown
- 2005-02-18 PT PT05779890T patent/PT1723140E/pt unknown
- 2005-02-18 CN CN2008101787837A patent/CN101429194B/zh not_active Expired - Fee Related
- 2005-02-18 DK DK05779890.2T patent/DK1723140T3/da active
- 2005-02-18 RU RU2006134623/04A patent/RU2378271C2/ru not_active IP Right Cessation
-
2006
- 2006-08-15 TN TNP2006000260A patent/TNSN06260A1/en unknown
-
2013
- 2013-04-11 US US13/861,066 patent/US20130225825A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2183624C2 (ru) * | 1996-11-14 | 2002-06-20 | Акцо Нобель Н.В. | Производные пиперидина и фармацевтический препарат на их основе |
| WO1999018053A1 (en) * | 1997-10-02 | 1999-04-15 | The University Of Western Ontario | Preparation of radiolabelled haloaromatics via polymer-bound intermediates |
| WO2001090101A1 (en) * | 2000-05-22 | 2001-11-29 | Aventis Pharmaceuticals Inc. | Arylmethylamine derivatives for use as tryptase inhibitors |
Non-Patent Citations (1)
| Title |
|---|
| Djuric S. et al. Tetrahedron Letters, 1981, v.22, no.19, p.1787-1790. * |
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0508430A (pt) | 2007-07-24 |
| PT1723140E (pt) | 2010-01-13 |
| TNSN06260A1 (en) | 2007-12-03 |
| SI1723140T1 (sl) | 2010-02-26 |
| CA2557391C (en) | 2011-06-28 |
| CN1950362B (zh) | 2010-08-04 |
| PL1723140T3 (pl) | 2010-02-26 |
| UA85701C2 (ru) | 2009-02-25 |
| NZ549224A (en) | 2010-10-29 |
| AU2005229319B2 (en) | 2011-10-20 |
| ES2334245T3 (es) | 2010-03-08 |
| EP1571150A1 (en) | 2005-09-07 |
| EP1723140B1 (en) | 2009-11-04 |
| US20130225825A1 (en) | 2013-08-29 |
| ATE447567T1 (de) | 2009-11-15 |
| CN101429194A (zh) | 2009-05-13 |
| CN101429194B (zh) | 2011-12-14 |
| AU2005229319A1 (en) | 2005-10-13 |
| CN1950362A (zh) | 2007-04-18 |
| JP2007526264A (ja) | 2007-09-13 |
| EP1723140A1 (en) | 2006-11-22 |
| CA2557391A1 (en) | 2005-10-13 |
| WO2005095385A1 (en) | 2005-10-13 |
| RS51144B (sr) | 2010-10-31 |
| JP4851440B2 (ja) | 2012-01-11 |
| RU2006134623A (ru) | 2008-04-10 |
| DK1723140T3 (da) | 2010-03-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20150219 |