RU2376297C2 - Производные изотиомочевины и способ их получения, их применение и фармацевтическая композиция - Google Patents

Производные изотиомочевины и способ их получения, их применение и фармацевтическая композиция Download PDF

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Publication number
RU2376297C2
RU2376297C2 RU2006134019/04A RU2006134019A RU2376297C2 RU 2376297 C2 RU2376297 C2 RU 2376297C2 RU 2006134019/04 A RU2006134019/04 A RU 2006134019/04A RU 2006134019 A RU2006134019 A RU 2006134019A RU 2376297 C2 RU2376297 C2 RU 2376297C2
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formula
isothiourea
dihydroimidazo
compound
compounds
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RU2006134019/04A
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RU2006134019A (ru
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Фрейсер ГЛИКМАН (CH)
Фрейсер ГЛИКМАН
Маркус ШТРАЙФФ (CH)
Маркус ШТРАЙФФ
Гебхард ТОМА (DE)
Гебхард Тома
Ханс-Гюнтер ЦЕРВЕС (DE)
Ханс-Гюнтер ЦЕРВЕС
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Новартис Аг
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38Nitrogen atoms
    • C07D277/42Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2006134019/04A 2004-02-27 2005-02-25 Производные изотиомочевины и способ их получения, их применение и фармацевтическая композиция RU2376297C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0404434.3 2004-02-27
GBGB0404434.3A GB0404434D0 (en) 2004-02-27 2004-02-27 Organic compounds

Publications (2)

Publication Number Publication Date
RU2006134019A RU2006134019A (ru) 2008-04-10
RU2376297C2 true RU2376297C2 (ru) 2009-12-20

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RU2006134019/04A RU2376297C2 (ru) 2004-02-27 2005-02-25 Производные изотиомочевины и способ их получения, их применение и фармацевтическая композиция

Country Status (10)

Country Link
US (1) US7671078B2 (https=)
EP (1) EP1720845A1 (https=)
JP (1) JP2007523941A (https=)
KR (1) KR20060124722A (https=)
CN (1) CN1922158A (https=)
AU (1) AU2005219531B2 (https=)
CA (1) CA2556386A1 (https=)
GB (1) GB0404434D0 (https=)
RU (1) RU2376297C2 (https=)
WO (1) WO2005085219A1 (https=)

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RU2503450C1 (ru) * 2012-04-19 2014-01-10 Федеральное Государственное Бюджетное Учреждение "Медицинский Радиологический Научный Центр" Министерства Здравоохранения и Социального Развития Российской Федерации (ФГБУ МРНЦ Минздравсоцразвития России) Противоопухолевое средство

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WO2007022385A2 (en) * 2005-08-18 2007-02-22 Novartis Ag Use of cxcr4 binding molecules for the treatment of whim syndrome
PT1942108E (pt) 2005-10-28 2013-10-24 Ono Pharmaceutical Co Composto com um grupo básico e a sua utilização
WO2007058322A1 (ja) 2005-11-18 2007-05-24 Ono Pharmaceutical Co., Ltd. 塩基性基を含有する化合物およびその用途
WO2009005675A1 (en) 2007-06-28 2009-01-08 Abbott Laboratories Novel triazolopyridazines
US12011423B2 (en) 2007-11-06 2024-06-18 Foraviset Ltd. S-alkylisothiouronium derivatives for treating uterine hypercontractility disorders
US20100305210A1 (en) * 2007-11-06 2010-12-02 Barkan-Farma S.R.L. S-alkylisothiouronium derivatives for treating abnormal uterine bleeding disorders
CN102088856B (zh) 2008-07-09 2015-11-25 巴斯夫欧洲公司 包含异*唑啉化合物的杀虫活性混合物i
US8921328B2 (en) 2010-09-14 2014-12-30 Glycomimetics, Inc. E-selectin antagonists
WO2012061662A1 (en) * 2010-11-03 2012-05-10 Glycomimetics, Inc. Glycomimetic-peptidomimetic inhibitors of e-selectins and cxcr4 chemokine receptors
PT2794626T (pt) 2011-12-22 2018-01-12 Glycomimetics Inc Compostos de antagonistas de e-selectina
CA2891514C (en) 2012-12-07 2020-08-25 Glycomimetics, Inc. Compounds, compositions and methods using e-selectin antagonists for mobilization of hematopoietic cells
ES2754549T3 (es) 2014-12-03 2020-04-20 Glycomimetics Inc Inhibidores heterobifuncionales de E-selectinas y receptores de quimioquinas CXCR4
WO2017151708A1 (en) 2016-03-02 2017-09-08 Glycomimetics, Inc. Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin
EP3497131B1 (en) 2016-08-08 2022-03-09 GlycoMimetics, Inc. Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4.
US11072625B2 (en) 2016-10-07 2021-07-27 Glycomimetics, Inc. Highly potent multimeric e-selectin antagonists
CA3054605A1 (en) 2017-03-15 2018-09-20 Glycomimetics, Inc. Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists
WO2019108750A1 (en) 2017-11-30 2019-06-06 Glycomimetics, Inc. Methods of mobilizing marrow infiltrating lymphocytes and uses thereof
CN111566117A (zh) 2017-12-29 2020-08-21 糖模拟物有限公司 E-选择蛋白和半乳凝素-3的异双功能抑制剂
WO2019173229A1 (en) 2018-03-05 2019-09-12 Glycomimetics, Inc. Methods for treating acute myeloid leukemia and related conditions
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
CA3174634A1 (en) * 2020-03-11 2021-09-16 Biolinerx Ltd. Cxcr4 inhibitor for the treatment of acute respiratory distress syndrome and viral infections
MX2023003409A (es) * 2020-09-28 2023-06-26 Ermium Therapeutics Derivados de isotiourea ciclica como moduladores de cxcr4.

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US3542802A (en) * 1968-07-03 1970-11-24 Searle & Co 3-(n - benzylthiocarbamoylthiomethyl)-6,7-dihydro - 5h - imidazo(2,1-b)thiazolium chloride and congeners
US3881015A (en) * 1969-10-29 1975-04-29 Smith Kline French Lab Pharmaceutical compositions and methods of inhibiting histamine activity with isothiourea compounds
US4041167A (en) * 1976-01-19 1977-08-09 Diamond Shamrock Corporation Antiinflammatory imidazothiazoles
US4098898A (en) * 1975-05-21 1978-07-04 Smith Kline & French Laboratories Limited Imidazolyl alkylguanidine compounds
GB2031426A (en) * 1978-09-28 1980-04-23 Yoshitomi Pharmaceutical Imidazo(2',1':2,3)thiazolo(5,4-c)pyridines and related compounds
US4293549A (en) * 1977-11-07 1981-10-06 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktion-Saktieselskab) Quinolinyl guanidines having antiinflammatory, analgesic or antipyretic activity
US4556669A (en) * 1981-04-10 1985-12-03 Kumiai Kagaku Kogyo Kabushiki Kaisha 2,-3-Di-substituted-5,6-dihydroimidazo [2,1-b] thiazole, its salts, production thereof and anti-inflammatory agent containing the same
US4736038A (en) * 1985-04-22 1988-04-05 Kumiai Chemical Industry Co., Ltd. 5,6-dihydroimidazo(2,1-b)thiazole-2-carboxamide derivatives or salts thereof
WO2000046187A2 (en) * 1999-02-05 2000-08-10 Oridigm Corporation Antizyme modulators and their use
WO2002024711A1 (en) * 2000-09-20 2002-03-28 Nikken Chemicals Co., Ltd. Novel thiazole bicyclic compounds
WO2002072585A2 (de) * 2001-03-14 2002-09-19 Grünenthal GmbH Substituierte pyrazolo- und thiazolopyrimidine als analgetika

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BE758145A (fr) * 1969-10-29 1971-04-28 Smith Kline French Lab Iso-thio-urees et derives

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US3542802A (en) * 1968-07-03 1970-11-24 Searle & Co 3-(n - benzylthiocarbamoylthiomethyl)-6,7-dihydro - 5h - imidazo(2,1-b)thiazolium chloride and congeners
US3881015A (en) * 1969-10-29 1975-04-29 Smith Kline French Lab Pharmaceutical compositions and methods of inhibiting histamine activity with isothiourea compounds
US4098898A (en) * 1975-05-21 1978-07-04 Smith Kline & French Laboratories Limited Imidazolyl alkylguanidine compounds
US4041167A (en) * 1976-01-19 1977-08-09 Diamond Shamrock Corporation Antiinflammatory imidazothiazoles
US4293549A (en) * 1977-11-07 1981-10-06 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktion-Saktieselskab) Quinolinyl guanidines having antiinflammatory, analgesic or antipyretic activity
GB2031426A (en) * 1978-09-28 1980-04-23 Yoshitomi Pharmaceutical Imidazo(2',1':2,3)thiazolo(5,4-c)pyridines and related compounds
US4556669A (en) * 1981-04-10 1985-12-03 Kumiai Kagaku Kogyo Kabushiki Kaisha 2,-3-Di-substituted-5,6-dihydroimidazo [2,1-b] thiazole, its salts, production thereof and anti-inflammatory agent containing the same
US4736038A (en) * 1985-04-22 1988-04-05 Kumiai Chemical Industry Co., Ltd. 5,6-dihydroimidazo(2,1-b)thiazole-2-carboxamide derivatives or salts thereof
WO2000046187A2 (en) * 1999-02-05 2000-08-10 Oridigm Corporation Antizyme modulators and their use
WO2002024711A1 (en) * 2000-09-20 2002-03-28 Nikken Chemicals Co., Ltd. Novel thiazole bicyclic compounds
WO2002072585A2 (de) * 2001-03-14 2002-09-19 Grünenthal GmbH Substituierte pyrazolo- und thiazolopyrimidine als analgetika

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2503450C1 (ru) * 2012-04-19 2014-01-10 Федеральное Государственное Бюджетное Учреждение "Медицинский Радиологический Научный Центр" Министерства Здравоохранения и Социального Развития Российской Федерации (ФГБУ МРНЦ Минздравсоцразвития России) Противоопухолевое средство

Also Published As

Publication number Publication date
GB0404434D0 (en) 2004-03-31
RU2006134019A (ru) 2008-04-10
CN1922158A (zh) 2007-02-28
US20070161618A1 (en) 2007-07-12
CA2556386A1 (en) 2005-09-15
US7671078B2 (en) 2010-03-02
WO2005085219A1 (en) 2005-09-15
JP2007523941A (ja) 2007-08-23
KR20060124722A (ko) 2006-12-05
AU2005219531B2 (en) 2009-01-15
AU2005219531A1 (en) 2005-09-15
EP1720845A1 (en) 2006-11-15

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