RU2376297C2 - Производные изотиомочевины и способ их получения, их применение и фармацевтическая композиция - Google Patents

Производные изотиомочевины и способ их получения, их применение и фармацевтическая композиция Download PDF

Info

Publication number
RU2376297C2
RU2376297C2 RU2006134019/04A RU2006134019A RU2376297C2 RU 2376297 C2 RU2376297 C2 RU 2376297C2 RU 2006134019/04 A RU2006134019/04 A RU 2006134019/04A RU 2006134019 A RU2006134019 A RU 2006134019A RU 2376297 C2 RU2376297 C2 RU 2376297C2
Authority
RU
Russia
Prior art keywords
formula
isothiourea
dihydroimidazo
compound
compounds
Prior art date
Application number
RU2006134019/04A
Other languages
English (en)
Russian (ru)
Other versions
RU2006134019A (ru
Inventor
Фрейсер ГЛИКМАН (CH)
Фрейсер ГЛИКМАН
Маркус ШТРАЙФФ (CH)
Маркус ШТРАЙФФ
Гебхард ТОМА (DE)
Гебхард Тома
Ханс-Гюнтер ЦЕРВЕС (DE)
Ханс-Гюнтер ЦЕРВЕС
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of RU2006134019A publication Critical patent/RU2006134019A/ru
Application granted granted Critical
Publication of RU2376297C2 publication Critical patent/RU2376297C2/ru

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38Nitrogen atoms
    • C07D277/42Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2006134019/04A 2004-02-27 2005-02-25 Производные изотиомочевины и способ их получения, их применение и фармацевтическая композиция RU2376297C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0404434.3 2004-02-27
GBGB0404434.3A GB0404434D0 (en) 2004-02-27 2004-02-27 Organic compounds

Publications (2)

Publication Number Publication Date
RU2006134019A RU2006134019A (ru) 2008-04-10
RU2376297C2 true RU2376297C2 (ru) 2009-12-20

Family

ID=32051024

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2006134019/04A RU2376297C2 (ru) 2004-02-27 2005-02-25 Производные изотиомочевины и способ их получения, их применение и фармацевтическая композиция

Country Status (10)

Country Link
US (1) US7671078B2 (https=)
EP (1) EP1720845A1 (https=)
JP (1) JP2007523941A (https=)
KR (1) KR20060124722A (https=)
CN (1) CN1922158A (https=)
AU (1) AU2005219531B2 (https=)
CA (1) CA2556386A1 (https=)
GB (1) GB0404434D0 (https=)
RU (1) RU2376297C2 (https=)
WO (1) WO2005085219A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2503450C1 (ru) * 2012-04-19 2014-01-10 Федеральное Государственное Бюджетное Учреждение "Медицинский Радиологический Научный Центр" Министерства Здравоохранения и Социального Развития Российской Федерации (ФГБУ МРНЦ Минздравсоцразвития России) Противоопухолевое средство

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007022385A2 (en) * 2005-08-18 2007-02-22 Novartis Ag Use of cxcr4 binding molecules for the treatment of whim syndrome
EP2657235A1 (en) 2005-10-28 2013-10-30 Ono Pharmaceutical Co., Ltd. Compound containing basic group and use thereof
WO2007058322A1 (ja) 2005-11-18 2007-05-24 Ono Pharmaceutical Co., Ltd. 塩基性基を含有する化合物およびその用途
WO2009005675A1 (en) 2007-06-28 2009-01-08 Abbott Laboratories Novel triazolopyridazines
US12011423B2 (en) 2007-11-06 2024-06-18 Foraviset Ltd. S-alkylisothiouronium derivatives for treating uterine hypercontractility disorders
EA030035B1 (ru) * 2007-11-06 2018-06-29 Меламед, Лемуил Применение s-этилизотиоурония диэтилфосфата для изготовления лекарственного средства для лечения нарушения матки
CN102088856B (zh) 2008-07-09 2015-11-25 巴斯夫欧洲公司 包含异*唑啉化合物的杀虫活性混合物i
US8921328B2 (en) 2010-09-14 2014-12-30 Glycomimetics, Inc. E-selectin antagonists
WO2012061662A1 (en) * 2010-11-03 2012-05-10 Glycomimetics, Inc. Glycomimetic-peptidomimetic inhibitors of e-selectins and cxcr4 chemokine receptors
KR102055958B1 (ko) 2011-12-22 2019-12-13 글리코미메틱스, 인크. E-셀렉틴 길항제 화합물, 조성물, 및 이용 방법
US9867841B2 (en) 2012-12-07 2018-01-16 Glycomimetics, Inc. Compounds, compositions and methods using E-selectin antagonists for mobilization of hematopoietic cells
JP6689854B2 (ja) 2014-12-03 2020-04-28 グリコミメティクス, インコーポレイテッド E−セレクチンおよびcxcr4ケモカイン受容体のヘテロ二官能性阻害剤
WO2017151708A1 (en) 2016-03-02 2017-09-08 Glycomimetics, Inc. Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin
US11433086B2 (en) 2016-08-08 2022-09-06 Glycomimetics, Inc. Combination of T-cell checkpoint inhibitors with inhibitors of e-selectin or CXCR4, or with heterobifunctional inhibitors of both E-selectin and CXCR4
AU2017341065B2 (en) 2016-10-07 2023-04-06 Crescent Biopharma, Inc. Highly potent multimeric E-selectin antagonists
EP3596096A1 (en) 2017-03-15 2020-01-22 GlycoMimetics, Inc. Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists
JP7275131B2 (ja) 2017-11-30 2023-05-17 グリコミメティクス, インコーポレイテッド 骨髄浸潤リンパ球を動員する方法、およびその使用
KR20200104889A (ko) 2017-12-29 2020-09-04 글리코미메틱스, 인크. E-셀렉틴 및 갈렉틴-3의 이종이기능성 억제제
KR20200128025A (ko) 2018-03-05 2020-11-11 글리코미메틱스, 인크. 급성 골수성 백혈병 및 관련 병태의 치료 방법
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
JP2023517616A (ja) * 2020-03-11 2023-04-26 バイオラインアールエックス・リミテッド 急性呼吸窮迫症候群およびウイルス感染の治療用のcxcr4阻害剤
US20240018125A1 (en) * 2020-09-28 2024-01-18 Ermium Therapeutics Cyclic isothiourea derivatives as cxcr4 modulators

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3542802A (en) * 1968-07-03 1970-11-24 Searle & Co 3-(n - benzylthiocarbamoylthiomethyl)-6,7-dihydro - 5h - imidazo(2,1-b)thiazolium chloride and congeners
US3881015A (en) * 1969-10-29 1975-04-29 Smith Kline French Lab Pharmaceutical compositions and methods of inhibiting histamine activity with isothiourea compounds
US4041167A (en) * 1976-01-19 1977-08-09 Diamond Shamrock Corporation Antiinflammatory imidazothiazoles
US4098898A (en) * 1975-05-21 1978-07-04 Smith Kline & French Laboratories Limited Imidazolyl alkylguanidine compounds
GB2031426A (en) * 1978-09-28 1980-04-23 Yoshitomi Pharmaceutical Imidazo(2',1':2,3)thiazolo(5,4-c)pyridines and related compounds
US4293549A (en) * 1977-11-07 1981-10-06 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktion-Saktieselskab) Quinolinyl guanidines having antiinflammatory, analgesic or antipyretic activity
US4556669A (en) * 1981-04-10 1985-12-03 Kumiai Kagaku Kogyo Kabushiki Kaisha 2,-3-Di-substituted-5,6-dihydroimidazo [2,1-b] thiazole, its salts, production thereof and anti-inflammatory agent containing the same
US4736038A (en) * 1985-04-22 1988-04-05 Kumiai Chemical Industry Co., Ltd. 5,6-dihydroimidazo(2,1-b)thiazole-2-carboxamide derivatives or salts thereof
WO2000046187A2 (en) * 1999-02-05 2000-08-10 Oridigm Corporation Antizyme modulators and their use
WO2002024711A1 (en) * 2000-09-20 2002-03-28 Nikken Chemicals Co., Ltd. Novel thiazole bicyclic compounds
WO2002072585A2 (de) * 2001-03-14 2002-09-19 Grünenthal GmbH Substituierte pyrazolo- und thiazolopyrimidine als analgetika

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE758145A (fr) * 1969-10-29 1971-04-28 Smith Kline French Lab Iso-thio-urees et derives

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3542802A (en) * 1968-07-03 1970-11-24 Searle & Co 3-(n - benzylthiocarbamoylthiomethyl)-6,7-dihydro - 5h - imidazo(2,1-b)thiazolium chloride and congeners
US3881015A (en) * 1969-10-29 1975-04-29 Smith Kline French Lab Pharmaceutical compositions and methods of inhibiting histamine activity with isothiourea compounds
US4098898A (en) * 1975-05-21 1978-07-04 Smith Kline & French Laboratories Limited Imidazolyl alkylguanidine compounds
US4041167A (en) * 1976-01-19 1977-08-09 Diamond Shamrock Corporation Antiinflammatory imidazothiazoles
US4293549A (en) * 1977-11-07 1981-10-06 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktion-Saktieselskab) Quinolinyl guanidines having antiinflammatory, analgesic or antipyretic activity
GB2031426A (en) * 1978-09-28 1980-04-23 Yoshitomi Pharmaceutical Imidazo(2',1':2,3)thiazolo(5,4-c)pyridines and related compounds
US4556669A (en) * 1981-04-10 1985-12-03 Kumiai Kagaku Kogyo Kabushiki Kaisha 2,-3-Di-substituted-5,6-dihydroimidazo [2,1-b] thiazole, its salts, production thereof and anti-inflammatory agent containing the same
US4736038A (en) * 1985-04-22 1988-04-05 Kumiai Chemical Industry Co., Ltd. 5,6-dihydroimidazo(2,1-b)thiazole-2-carboxamide derivatives or salts thereof
WO2000046187A2 (en) * 1999-02-05 2000-08-10 Oridigm Corporation Antizyme modulators and their use
WO2002024711A1 (en) * 2000-09-20 2002-03-28 Nikken Chemicals Co., Ltd. Novel thiazole bicyclic compounds
WO2002072585A2 (de) * 2001-03-14 2002-09-19 Grünenthal GmbH Substituierte pyrazolo- und thiazolopyrimidine als analgetika

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Mellor J.M.; Rataj H., TETRAHEDRON LETTERS, 1996, 37, 15, 2619-2622. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2503450C1 (ru) * 2012-04-19 2014-01-10 Федеральное Государственное Бюджетное Учреждение "Медицинский Радиологический Научный Центр" Министерства Здравоохранения и Социального Развития Российской Федерации (ФГБУ МРНЦ Минздравсоцразвития России) Противоопухолевое средство

Also Published As

Publication number Publication date
US7671078B2 (en) 2010-03-02
RU2006134019A (ru) 2008-04-10
US20070161618A1 (en) 2007-07-12
AU2005219531B2 (en) 2009-01-15
CA2556386A1 (en) 2005-09-15
AU2005219531A1 (en) 2005-09-15
GB0404434D0 (en) 2004-03-31
KR20060124722A (ko) 2006-12-05
EP1720845A1 (en) 2006-11-15
JP2007523941A (ja) 2007-08-23
CN1922158A (zh) 2007-02-28
WO2005085219A1 (en) 2005-09-15

Similar Documents

Publication Publication Date Title
RU2376297C2 (ru) Производные изотиомочевины и способ их получения, их применение и фармацевтическая композиция
KR100583704B1 (ko) 4-아미노-5-페닐-7-시클로부틸-피롤로 (2,3-d) 피리미딘유도체
CN1918158B (zh) 作为蛋白激酶抑制剂的化合物和组合物
JP6275846B2 (ja) 求電子性官能基を有するヘテロアリールピリドン及びアザ−ピリドン化合物
CN105481862B (zh) Flt3激酶的新型抑制剂及其用途
CN100413867C (zh) 4-氨基-5-苯基-7-环己基-吡咯并[2,3-d]嘧啶衍生物
US20080234294A1 (en) Cxcr4 Binding Molecules
KR20110005819A (ko) 케모카인 수용체 조절제
KR20070097493A (ko) 키나제 억제제로서의 이치환된 우레아
CN108368060B (zh) 一类嘧啶类衍生物激酶抑制剂
JP2017149755A (ja) キナーゼ阻害活性を有するベンズヒドロール−ピラゾール誘導体及びその使用
KR20060127032A (ko) Igf―ir 억제제로서의페닐-[4-(3-페닐-1h-피라졸-4-일)-피리미딘-2-일]-아민유도체
EP3466952B1 (en) 1-(4-(4-amino-3-phenyl-1h-pyrazolo[3,4-d]pyrimidin-1-yl)-phenyl)-urea derivatives as flt3 kinase inhibitors for treating cancer
JP2015516462A (ja) 単環式ヘテロアリールシクロアルキルジアミン誘導体
JP2009532400A (ja) キナーゼ阻害剤としての3−非置換N−(アリール−もしくはヘテロアリール)−ピラゾロ[1,5−a]ピリミジン
EP1742937B1 (en) Pyrrolopyrimidine derivatives for treating proliferative diseases
EP1556380B1 (fr) Derives de pyridoindolone substitues en -3 par un groupe heterocyclique, leur preparation et leur application en therapeutique
MXPA06009696A (en) Isothiourea derivatives
JPH09183764A (ja) N−ベンゾイルプロリンエステル誘導体
JP4122441B2 (ja) 新規cxcr4拮抗剤及びその用途

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20100226