CA2556386A1 - Isothiourea derivatives - Google Patents
Isothiourea derivatives Download PDFInfo
- Publication number
- CA2556386A1 CA2556386A1 CA002556386A CA2556386A CA2556386A1 CA 2556386 A1 CA2556386 A1 CA 2556386A1 CA 002556386 A CA002556386 A CA 002556386A CA 2556386 A CA2556386 A CA 2556386A CA 2556386 A1 CA2556386 A1 CA 2556386A1
- Authority
- CA
- Canada
- Prior art keywords
- formula
- compound
- optionally
- dihydro
- isothiourea
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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Landscapes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0404434.3 | 2004-02-27 | ||
| GBGB0404434.3A GB0404434D0 (en) | 2004-02-27 | 2004-02-27 | Organic compounds |
| PCT/EP2005/002014 WO2005085219A1 (en) | 2004-02-27 | 2005-02-25 | Isothiourea derivatives |
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| CA2556386A1 true CA2556386A1 (en) | 2005-09-15 |
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| CA002556386A Abandoned CA2556386A1 (en) | 2004-02-27 | 2005-02-25 | Isothiourea derivatives |
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| US (1) | US7671078B2 (https=) |
| EP (1) | EP1720845A1 (https=) |
| JP (1) | JP2007523941A (https=) |
| KR (1) | KR20060124722A (https=) |
| CN (1) | CN1922158A (https=) |
| AU (1) | AU2005219531B2 (https=) |
| CA (1) | CA2556386A1 (https=) |
| GB (1) | GB0404434D0 (https=) |
| RU (1) | RU2376297C2 (https=) |
| WO (1) | WO2005085219A1 (https=) |
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| WO2007022385A2 (en) * | 2005-08-18 | 2007-02-22 | Novartis Ag | Use of cxcr4 binding molecules for the treatment of whim syndrome |
| PT1942108E (pt) | 2005-10-28 | 2013-10-24 | Ono Pharmaceutical Co | Composto com um grupo básico e a sua utilização |
| WO2007058322A1 (ja) | 2005-11-18 | 2007-05-24 | Ono Pharmaceutical Co., Ltd. | 塩基性基を含有する化合物およびその用途 |
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| US12011423B2 (en) | 2007-11-06 | 2024-06-18 | Foraviset Ltd. | S-alkylisothiouronium derivatives for treating uterine hypercontractility disorders |
| US20100305210A1 (en) * | 2007-11-06 | 2010-12-02 | Barkan-Farma S.R.L. | S-alkylisothiouronium derivatives for treating abnormal uterine bleeding disorders |
| CN102088856B (zh) | 2008-07-09 | 2015-11-25 | 巴斯夫欧洲公司 | 包含异*唑啉化合物的杀虫活性混合物i |
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| PT2794626T (pt) | 2011-12-22 | 2018-01-12 | Glycomimetics Inc | Compostos de antagonistas de e-selectina |
| RU2503450C1 (ru) * | 2012-04-19 | 2014-01-10 | Федеральное Государственное Бюджетное Учреждение "Медицинский Радиологический Научный Центр" Министерства Здравоохранения и Социального Развития Российской Федерации (ФГБУ МРНЦ Минздравсоцразвития России) | Противоопухолевое средство |
| CA2891514C (en) | 2012-12-07 | 2020-08-25 | Glycomimetics, Inc. | Compounds, compositions and methods using e-selectin antagonists for mobilization of hematopoietic cells |
| ES2754549T3 (es) | 2014-12-03 | 2020-04-20 | Glycomimetics Inc | Inhibidores heterobifuncionales de E-selectinas y receptores de quimioquinas CXCR4 |
| WO2017151708A1 (en) | 2016-03-02 | 2017-09-08 | Glycomimetics, Inc. | Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin |
| EP3497131B1 (en) | 2016-08-08 | 2022-03-09 | GlycoMimetics, Inc. | Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4. |
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| CN111566117A (zh) | 2017-12-29 | 2020-08-21 | 糖模拟物有限公司 | E-选择蛋白和半乳凝素-3的异双功能抑制剂 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3542802A (en) * | 1968-07-03 | 1970-11-24 | Searle & Co | 3-(n - benzylthiocarbamoylthiomethyl)-6,7-dihydro - 5h - imidazo(2,1-b)thiazolium chloride and congeners |
| BE758145A (fr) * | 1969-10-29 | 1971-04-28 | Smith Kline French Lab | Iso-thio-urees et derives |
| BE758146A (fr) * | 1969-10-29 | 1971-04-28 | Smith Kline French Lab | Derives de l'amidine |
| IL49528A (en) | 1975-05-21 | 1980-11-30 | Smith Kline French Lab | Imidazolyl(or thiazolyl)methylthio(or butyl)guanidine or thiourea derivatives,their preparation and pharmaceutical compositions comprising them |
| US4041167A (en) * | 1976-01-19 | 1977-08-09 | Diamond Shamrock Corporation | Antiinflammatory imidazothiazoles |
| IE47458B1 (en) * | 1977-11-07 | 1984-03-21 | Leo Pharm Prod Ltd | Quinolylguanidine derivatives |
| CA1131226A (en) * | 1978-09-28 | 1982-09-07 | Tomohiko Munakata | Heterocyclic compounds |
| JPS57169490A (en) * | 1981-04-10 | 1982-10-19 | Kumiai Chem Ind Co Ltd | 2,3-disubstituted-5,6-dihydro-imidazo(2,1-b)thiazole, its salt and their preparation |
| CA1271480A (en) * | 1985-04-22 | 1990-07-10 | Toyo Jozo Co., Ltd. | 5,6-dihydroimidazo[2,1-b]thiazole-2-carboxamide derivatives or salts thereof |
| ATE308515T1 (de) | 1999-02-05 | 2005-11-15 | Oridigm Corp | Antizymmodulatoren sowie deren verwendung |
| AU2001290243A1 (en) * | 2000-09-20 | 2002-04-02 | Nikken Chemicals Co., Ltd. | Novel thiazole bicyclic compounds |
| EP1368355B1 (de) * | 2001-03-14 | 2006-06-07 | Grünenthal GmbH | Substituierte pyrazolo- und thiazolopyrimidine als analgetika |
-
2004
- 2004-02-27 GB GBGB0404434.3A patent/GB0404434D0/en not_active Ceased
-
2005
- 2005-02-25 KR KR1020067017114A patent/KR20060124722A/ko not_active Withdrawn
- 2005-02-25 EP EP05715554A patent/EP1720845A1/en not_active Withdrawn
- 2005-02-25 WO PCT/EP2005/002014 patent/WO2005085219A1/en not_active Ceased
- 2005-02-25 US US10/590,399 patent/US7671078B2/en not_active Expired - Fee Related
- 2005-02-25 RU RU2006134019/04A patent/RU2376297C2/ru not_active IP Right Cessation
- 2005-02-25 JP JP2007500168A patent/JP2007523941A/ja active Pending
- 2005-02-25 CA CA002556386A patent/CA2556386A1/en not_active Abandoned
- 2005-02-25 AU AU2005219531A patent/AU2005219531B2/en not_active Ceased
- 2005-02-25 CN CNA2005800060942A patent/CN1922158A/zh active Pending
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|---|---|
| GB0404434D0 (en) | 2004-03-31 |
| RU2006134019A (ru) | 2008-04-10 |
| CN1922158A (zh) | 2007-02-28 |
| US20070161618A1 (en) | 2007-07-12 |
| US7671078B2 (en) | 2010-03-02 |
| WO2005085219A1 (en) | 2005-09-15 |
| JP2007523941A (ja) | 2007-08-23 |
| KR20060124722A (ko) | 2006-12-05 |
| AU2005219531B2 (en) | 2009-01-15 |
| RU2376297C2 (ru) | 2009-12-20 |
| AU2005219531A1 (en) | 2005-09-15 |
| EP1720845A1 (en) | 2006-11-15 |
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