JP2007523941A - イソチオウレア誘導体 - Google Patents
イソチオウレア誘導体 Download PDFInfo
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- JP2007523941A JP2007523941A JP2007500168A JP2007500168A JP2007523941A JP 2007523941 A JP2007523941 A JP 2007523941A JP 2007500168 A JP2007500168 A JP 2007500168A JP 2007500168 A JP2007500168 A JP 2007500168A JP 2007523941 A JP2007523941 A JP 2007523941A
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- alkyl
- aryl
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- 125000001072 heteroaryl group Chemical group 0.000 claims description 18
- 125000003118 aryl group Chemical group 0.000 claims description 17
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 14
- 125000000217 alkyl group Chemical group 0.000 claims description 13
- -1 heptyl-2- (6,6-dimethyl-5,6-dihydro-imidazo [2,1-b] thiazol-3-ylmethyl) -isothiourea Chemical compound 0.000 claims description 13
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Classifications
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- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
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- C07—ORGANIC CHEMISTRY
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- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
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Landscapes
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0404434.3A GB0404434D0 (en) | 2004-02-27 | 2004-02-27 | Organic compounds |
| PCT/EP2005/002014 WO2005085219A1 (en) | 2004-02-27 | 2005-02-25 | Isothiourea derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007523941A true JP2007523941A (ja) | 2007-08-23 |
| JP2007523941A5 JP2007523941A5 (https=) | 2008-04-10 |
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| JP2007500168A Pending JP2007523941A (ja) | 2004-02-27 | 2005-02-25 | イソチオウレア誘導体 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7671078B2 (https=) |
| EP (1) | EP1720845A1 (https=) |
| JP (1) | JP2007523941A (https=) |
| KR (1) | KR20060124722A (https=) |
| CN (1) | CN1922158A (https=) |
| AU (1) | AU2005219531B2 (https=) |
| CA (1) | CA2556386A1 (https=) |
| GB (1) | GB0404434D0 (https=) |
| RU (1) | RU2376297C2 (https=) |
| WO (1) | WO2005085219A1 (https=) |
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| WO2007022385A2 (en) * | 2005-08-18 | 2007-02-22 | Novartis Ag | Use of cxcr4 binding molecules for the treatment of whim syndrome |
| EP2657235A1 (en) | 2005-10-28 | 2013-10-30 | Ono Pharmaceutical Co., Ltd. | Compound containing basic group and use thereof |
| WO2007058322A1 (ja) | 2005-11-18 | 2007-05-24 | Ono Pharmaceutical Co., Ltd. | 塩基性基を含有する化合物およびその用途 |
| WO2009005675A1 (en) | 2007-06-28 | 2009-01-08 | Abbott Laboratories | Novel triazolopyridazines |
| US12011423B2 (en) | 2007-11-06 | 2024-06-18 | Foraviset Ltd. | S-alkylisothiouronium derivatives for treating uterine hypercontractility disorders |
| EA030035B1 (ru) * | 2007-11-06 | 2018-06-29 | Меламед, Лемуил | Применение s-этилизотиоурония диэтилфосфата для изготовления лекарственного средства для лечения нарушения матки |
| CN102088856B (zh) | 2008-07-09 | 2015-11-25 | 巴斯夫欧洲公司 | 包含异*唑啉化合物的杀虫活性混合物i |
| US8921328B2 (en) | 2010-09-14 | 2014-12-30 | Glycomimetics, Inc. | E-selectin antagonists |
| WO2012061662A1 (en) * | 2010-11-03 | 2012-05-10 | Glycomimetics, Inc. | Glycomimetic-peptidomimetic inhibitors of e-selectins and cxcr4 chemokine receptors |
| KR102055958B1 (ko) | 2011-12-22 | 2019-12-13 | 글리코미메틱스, 인크. | E-셀렉틴 길항제 화합물, 조성물, 및 이용 방법 |
| RU2503450C1 (ru) * | 2012-04-19 | 2014-01-10 | Федеральное Государственное Бюджетное Учреждение "Медицинский Радиологический Научный Центр" Министерства Здравоохранения и Социального Развития Российской Федерации (ФГБУ МРНЦ Минздравсоцразвития России) | Противоопухолевое средство |
| US9867841B2 (en) | 2012-12-07 | 2018-01-16 | Glycomimetics, Inc. | Compounds, compositions and methods using E-selectin antagonists for mobilization of hematopoietic cells |
| JP6689854B2 (ja) | 2014-12-03 | 2020-04-28 | グリコミメティクス， インコーポレイテッド | Ｅ−セレクチンおよびｃｘｃｒ４ケモカイン受容体のヘテロ二官能性阻害剤 |
| WO2017151708A1 (en) | 2016-03-02 | 2017-09-08 | Glycomimetics, Inc. | Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin |
| US11433086B2 (en) | 2016-08-08 | 2022-09-06 | Glycomimetics, Inc. | Combination of T-cell checkpoint inhibitors with inhibitors of e-selectin or CXCR4, or with heterobifunctional inhibitors of both E-selectin and CXCR4 |
| AU2017341065B2 (en) | 2016-10-07 | 2023-04-06 | Crescent Biopharma, Inc. | Highly potent multimeric E-selectin antagonists |
| EP3596096A1 (en) | 2017-03-15 | 2020-01-22 | GlycoMimetics, Inc. | Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists |
| JP7275131B2 (ja) | 2017-11-30 | 2023-05-17 | グリコミメティクス， インコーポレイテッド | 骨髄浸潤リンパ球を動員する方法、およびその使用 |
| KR20200104889A (ko) | 2017-12-29 | 2020-09-04 | 글리코미메틱스, 인크. | E-셀렉틴 및 갈렉틴-3의 이종이기능성 억제제 |
| KR20200128025A (ko) | 2018-03-05 | 2020-11-11 | 글리코미메틱스, 인크. | 급성 골수성 백혈병 및 관련 병태의 치료 방법 |
| US11845771B2 (en) | 2018-12-27 | 2023-12-19 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
| JP2023517616A (ja) * | 2020-03-11 | 2023-04-26 | バイオラインアールエックス・リミテッド | 急性呼吸窮迫症候群およびウイルス感染の治療用のｃｘｃｒ４阻害剤 |
| US20240018125A1 (en) * | 2020-09-28 | 2024-01-18 | Ermium Therapeutics | Cyclic isothiourea derivatives as cxcr4 modulators |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4917262B1 (https=) * | 1969-10-29 | 1974-04-27 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3542802A (en) * | 1968-07-03 | 1970-11-24 | Searle & Co | 3-(n - benzylthiocarbamoylthiomethyl)-6,7-dihydro - 5h - imidazo(2,1-b)thiazolium chloride and congeners |
| BE758146A (fr) * | 1969-10-29 | 1971-04-28 | Smith Kline French Lab | Derives de l'amidine |
| IL49528A (en) | 1975-05-21 | 1980-11-30 | Smith Kline French Lab | Imidazolyl(or thiazolyl)methylthio(or butyl)guanidine or thiourea derivatives,their preparation and pharmaceutical compositions comprising them |
| US4041167A (en) * | 1976-01-19 | 1977-08-09 | Diamond Shamrock Corporation | Antiinflammatory imidazothiazoles |
| IE47458B1 (en) | 1977-11-07 | 1984-03-21 | Leo Pharm Prod Ltd | Quinolylguanidine derivatives |
| CA1131226A (en) * | 1978-09-28 | 1982-09-07 | Tomohiko Munakata | Heterocyclic compounds |
| JPS57169490A (en) * | 1981-04-10 | 1982-10-19 | Kumiai Chem Ind Co Ltd | 2,3-disubstituted-5,6-dihydro-imidazo(2,1-b)thiazole, its salt and their preparation |
| CA1271480A (en) * | 1985-04-22 | 1990-07-10 | Toyo Jozo Co., Ltd. | 5,6-dihydroimidazo[2,1-b]thiazole-2-carboxamide derivatives or salts thereof |
| JP4094230B2 (ja) * | 1999-02-05 | 2008-06-04 | メディクエスト セラピューティックス インク | アンチザイムモジュレーターおよびその使用 |
| AU2001290243A1 (en) * | 2000-09-20 | 2002-04-02 | Nikken Chemicals Co., Ltd. | Novel thiazole bicyclic compounds |
| DE50207103D1 (en) * | 2001-03-14 | 2006-07-20 | Gruenenthal Gmbh | Substituierte pyrazolo- und thiazolopyrimidine als analgetika |
-
2004
- 2004-02-27 GB GBGB0404434.3A patent/GB0404434D0/en not_active Ceased
-
2005
- 2005-02-25 EP EP05715554A patent/EP1720845A1/en not_active Withdrawn
- 2005-02-25 JP JP2007500168A patent/JP2007523941A/ja active Pending
- 2005-02-25 RU RU2006134019/04A patent/RU2376297C2/ru not_active IP Right Cessation
- 2005-02-25 US US10/590,399 patent/US7671078B2/en not_active Expired - Fee Related
- 2005-02-25 WO PCT/EP2005/002014 patent/WO2005085219A1/en not_active Ceased
- 2005-02-25 CN CNA2005800060942A patent/CN1922158A/zh active Pending
- 2005-02-25 AU AU2005219531A patent/AU2005219531B2/en not_active Ceased
- 2005-02-25 KR KR1020067017114A patent/KR20060124722A/ko not_active Withdrawn
- 2005-02-25 CA CA002556386A patent/CA2556386A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4917262B1 (https=) * | 1969-10-29 | 1974-04-27 |
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| US7671078B2 (en) | 2010-03-02 |
| RU2006134019A (ru) | 2008-04-10 |
| US20070161618A1 (en) | 2007-07-12 |
| AU2005219531B2 (en) | 2009-01-15 |
| CA2556386A1 (en) | 2005-09-15 |
| AU2005219531A1 (en) | 2005-09-15 |
| GB0404434D0 (en) | 2004-03-31 |
| KR20060124722A (ko) | 2006-12-05 |
| RU2376297C2 (ru) | 2009-12-20 |
| EP1720845A1 (en) | 2006-11-15 |
| CN1922158A (zh) | 2007-02-28 |
| WO2005085219A1 (en) | 2005-09-15 |
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