JP2007523941A - イソチオウレア誘導体 - Google Patents
イソチオウレア誘導体 Download PDFInfo
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- JP2007523941A JP2007523941A JP2007500168A JP2007500168A JP2007523941A JP 2007523941 A JP2007523941 A JP 2007523941A JP 2007500168 A JP2007500168 A JP 2007500168A JP 2007500168 A JP2007500168 A JP 2007500168A JP 2007523941 A JP2007523941 A JP 2007523941A
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- alkyl
- aryl
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- 125000001072 heteroaryl group Chemical group 0.000 claims description 18
- 125000003118 aryl group Chemical group 0.000 claims description 17
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 14
- 125000000217 alkyl group Chemical group 0.000 claims description 13
- -1 heptyl-2- (6,6-dimethyl-5,6-dihydro-imidazo [2,1-b] thiazol-3-ylmethyl) -isothiourea Chemical compound 0.000 claims description 13
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- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Landscapes
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| GBGB0404434.3A GB0404434D0 (en) | 2004-02-27 | 2004-02-27 | Organic compounds |
| PCT/EP2005/002014 WO2005085219A1 (en) | 2004-02-27 | 2005-02-25 | Isothiourea derivatives |
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| JP2007523941A true JP2007523941A (ja) | 2007-08-23 |
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| JP (1) | JP2007523941A (https=) |
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| PT1942108E (pt) | 2005-10-28 | 2013-10-24 | Ono Pharmaceutical Co | Composto com um grupo básico e a sua utilização |
| WO2007058322A1 (ja) | 2005-11-18 | 2007-05-24 | Ono Pharmaceutical Co., Ltd. | 塩基性基を含有する化合物およびその用途 |
| WO2009005675A1 (en) | 2007-06-28 | 2009-01-08 | Abbott Laboratories | Novel triazolopyridazines |
| US12011423B2 (en) | 2007-11-06 | 2024-06-18 | Foraviset Ltd. | S-alkylisothiouronium derivatives for treating uterine hypercontractility disorders |
| US20100305210A1 (en) * | 2007-11-06 | 2010-12-02 | Barkan-Farma S.R.L. | S-alkylisothiouronium derivatives for treating abnormal uterine bleeding disorders |
| CN102088856B (zh) | 2008-07-09 | 2015-11-25 | 巴斯夫欧洲公司 | 包含异*唑啉化合物的杀虫活性混合物i |
| US8921328B2 (en) | 2010-09-14 | 2014-12-30 | Glycomimetics, Inc. | E-selectin antagonists |
| WO2012061662A1 (en) * | 2010-11-03 | 2012-05-10 | Glycomimetics, Inc. | Glycomimetic-peptidomimetic inhibitors of e-selectins and cxcr4 chemokine receptors |
| PT2794626T (pt) | 2011-12-22 | 2018-01-12 | Glycomimetics Inc | Compostos de antagonistas de e-selectina |
| RU2503450C1 (ru) * | 2012-04-19 | 2014-01-10 | Федеральное Государственное Бюджетное Учреждение "Медицинский Радиологический Научный Центр" Министерства Здравоохранения и Социального Развития Российской Федерации (ФГБУ МРНЦ Минздравсоцразвития России) | Противоопухолевое средство |
| CA2891514C (en) | 2012-12-07 | 2020-08-25 | Glycomimetics, Inc. | Compounds, compositions and methods using e-selectin antagonists for mobilization of hematopoietic cells |
| ES2754549T3 (es) | 2014-12-03 | 2020-04-20 | Glycomimetics Inc | Inhibidores heterobifuncionales de E-selectinas y receptores de quimioquinas CXCR4 |
| WO2017151708A1 (en) | 2016-03-02 | 2017-09-08 | Glycomimetics, Inc. | Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin |
| EP3497131B1 (en) | 2016-08-08 | 2022-03-09 | GlycoMimetics, Inc. | Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4. |
| US11072625B2 (en) | 2016-10-07 | 2021-07-27 | Glycomimetics, Inc. | Highly potent multimeric e-selectin antagonists |
| CA3054605A1 (en) | 2017-03-15 | 2018-09-20 | Glycomimetics, Inc. | Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists |
| WO2019108750A1 (en) | 2017-11-30 | 2019-06-06 | Glycomimetics, Inc. | Methods of mobilizing marrow infiltrating lymphocytes and uses thereof |
| CN111566117A (zh) | 2017-12-29 | 2020-08-21 | 糖模拟物有限公司 | E-选择蛋白和半乳凝素-3的异双功能抑制剂 |
| WO2019173229A1 (en) | 2018-03-05 | 2019-09-12 | Glycomimetics, Inc. | Methods for treating acute myeloid leukemia and related conditions |
| US11845771B2 (en) | 2018-12-27 | 2023-12-19 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
| CA3174634A1 (en) * | 2020-03-11 | 2021-09-16 | Biolinerx Ltd. | Cxcr4 inhibitor for the treatment of acute respiratory distress syndrome and viral infections |
| MX2023003409A (es) * | 2020-09-28 | 2023-06-26 | Ermium Therapeutics | Derivados de isotiourea ciclica como moduladores de cxcr4. |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4917262B1 (https=) * | 1969-10-29 | 1974-04-27 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3542802A (en) * | 1968-07-03 | 1970-11-24 | Searle & Co | 3-(n - benzylthiocarbamoylthiomethyl)-6,7-dihydro - 5h - imidazo(2,1-b)thiazolium chloride and congeners |
| BE758146A (fr) * | 1969-10-29 | 1971-04-28 | Smith Kline French Lab | Derives de l'amidine |
| IL49528A (en) | 1975-05-21 | 1980-11-30 | Smith Kline French Lab | Imidazolyl(or thiazolyl)methylthio(or butyl)guanidine or thiourea derivatives,their preparation and pharmaceutical compositions comprising them |
| US4041167A (en) * | 1976-01-19 | 1977-08-09 | Diamond Shamrock Corporation | Antiinflammatory imidazothiazoles |
| IE47458B1 (en) * | 1977-11-07 | 1984-03-21 | Leo Pharm Prod Ltd | Quinolylguanidine derivatives |
| CA1131226A (en) * | 1978-09-28 | 1982-09-07 | Tomohiko Munakata | Heterocyclic compounds |
| JPS57169490A (en) * | 1981-04-10 | 1982-10-19 | Kumiai Chem Ind Co Ltd | 2,3-disubstituted-5,6-dihydro-imidazo(2,1-b)thiazole, its salt and their preparation |
| CA1271480A (en) * | 1985-04-22 | 1990-07-10 | Toyo Jozo Co., Ltd. | 5,6-dihydroimidazo[2,1-b]thiazole-2-carboxamide derivatives or salts thereof |
| ATE308515T1 (de) | 1999-02-05 | 2005-11-15 | Oridigm Corp | Antizymmodulatoren sowie deren verwendung |
| AU2001290243A1 (en) * | 2000-09-20 | 2002-04-02 | Nikken Chemicals Co., Ltd. | Novel thiazole bicyclic compounds |
| EP1368355B1 (de) * | 2001-03-14 | 2006-06-07 | Grünenthal GmbH | Substituierte pyrazolo- und thiazolopyrimidine als analgetika |
-
2004
- 2004-02-27 GB GBGB0404434.3A patent/GB0404434D0/en not_active Ceased
-
2005
- 2005-02-25 KR KR1020067017114A patent/KR20060124722A/ko not_active Withdrawn
- 2005-02-25 EP EP05715554A patent/EP1720845A1/en not_active Withdrawn
- 2005-02-25 WO PCT/EP2005/002014 patent/WO2005085219A1/en not_active Ceased
- 2005-02-25 US US10/590,399 patent/US7671078B2/en not_active Expired - Fee Related
- 2005-02-25 RU RU2006134019/04A patent/RU2376297C2/ru not_active IP Right Cessation
- 2005-02-25 JP JP2007500168A patent/JP2007523941A/ja active Pending
- 2005-02-25 CA CA002556386A patent/CA2556386A1/en not_active Abandoned
- 2005-02-25 AU AU2005219531A patent/AU2005219531B2/en not_active Ceased
- 2005-02-25 CN CNA2005800060942A patent/CN1922158A/zh active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4917262B1 (https=) * | 1969-10-29 | 1974-04-27 |
Also Published As
| Publication number | Publication date |
|---|---|
| GB0404434D0 (en) | 2004-03-31 |
| RU2006134019A (ru) | 2008-04-10 |
| CN1922158A (zh) | 2007-02-28 |
| US20070161618A1 (en) | 2007-07-12 |
| CA2556386A1 (en) | 2005-09-15 |
| US7671078B2 (en) | 2010-03-02 |
| WO2005085219A1 (en) | 2005-09-15 |
| KR20060124722A (ko) | 2006-12-05 |
| AU2005219531B2 (en) | 2009-01-15 |
| RU2376297C2 (ru) | 2009-12-20 |
| AU2005219531A1 (en) | 2005-09-15 |
| EP1720845A1 (en) | 2006-11-15 |
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