RU2369635C2 - Иммунизация рыб против вирусной инфекции - Google Patents
Иммунизация рыб против вирусной инфекции Download PDFInfo
- Publication number
- RU2369635C2 RU2369635C2 RU2005120158A RU2005120158A RU2369635C2 RU 2369635 C2 RU2369635 C2 RU 2369635C2 RU 2005120158 A RU2005120158 A RU 2005120158A RU 2005120158 A RU2005120158 A RU 2005120158A RU 2369635 C2 RU2369635 C2 RU 2369635C2
- Authority
- RU
- Russia
- Prior art keywords
- virus
- fish
- dna
- carp
- live attenuated
- Prior art date
Links
- 241000251468 Actinopterygii Species 0.000 title claims abstract description 242
- 230000009385 viral infection Effects 0.000 title claims description 6
- 238000002649 immunization Methods 0.000 title abstract description 16
- 241000700605 Viruses Species 0.000 claims abstract description 363
- 241000252233 Cyprinus carpio Species 0.000 claims abstract description 72
- 230000002238 attenuated effect Effects 0.000 claims abstract description 71
- 238000000034 method Methods 0.000 claims abstract description 62
- 239000000203 mixture Substances 0.000 claims abstract description 22
- 230000028993 immune response Effects 0.000 claims abstract description 10
- 230000001018 virulence Effects 0.000 claims abstract description 8
- 108020004414 DNA Proteins 0.000 claims description 109
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 56
- 201000010099 disease Diseases 0.000 claims description 55
- 229960005486 vaccine Drugs 0.000 claims description 46
- 208000015181 infectious disease Diseases 0.000 claims description 45
- 230000003612 virological effect Effects 0.000 claims description 27
- 230000003053 immunization Effects 0.000 claims description 26
- 210000002966 serum Anatomy 0.000 claims description 24
- 210000000234 capsid Anatomy 0.000 claims description 22
- 241001465754 Metazoa Species 0.000 claims description 12
- 238000001493 electron microscopy Methods 0.000 claims description 12
- 102000053602 DNA Human genes 0.000 claims description 11
- 238000004113 cell culture Methods 0.000 claims description 10
- 230000036039 immunity Effects 0.000 claims description 10
- 239000007924 injection Substances 0.000 claims description 10
- 238000002347 injection Methods 0.000 claims description 10
- 230000008569 process Effects 0.000 claims description 9
- 239000002245 particle Substances 0.000 claims description 8
- 238000009360 aquaculture Methods 0.000 claims description 6
- 244000144974 aquaculture Species 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 6
- 238000002955 isolation Methods 0.000 claims description 6
- 244000005700 microbiome Species 0.000 claims description 6
- 238000012545 processing Methods 0.000 claims description 6
- 230000002829 reductive effect Effects 0.000 claims description 6
- 230000002498 deadly effect Effects 0.000 claims description 5
- 235000013305 food Nutrition 0.000 claims description 5
- 208000036142 Viral infection Diseases 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 3
- 238000007747 plating Methods 0.000 claims description 2
- 238000005507 spraying Methods 0.000 claims description 2
- 238000000386 microscopy Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 abstract description 11
- 239000003814 drug Substances 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 210000004027 cell Anatomy 0.000 description 40
- 238000002360 preparation method Methods 0.000 description 26
- 210000001519 tissue Anatomy 0.000 description 25
- 108020005202 Viral DNA Proteins 0.000 description 17
- 239000002609 medium Substances 0.000 description 17
- 239000008055 phosphate buffer solution Substances 0.000 description 17
- 241000283973 Oryctolagus cuniculus Species 0.000 description 16
- 239000000427 antigen Substances 0.000 description 15
- 102000036639 antigens Human genes 0.000 description 15
- 108091007433 antigens Proteins 0.000 description 15
- 239000002671 adjuvant Substances 0.000 description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
- 239000012634 fragment Substances 0.000 description 12
- 210000000056 organ Anatomy 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- 239000000243 solution Substances 0.000 description 11
- 238000011282 treatment Methods 0.000 description 11
- 241001529453 unidentified herpesvirus Species 0.000 description 11
- 238000002474 experimental method Methods 0.000 description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 9
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 9
- 239000002253 acid Substances 0.000 description 9
- 238000004458 analytical method Methods 0.000 description 9
- 208000024891 symptom Diseases 0.000 description 9
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 8
- 230000000120 cytopathologic effect Effects 0.000 description 8
- 238000011534 incubation Methods 0.000 description 8
- 210000003734 kidney Anatomy 0.000 description 8
- 239000007788 liquid Substances 0.000 description 8
- 102000004169 proteins and genes Human genes 0.000 description 8
- 108090000623 proteins and genes Proteins 0.000 description 8
- 241000701959 Escherichia virus Lambda Species 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 239000008280 blood Substances 0.000 description 7
- 239000000523 sample Substances 0.000 description 7
- 241000701161 unidentified adenovirus Species 0.000 description 7
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 6
- 241000252210 Cyprinidae Species 0.000 description 6
- 238000009007 Diagnostic Kit Methods 0.000 description 6
- 238000002965 ELISA Methods 0.000 description 6
- 150000007513 acids Chemical class 0.000 description 6
- 239000003242 anti bacterial agent Substances 0.000 description 6
- 229940088710 antibiotic agent Drugs 0.000 description 6
- 239000000284 extract Substances 0.000 description 6
- 210000004185 liver Anatomy 0.000 description 6
- 239000003550 marker Substances 0.000 description 6
- 239000002773 nucleotide Substances 0.000 description 6
- 125000003729 nucleotide group Chemical group 0.000 description 6
- 239000013612 plasmid Substances 0.000 description 6
- 239000011780 sodium chloride Substances 0.000 description 6
- 238000005303 weighing Methods 0.000 description 6
- 241000252231 Cyprinus Species 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- 238000005119 centrifugation Methods 0.000 description 5
- 239000013604 expression vector Substances 0.000 description 5
- 239000000499 gel Substances 0.000 description 5
- 230000014509 gene expression Effects 0.000 description 5
- 210000002816 gill Anatomy 0.000 description 5
- 230000003308 immunostimulating effect Effects 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 108091008146 restriction endonucleases Proteins 0.000 description 5
- 241000252229 Carassius auratus Species 0.000 description 4
- 241000252230 Ctenopharyngodon idella Species 0.000 description 4
- 108010067770 Endopeptidase K Proteins 0.000 description 4
- 229930006000 Sucrose Natural products 0.000 description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 4
- 108010067390 Viral Proteins Proteins 0.000 description 4
- 239000011543 agarose gel Substances 0.000 description 4
- 239000003638 chemical reducing agent Substances 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 238000011161 development Methods 0.000 description 4
- 239000012894 fetal calf serum Substances 0.000 description 4
- 235000011187 glycerol Nutrition 0.000 description 4
- 239000001963 growth medium Substances 0.000 description 4
- 229960001438 immunostimulant agent Drugs 0.000 description 4
- 239000003022 immunostimulating agent Substances 0.000 description 4
- 238000011081 inoculation Methods 0.000 description 4
- 230000000670 limiting effect Effects 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 230000017074 necrotic cell death Effects 0.000 description 4
- 239000003755 preservative agent Substances 0.000 description 4
- 238000003906 pulsed field gel electrophoresis Methods 0.000 description 4
- 239000003381 stabilizer Substances 0.000 description 4
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 4
- 239000005720 sucrose Substances 0.000 description 4
- 238000002255 vaccination Methods 0.000 description 4
- 229960004854 viral vaccine Drugs 0.000 description 4
- LHEJDBBHZGISGW-UHFFFAOYSA-N 5-fluoro-3-(3-oxo-1h-2-benzofuran-1-yl)-1h-pyrimidine-2,4-dione Chemical compound O=C1C(F)=CNC(=O)N1C1C2=CC=CC=C2C(=O)O1 LHEJDBBHZGISGW-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 3
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 3
- 241000252211 Carassius Species 0.000 description 3
- 208000032843 Hemorrhage Diseases 0.000 description 3
- 241000700588 Human alphaherpesvirus 1 Species 0.000 description 3
- 241000713772 Human immunodeficiency virus 1 Species 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 241000269808 Sparus Species 0.000 description 3
- 230000000840 anti-viral effect Effects 0.000 description 3
- 230000034994 death Effects 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 3
- 238000004108 freeze drying Methods 0.000 description 3
- 230000002458 infectious effect Effects 0.000 description 3
- 239000007928 intraperitoneal injection Substances 0.000 description 3
- 230000035772 mutation Effects 0.000 description 3
- 239000013642 negative control Substances 0.000 description 3
- 230000001717 pathogenic effect Effects 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- 210000000952 spleen Anatomy 0.000 description 3
- 235000000346 sugar Nutrition 0.000 description 3
- 150000008163 sugars Chemical class 0.000 description 3
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 3
- 229910052721 tungsten Inorganic materials 0.000 description 3
- 239000010937 tungsten Substances 0.000 description 3
- QFVHZQCOUORWEI-UHFFFAOYSA-N 4-[(4-anilino-5-sulfonaphthalen-1-yl)diazenyl]-5-hydroxynaphthalene-2,7-disulfonic acid Chemical compound C=12C(O)=CC(S(O)(=O)=O)=CC2=CC(S(O)(=O)=O)=CC=1N=NC(C1=CC=CC(=C11)S(O)(=O)=O)=CC=C1NC1=CC=CC=C1 QFVHZQCOUORWEI-UHFFFAOYSA-N 0.000 description 2
- 241000710780 Bovine viral diarrhea virus 1 Species 0.000 description 2
- 241000283707 Capra Species 0.000 description 2
- 201000009030 Carcinoma Diseases 0.000 description 2
- 208000035473 Communicable disease Diseases 0.000 description 2
- 241000557626 Corvus corax Species 0.000 description 2
- 241000195493 Cryptophyta Species 0.000 description 2
- 241001051708 Cyprinid herpesvirus 3 Species 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- 241001522035 Ectocarpus siliculosus virus 1 Species 0.000 description 2
- 241000283086 Equidae Species 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 241000700586 Herpesviridae Species 0.000 description 2
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 2
- 241000598171 Human adenovirus sp. Species 0.000 description 2
- 241000340965 Human papillomavirus type 27 Species 0.000 description 2
- 241000720946 Hypophthalmichthys molitrix Species 0.000 description 2
- 241000252234 Hypophthalmichthys nobilis Species 0.000 description 2
- 206010024264 Lethargy Diseases 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 description 2
- 241000188845 Porcine adenovirus Species 0.000 description 2
- 241000407608 Porcine endogenous retrovirus C Species 0.000 description 2
- 108010059712 Pronase Proteins 0.000 description 2
- 208000035415 Reinfection Diseases 0.000 description 2
- 241000701026 Saimiriine alphaherpesvirus 1 Species 0.000 description 2
- 241000700584 Simplexvirus Species 0.000 description 2
- 241000701421 Spodoptera exigua multiple nucleopolyhedrovirus Species 0.000 description 2
- 241000701093 Suid alphaherpesvirus 1 Species 0.000 description 2
- 241000282887 Suidae Species 0.000 description 2
- 241000500379 Xestia c-nigrum granulovirus Species 0.000 description 2
- 238000000246 agarose gel electrophoresis Methods 0.000 description 2
- 235000010443 alginic acid Nutrition 0.000 description 2
- 229920000615 alginic acid Polymers 0.000 description 2
- 229940098773 bovine serum albumin Drugs 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- PPBOKXIGFIBOGK-BDTUAEFFSA-N bvdv Chemical compound C([C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)C(C)C)[C@@H](C)CC)C1=CN=CN1 PPBOKXIGFIBOGK-BDTUAEFFSA-N 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000005684 electric field Effects 0.000 description 2
- 208000010932 epithelial neoplasm Diseases 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- -1 for example Substances 0.000 description 2
- 239000013505 freshwater Substances 0.000 description 2
- 230000002068 genetic effect Effects 0.000 description 2
- 238000007654 immersion Methods 0.000 description 2
- 230000002519 immonomodulatory effect Effects 0.000 description 2
- 229940031551 inactivated vaccine Drugs 0.000 description 2
- 210000003292 kidney cell Anatomy 0.000 description 2
- 239000010410 layer Substances 0.000 description 2
- 231100000518 lethal Toxicity 0.000 description 2
- 230000001665 lethal effect Effects 0.000 description 2
- 238000012792 lyophilization process Methods 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 238000004264 monolayer culture Methods 0.000 description 2
- 239000003471 mutagenic agent Substances 0.000 description 2
- 231100000707 mutagenic chemical Toxicity 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 230000000644 propagated effect Effects 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 238000010186 staining Methods 0.000 description 2
- 239000008223 sterile water Substances 0.000 description 2
- 229960005322 streptomycin Drugs 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 239000013598 vector Substances 0.000 description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- VLEIUWBSEKKKFX-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetic acid Chemical compound OCC(N)(CO)CO.OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O VLEIUWBSEKKKFX-UHFFFAOYSA-N 0.000 description 1
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- 108700025333 4'-azido-Phe(6)- herpes simplex virus H2 (6-15) Proteins 0.000 description 1
- NMUSYJAQQFHJEW-UHFFFAOYSA-N 5-Azacytidine Natural products O=C1N=C(N)N=CN1C1C(O)C(O)C(CO)O1 NMUSYJAQQFHJEW-UHFFFAOYSA-N 0.000 description 1
- NMUSYJAQQFHJEW-KVTDHHQDSA-N 5-azacytidine Chemical compound O=C1N=C(N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NMUSYJAQQFHJEW-KVTDHHQDSA-N 0.000 description 1
- WOVKYSAHUYNSMH-RRKCRQDMSA-N 5-bromodeoxyuridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(Br)=C1 WOVKYSAHUYNSMH-RRKCRQDMSA-N 0.000 description 1
- 206010000117 Abnormal behaviour Diseases 0.000 description 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
- 208000009663 Acute Necrotizing Pancreatitis Diseases 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- WOVKYSAHUYNSMH-UHFFFAOYSA-N BROMODEOXYURIDINE Natural products C1C(O)C(CO)OC1N1C(=O)NC(=O)C(Br)=C1 WOVKYSAHUYNSMH-UHFFFAOYSA-N 0.000 description 1
- 108010077805 Bacterial Proteins Proteins 0.000 description 1
- 241000701412 Baculoviridae Species 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 238000011537 Coomassie blue staining Methods 0.000 description 1
- 241000711573 Coronaviridae Species 0.000 description 1
- 241000256054 Culex <genus> Species 0.000 description 1
- 241000701022 Cytomegalovirus Species 0.000 description 1
- 230000004544 DNA amplification Effects 0.000 description 1
- 241000537219 Deltabaculovirus Species 0.000 description 1
- 208000035240 Disease Resistance Diseases 0.000 description 1
- 206010061818 Disease progression Diseases 0.000 description 1
- 241000408655 Dispar Species 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000710831 Flavivirus Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229920001503 Glucan Polymers 0.000 description 1
- 239000007995 HEPES buffer Substances 0.000 description 1
- 241000701074 Human alphaherpesvirus 2 Species 0.000 description 1
- 241000701024 Human betaherpesvirus 5 Species 0.000 description 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 description 1
- 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 description 1
- 241000701372 Iridovirus Species 0.000 description 1
- 231100000111 LD50 Toxicity 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 229930193140 Neomycin Natural products 0.000 description 1
- 206010029164 Nephrotic syndrome Diseases 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 208000025966 Neurological disease Diseases 0.000 description 1
- 206010060860 Neurological symptom Diseases 0.000 description 1
- 241001465800 Orgyia Species 0.000 description 1
- 238000010222 PCR analysis Methods 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 239000002033 PVDF binder Substances 0.000 description 1
- 206010058096 Pancreatic necrosis Diseases 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 241000710799 Rubella virus Species 0.000 description 1
- 241000519995 Stachys sylvatica Species 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 239000007984 Tris EDTA buffer Substances 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 241000700647 Variola virus Species 0.000 description 1
- 108010003533 Viral Envelope Proteins Proteins 0.000 description 1
- 206010051511 Viral diarrhoea Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 210000004690 animal fin Anatomy 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000011888 autopsy Methods 0.000 description 1
- 229960002756 azacitidine Drugs 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000003542 behavioural effect Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 239000001045 blue dye Substances 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 229950004398 broxuridine Drugs 0.000 description 1
- 238000012993 chemical processing Methods 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 201000003740 cowpox Diseases 0.000 description 1
- 239000012531 culture fluid Substances 0.000 description 1
- 238000005202 decontamination Methods 0.000 description 1
- 230000003588 decontaminative effect Effects 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 231100000676 disease causative agent Toxicity 0.000 description 1
- 230000005750 disease progression Effects 0.000 description 1
- VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 238000000635 electron micrograph Methods 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001976 enzyme digestion Methods 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 208000010824 fish disease Diseases 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 239000012737 fresh medium Substances 0.000 description 1
- 239000012520 frozen sample Substances 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000028996 humoral immune response Effects 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 238000010820 immunofluorescence microscopy Methods 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 238000003364 immunohistochemistry Methods 0.000 description 1
- 230000000415 inactivating effect Effects 0.000 description 1
- 230000004941 influx Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 239000010977 jade Substances 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 230000021633 leukocyte mediated immunity Effects 0.000 description 1
- 210000005229 liver cell Anatomy 0.000 description 1
- 210000005228 liver tissue Anatomy 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 208000018883 loss of balance Diseases 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 238000010369 molecular cloning Methods 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 230000003843 mucus production Effects 0.000 description 1
- 230000004719 natural immunity Effects 0.000 description 1
- 229960004927 neomycin Drugs 0.000 description 1
- 208000009928 nephrosis Diseases 0.000 description 1
- 231100001027 nephrosis Toxicity 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 description 1
- 229940047091 other immunostimulants in atc Drugs 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 210000004303 peritoneum Anatomy 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 238000009372 pisciculture Methods 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 238000007781 pre-processing Methods 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000011535 reaction buffer Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 210000005084 renal tissue Anatomy 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 201000005404 rubella Diseases 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000000528 statistical test Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 241000701447 unidentified baculovirus Species 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/245—Herpetoviridae, e.g. herpes simplex virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/00021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/00034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/00061—Methods of inactivation or attenuation
- C12N2710/00064—Methods of inactivation or attenuation by serial passage
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/01—DNA viruses
- G01N2333/03—Herpetoviridae, e.g. pseudorabies virus
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Fodder In General (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Feed For Specific Animals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL15377503A IL153775A0 (en) | 2003-01-01 | 2003-01-01 | Immunizing fish against viral infection |
| IL153775 | 2003-01-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2005120158A RU2005120158A (ru) | 2006-01-20 |
| RU2369635C2 true RU2369635C2 (ru) | 2009-10-10 |
Family
ID=29798413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005120158A RU2369635C2 (ru) | 2003-01-01 | 2003-12-22 | Иммунизация рыб против вирусной инфекции |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7351527B2 (enExample) |
| EP (1) | EP1578959B1 (enExample) |
| JP (2) | JP4690049B2 (enExample) |
| CN (1) | CN100535108C (enExample) |
| AT (1) | ATE507286T1 (enExample) |
| AU (1) | AU2003288510A1 (enExample) |
| DE (1) | DE60336927D1 (enExample) |
| DK (1) | DK1578959T3 (enExample) |
| IL (2) | IL153775A0 (enExample) |
| PL (1) | PL209978B1 (enExample) |
| RU (1) | RU2369635C2 (enExample) |
| WO (1) | WO2004061093A1 (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2640346C1 (ru) * | 2016-08-11 | 2017-12-27 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Государственный аграрный университет Северного Зауралья" (ФГБОУ ВО ГАУ Северного Зауралья) | Способ антиоксидантной защиты мальков карпа |
| RU2662768C2 (ru) * | 2011-12-30 | 2018-07-31 | Гесвал с.а. | Рекомбинантный герпесвирус кои (khv) и вакцина для профилактики заболевания, вызываемого khv |
| RU2663244C2 (ru) * | 2013-03-15 | 2018-08-03 | Атлантиум Текнолоджиз Лтд. | Система и способ для инактивации вируса инфекционного панкреатического некроза (ipnv) посредством оптимизированного ультрафиолетового излучения |
| RU2813731C2 (ru) * | 2019-02-05 | 2024-02-16 | Фармак Ас | Новый коронавирус рыб |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5109114B2 (ja) * | 2006-02-24 | 2012-12-26 | 国立大学法人三重大学 | 魚類抗体産生の新規検出法 |
| US8052977B2 (en) * | 2006-04-13 | 2011-11-08 | National University Corporation Tokyo University Of Marine Science And Technology | DNA vaccine for Koi herpes virus (KHV) disease |
| JP5567244B2 (ja) * | 2006-06-06 | 2014-08-06 | 共立製薬株式会社 | 魚類ストレプトコッカス・ディスガラクティエを抗原とする不活化ワクチン |
| RU2010111725A (ru) * | 2007-08-28 | 2011-10-10 | Юниверсите Де Льеж (Be) | Рекомбинантный герпесвирус кои (khv) или герпесвирус 3 семейства карповых (cyhv-3) и вакцина для профилактики заболевания, вызванного khv/cyhv-3 у cyprinus carpio или cyprinus carpio koi |
| EP2031065A1 (en) * | 2007-08-28 | 2009-03-04 | Université de Liège | A recombinant koi herpesvirus (KHV) or Cyprinid herpesvirus 3 (CyHV-3) and a vaccine for the prevention of a disease caused by KHV/CyHV-3 in Cyprinus carpio carpio or Cyprinus carpio koi |
| JP2010143860A (ja) * | 2008-12-19 | 2010-07-01 | Chisso Corp | タンパク質の安定化剤 |
| JP5462518B2 (ja) * | 2009-04-09 | 2014-04-02 | 公益財団法人ヒューマンサイエンス振興財団 | 抗体精製方法 |
| EP2487241A1 (en) | 2011-02-09 | 2012-08-15 | Westfälische Wilhelms-Universität Münster | RNAi agents and compositions useful as carp therapeutics |
| JP6406703B2 (ja) * | 2013-05-15 | 2018-10-17 | 国立研究開発法人水産研究・教育機構 | コイ科ヘルペスウイルス−2(Cyprinidherpesvirus−2:CyHV−2)感染症用ワクチンおよびその製造方法、ならびにCyHV−2ウイルス製造方法 |
| CN103430936A (zh) * | 2013-09-06 | 2013-12-11 | 中国水产科学研究院黑龙江水产研究所 | 一种用于鱼类基因组dna提取的鱼鳍组织的制备方法 |
| IL230970A0 (en) * | 2014-02-13 | 2014-09-30 | Univ Ramot | Tilapia virus vaccines |
| CN104774802B (zh) * | 2015-04-27 | 2017-12-08 | 上海海洋大学 | 银鲫鱼背鳍细胞系 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5780448A (en) * | 1995-11-07 | 1998-07-14 | Ottawa Civic Hospital Loeb Research | DNA-based vaccination of fish |
-
2003
- 2003-01-01 IL IL15377503A patent/IL153775A0/xx unknown
- 2003-12-22 AU AU2003288510A patent/AU2003288510A1/en not_active Abandoned
- 2003-12-22 CN CNB2003801080535A patent/CN100535108C/zh not_active Expired - Lifetime
- 2003-12-22 PL PL376441A patent/PL209978B1/pl unknown
- 2003-12-22 RU RU2005120158A patent/RU2369635C2/ru not_active IP Right Cessation
- 2003-12-22 EP EP03780585A patent/EP1578959B1/en not_active Expired - Lifetime
- 2003-12-22 AT AT03780585T patent/ATE507286T1/de not_active IP Right Cessation
- 2003-12-22 WO PCT/IL2003/001097 patent/WO2004061093A1/en not_active Ceased
- 2003-12-22 DE DE60336927T patent/DE60336927D1/de not_active Expired - Lifetime
- 2003-12-22 DK DK03780585T patent/DK1578959T3/da active
- 2003-12-22 JP JP2004564397A patent/JP4690049B2/ja not_active Expired - Fee Related
-
2005
- 2005-06-27 IL IL169412A patent/IL169412A/en active IP Right Grant
- 2005-06-30 US US11/170,793 patent/US7351527B2/en not_active Expired - Lifetime
-
2010
- 2010-08-20 JP JP2010185273A patent/JP2011024584A/ja not_active Withdrawn
Non-Patent Citations (1)
| Title |
|---|
| GILAD О. et al., "Initial characteristics of koi herpesvims and development of a polymerase chain reaction assay to detect the vims in koi, Cyprinus carpio koi", Dis Aquat Organ. 2002 Mar 11; 48(2):101-8. DATABASE ENTREZ NUCLEOTIDES 'Online! ncbi; 15.06.2007, AOKI T. et al.: "Genome sequences of three koi herpesvirus isolates representing the expanding distribution of an emerging disease threatening koi and common carp worldwide", Database accession no. NC-009127, 01:131840030, abstract. БЕЛОУСОВА P.B. и др. ВЕТЕРИНАРНАЯ ВИРУСОЛОГИЯ. - М.: Колос, 2007, с.191-193. * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2662768C2 (ru) * | 2011-12-30 | 2018-07-31 | Гесвал с.а. | Рекомбинантный герпесвирус кои (khv) и вакцина для профилактики заболевания, вызываемого khv |
| RU2663244C2 (ru) * | 2013-03-15 | 2018-08-03 | Атлантиум Текнолоджиз Лтд. | Система и способ для инактивации вируса инфекционного панкреатического некроза (ipnv) посредством оптимизированного ультрафиолетового излучения |
| RU2640346C1 (ru) * | 2016-08-11 | 2017-12-27 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Государственный аграрный университет Северного Зауралья" (ФГБОУ ВО ГАУ Северного Зауралья) | Способ антиоксидантной защиты мальков карпа |
| RU2818370C2 (ru) * | 2018-12-21 | 2024-05-02 | Интервет Интернэшнл Б.В. | Вакцина против внутриклеточного патогена, не содержащая сыворотки |
| RU2813731C2 (ru) * | 2019-02-05 | 2024-02-16 | Фармак Ас | Новый коронавирус рыб |
Also Published As
| Publication number | Publication date |
|---|---|
| ATE507286T1 (de) | 2011-05-15 |
| PL209978B1 (pl) | 2011-11-30 |
| AU2003288510A1 (en) | 2004-07-29 |
| IL169412A (en) | 2011-04-28 |
| DK1578959T3 (da) | 2011-08-15 |
| EP1578959B1 (en) | 2011-04-27 |
| AU2003288510A8 (en) | 2004-07-29 |
| CN1742083A (zh) | 2006-03-01 |
| PL376441A1 (en) | 2005-12-27 |
| EP1578959A1 (en) | 2005-09-28 |
| JP2011024584A (ja) | 2011-02-10 |
| US7351527B2 (en) | 2008-04-01 |
| WO2004061093A1 (en) | 2004-07-22 |
| CN100535108C (zh) | 2009-09-02 |
| IL153775A0 (en) | 2003-07-31 |
| JP2006512078A (ja) | 2006-04-13 |
| US20060013828A1 (en) | 2006-01-19 |
| DE60336927D1 (enExample) | 2011-06-09 |
| JP4690049B2 (ja) | 2011-06-01 |
| RU2005120158A (ru) | 2006-01-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011024584A (ja) | ウイルス感染に対する免疫魚 | |
| Ilouze et al. | Characterization of a novel virus causing a lethal disease in carp and koi | |
| Torres et al. | First field trial of a transmissible recombinant vaccine against myxomatosis and rabbit hemorrhagic disease | |
| Krametter‐Frötscher et al. | Serological survey for antibodies against pestiviruses in sheep in Austria | |
| Borie et al. | Microbiological hazards related to xenotransplantation of porcine organs into man | |
| Conraths et al. | Bluetongue disease: an analysis of the epidemic in Germany 2006–2009 | |
| Lavazza et al. | How many caliciviruses are there in rabbits? A review on RHDV and correlated viruses | |
| Savini et al. | Monovalent modified-live vaccine against bluetongue virus serotype 2: immunity studies in cows | |
| AU2002253542B2 (en) | Purified subfragment encoding neuroaminidase, recombinant neuroaminidase and its use in zooprophylaxis | |
| CN118480515B (zh) | 一种猪繁殖与呼吸综合征病毒nadc30病毒株及其应用 | |
| Frölich et al. | European brown hare syndrome | |
| Garland et al. | Attempts to infect pigs with coxsackie virus type B5 | |
| CN105866424B (zh) | 一种鸭坦布苏病毒病疫苗的效力检验方法 | |
| CN100384988C (zh) | 2型鸡星状病毒 | |
| Goswami et al. | A review on lumpy skin disease: one of the most neglected diseases of cattle with an unprecedented incidence in non-endemic countries | |
| JPH02295934A (ja) | イヌコロナウイルスワクチン | |
| Chandra et al. | Haemorrhagic enteritis of turkeys and related infections of pheasants and domestic fowl: a review | |
| CN118931848B (zh) | 一种猪圆环病毒3型病毒株及其应用 | |
| JP4785531B2 (ja) | マーカーワクチンとしてのニューカッスル病ウイルスのエスケープミュータント | |
| Abd El-Ghany | Forms of avian reovirus in poultry production: An overview | |
| KR100391265B1 (ko) | 흑염소 로타 바이러스 순화주, 이의 제조 방법 및 용도 | |
| KWONG | Vaccination Efficacies against Myxomatosis | |
| BARUA | MASTER OF VETERINARY SCIENCE IN VETERINARY MICROBIOLOGY | |
| Mukiibi-Muka | Studies on local and systemic antibody responses in chicken to avian reovirus infections. | |
| Lavazza et al. | 3.7. Rabbit haemorrhagic disease (RHD) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20131223 |