RU2340623C2 - Частичные и полные агонисты аденозиновых рецепторов a1 - Google Patents

Частичные и полные агонисты аденозиновых рецепторов a1 Download PDF

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Publication number
RU2340623C2
RU2340623C2 RU2005106997/04A RU2005106997A RU2340623C2 RU 2340623 C2 RU2340623 C2 RU 2340623C2 RU 2005106997/04 A RU2005106997/04 A RU 2005106997/04A RU 2005106997 A RU2005106997 A RU 2005106997A RU 2340623 C2 RU2340623 C2 RU 2340623C2
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RU
Russia
Prior art keywords
purin
formula
optionally substituted
oxolan
diol
Prior art date
Application number
RU2005106997/04A
Other languages
English (en)
Russian (ru)
Other versions
RU2005106997A (ru
Inventor
Джефф ЗАБЛОЦКИ (US)
Джефф ЗАБЛОЦКИ
Венката ПАЛЛЕ (IN)
Венката ПАЛЛЕ
Элфатих ЭЛЗЕИН (US)
Элфатих ЭЛЗЕИН
Ксиаофен ЛИ (US)
Ксиаофен ЛИ
Original Assignee
Си Ви Терапьютикс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Си Ви Терапьютикс, Инк. filed Critical Си Ви Терапьютикс, Инк.
Publication of RU2005106997A publication Critical patent/RU2005106997A/ru
Application granted granted Critical
Publication of RU2340623C2 publication Critical patent/RU2340623C2/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
RU2005106997/04A 2002-08-15 2003-08-15 Частичные и полные агонисты аденозиновых рецепторов a1 RU2340623C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US40371202P 2002-08-15 2002-08-15
US60/403,712 2002-08-15
US45009403P 2003-02-25 2003-02-25
US60/450,094 2003-02-25

Publications (2)

Publication Number Publication Date
RU2005106997A RU2005106997A (ru) 2005-11-10
RU2340623C2 true RU2340623C2 (ru) 2008-12-10

Family

ID=31891396

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2005106997/04A RU2340623C2 (ru) 2002-08-15 2003-08-15 Частичные и полные агонисты аденозиновых рецепторов a1

Country Status (15)

Country Link
US (2) US7022681B2 (no)
EP (1) EP1537133B1 (no)
JP (1) JP4596913B2 (no)
KR (1) KR20050067384A (no)
CN (1) CN100480255C (no)
AT (1) ATE368048T1 (no)
AU (1) AU2003263846B2 (no)
CA (1) CA2495370A1 (no)
DE (1) DE60315164T2 (no)
ES (1) ES2288632T3 (no)
MX (1) MXPA05001844A (no)
NO (1) NO20051296L (no)
NZ (1) NZ538590A (no)
RU (1) RU2340623C2 (no)
WO (1) WO2004016635A2 (no)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005009343A2 (en) * 2003-06-06 2005-02-03 Endacea, Inc. A1 adenosine receptor antogonists
PT2158208E (pt) * 2007-05-17 2015-06-11 Gilead Sciences Inc Processo para preparar um agonista de recetor de adenosina-a2a e seus polimorfos
EP2771012A4 (en) * 2011-10-24 2015-06-24 Glaxosmithkline Ip No 2 Ltd NEW CONNECTIONS
CN107278205A (zh) * 2015-02-24 2017-10-20 辉瑞大药厂 用作抗癌药的取代的核苷衍生物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1254888A (en) * 1984-10-26 1989-05-30 Bharat Trivedi N.sup.6-bicycloadenosines
US5140015A (en) * 1990-02-20 1992-08-18 Whitby Research, Inc. 2-aralkoxy and 2-alkoxy adenosine derivatives as coronary vasodilators and antihypertensive agents
USRE36494E (en) * 1990-02-20 2000-01-11 Discovery Therapeutics, Inc. 2-aralkoxy and 2-alkoxy adenosine derivatives as coronary vasodilators and antihypertensive agents
US5278150A (en) * 1992-04-24 1994-01-11 Whitby Research, Inc. 2-hydrazoadenosines and their utility for the treatmeat of vascular conditions
US5589467A (en) * 1993-09-17 1996-12-31 Novo Nordisk A/S 2,5',N6-trisubstituted adenosine derivatives
WO1997033591A1 (en) 1996-03-13 1997-09-18 Novo Nordisk A/S A method of treating disorders related to cytokines in mammals
AU4377397A (en) * 1996-10-14 1998-05-11 Novo Nordisk A/S Novel therapeutically active adenosine derivatives
GB9723589D0 (en) * 1997-11-08 1998-01-07 Glaxo Group Ltd Chemical compounds
GB9813554D0 (en) * 1998-06-23 1998-08-19 Glaxo Group Ltd Chemical compounds
US20040162422A1 (en) * 2001-03-20 2004-08-19 Adrian Hall Chemical compounds

Also Published As

Publication number Publication date
DE60315164T2 (de) 2008-04-30
MXPA05001844A (es) 2005-04-19
ES2288632T3 (es) 2008-01-16
DE60315164D1 (de) 2007-09-06
JP4596913B2 (ja) 2010-12-15
CN100480255C (zh) 2009-04-22
KR20050067384A (ko) 2005-07-01
NO20051296L (no) 2005-05-13
EP1537133B1 (en) 2007-07-25
US20040043960A1 (en) 2004-03-04
JP2006505525A (ja) 2006-02-16
CN1675235A (zh) 2005-09-28
NZ538590A (en) 2006-10-27
AU2003263846B2 (en) 2009-12-17
AU2003263846A1 (en) 2004-03-03
ATE368048T1 (de) 2007-08-15
WO2004016635A2 (en) 2004-02-26
WO2004016635A3 (en) 2004-04-08
US20060135467A1 (en) 2006-06-22
US7022681B2 (en) 2006-04-04
RU2005106997A (ru) 2005-11-10
EP1537133A2 (en) 2005-06-08
CA2495370A1 (en) 2004-02-26

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20110816