RU2331649C2 - Серосодержащие фосфолипидные производные, содержащая их фармацевтическая композиция, их применение для лечения заболеваний и способ их получения - Google Patents
Серосодержащие фосфолипидные производные, содержащая их фармацевтическая композиция, их применение для лечения заболеваний и способ их получения Download PDFInfo
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- RU2331649C2 RU2331649C2 RU2005101196/04A RU2005101196A RU2331649C2 RU 2331649 C2 RU2331649 C2 RU 2331649C2 RU 2005101196/04 A RU2005101196/04 A RU 2005101196/04A RU 2005101196 A RU2005101196 A RU 2005101196A RU 2331649 C2 RU2331649 C2 RU 2331649C2
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- compound according
- lipid compound
- independently selected
- lipid
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- NPDHPQKEQGUAOQ-ULUSZKPHSA-N COC[C@H](COP(O)(OCC(C(O)=O)N)=O)OC Chemical compound COC[C@H](COP(O)(OCC(C(O)=O)N)=O)OC NPDHPQKEQGUAOQ-ULUSZKPHSA-N 0.000 description 1
- SPJAJCQSUMHZMQ-UHFFFAOYSA-N C[N](C)(C)CCOP(O)(OCCCOC)=O Chemical compound C[N](C)(C)CCOP(O)(OCCCOC)=O SPJAJCQSUMHZMQ-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C329/00—Thiocarbonic acids; Halides, esters or anhydrides thereof
- C07C329/02—Monothiocarbonic acids; Derivatives thereof
- C07C329/04—Esters of monothiocarbonic acids
- C07C329/06—Esters of monothiocarbonic acids having sulfur atoms of thiocarbonic groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
-
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Dispersion Chemistry (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Virology (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- AIDS & HIV (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0214267.7 | 2002-06-20 | ||
| GB0214267A GB0214267D0 (en) | 2002-06-20 | 2002-06-20 | Compound |
| GB0217506A GB0217506D0 (en) | 2002-07-29 | 2002-07-29 | Compound |
| GB0217506.5 | 2002-07-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2005101196A RU2005101196A (ru) | 2005-10-10 |
| RU2331649C2 true RU2331649C2 (ru) | 2008-08-20 |
Family
ID=30001967
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005101196/04A RU2331649C2 (ru) | 2002-06-20 | 2003-06-16 | Серосодержащие фосфолипидные производные, содержащая их фармацевтическая композиция, их применение для лечения заболеваний и способ их получения |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8178713B2 (https=) |
| EP (1) | EP1515978A1 (https=) |
| JP (1) | JP5008258B2 (https=) |
| KR (1) | KR20050061400A (https=) |
| CN (1) | CN100351259C (https=) |
| AU (1) | AU2003278602C1 (https=) |
| CA (1) | CA2490121C (https=) |
| NO (1) | NO20045562L (https=) |
| NZ (1) | NZ537762A (https=) |
| RU (1) | RU2331649C2 (https=) |
| WO (1) | WO2004000854A1 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO328803B1 (no) | 2000-03-03 | 2010-05-18 | Thia Medica | Nye fettsyreanaloger |
| FR2828487B1 (fr) * | 2001-08-09 | 2005-05-27 | Genfit S A | Nouveaux composes derives d'acides gras, preparation et utilisations |
| FR2850870B1 (fr) * | 2003-02-12 | 2006-07-28 | Genfit S A | Utilisation therapeutique de glycerols acyles et de leurs analogues azotes et sulfures |
| RU2388490C2 (ru) * | 2004-07-19 | 2010-05-10 | Тиа Медика Ас | Композиция, содержащая растительный или рыбий жир, и соединения, содержащие неокисляющиеся структурные элементы жирных кислот |
| JP2008506774A (ja) * | 2004-07-19 | 2008-03-06 | ティア メディカ アクスイェ セルスカプ | タンパク質材料と非酸化性脂肪酸体を含む組成物 |
| WO2006086992A2 (en) * | 2005-02-18 | 2006-08-24 | Liplasome Pharma A/S | Drug delivery systems containing phqspholipase a2 degradable lipid prodrug derivatives and the therapeutic uses thereof as. e.g. wound healing agents and peroxisome proliferator activated receptor ligands |
| NO20053519L (no) * | 2005-07-18 | 2007-01-19 | Thia Medica As | Anvendelse av forbindelser som omfatter fettsyrer |
| NO20055541L (no) * | 2005-11-23 | 2007-05-24 | Berge Biomed As | Use of fatty acid analogues |
| CA2835365A1 (en) * | 2006-01-13 | 2007-07-26 | Ventana Medical Systems, Inc. | Biological sample processing composition and method |
| US20070276042A1 (en) * | 2006-05-26 | 2007-11-29 | Auspex Pharmaceuticals, Inc. | Preparation and utility of substituted carboxylic acid compounds |
| JP3944864B1 (ja) * | 2006-07-31 | 2007-07-18 | 株式会社Ｊ−オイルミルズ | メタボリックシンドロームの予防および改善用組成物 |
| DE102007051339A1 (de) * | 2007-10-26 | 2009-04-30 | Müller-Enoch, Dieter, Prof. Dr. | Verwendung von Verbindungen der Formel A-R-X oder deren pharmazeutisch akzeptablen Salze zur Herstellung einer pharmazeutischen Zubereitung zur Behandlung und zur Vorbeugung von Dyslipidämien |
| EP2147910A1 (en) | 2008-07-15 | 2010-01-27 | Pronova BioPharma Norge AS | Novel lipid compounds |
| CN102639504A (zh) * | 2009-11-21 | 2012-08-15 | 弗·哈夫曼-拉罗切有限公司 | 杂环抗病毒化合物 |
| HUE047354T2 (hu) | 2011-05-18 | 2020-04-28 | Vertex Pharmaceuticals Europe Ltd | Ivacaftor deuterizált származékai |
| JP6146990B2 (ja) * | 2012-11-16 | 2017-06-14 | コンサート ファーマシューティカルズ インコーポレイテッド | 重水素化されたｃｆｔｒ増強物質 |
| AU2014229506B2 (en) | 2013-03-11 | 2017-04-13 | Nobesita As | Natural lipids containing non-oxidizable fatty acids |
| WO2015187295A2 (en) * | 2014-06-02 | 2015-12-10 | Armo Biosciences, Inc. | Methods of lowering serum cholesterol |
| JP2018500144A (ja) * | 2014-11-03 | 2018-01-11 | ボヴィン、ニコライ ウラジミロヴィチＢＯＶＩＮ，Ｎｉｃｏｌａｉ Ｖｌａｄｉｍｉｒｏｖｉｃｈ | 抗微生物性表面処理 |
| HK1249893A1 (zh) | 2015-03-31 | 2018-11-16 | Vertex Pharmaceuticals (Europe) Limited | 氘代vx-661 |
| HK1258473A1 (zh) | 2015-09-25 | 2019-11-15 | Vertex Pharmaceuticals (Europe) Limited | 氘代cftr增效剂 |
| JP2017105824A (ja) * | 2017-02-10 | 2017-06-15 | コンサート ファーマシューティカルズ インコーポレイテッド | 重水素化されたｃｆｔｒ増強物質 |
| CZ308596B6 (cs) * | 2017-04-03 | 2020-12-23 | Ústav molekulární genetiky AV ČR, v. v. i. | Deriváty fosfolipidů a jejich použití jako léčiva |
| CA3082444A1 (en) | 2017-12-01 | 2019-06-06 | Vertex Pharmaceuticals Incorporated | Processes for making modulators of cystic fibrosis transmembrane conductance regulator |
| WO2019208392A1 (ja) * | 2018-04-27 | 2019-10-31 | 株式会社レオロジー機能食品研究所 | 新規プラズマローゲン誘導体 |
| JP6654223B2 (ja) * | 2018-08-13 | 2020-02-26 | バーテックス ファーマシューティカルズ （ヨーロッパ） リミテッド | 重水素化されたｃｆｔｒ増強物質 |
| US20220362151A1 (en) * | 2019-06-11 | 2022-11-17 | Rosi Charni As | Liposome formulation |
| CN110200920B (zh) * | 2019-06-18 | 2022-03-08 | 东南大学 | 一种还原敏感药物组合物及其制备和应用 |
| CN110302159B (zh) * | 2019-06-18 | 2021-12-24 | 东南大学 | 一种还原敏感脂质药物组合物及其制备方法和应用 |
| CN110251485A (zh) * | 2019-07-16 | 2019-09-20 | 东南大学 | 一种氧化敏感药物组合物及其制备和应用 |
| CN110343131A (zh) * | 2019-07-16 | 2019-10-18 | 东南大学 | 一种硫代磷脂化合物及其制备方法 |
| CN118126079B (zh) * | 2024-03-05 | 2025-02-25 | 南开大学 | 硒磷脂化合物及合成方法与脂质体制剂 |
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| EP0345038A2 (en) * | 1988-06-02 | 1989-12-06 | Norsk Hydro A/S | Non-beta-oxidizable fatty acid analogues with the effect to reduce the concentration of cholesterol and triglycerides in blood of mammals |
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| BE809894A (nl) | 1973-01-30 | 1974-07-18 | Antikleursluierstoffen voor fotografische kleurenmaterialen | |
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| US5290960A (en) | 1993-02-25 | 1994-03-01 | The United States Of America As Represented By The Secretary Of The Navy | Diacetylenic phospholipids containing heteroatom near diacetylenic functionality for modulation of microstructure morphology |
| JPH10507179A (ja) | 1994-10-13 | 1998-07-14 | ペプチド テクノロジー リミテッド | 修飾ポリ不飽和脂肪酸 |
| WO2000030444A1 (en) * | 1998-11-25 | 2000-06-02 | Vanderbilt University | Cationic liposomes for gene transfer |
| FR2792312B1 (fr) | 1999-04-15 | 2001-06-08 | Oreal | Composes (poly)thia-alcynoiques et leurs derives, compositions les comprenant et leur utilisation |
| NO20003591L (no) | 2000-07-13 | 2002-01-14 | Thia Medica As | Fettsyreanaloger for behandling av kreft |
| NO20004844L (no) | 2000-09-27 | 2002-05-10 | Thia Medica As | Fettsyre analoger for behandling av proliferative hudsykdommer |
| NO20006008L (no) | 2000-11-28 | 2002-05-29 | Thia Medica As | Fettsyreanaloger for behandling av inflammatoriske og autoimmune sykdommer |
| US20020188023A1 (en) * | 2000-12-12 | 2002-12-12 | Michael Jorgensen | Compound |
| GB0118517D0 (en) * | 2001-07-30 | 2001-09-19 | Mitsubishi Tokyo Pharm Inc | Compound |
| FR2828487B1 (fr) | 2001-08-09 | 2005-05-27 | Genfit S A | Nouveaux composes derives d'acides gras, preparation et utilisations |
| JP2008506774A (ja) * | 2004-07-19 | 2008-03-06 | ティア メディカ アクスイェ セルスカプ | タンパク質材料と非酸化性脂肪酸体を含む組成物 |
-
2003
- 2003-06-16 NZ NZ537762A patent/NZ537762A/en not_active IP Right Cessation
- 2003-06-16 JP JP2004515006A patent/JP5008258B2/ja not_active Expired - Fee Related
- 2003-06-16 AU AU2003278602A patent/AU2003278602C1/en not_active Ceased
- 2003-06-16 US US10/518,427 patent/US8178713B2/en not_active Expired - Fee Related
- 2003-06-16 CA CA2490121A patent/CA2490121C/en not_active Expired - Fee Related
- 2003-06-16 RU RU2005101196/04A patent/RU2331649C2/ru not_active IP Right Cessation
- 2003-06-16 WO PCT/GB2003/002582 patent/WO2004000854A1/en not_active Ceased
- 2003-06-16 KR KR1020047020760A patent/KR20050061400A/ko not_active Ceased
- 2003-06-16 EP EP03740736A patent/EP1515978A1/en not_active Withdrawn
- 2003-06-16 CN CNB038174340A patent/CN100351259C/zh not_active Expired - Fee Related
-
2004
- 2004-12-20 NO NO20045562A patent/NO20045562L/no not_active Application Discontinuation
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2011
- 2011-11-23 US US13/303,173 patent/US20120264966A1/en not_active Abandoned
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| EP0345038A2 (en) * | 1988-06-02 | 1989-12-06 | Norsk Hydro A/S | Non-beta-oxidizable fatty acid analogues with the effect to reduce the concentration of cholesterol and triglycerides in blood of mammals |
| WO1997003663A1 (en) * | 1995-07-14 | 1997-02-06 | Rolf Berge | NON-β-OXIDIZABLE FATTY ACID ANALOGUES, THEIR USES AS THERAPEUTIC ACTIVE MEDICAMENTS, AND PREPARATION THEREOF |
| WO1999058120A1 (en) * | 1998-05-08 | 1999-11-18 | Rolf Berge | USE OF NON-β-OXIDIZABLE FATTY ACID ANALOGUES FOR TREATMENT OF SYNDROME-X CONDITIONS |
| WO2001068582A1 (en) * | 2000-03-03 | 2001-09-20 | Thia Medica As | Novel fatty acid analogous |
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Also Published As
| Publication number | Publication date |
|---|---|
| NO20045562L (no) | 2005-02-17 |
| AU2003278602C1 (en) | 2010-08-12 |
| EP1515978A1 (en) | 2005-03-23 |
| WO2004000854A1 (en) | 2003-12-31 |
| US20120264966A1 (en) | 2012-10-18 |
| AU2003278602A1 (en) | 2004-01-06 |
| JP2005529969A (ja) | 2005-10-06 |
| US8178713B2 (en) | 2012-05-15 |
| NZ537762A (en) | 2007-02-23 |
| CN1675229A (zh) | 2005-09-28 |
| CA2490121A1 (en) | 2003-12-31 |
| US20060105987A1 (en) | 2006-05-18 |
| CA2490121C (en) | 2013-01-08 |
| CN100351259C (zh) | 2007-11-28 |
| KR20050061400A (ko) | 2005-06-22 |
| RU2005101196A (ru) | 2005-10-10 |
| AU2003278602B2 (en) | 2009-06-04 |
| JP5008258B2 (ja) | 2012-08-22 |
| HK1077829A1 (zh) | 2006-02-24 |
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