RU2330653C2 - Эйкозапентаеновая кислота (эпк) для лечения нервно-психической анорексии (на) и булимии - Google Patents
Эйкозапентаеновая кислота (эпк) для лечения нервно-психической анорексии (на) и булимии Download PDFInfo
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- RU2330653C2 RU2330653C2 RU2005107416/14A RU2005107416A RU2330653C2 RU 2330653 C2 RU2330653 C2 RU 2330653C2 RU 2005107416/14 A RU2005107416/14 A RU 2005107416/14A RU 2005107416 A RU2005107416 A RU 2005107416A RU 2330653 C2 RU2330653 C2 RU 2330653C2
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- epa
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- bulimia
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- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 title claims abstract description 67
- 229960005135 eicosapentaenoic acid Drugs 0.000 title claims abstract description 67
- 235000020673 eicosapentaenoic acid Nutrition 0.000 title claims abstract description 67
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 title claims abstract description 67
- 238000011282 treatment Methods 0.000 title claims abstract description 50
- 208000022531 anorexia Diseases 0.000 title abstract description 8
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- 206010006550 Bulimia nervosa Diseases 0.000 claims abstract description 12
- 239000003814 drug Substances 0.000 claims abstract description 10
- 238000000034 method Methods 0.000 claims description 17
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims description 16
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- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 claims description 11
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- DVSZKTAMJJTWFG-SKCDLICFSA-N (2e,4e,6e,8e,10e,12e)-docosa-2,4,6,8,10,12-hexaenoic acid Chemical compound CCCCCCCCC\C=C\C=C\C=C\C=C\C=C\C=C\C(O)=O DVSZKTAMJJTWFG-SKCDLICFSA-N 0.000 description 1
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- KAUVQQXNCKESLC-UHFFFAOYSA-N docosahexaenoic acid (DHA) Natural products COC(=O)C(C)NOCC1=CC=CC=C1 KAUVQQXNCKESLC-UHFFFAOYSA-N 0.000 description 1
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0221480.7A GB0221480D0 (en) | 2002-09-16 | 2002-09-16 | Treatment of anorexia nervosa (AN) and bulimia |
| GB0221480.7 | 2002-09-16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2005107416A RU2005107416A (ru) | 2006-01-20 |
| RU2330653C2 true RU2330653C2 (ru) | 2008-08-10 |
Family
ID=9944164
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005107416/14A RU2330653C2 (ru) | 2002-09-16 | 2003-09-16 | Эйкозапентаеновая кислота (эпк) для лечения нервно-психической анорексии (на) и булимии |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20060135608A1 (enExample) |
| EP (1) | EP1556028A1 (enExample) |
| JP (1) | JP2006503031A (enExample) |
| KR (1) | KR20050042823A (enExample) |
| CN (1) | CN1694694A (enExample) |
| AU (1) | AU2003269138A1 (enExample) |
| BR (1) | BR0317857A (enExample) |
| CA (1) | CA2499142A1 (enExample) |
| GB (1) | GB0221480D0 (enExample) |
| HR (1) | HRP20050245A2 (enExample) |
| IS (1) | IS7744A (enExample) |
| MX (1) | MXPA05002943A (enExample) |
| NO (1) | NO20051847L (enExample) |
| NZ (1) | NZ538793A (enExample) |
| PL (1) | PL375726A1 (enExample) |
| RS (1) | RS20050226A (enExample) |
| RU (1) | RU2330653C2 (enExample) |
| TW (1) | TW200410682A (enExample) |
| WO (1) | WO2004024136A1 (enExample) |
| ZA (1) | ZA200502161B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2545988C1 (ru) * | 2013-11-12 | 2015-04-10 | Государственное бюджетное учреждение здравоохранения города Москвы Московский клинический научно-практический центр Департамента здравоохранения города Москвы | Способ лечения хронического запора и функциональной анорексии |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003048831A (ja) | 2001-08-02 | 2003-02-21 | Suntory Ltd | 脳機能の低下に起因する症状あるいは疾患の予防又は改善作用を有する組成物 |
| EP1683519A4 (en) * | 2003-11-14 | 2009-04-01 | Mochida Pharm Co Ltd | PREVENTIVE / THERAPEUTIC AGENT FOR TREATING SPEECH DISORDERS |
| JP4993852B2 (ja) | 2004-09-17 | 2012-08-08 | サントリーホールディングス株式会社 | ストレスに起因する行動異常を伴う症状あるいは疾患の予防又は改善作用を有する組成物 |
| JP5967855B2 (ja) | 2005-06-30 | 2016-08-10 | サントリーホールディングス株式会社 | 日中活動量の低下および／又はうつ症状の改善作用を有する組成物 |
| CN101631542B (zh) | 2006-12-28 | 2011-12-21 | 三得利控股株式会社 | 神经再生剂 |
| ES2561482T3 (es) | 2007-02-15 | 2016-02-26 | Centre De Recherche Sur Les Biotechnologies Marine | Monoglicéridos de ácido graso poliinsaturado, derivados, y sus usos |
| US8816110B2 (en) | 2007-02-15 | 2014-08-26 | Scf Pharma Inc. | Polyunsaturated fatty acid monoglycerides, derivatives, and uses thereof |
| WO2008113177A1 (en) | 2007-03-20 | 2008-09-25 | Centre De Recherche Sur Les Biotechnologies Marines | Compositions comprising polyunsaturated fatty acid monoglycerides or derivatives thereof and uses thereof |
| US8343753B2 (en) | 2007-11-01 | 2013-01-01 | Wake Forest University School Of Medicine | Compositions, methods, and kits for polyunsaturated fatty acids from microalgae |
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| BR112013020346A2 (pt) * | 2011-02-11 | 2019-09-24 | Du Pont | concentrado de ácido eicosapentaenoico, produto farmac~eutico, método de elaboração de um concentrado de ácido eicosapentaenoico e uso de óleo microbiano |
| US9447020B2 (en) | 2013-10-31 | 2016-09-20 | Scf Pharma Inc. | Polyunsaturated fatty acid monoglycerides, derivatives, and uses thereof |
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| CA3054203C (en) | 2018-05-03 | 2021-01-05 | Scf Pharma Inc. | Polyunsaturated fatty acid monoglycerides, compositions, methods and uses thereof |
| CN109276262B (zh) * | 2018-07-30 | 2021-01-26 | 中国科学院心理研究所 | 一种用于筛选高危进食障碍的检测系统 |
| US12226390B2 (en) | 2019-07-21 | 2025-02-18 | Scf Pharma Inc. | Cannabinoids compositions with polyunsaturated fatty acid monoglycerides, methods and uses thereof |
| US12144786B2 (en) | 2020-03-27 | 2024-11-19 | Homeostasis Therapeutics LLC | Methods of treatment for anorexia nervosa, bulimia and related clinical syndromes |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2123844C1 (ru) * | 1992-11-26 | 1998-12-27 | Скотиа Холдингс ПЛС | Способ лечения шизофрении |
Family Cites Families (2)
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| US6077828A (en) * | 1996-04-25 | 2000-06-20 | Abbott Laboratories | Method for the prevention and treatment of cachexia and anorexia |
| GB9901809D0 (en) * | 1999-01-27 | 1999-03-17 | Scarista Limited | Highly purified ethgyl epa and other epa derivatives for psychiatric and neurological disorderes |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2123844C1 (ru) * | 1992-11-26 | 1998-12-27 | Скотиа Холдингс ПЛС | Способ лечения шизофрении |
Non-Patent Citations (3)
| Title |
|---|
| abstract. КРЫЛОВ Ю.Ф., Перспективы использования эйкозапентаеновой и докозагексаеновой кислот как лекарственных средств. Хим.-фармац. журн. 1991, т.25, №9, с.4-10. * |
| KATE LOVETT. Bulimia and Depression. May 2001 (2001-05-02), p.1-5, [он-лайн] [Найдено 2007.06.27] найдено из Интернет http://www.vanderbilt.edu/AnS/psychology/health_psychology/bulimia_depressio n.htm. * |
| формула. * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2545988C1 (ru) * | 2013-11-12 | 2015-04-10 | Государственное бюджетное учреждение здравоохранения города Москвы Московский клинический научно-практический центр Департамента здравоохранения города Москвы | Способ лечения хронического запора и функциональной анорексии |
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| NZ538793A (en) | 2007-05-31 |
| BR0317857A (pt) | 2005-12-06 |
| JP2006503031A (ja) | 2006-01-26 |
| US20060135608A1 (en) | 2006-06-22 |
| EP1556028A1 (en) | 2005-07-27 |
| PL375726A1 (en) | 2005-12-12 |
| TW200410682A (en) | 2004-07-01 |
| WO2004024136A1 (en) | 2004-03-25 |
| CA2499142A1 (en) | 2004-03-25 |
| NO20051847L (no) | 2005-04-15 |
| RU2005107416A (ru) | 2006-01-20 |
| MXPA05002943A (es) | 2005-06-03 |
| CN1694694A (zh) | 2005-11-09 |
| ZA200502161B (en) | 2005-09-15 |
| GB0221480D0 (en) | 2002-10-23 |
| AU2003269138A1 (en) | 2004-04-30 |
| RS20050226A (sr) | 2007-09-21 |
| KR20050042823A (ko) | 2005-05-10 |
| IS7744A (is) | 2005-03-15 |
| HRP20050245A2 (en) | 2005-10-31 |
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