RU2322260C2 - Пассивная иммунизационная терапия на основе пептидов для лечения атеросклероза - Google Patents

Пассивная иммунизационная терапия на основе пептидов для лечения атеросклероза Download PDF

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Publication number
RU2322260C2
RU2322260C2 RU2005113235/15A RU2005113235A RU2322260C2 RU 2322260 C2 RU2322260 C2 RU 2322260C2 RU 2005113235/15 A RU2005113235/15 A RU 2005113235/15A RU 2005113235 A RU2005113235 A RU 2005113235A RU 2322260 C2 RU2322260 C2 RU 2322260C2
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RU
Russia
Prior art keywords
seq
variable region
antibody
antibody fragment
fragment
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RU2005113235/15A
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English (en)
Russian (ru)
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RU2005113235A (ru
Inventor
Ян НИЛЬССОН (SE)
Ян НИЛЬССОН
Роланд КАРЛССОН (SE)
Роланд КАРЛССОН
Дженни БЕНГТССОН (SE)
Дженни БЕНГТССОН
Лейф СТРАНДБЕРГ (SE)
Лейф СТРАНДБЕРГ
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Форскарпатент И Сюд Аб
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Priority claimed from SE0202959A external-priority patent/SE0202959D0/xx
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
RU2005113235/15A 2002-10-04 2003-10-06 Пассивная иммунизационная терапия на основе пептидов для лечения атеросклероза RU2322260C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SE0202959-3 2002-10-04
SE0202959A SE0202959D0 (sv) 2002-10-04 2002-10-04 Peptide-Base passive immunization therapy for treatment of atherosclerosis
SE0302312A SE0302312D0 (sv) 2002-10-04 2003-08-27 Peptide-based passive immunization therapy for treatment of atherosclerosis
SE0302312-4 2003-08-27
SEPCT/SE03/01469 2003-09-22

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2007140978/15A Division RU2007140978A (ru) 2002-10-04 2007-11-02 Пассивная иммунизационная терапия на основе пептидов для лечения атеросклероза

Publications (2)

Publication Number Publication Date
RU2005113235A RU2005113235A (ru) 2006-01-20
RU2322260C2 true RU2322260C2 (ru) 2008-04-20

Family

ID=28677712

Family Applications (2)

Application Number Title Priority Date Filing Date
RU2005113235/15A RU2322260C2 (ru) 2002-10-04 2003-10-06 Пассивная иммунизационная терапия на основе пептидов для лечения атеросклероза
RU2007140978/15A RU2007140978A (ru) 2002-10-04 2007-11-02 Пассивная иммунизационная терапия на основе пептидов для лечения атеросклероза

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RU2007140978/15A RU2007140978A (ru) 2002-10-04 2007-11-02 Пассивная иммунизационная терапия на основе пептидов для лечения атеросклероза

Country Status (19)

Country Link
US (6) US7468183B2 (https=)
EP (3) EP2361633A1 (https=)
JP (5) JP2006506450A (https=)
CN (3) CN102380097A (https=)
AT (1) ATE498407T1 (https=)
AU (2) AU2003263712A1 (https=)
BR (1) BR0315042A (https=)
CY (1) CY1112229T1 (https=)
DE (1) DE60336068D1 (https=)
DK (1) DK1545609T3 (https=)
EE (1) EE200500012A (https=)
ES (1) ES2387423T3 (https=)
PL (1) PL376964A1 (https=)
PT (1) PT1545609E (https=)
RU (2) RU2322260C2 (https=)
SE (1) SE0302312D0 (https=)
SI (1) SI1545609T1 (https=)
TW (2) TW200835517A (https=)
WO (1) WO2004030698A1 (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1531162A1 (en) * 2003-11-14 2005-05-18 Heinz Vollmers Adenocarcinoma specific antibody SAM-6, and uses thereof
DE10353175A1 (de) * 2003-11-14 2005-06-16 Müller-Hermelink, Hans Konrad, Prof. Dr. Humaner monoklonaler Antikörper mit fettsenkender Wirkung
GB0517878D0 (en) * 2005-09-02 2005-10-12 Bioinvent Int Ab Immunotherapeutic treatment
UA100255C2 (uk) * 2007-12-28 2012-12-10 Біоінвент Інтернешенл Аб Фармацевтична композиція
JP5913980B2 (ja) 2008-10-14 2016-05-11 ジェネンテック， インコーポレイテッド 免疫グロブリン変異体及びその用途
WO2010088739A1 (en) * 2009-02-09 2010-08-12 Patrys Limited Sam-6 variants, target and methods of use
EP2408812B1 (en) 2009-03-17 2015-12-16 CardioVax, LLC Immunomodulatory methods and systems for treatment and/or prevention of atherosclerosis and related proteins, peptides and compositions
CU23736A1 (es) 2009-05-04 2011-11-15 Centro Inmunologia Molecular Anticuerpos que reconocen sulfatidos y proteoglicanos sulfatados y su uso
AU2010286532A1 (en) * 2009-08-28 2012-04-12 Bioinvent International Methods of treatment using anti-oxidized LDL antibodies
WO2011060329A1 (en) 2009-11-14 2011-05-19 Kuang-Yuh Chyu Immunomodulatory methods and systems for treatment and/or prevention of atherosclerosis
CN103501806A (zh) 2010-11-12 2014-01-08 赛达斯西奈医疗中心 用于治疗和/或预防动脉瘤的免疫调节方法和系统
RU2013126626A (ru) 2010-11-12 2014-12-20 Седарс-Синаи Медикал Сентер Иммуномодулирующие способы и системы для лечения и/или предотвращения гипертензий
PE20150863A1 (es) * 2012-06-21 2015-06-11 Univ Indiana Res & Tech Corp Analogos de glucagon que exhiben actividad de receptor de gip
US10858422B2 (en) 2016-05-31 2020-12-08 Abcentra, Llc Methods for treating systemic lupus erythematosus with an anti-apolipoprotein B antibody
US10434141B2 (en) 2016-05-31 2019-10-08 Abcentra, Llc Methods for treating systemic lupus erythematosus with an anti-apolipoprotein B antibody
CN110950952A (zh) * 2019-12-17 2020-04-03 东莞市东阳光生物药研发有限公司 制备抗体的方法

Citations (8)

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US5494791A (en) * 1992-06-26 1996-02-27 Exocell, Inc. Monoclonal antibodies against glycated low density lipoprotein
US5861276A (en) * 1995-11-02 1999-01-19 Korea Institute Of Science & Technology CDNAS encoding murine antibody against human plasma apolipoprotein B-100
WO1999008109A2 (en) * 1997-08-07 1999-02-18 The Regents Of The University Of California Antibodies to oxidation-specific epitopes on lipoprotein and methods for their use in detecting, monitoring and inhibiting the growth of atheroma
RU2134696C1 (ru) * 1991-12-13 1999-08-20 Каби Фармациа АБ Димер молекулярного варианта апо-липопротеина, способ его получения и фармацевтическая композиция на его основе
US5972890A (en) * 1988-05-02 1999-10-26 New England Deaconess Hospital Corporation Synthetic peptides for arterial imaging
WO2001032070A2 (en) * 1999-10-26 2001-05-10 The Regents Of The University Of California Reagents and methods for diagnosing, imaging and treating atherosclerotic disease
WO2001064008A2 (en) * 2000-03-03 2001-09-07 Smithkline Beecham Biologicals S.A. Vaccine for the treatment of artherosclerosis
WO2002080954A1 (en) * 2001-04-05 2002-10-17 Forskarpatent I Syd Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein

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US4970144A (en) * 1984-12-31 1990-11-13 International Genetic Engineering Peptide fragments of human apolipoprotein, type-specific antibodies and methods of use
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5196324A (en) * 1989-12-15 1993-03-23 Eli Lilly And Company Monoclonal antibodies reactive with a human atheroma associated antigen
US5678548A (en) 1995-07-20 1997-10-21 The United States Of America As Represented By The Department Of Health And Human Services System and method for performing in vivo imaging and oxymetry and FT microscopy by pulsed radiofrequency electron paramagnetic resonance
CN1206421A (zh) * 1995-11-01 1999-01-27 科斯药品公司 载脂蛋白e2和阿尔采默氏病的治疗
GB9620153D0 (en) 1996-09-27 1996-11-13 Univ Strathclyde Non-naturally occurring lipoprotein particle
GB9701425D0 (en) 1997-01-24 1997-03-12 Bioinvent Int Ab A method for in vitro molecular evolution of protein function
GB9705831D0 (en) * 1997-03-20 1997-05-07 Univ Leicester Oxidised ldl
US6635623B1 (en) 1997-06-13 2003-10-21 Baylor College Of Medicine Lipoproteins as nucleic acid vectors
NZ502800A (en) * 1997-08-12 2002-10-25 Leadd B The use of apoptin in determining the transforming capability of tumorigenic or tumor promoting agents
US6156315A (en) 1997-10-10 2000-12-05 The Trustees Of Columbia University In The City Of New York Method for inhibiting the binding of low density lipoprotein to blood vessel matrix
AU5200699A (en) 1998-07-13 2000-02-01 University Of Otago Inhibition of lipoprotein formation
US20030105003A1 (en) * 2001-04-05 2003-06-05 Jan Nilsson Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein
JP4159300B2 (ja) 2001-07-05 2008-10-01 株式会社リコー 画像定着装置及び画像形成装置

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5972890A (en) * 1988-05-02 1999-10-26 New England Deaconess Hospital Corporation Synthetic peptides for arterial imaging
RU2134696C1 (ru) * 1991-12-13 1999-08-20 Каби Фармациа АБ Димер молекулярного варианта апо-липопротеина, способ его получения и фармацевтическая композиция на его основе
US5494791A (en) * 1992-06-26 1996-02-27 Exocell, Inc. Monoclonal antibodies against glycated low density lipoprotein
US5861276A (en) * 1995-11-02 1999-01-19 Korea Institute Of Science & Technology CDNAS encoding murine antibody against human plasma apolipoprotein B-100
WO1999008109A2 (en) * 1997-08-07 1999-02-18 The Regents Of The University Of California Antibodies to oxidation-specific epitopes on lipoprotein and methods for their use in detecting, monitoring and inhibiting the growth of atheroma
WO2001032070A2 (en) * 1999-10-26 2001-05-10 The Regents Of The University Of California Reagents and methods for diagnosing, imaging and treating atherosclerotic disease
WO2001064008A2 (en) * 2000-03-03 2001-09-07 Smithkline Beecham Biologicals S.A. Vaccine for the treatment of artherosclerosis
WO2002080954A1 (en) * 2001-04-05 2002-10-17 Forskarpatent I Syd Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein

Also Published As

Publication number Publication date
RU2007140978A (ru) 2009-05-10
AU2009201260A1 (en) 2009-04-23
DE60336068D1 (de) 2011-03-31
EP2361633A1 (en) 2011-08-31
PT1545609E (pt) 2011-05-11
DK1545609T3 (da) 2011-05-02
JP2010104374A (ja) 2010-05-13
EP2359848A1 (en) 2011-08-24
JP2010222378A (ja) 2010-10-07
PL376964A1 (pl) 2006-01-09
US20120070426A1 (en) 2012-03-22
SE0302312D0 (sv) 2003-08-27
BR0315042A (pt) 2005-08-23
US20070098723A1 (en) 2007-05-03
TW200835517A (en) 2008-09-01
US20040202653A1 (en) 2004-10-14
JP2010104375A (ja) 2010-05-13
AU2003263712A1 (en) 2004-04-23
EP1545609B1 (en) 2011-02-16
ES2387423T3 (es) 2012-09-21
ATE498407T1 (de) 2011-03-15
CY1112229T1 (el) 2015-12-09
JP2006506450A (ja) 2006-02-23
SI1545609T1 (sl) 2011-05-31
TWI299666B (en) 2008-08-11
CN102319429A (zh) 2012-01-18
CN102380097A (zh) 2012-03-21
JP2010136721A (ja) 2010-06-24
TW200418504A (en) 2004-10-01
HK1087018A1 (en) 2006-10-06
WO2004030698A1 (en) 2004-04-15
CN102172400A (zh) 2011-09-07
US20090155258A1 (en) 2009-06-18
US7468183B2 (en) 2008-12-23
US7601353B2 (en) 2009-10-13
US8114966B2 (en) 2012-02-14
US7521046B2 (en) 2009-04-21
US20080008702A1 (en) 2008-01-10
RU2005113235A (ru) 2006-01-20
EP1545609A2 (en) 2005-06-29
US20080075716A1 (en) 2008-03-27
EE200500012A (et) 2005-08-15
AU2009201260B2 (en) 2011-07-28

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Effective date: 20121007