RU2320380C1 - Method for correcting immunity status in acne patients - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: method involves applying drug and magnetic field therapy. Polyoxidonium is additionally intramuscularly introduced at a dose of 6 mg/day at the first, third, fifth, seventh and ninth treatment day. Magnetic therapy is carried out in contact mode applied to front region for 10-12 min at the second, fourth, sixth, eighth and tenth treatment day and further in daily mode. The total treatment course is 10-12 procedures long. Permanent magnetic field of 30±10 mTesla units and low frequency alternating sinusoid magnetic field of 50 Hz of 30±10 mTesla units are concurrently applied. When detecting frequent respiratory inflammatory diseases and chronic infectious lesions in nasopharyngeal ring region in anamnesis, Polyoxidonium is sublingually introduced at a daily dose of 12 mg twice a day during 7-9 days, and magnetic therapy is applied every day with the total treatment course being 12 procedure long.

EFFECT: enhanced effectiveness of treatment; reduced risk of adverse side effects.

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Description

The present invention relates to medicine, in particular to dermatology, cosmetology, physiotherapy, and can be applied in skin and venereological clinics, cosmetic hospitals, in various medical and preventive and spa institutions, including in a specialized dermatological clinic.

As you know, acne is one of the most common dermatoses in young people and occurs in 85% of people under the age of 25 years.

Damage to the face, as well as scars remaining after resolving severe forms of acne, lead to serious psychological problems, a decrease in social activity and the quality of life of young people and require further dermato-surgical correction.

A recurrent course of the disease and torpidity to existing treatment methods is characteristic, which is associated with an increase in antibiotic resistance of the bacterial microflora of the skin of patients with acne.

Therefore, in recent years, in the treatment of acne patients, immunocorrection is relevant.

A known method of treatment with an immunotropic drug imunofan in combination with antibiotics, in particular with doxycycline, 1.0 ml of a 0.005% solution i / m once a day every other day with two 5-day courses with a 2-week break [N. Kiseleva. The role of histocompatibility antigens in the development of various forms of acne and methods for their correction. Dis ... can. honey. sciences. - M., 2001. - 114 s].

However, the immunostimulating effect of this drug applies only to T cells, macrophages, cytokine production, without affecting the B-cell immunity. The duration of clinical remission is insufficient and requires repeated courses of treatment. Side effects of treatment from the use of antibacterial therapy are possible, in particular the development of dysbiosis with a subsequent decrease in immunity.

Given the immune disorders in severe forms of acne, a method is known which consists in administering 2 ml splenin injections every other day, for a course of 10 v / m injections [B. Lyantsevich. The use of splenin in the complex treatment of patients with chronic furunculosis. // Honey. news. - 1999. - No. 6. - S. 44-45, Sidorova I.L. A treatment for severe acne. // Honey. news. - 2001. - No. 4. - S. 61-63]. There is evidence of splenin's ability to exert an immunostimulating effect. The disadvantage of this method is the low clinical effectiveness, injection method of administration.

There is also a method of correction by including injections of leukinferon in courses of antibiotic therapy of inflammatory acne.

Leukinferon is a complex of cytokines of the first phase of the immune response in their natural ratio of natural origin (obtained in vitro by inducing the leukomass of healthy donors with a vaccine strain of the Newcastle disease virus). The drug contains interleukin-1 (IL-1), IL-6, IL-8, macrophage inhibition factor (MIF), tumor necrosis factor-alpha (TNF), an interferon-alpha complex. This drug acts on cells involved in inflammation, regeneration processes, and the immune response.

[Kotova N.V. Comprehensive treatment of juvenile acne using leukinferon. Dis ... can. honey. Sciences, M. - 1999. - 130 p.]

The disadvantage of this method is the complex use of the drug together with antibacterial agents, which causes undesirable side effects, including dysbiosis, leading to a further decrease in immunity, the development of resistance and relapse of the disease.

The closest (prototype) in technical essence to the proposed one is a method of correcting the immune status in patients with inflammatory forms of acne, which consists in the fact that patients with inflammatory forms of acne were treated simultaneously with a combined magnetic field (PMF induction of 30 + 10 mT and low-frequency - 50 Hz PeMP intensity of 30 + 10 mT sinusoidal) and infrared incoherent radiation (wavelength 0.87 μm) transcerebral [Vasilieva ES "The use of combined (constant and variable) magnetic fraction and infrared radiation in the complex treatment of acne patients" Abstract. dis ... can. honey. sciences. - M., 2004. - P.20].

The disadvantage of this method is its lack of effectiveness in patients with a more severe form of the disease - nodular (71%) and the development of relapses during the year with papular-pustular form in 79% of patients and for 6 months - with nodular in 83% of cases. In addition, the improvement of immunological parameters when using combined physiotherapy most often reaches only the lower limits of the norm. As a rule, not reaching the average norm.

The technical result of the proposed method for the correction of immune status is the normalization of initially impaired immunological parameters; high treatment efficiency, reduction of treatment time, duration of remission, improvement of the general condition of the patient, no need for antibiotic therapy and its side effects.

The specified technical result is achieved by the fact that patients with inflammatory forms of acne, depending on the initial state of their immune status, undergo drug therapy and magnetotherapy, which is carried out transcerebrally, simultaneously acting with a constant magnetic field of induction of 30 ± 10 mT and low-frequency - 50 Hz with an alternating magnetic field of induction 30 ± 10 mT of a sinusoidal shape, characterized in that polyoxidonium is additionally administered intramuscularly at 6 mg / day on the 1st, 3rd, 5th, 7th, 9th days of treatment, and magnetotherapy June is carried out in contact, on the frontal region for 10-12 minutes, on the 2nd, 4th, 6th, 8th, 10th days of treatment, then daily, for a course of 10-12 procedures, and when detection of a history of frequent respiratory diseases and chronic foci of infection in the nasopharyngeal ring, polyoxidonium is administered sublingually 12 mg daily 3 times a day for 7-9 days and magnetotherapy is carried out daily for a course of 12 procedures.

The duration of the exposure time cannot be selected less than 10 minutes due to the fact that the shorter exposure time does not have a significant therapeutic effect. The magnitude of the exposure time cannot be selected for more than 10-12 minutes, because with a longer duration, the damaging effect on the brain cells is not ruled out. The magnitude of the magnetic induction cannot be chosen less than 30 ± 10 mT due to the fact that a smaller value of the magnetic induction does not have the necessary therapeutic effect and cannot be selected more than 30 ± 10 mT due to the possible occurrence of a damaging effect on the tissue.

Immunomodulator polyoxidonium refers to high molecular weight, chemically pure immunomodulators obtained using directional chemical synthesis. It is an N-oxidized derivative of polyethylene piperazine with a molecular weight of about 100 kD. The drug has immunomodulatory, detoxifying, antioxidant and membrane protective effects.

The immunomodulatory effect of polyoxidonium is determined by:

- increased ability of neutrophils to capture and kill absorbed Staphylococcus aureus;

- modulation of the production of pro-inflammatory cytokines by peripheral blood mononucleators, which is manifested by a decrease in elevated and increased decreased levels of IL-1, IL-6 and TNF;

- increased cytotoxic activity of NK cells, especially with its initially lowered level;

- activation of resident macrophages of the reticuloendothelial system, which leads to faster elimination of foreign particles from the body;

- an increase in the body's natural resistance to bacterial and viral infections;

- increased antibody formation to T-dependent and T-independent antigens of both animal and microbial origin.

The detoxifying properties of the drug are associated with its high molecular weight and the presence on the surface of the molecule of a large number of different active groups. Therefore, it intensively adsorbes soluble toxic substances and microparticles circulating in the blood.

(The collection "The mechanism of action and clinical use of" Polyoxidonium ", issue No. 3 - M., 2004; Clinical aspects of the use of the immunomodulator polyoxidonium. A manual for doctors - M., 2004").

When applying magnetotherapy due to the synchronizing effect of low frequencies of the magnetic field on biochemical processes, correction of shifts in the temporary organization of the functional systems of the body, elimination of desynchronosis caused by the pathological process, the body's resistance and adaptive capabilities increase, which underlies the processes of self-healing of impaired homeostasis.

Given the increased sensitivity of the hypothalamus (increased neurosecretory activity of its nuclei) and the cerebral cortex to the influence of a low-frequency magnetic field, the therapeutic effect of the transcerebral effect of the combined magnetic field on the body is realized through the regulation of subcortical-cortical bioelectric processes, the exchange of neurotransmitters. There is a stimulation of the neuroendocrine system and, first of all, the hypothalamic-pituitary-adrenal system, which provides homeostatic regulation of the functional systems of the body, and in turn the correction of the function of the endocrine and immune systems.

As a result of the influence of low-frequency magnetotherapy, the initially increased content of stab neutrophils decreases, the initially reduced percentage of T-lymphocytes with both helper and suppressor activity increases, the absorption and digestion ability of neutrophils increases, the content of B cells increases, the level of cortisol is normalized, the system is activated complement, which indicates the normalization of the immunoregulatory balance, strengthening the anti-infective potential of the body, reduction of the process of inflammation and toxic toxic stress (Milyutin A.A., Novikov A.E., Petrakovsky V.V., Olvinsky L.V., Tarasova E.E., Sukalo A.V., Prilutskaya V.A. Correction of the functions of the immune system using a low-frequency magnetic field. // Mater. Russian Conference "Organism and the environment: life support and human protection in extreme conditions." - M., 2000. - T.1.- P.283-284).

Under the influence of low-frequency magnetotherapy, there is a tendency to normalize indicators of humoral immunity (immunoglobulins A, M, G), an increase in the total number of T-lymphocytes, an increase in the functional activity of T-lymphocytes of the dermis, a decrease in leukocytosis and an initially increased ESR. And also the phagocytic activity of leukocytes, the phagocytic number, the activity of lysozyme, beta-lysines, complement increase, a pronounced anti-inflammatory effect and an increase in nonspecific resistance of the body are observed.

A low-frequency alternating magnetic field is capable of enhancing the effectiveness of a constant magnetic field in the presence of an alternating magnetic field parallel to it. Due to this, there is a significant increase in the effectiveness of exposure to a superposition of such magnetic fields, contributes to a slower and rarer development of adaptation, the appearance of a general reaction of the body with the involvement of the neurohumoral regulation system, prolongation of the aftereffect, which ensures the duration of the therapeutic effect and is optimal for resolving inflammatory reactions and restoring vascular metabolic disorders [Komarova L.A., Egorova G.I. Combined methods of physiotherapy and balneotherapy. - SPb., 1994. - S.126-127; Clerk B.C. On the influence of physical factors on the effect of other therapeutic agents (on the problem of therapeutic interference) // Vopr. balneology physiotherapy and lay down. physical education. - 1998. No. 3. - S. 46-49].

An immunomodulator polyoxidonium has a more pronounced effect on the immunoregulatory population of T-helpers / inducers (CD4), as a result of which the immunoregulatory index (IRI) is normalized and the total pool of B lymphocytes increases, although immunoglobulins IgA, IgG, IgM are not normalized. While combined physiotherapy more clearly affects the immunoregulatory subpopulation (T8-SD8) of suppressors / cytotoxic lymphocytes, it increases the functional activity of the cellular immunity according to RBT on PHA and normalizes initially elevated levels of IgA, IgG, IgM.

As a result of treatment by the proposed method, a pronounced immunocorrective effect of combined physiotherapy in combination with an immunomodulator polyoxidonium occurs.

DESCRIPTION OF THE METHOD of correction of immune disorders.

In the proposed method for the treatment of patients with inflammatory forms of acne, drug therapy and magnetotherapy are carried out, which is carried out transcerebrally, simultaneously exposed to a constant magnetic field by induction of 30 ± 10 mT and low-frequency - 50 Hz by an alternating magnetic field by induction of 30 ± 10 mT of a sinusoidal shape, characterized in that additionally, 6 mg / day polyoxidonium is administered intramuscularly on the 1st, 3rd, 5th, 7th, 9th days of treatment, and magnetotherapy is carried out contactly, on the frontal region for 10-12 minutes, in 2- 4th, 6th, 8th, 10th days of treatment, then daily, for a course of 10-12 procedures, and if there is a history of frequent respiratory diseases and chronic foci of infection in the nasopharyngeal ring, polyoxidonium is administered sublingually 12 mg daily 3 times a day for 7-9 days and magnetotherapy is carried out daily, for a course of 12 procedures using the MUM-50 EDMA apparatus (Moscow) // registered in the Russian Federation, Registration Certificate of the Ministry of Health of the Russian Federation No. 29/06030394 / 5235-03 and Certificate of Conformity No. РОСС RU ИМ02. B10763.

The proposed method for the correction of immune disorders in patients with inflammatory forms of acne is carried out against the background of the traditional drug treatment of this disease (calcium pantothenate, aevit, enterosorbents, preparations containing bifidobacteria and lactobacilli, zinc preparations. Shake mixtures with sulfur, resorcinol, dimexide were used externally. erythromycin No antibiotics per os prescribed.

EXAMPLES OF IMPLEMENTING THE METHOD

Example 1. Patient P., 20 years old, with a diagnosis of nodular form of acne of moderate severity. On admission - complaints of inflammatory acne elements on the skin of the face, chest, and back. Dermatological status: facial skin is oily, multiple papules and pustules in the forehead, both cheeks, congestive infiltrates and post-acne scars on the back and chest. The duration of the disease is 6 years, without visible improvement from the treatment. In the anamnesis: frequent respiratory diseases, chronic foci of infection (chronic tonsillitis).

Standard study of immune status: white blood cells 6000 abs / L × 106, lymphocytes 18%, lymphocytes 1080 abs / L × 106, T lymphocytes 35%, T lymphocytes 378.0 abs / L × 106, B lymphocytes 18%, B lymphocytes 194.4 abs / l × 106, Tg 38%, Tg 143.6 abs / l × 106, Tm 18%, Tm 68.0 abs / l × 106, IRI 0, 47, IgG 10.4 g / l, IgA 2.1 g / l, IgM 1.4 g / l.

A patient in the supine position on the 1st day of treatment is given an intramuscular injection of an immunomodulator polyoxidonium 6 mg The drug in a 6 mg vial is diluted with water for injection 2 ml and shaken until the drug is completely dissolved.

On the 2nd day of treatment, a simultaneous exposure to a combined magnetic field (constant magnetic field with an induction of 30 ± 10 mT and low-frequency - 50 Hz alternating magnetic field of intensity 30 ± 10 mT of a sinusoidal shape) is carried out using the MUM-50 (EDMA) apparatus, which the contact surface is placed through thin filter paper on the frontal area of the patient (projection of the frontal cortex of the brain), for 10-12 minutes, Physiotherapeutic effects continue every other day on the 2nd, 4th, 6th, 8th, 10th the first days of treatment, d Lee every day, for a course of 10-12 procedures with traditional medical therapy.

The injection course of the immunomodulator polyoxidonium 6 mg, alternating with magnetotherapy, continues according to the scheme: on the 1st, 3rd, 5th, 7th, 9th days of treatment.

The treatment of the proposed method was carried out for 15 days (see table 1). After the course of treatment, no new rashes appeared. The duration of remission was 12 months. In this case, the patient received calcium pantothenate 1 t × 3 times a day for 3 weeks, aevit 1 capsule × 3 r per day for 1 month, enterosorbents, biovestin-lacto, 1 bottle per day for 30 days.

Shaken mixtures with sulfur, resorcinol, dimexide, erythromycin were used externally. The patient did not take antibacterial drugs during treatment.

Table 1 Algorithm for treating patient N., 20 years old, with a nodular form of acne of moderate severity, with a history of frequent respiratory diseases. Days of introduction one 2 3 four 5 6 7 8 9 10 eleven 12 13 fourteen fifteen 16 P tue wed thu Fri Sat sun Mon tue wed thu Fri Sat sun P tue Injections polyoxidonium + - + - + - - + - + - - - - - - im 6 mg Momentary impact on the frontal area combined magnetic field (PMP induction 30 ± 10 mT and - + - + - + - - + - + + + + + + low frequency 50 Hz PeMP intensity 30 ± 10 mT sinusoidal forms) 10 minutes Note: "+" is the day of taking the procedures, "-" is the day of rest from the procedures.

A standard study of the immune status after treatment: leukocytes 5600 abs / L × 106, lymphocytes 27%, lymphocytes 1512 abs / L × 106, T lymphocytes 65%, T lymphocytes 982.8 abs / L x106, B lymphocytes 24%, B-lymphocytes 362.9 abs / L × 106, Tg 21%, Tg 206.4 abs / L × 106, Tm 35%, Tm 344.0 abs / L × 106, IRI 1 , 67, IgG 8.8 g / L, IgA 1.9 g / L, IgM 1.6 g / L.

Example 2. Patient B., 23 years old, with a diagnosis of papulopustular form of acne of moderate severity. On admission, complaints of inflammatory acne elements on the skin of the face and chest. Dermatological status: facial skin combined, in the nose, chin and forehead - oily, with enlarged pores, comedones, multiple papules and pustules in the forehead, cheeks, congestive infiltrates. Single rashes are localized on the chest and shoulders. The duration of the disease is 8 years, without visible improvement from the treatment. A history of chronic foci of infection (frequent sore throats, chronic tonsillitis, sinusitis).

Standard study of immune status: white blood cells 5000 abs / L × 106, lymphocytes 34%, lymphocytes 1700 abs / L × 106, T lymphocytes 61%, T lymphocytes 1037.0 abs / L × 106, B lymphocytes 18%, B lymphocytes 306.0 abs / L × 106, Tg 28%, Tg 276.1 abs / L × 106, 16% Tm 157.8 abs / L × 106, IRI 0, 6, IgG 13.6 g / l, IgA 2.5 g / l, IgM 1.5 g / l.

A patient is treated with an immunomodulator polyoxidonium sublingually 12 mg every day 3 times a day for 10-15 days and is subjected to simultaneous exposure with a combined magnetic field (constant magnetic field induction 30 ± 10 mT and low-frequency 50 Hz variable magnetic field intensity 30 ± 10 mTl sinusoidal form) lasting 10-12 minutes. The effects are carried out using the MUM-50 apparatus (EDMA), which is contacted through a thin filter paper with a working surface on the frontal region of the patient (projection of the frontal cortex). On a course of 10-12 daily procedures against the background of traditional drug therapy.

The proposed method of treatment was carried out by the patient for 12 days (see Table 2) while taking calcium pantothenate 1 t × 3 times a day for 3 weeks, Aevita 1 caps × 3 r per day for 1 month, entgine 1t × 2p per day, bio-vestin-lacto 1 bottle per day for 30 days. The patient did not take antibacterial drugs during treatment.

After the course of treatment, there are no complaints. No new papular-pustular rashes appeared. The duration of remission was 1.5 years.

table 2 Algorithm for treating patient B., 23 years old, with a papulopustular form of acne of moderate severity, having a history of chronic foci of infection in the nasopharyngeal ring. one 2 3 four 5 6 7 8 9 10 eleven 12 Mon tue wed thu Fri Sat sun Mon tue Wed thu Fri immunomodulator polyoxidonium sublingual use of 12 mg - + + + + + + + + + + + + daily 3 times a day Simultaneous impact on the frontal region combined magnetic field (PMP induction 30 ± 10 mT and low hours + + + + + + + + + + + total 50 Hz PeMP intensity 30 ± 10 mT sinusoidal forms) duration 10 min Note: “+” is the day of receiving the procedures, “-” is the day of rest from the procedures.

A standard study of the immune status after treatment: leukocytes 6200 abs / L × 106, lymphocytes 50%, lymphocytes 3100 abs / L × 106, T-lymphocytes 58%, T-lymphocytes 1798.0 abs / L × 106, B-lymphocytes 21% , B lymphocytes 651.0 abs / L × 106, Tg 17%, Tg 305.7 abs / L × 106, Tm 29%, Tm 521.4 abs / L × 106, IRI 1.7, IgG 13.6 g / L, IgA 2.5 g / L, IgM 1.0 g / L.

The proposed correction method for patients with acne has been tested in the Department of Dermatosurgery of the Institute of Plastic Surgery and Cosmetology of the Ministry of Health of the Russian Federation and in the Department of Immunology of the Russian Scientific Center for Reconstructive Medicine and Balneology of the Ministry of Health of the Russian Federation. We observed 63 patients with inflammatory forms of acne of varying severity, with a long, sluggish course and torpidity to the traditional therapy (including antibiotic therapy), which had initially significant immune disorders affecting both T and B lymphocytes, lymphopenia. Of these, more than 76% revealed certain changes in the immune status. Among concomitant diseases, the gastrointestinal tract pathology was most often observed - in 64% of cases, diseases of ENT organs in 26%.

At admission, patients complained of a rash of acne in the face, back, and chest. After the differentiated correction of the immune status, the appearance of new rashes was not observed.

Table 3 The dynamics of the initially altered immunological parameters of patients with inflammatory forms of acne under the influence of the course of immunocorrection. Immunological indicators Before treatment After treatment Norm T-lymphocytes,% 38.2 ± 2.4 54.0 ± 4.3 * 55.0 ± 5.2 T-lymphocytes, abs. 559.1 ± 22.9 930.3 ± 110.1 * 1142 ± 65.4 B-lymphocytes,% 11.9 + 0.5 19.1 + 1.0 * 21.8 + 2.5 Tγ (suppressors / killers) SD8-T8,% 8.3 ± 0.6 17.7 ± 1.8 * 16.2 ± 2.6 T-γ (suppressors / killers) SD8-T8, abs. 96.1 ± 8.9 136.5 ± 12.2 * 176.2 ± 13.8 Tγ (suppressors / killers) SD8-T8,% 28.0 ± 0.7 17.9 ± 1.6 * 16.2 ± 2.6 T-γ (suppressors / killers) SD8-T8, abs. 317.0 ± 25.7 240.1 ± 30.1 * 176.2 ± 13.8 Tμ (helpers / inductors) SD4-T4,% 16.8 ± 0.5 28.6 ± 2.5 * 24.7 ± 2.3 Tμ (helpers / inductors) SD4-T4, abs. 171.5 ± 10.8 275.6 ± 40.0 * 295.0 ± 21.4 IRI (Tμ / Tγ) 1.0 ± 0.1 1.6 ± 0.1 * 1.75 ± 0.2 RBT without PHA, control, imp / min 1740.6 ± 202.2 1383.5 + 233.6 1037 ± 71.0 RBT with PHA, imp / min 10,466.4 + 1,447.1 21275.6 + 4829.1 * 50403 ± 3552 Stimulation index 15.6 ± 1.6 31.2 ± 6.7 * 54.6 ± 4.5 Ig A g / l 2.0 + 0.1 * 1.7 + 0.1 *) 1.6 + 0.1 Ig G g / l 12.9 ± 0.3 * 11.9 ± 0.3 *) 11.8 ± 0.4 Note: * p <0.1; ** p <0.05 * - level of significance of differences before and after treatment.

According to table 3, in the blood of patients after applying the proposed method for the correction of immune disorders, there is a decrease to normal values of the immunoregulatory subpopulation of Tγ suppressors / cytotoxic lymphocytes, an increase in T helper / inductors, normalization of the immunoregulatory index and functional activity of lymphocytes, restoration to normal values of the B lymphocyte population . An increase in the functional activity of the cellular immunity link according to RBT on PHA, an increase in the stimulation index was noted. The content of immunoglobulins IgA, IgG, IgM was significantly normalized.

Thus, as a result of the application of the proposed method, it was found that all the changed indicators approached the normal range, which is important for a long-term favorable prognosis of the disease (Schmidt et al., 1976) and indicates a general increase in the immunoreactivity of the patient’s body.

When using the proposed method for the correction of immune disorders, its immunomodulating effect was associated both with the regulation of subcortical-cortical bioelectric processes, the exchange of neurotransmitters, the normalization of microcirculatory disorders, which contributes to the correction of the function of the endocrine and immune systems, and due to the parallel increase in the activity of cells of the monocytic-macrophage system. The consequence of this is an increase in the functional activity of almost all parts of the body's immune defense.

When applying the proposed method of treatment, bacteriostatic and anti-inflammatory effects were associated mainly with an increase in the immunoreactivity of the body.

Indications for the appointment of the proposed method of correction are: inflammatory forms of acne that occur on the background of various immune disorders; prolonged (over 5 years), often recurrent course of the disease, torpid to previous treatment; a disease that occurs against the background of concomitant foci of chronic infection.

Contraindications to the use of this method of immunocorrection are kidney diseases, as well as general contraindications for magnetotherapy and transcerebral effects, hypotension, and individual intolerance to physical factors.

The method contributes to the correction of immune disorders in patients with inflammatory forms of acne, increasing the effectiveness of treatment and lengthening the period of remission. The achieved therapeutic effect lasts from 12 months to 2 years.

In addition, the correction of immune disorders in patients with inflammatory forms of acne allows to exclude antibiotic therapy and, accordingly, to avoid its side effects.

The proposed method for the treatment of patients with inflammatory forms of acne that occurs against a background of various immune disorders has, compared with the prototype (nodular form (71%) and other therapeutic methods, higher therapeutic efficacy (93.2%) and prolongs remission to 1-2 years with a papular-pustular form in 89.6% of patients and up to 10-12 months with a nodular form of the disease in 67% of cases (while the prototype has relapses during the year with a papular-pustular form in 79% of patients and for 6 months - with knobby 83% of cases).

No complaints were made during or after treatment.

The proposed method of treatment differs in comparison with the known simplicity of the technique, good tolerance to patients and the possibility of its use in outpatient, inpatient and spa facilities.

Claims (1)

A method for the correction of immune disorders in patients with inflammatory forms of acne, including drug therapy and magnetotherapy, which is carried out transcerebrally, simultaneously exposed to a constant magnetic field by induction of 30 ± 10 mT and low-frequency - 50 Hz by an alternating magnetic field by induction of 30 ± 10 mT of a sinusoidal shape, characterized in that polyoxidonium is additionally administered intramuscularly at 6 mg / day on the 1st, 3rd, 5th, 7th, 9th days of treatment, and magnetotherapy is carried out contactly, on the frontal area for 10-12 minutes, during 2nd, 4th, 6th, 8th , The 10th day of treatment, then daily, for a course of 10-12 procedures, and if a history of frequent respiratory diseases and chronic foci of infection in the nasopharyngeal ring polyoxidonium is administered sublingually 12 mg daily 2 times a day, for 7- 9 days and daily carry out magnetotherapy, for a course of 12 procedures.