RU2229864C1 - Method for treating infectious ulcers and keratitis - Google Patents

Abstract

FIELD: medicine, ophthalmology. SUBSTANCE: the method deals with applying medicinal preparation onto pathological focus. As medicinal preparation one should apply unstable emulsion based upon either sea buckthorn or olive oil containing about 60 - 65 weight% of electrolytic aqueous solution of sodium hypochlorite. One should apply 1 - 2 drops of emulsion mentioned onto pathological focus once or twice daily for 3 - 10 d. In unstable emulsion one should apply electrolytic aqueous solution of sodium hypochlorite at 45 - 80 mg/l concentration. Moreover, as electrolytic aqueous solution of sodium hypochlorite one should apply its buffered solution at 0.35 - 0.45 g (NaH₂PO₄) /100 ml sodium hypochlorite. The method suggested excludes evisceration of an affected eye. EFFECT: higher efficiency of therapy. 2 cl, 4 ex

Description

The invention relates to medicine, namely to ophthalmology, to methods of treating infectious ulcers and keratitis.

A known method of treating ulcerative keratitis, comprising coating the affected area with a drug (RF patent No. 2049450, A 61 F 9/00, 1993).

However, the known method in the treatment of infectious ulcers and keratitis does not allow to completely eliminate the recurrence of the purulent process, does not completely eliminate the evisceration of the affected eye and does not provide high healing of corneal ulcers. However, it is not possible to eliminate clouding of the cornea and to achieve increased visual acuity.

An object of the invention is to remedy these shortcomings and create a method for the treatment of infectious ulcers and keratitis, which allows for its use to ensure high healing of infectious ulcers and keratitis, to exclude the recurrence of a purulent process and completely eliminate the evisceration of the affected eye.

The problem is solved in that a method for the treatment of infectious ulcers and keratitis is proposed, including applying a drug to a pathological focus, a distinctive feature of which is that as a drug use an unstable emulsion based on sea buckthorn or olive oil containing 60-65 wt.% an electrolysis aqueous solution of sodium hypochlorite (NaOCl), which is applied to the pathological focus in the amount of 1-2 drops 1-2 times a day for 3-10 days until the defect is healed. Moreover, in an unstable emulsion, an electrolysis aqueous solution of sodium hypochlorite with a concentration of 45-80 mg / L is used. Moreover, in an unstable emulsion, an electrolytic aqueous solution of sodium hypochlorite is used in its buffered solution at the rate of 0.35-0.45 g (NaH ₂ PO ₄ ) per 100 ml of sodium hypochlorite solution (NaOCl).

Experimental studies of the proposed method for the treatment of infectious ulcers and keratitis in the clinical setting showed that using all the distinguishing features of the proposed technical solution, high healing of the infectious ulcers and keratitis was ensured, the treatment of patients achieved the elimination of the recurrence of the purulent process and completely eliminated the evisceration of the affected eye. At the same time, it was found that the electrolytic solution of sodium hypochlorite used by us has powerful antimicrobial, detoxifying and immunomodulating properties and does not cause allergic reactions. The electrolysis solution of sodium hypochlorite in combination with sea buckthorn or olive oil is effective both against gram-positive and gram-negative bacteria - pathogens of purulent-inflammatory diseases, a number of viruses, fungi and protozoa. It is a broad spectrum antiseptic that allows you to use it without identifying microflora.

The implementation of the proposed method for the treatment of infectious ulcers and keratitis is illustrated by the following clinical examples.

Example 1. Patient F., 53 years old, was admitted to the Kaluga branch of GU MNTK “Eye Microsurgery” with a diagnosis of ulcerative keratitis, aphakia of the right eye. Visual acuity of the right eye - arm movement of 25 cm. Blepharospasm, photophobia, cornea completely depepithelized.

A freshly prepared unstable emulsion based on sea buckthorn oil containing 65 wt.% Electrolysis aqueous solution of sodium hypochlorite (NaOCl) with a concentration of 45 mg / L was applied to the pathological focus of the right eye. The unstable emulsion was applied to the pathological focus in the amount of 1 drop 2 times a day for 8 days. The complete healing of the infectious defect has been established. With prolonged observation, no re-occurrence of the purulent process was detected.

Example 2. Patient K., 33 years old, was admitted to the Kaluga branch of GU MNTK “Eye Microsurgery” with a diagnosis of Purulent corneal ulcer of the left eye. Visual acuity of the right eye of 0.05 n / a.

Freshly prepared unstable emulsion based on olive oil containing 60 wt.% Electrolysis aqueous solution of sodium hypochlorite (NaOCl) with a concentration of 80 mg / l, buffered at the rate of 0.35 g (NaH ₂ PO ₄ ) per 100 was applied to the pathological focus of the left eye ml of sodium hypochlorite solution (NaOCl). The unstable emulsion was applied to the pathological focus in the amount of 1 drop 2 times a day for 3 days. The complete healing of the infectious defect has been established. With prolonged observation, no re-occurrence of the purulent process was detected.

Example 3. Patient D., 62 years old, was admitted to the Kaluga branch of GU MNTK “Eye Microsurgery” with a diagnosis of Corneal ulcer of the left eye.

Freshly prepared unstable emulsion based on sea buckthorn oil containing 62 wt.% Electrolysis aqueous solution of sodium hypochlorite (NaOCl) with a concentration of 65 mg / l, buffered at the rate of 0.45 g (NaH ₂ PO ₄ ) per 100 was applied to the pathological focus of the left eye ml of sodium hypochlorite solution (NaOCl). The unstable emulsion was applied to the pathological focus in the amount of 2 drops 1 time per day for 5 days. Complete healing of a corneal defect has been established.

Example 4. Patient V., 67 years old, was admitted to the Kaluga branch of the State Institution of Scientific and Technological Centers “Eye Microsurgery” with a diagnosis of ulcerative keratitis of the left eye. Visual acuity of the right eye 30 cm arm movement. Blepharospasm, photophobia, cornea completely depepithelized.

Freshly prepared unstable emulsion based on sea buckthorn oil containing 65 wt.% Electrolysis aqueous solution of sodium hypochlorite (NaOCl) with a concentration of 45 mg / L was applied to the pathological focus of the left eye. The unstable emulsion was applied to the pathological focus in the amount of 1 drop 2 times a day for 10 days. The complete healing of the infectious defect has been established. With prolonged observation, no re-occurrence of the purulent process was detected.

The proposed method does not require the use of complex equipment and is easily feasible both in clinical treatment and on an outpatient basis.

Claims (3)

1. A method of treating infectious ulcers and keratitis, including applying the drug to a pathological lesion, characterized in that as a drug use an unstable emulsion based on sea buckthorn or olive oil containing 60-65 wt.% Electrolysis aqueous solution of sodium hypochlorite (NaOCl) , which is applied to the pathological lesion in the amount of 1-2 drops 1-2 times for 3-10 days before the healing of the defect. 2. The method according to claim 1, characterized in that in the unstable emulsion using an electrolytic aqueous solution of sodium hypochlorite with a concentration of 45-80 mg / L. 3. The method according to claim 1 or 2, characterized in that in the unstable emulsion as an electrolytic aqueous solution of sodium hypochlorite use a buffered solution at the rate of 0.35-0.45 g (NaHPO) per 100 ml of sodium hypochlorite (NaOCl).