RU2317828C2 - Новые лекарственные композиции на основе новых антихолинергических средств и ингибиторов egfr-киназы - Google Patents

Новые лекарственные композиции на основе новых антихолинергических средств и ингибиторов egfr-киназы Download PDF

Info

Publication number
RU2317828C2
RU2317828C2 RU2005103397/04A RU2005103397A RU2317828C2 RU 2317828 C2 RU2317828 C2 RU 2317828C2 RU 2005103397/04 A RU2005103397/04 A RU 2005103397/04A RU 2005103397 A RU2005103397 A RU 2005103397A RU 2317828 C2 RU2317828 C2 RU 2317828C2
Authority
RU
Russia
Prior art keywords
amino
chloro
fluorophenyl
buten
oxo
Prior art date
Application number
RU2005103397/04A
Other languages
English (en)
Russian (ru)
Other versions
RU2005103397A (ru
Inventor
Мишель ПАЙРЕ (DE)
Мишель ПАЙРЕ
Кристофер Джон Монтагью МИД (DE)
Кристофер Джон Монтагью Мид
Михаэль П. ПИПЕР (DE)
Михаэль П. Пипер
Биргит ЮНГ (DE)
Биргит Юнг
Original Assignee
БЁРИНГЕР ИНГЕЛЬХАЙМ ФАРМА ГМБХ УНД Ко.КГ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by БЁРИНГЕР ИНГЕЛЬХАЙМ ФАРМА ГМБХ УНД Ко.КГ filed Critical БЁРИНГЕР ИНГЕЛЬХАЙМ ФАРМА ГМБХ УНД Ко.КГ
Publication of RU2005103397A publication Critical patent/RU2005103397A/ru
Application granted granted Critical
Publication of RU2317828C2 publication Critical patent/RU2317828C2/ru

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
RU2005103397/04A 2002-07-09 2003-06-26 Новые лекарственные композиции на основе новых антихолинергических средств и ингибиторов egfr-киназы RU2317828C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10230751.2 2002-07-09
DE10230751A DE10230751A1 (de) 2002-07-09 2002-07-09 Neue Arzneimittelkompositionen auf der Basis neuer Anticholinergika und EGFR-Kinase-Hemmern

Publications (2)

Publication Number Publication Date
RU2005103397A RU2005103397A (ru) 2006-03-20
RU2317828C2 true RU2317828C2 (ru) 2008-02-27

Family

ID=29761746

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2005103397/04A RU2317828C2 (ru) 2002-07-09 2003-06-26 Новые лекарственные композиции на основе новых антихолинергических средств и ингибиторов egfr-киназы

Country Status (16)

Country Link
EP (2) EP1521595B1 (enExample)
JP (1) JP2005537250A (enExample)
CN (1) CN1665539A (enExample)
AT (1) ATE320269T1 (enExample)
AU (1) AU2003242771B2 (enExample)
BR (1) BR0312507A (enExample)
CA (1) CA2492037A1 (enExample)
DE (2) DE10230751A1 (enExample)
ES (1) ES2259769T3 (enExample)
MX (1) MXPA05000163A (enExample)
NZ (1) NZ538096A (enExample)
PL (1) PL374022A1 (enExample)
RU (1) RU2317828C2 (enExample)
TW (1) TW200520757A (enExample)
WO (1) WO2004004775A1 (enExample)
ZA (1) ZA200409676B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE520772T1 (de) 2000-10-31 2011-09-15 Eisai Inc Nucleinsäure kodierend für cyp1b1 und methoden zur verwendung
US7056916B2 (en) 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
EA013157B1 (ru) * 2004-04-22 2010-02-26 Бёрингер Ингельхайм Интернациональ Гмбх Содержащие бензоксазины лекарственные комбинации для лечения заболеваний дыхательных путей
US7220742B2 (en) 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
WO2006094924A2 (en) * 2005-03-09 2006-09-14 Boehringer Ingelheim International Gmbh New pharmaceutical compositions based on anticholinergics and pde 5-inhibitors
CN101208316B (zh) 2005-08-15 2012-05-09 贝林格尔·英格海姆国际有限公司 制备β-模拟物的方法
EP2301923B1 (en) 2006-03-31 2016-06-08 Novartis AG Pyridine derivatives as dgat inhibitors
US8507502B2 (en) 2008-11-10 2013-08-13 National Health Research Institutes Fused bicyclic and tricyclic pyrimidine compounds as tyrosine kinase inhibitors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2927925A (en) * 1960-03-08 Scopine and sgopoline esters of alpha
RU2000105243A (ru) * 1997-08-01 2002-01-10 Американ Цианамид Компани Производные замещенных хиназолинов и их использование в качестве ингибиторов тирозин-киназы

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4570630A (en) 1983-08-03 1986-02-18 Miles Laboratories, Inc. Medicament inhalation device
AT396872B (de) 1985-07-30 1993-12-27 Glaxo Group Ltd Gerät zur verabreichung von medikamenten in pulverform
SG45171A1 (en) 1990-03-21 1998-01-16 Boehringer Ingelheim Int Atomising devices and methods
IL107120A (en) 1992-09-29 1997-09-30 Boehringer Ingelheim Int Atomising nozzle and filter and spray generating device
DE4318455A1 (de) 1993-06-03 1994-12-08 Boehringer Ingelheim Kg Kapselhalterung
DE19536903C2 (de) 1995-10-04 1998-09-10 Boehringer Ingelheim Int Vorrichtung zum Haltern eines fluidischen Bauteils
DE19536902A1 (de) 1995-10-04 1997-04-10 Boehringer Ingelheim Int Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung
DE19545226C1 (de) 1995-12-05 1997-06-19 Boehringer Ingelheim Int Sperrspannwerk für einen federbetätigten Abtrieb
TW436485B (en) * 1997-08-01 2001-05-28 American Cyanamid Co Substituted quinazoline derivatives
DE19921693A1 (de) * 1999-05-12 2000-11-16 Boehringer Ingelheim Pharma Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika
WO2000078735A1 (de) * 1999-06-21 2000-12-28 Boehringer Ingelheim Pharma Kg Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
US20020082270A1 (en) * 2000-08-26 2002-06-27 Frank Himmelsbach Aminoquinazolines which inhibit signal transduction mediated by tyrosine kinases
DE10050994A1 (de) 2000-10-14 2002-04-18 Boehringer Ingelheim Pharma Neue als Arneimittel einsetzbare Anticholinergika sowie Verfahren zu deren Herstellung
DE10206505A1 (de) * 2002-02-16 2003-08-28 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und EGFR-Kinase-Hemmern
DE10203753A1 (de) * 2002-01-31 2003-08-14 Boehringer Ingelheim Pharma Neue Xanthencarbonsäureester, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2927925A (en) * 1960-03-08 Scopine and sgopoline esters of alpha
RU2000105243A (ru) * 1997-08-01 2002-01-10 Американ Цианамид Компани Производные замещенных хиназолинов и их использование в качестве ингибиторов тирозин-киназы

Also Published As

Publication number Publication date
CN1665539A (zh) 2005-09-07
EP1521595A1 (de) 2005-04-13
BR0312507A (pt) 2005-04-12
DE50302675D1 (de) 2006-05-11
EP1658860A1 (de) 2006-05-24
ATE320269T1 (de) 2006-04-15
JP2005537250A (ja) 2005-12-08
WO2004004775A1 (de) 2004-01-15
DE10230751A1 (de) 2004-01-22
AU2003242771A1 (en) 2004-01-23
CA2492037A1 (en) 2004-01-15
ZA200409676B (en) 2006-05-31
ES2259769T3 (es) 2006-10-16
NZ538096A (en) 2007-04-27
RU2005103397A (ru) 2006-03-20
TW200520757A (en) 2005-07-01
PL374022A1 (en) 2005-09-19
AU2003242771B2 (en) 2009-07-30
MXPA05000163A (es) 2005-04-08
EP1521595B1 (de) 2006-03-15

Similar Documents

Publication Publication Date Title
US20090017036A1 (en) Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
US20030158196A1 (en) Pharmaceutical compositions based on anticholinergics and EGFR kinase inhibitors
ZA200108942B (en) Novel medicament compositions, based on anticholinergically effective compounds and beta-mimetics.
US7332175B2 (en) Long-acting drug combinations for the treatment of respiratory complaints
US20040048887A1 (en) Pharmaceutical compositions based on anticholinergics and EGFR kinase inhibitors
RU2317828C2 (ru) Новые лекарственные композиции на основе новых антихолинергических средств и ингибиторов egfr-киназы
RU2436578C2 (ru) Новые лекарственные комбинации для лечения заболеваний дыхательных путей
JP2005517039A5 (enExample)
JP2005537250A5 (enExample)
CA2476127A1 (en) New pharmaceutical compositions based on anticholinergics and egfr kinase inhibitors
CA2527178A1 (en) New long-acting drug combinations for the treatment of respiratory complaints
CA2441964A1 (en) New pharmaceutical compositions based on anticholinergics and endothelin antagonists
JP2007517819A (ja) スコピン又はトロパ酸エステル及びｅｇｆｒ−キナーゼ阻害剤を含有する新規医薬組成物
EP1959942A1 (en) Method for the treatment of dyspnea comprising combined administration of tiotropium salts and salts of salmeterol
US20080031828A1 (en) Method for the Treatment of Dyspnea Comprising Combined Administration of Tiotropium Salts and Salts of Salmeterol
KR20050016999A (ko) 신규한 항콜린제 및 ｅｇｆｒ-키나제의 억제제를 기초로한 신규한 약물 조성물
US20050203088A1 (en) Medicament combinations based on scopine- or tropene acid esters with EGFR-kinase inhibitors

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20110627