TW200520757A - New pharmaceutical compositions based on new anticholingerics and EGFR kinase inhibitors - Google Patents
New pharmaceutical compositions based on new anticholingerics and EGFR kinase inhibitors Download PDFInfo
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- TW200520757A TW200520757A TW092136571A TW92136571A TW200520757A TW 200520757 A TW200520757 A TW 200520757A TW 092136571 A TW092136571 A TW 092136571A TW 92136571 A TW92136571 A TW 92136571A TW 200520757 A TW200520757 A TW 200520757A
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- Prior art keywords
- amino
- keto
- chloro
- phenyl
- micrograms
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 50
- 229940043355 kinase inhibitor Drugs 0.000 title claims abstract description 7
- 239000003757 phosphotransferase inhibitor Substances 0.000 title claims abstract description 7
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- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 title abstract description 5
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 266
- -1 hornate Chemical compound 0.000 claims description 165
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- 125000003277 amino group Chemical group 0.000 claims description 40
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Otolaryngology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10230751A DE10230751A1 (de) | 2002-07-09 | 2002-07-09 | Neue Arzneimittelkompositionen auf der Basis neuer Anticholinergika und EGFR-Kinase-Hemmern |
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|---|---|
| TW200520757A true TW200520757A (en) | 2005-07-01 |
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| TW092136571A TW200520757A (en) | 2002-07-09 | 2003-12-23 | New pharmaceutical compositions based on new anticholingerics and EGFR kinase inhibitors |
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| Country | Link |
|---|---|
| EP (2) | EP1521595B1 (enExample) |
| JP (1) | JP2005537250A (enExample) |
| CN (1) | CN1665539A (enExample) |
| AT (1) | ATE320269T1 (enExample) |
| AU (1) | AU2003242771B2 (enExample) |
| BR (1) | BR0312507A (enExample) |
| CA (1) | CA2492037A1 (enExample) |
| DE (2) | DE10230751A1 (enExample) |
| ES (1) | ES2259769T3 (enExample) |
| MX (1) | MXPA05000163A (enExample) |
| NZ (1) | NZ538096A (enExample) |
| PL (1) | PL374022A1 (enExample) |
| RU (1) | RU2317828C2 (enExample) |
| TW (1) | TW200520757A (enExample) |
| WO (1) | WO2004004775A1 (enExample) |
| ZA (1) | ZA200409676B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| ATE520772T1 (de) | 2000-10-31 | 2011-09-15 | Eisai Inc | Nucleinsäure kodierend für cyp1b1 und methoden zur verwendung |
| US7056916B2 (en) | 2002-11-15 | 2006-06-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Medicaments for the treatment of chronic obstructive pulmonary disease |
| EA013157B1 (ru) * | 2004-04-22 | 2010-02-26 | Бёрингер Ингельхайм Интернациональ Гмбх | Содержащие бензоксазины лекарственные комбинации для лечения заболеваний дыхательных путей |
| US7220742B2 (en) | 2004-05-14 | 2007-05-22 | Boehringer Ingelheim International Gmbh | Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments |
| WO2006094924A2 (en) * | 2005-03-09 | 2006-09-14 | Boehringer Ingelheim International Gmbh | New pharmaceutical compositions based on anticholinergics and pde 5-inhibitors |
| CN101208316B (zh) | 2005-08-15 | 2012-05-09 | 贝林格尔·英格海姆国际有限公司 | 制备β-模拟物的方法 |
| EP2301923B1 (en) | 2006-03-31 | 2016-06-08 | Novartis AG | Pyridine derivatives as dgat inhibitors |
| US8507502B2 (en) | 2008-11-10 | 2013-08-13 | National Health Research Institutes | Fused bicyclic and tricyclic pyrimidine compounds as tyrosine kinase inhibitors |
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| US2927925A (en) * | 1960-03-08 | Scopine and sgopoline esters of alpha | ||
| US4570630A (en) | 1983-08-03 | 1986-02-18 | Miles Laboratories, Inc. | Medicament inhalation device |
| AT396872B (de) | 1985-07-30 | 1993-12-27 | Glaxo Group Ltd | Gerät zur verabreichung von medikamenten in pulverform |
| SG45171A1 (en) | 1990-03-21 | 1998-01-16 | Boehringer Ingelheim Int | Atomising devices and methods |
| IL107120A (en) | 1992-09-29 | 1997-09-30 | Boehringer Ingelheim Int | Atomising nozzle and filter and spray generating device |
| DE4318455A1 (de) | 1993-06-03 | 1994-12-08 | Boehringer Ingelheim Kg | Kapselhalterung |
| DE19536903C2 (de) | 1995-10-04 | 1998-09-10 | Boehringer Ingelheim Int | Vorrichtung zum Haltern eines fluidischen Bauteils |
| DE19536902A1 (de) | 1995-10-04 | 1997-04-10 | Boehringer Ingelheim Int | Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung |
| DE19545226C1 (de) | 1995-12-05 | 1997-06-19 | Boehringer Ingelheim Int | Sperrspannwerk für einen federbetätigten Abtrieb |
| TW436485B (en) * | 1997-08-01 | 2001-05-28 | American Cyanamid Co | Substituted quinazoline derivatives |
| DE19921693A1 (de) * | 1999-05-12 | 2000-11-16 | Boehringer Ingelheim Pharma | Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika |
| WO2000078735A1 (de) * | 1999-06-21 | 2000-12-28 | Boehringer Ingelheim Pharma Kg | Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
| US20020082270A1 (en) * | 2000-08-26 | 2002-06-27 | Frank Himmelsbach | Aminoquinazolines which inhibit signal transduction mediated by tyrosine kinases |
| DE10050994A1 (de) | 2000-10-14 | 2002-04-18 | Boehringer Ingelheim Pharma | Neue als Arneimittel einsetzbare Anticholinergika sowie Verfahren zu deren Herstellung |
| DE10206505A1 (de) * | 2002-02-16 | 2003-08-28 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und EGFR-Kinase-Hemmern |
| DE10203753A1 (de) * | 2002-01-31 | 2003-08-14 | Boehringer Ingelheim Pharma | Neue Xanthencarbonsäureester, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
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2002
- 2002-07-09 DE DE10230751A patent/DE10230751A1/de not_active Withdrawn
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2003
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- 2003-06-26 RU RU2005103397/04A patent/RU2317828C2/ru not_active IP Right Cessation
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- 2003-06-26 BR BR0312507-6A patent/BR0312507A/pt not_active IP Right Cessation
- 2003-06-26 PL PL03374022A patent/PL374022A1/xx not_active Application Discontinuation
- 2003-06-26 NZ NZ538096A patent/NZ538096A/en not_active IP Right Cessation
- 2003-06-26 CA CA002492037A patent/CA2492037A1/en not_active Abandoned
- 2003-06-26 CN CN038161370A patent/CN1665539A/zh active Pending
- 2003-06-26 MX MXPA05000163A patent/MXPA05000163A/es active IP Right Grant
- 2003-06-26 ES ES03762525T patent/ES2259769T3/es not_active Expired - Lifetime
- 2003-06-26 WO PCT/EP2003/006788 patent/WO2004004775A1/de not_active Ceased
- 2003-06-26 JP JP2004518591A patent/JP2005537250A/ja active Pending
- 2003-06-26 EP EP03762525A patent/EP1521595B1/de not_active Expired - Lifetime
- 2003-06-26 EP EP05109909A patent/EP1658860A1/de not_active Withdrawn
- 2003-12-23 TW TW092136571A patent/TW200520757A/zh unknown
-
2004
- 2004-11-30 ZA ZA200409676A patent/ZA200409676B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1665539A (zh) | 2005-09-07 |
| EP1521595A1 (de) | 2005-04-13 |
| BR0312507A (pt) | 2005-04-12 |
| DE50302675D1 (de) | 2006-05-11 |
| EP1658860A1 (de) | 2006-05-24 |
| ATE320269T1 (de) | 2006-04-15 |
| JP2005537250A (ja) | 2005-12-08 |
| WO2004004775A1 (de) | 2004-01-15 |
| DE10230751A1 (de) | 2004-01-22 |
| AU2003242771A1 (en) | 2004-01-23 |
| CA2492037A1 (en) | 2004-01-15 |
| ZA200409676B (en) | 2006-05-31 |
| ES2259769T3 (es) | 2006-10-16 |
| NZ538096A (en) | 2007-04-27 |
| RU2317828C2 (ru) | 2008-02-27 |
| RU2005103397A (ru) | 2006-03-20 |
| PL374022A1 (en) | 2005-09-19 |
| AU2003242771B2 (en) | 2009-07-30 |
| MXPA05000163A (es) | 2005-04-08 |
| EP1521595B1 (de) | 2006-03-15 |
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