RU2291689C2 - Композиции n-ацетилцистеина и способы лечения и профилактики токсичности лекарственных средств - Google Patents
Композиции n-ацетилцистеина и способы лечения и профилактики токсичности лекарственных средств Download PDFInfo
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- RU2291689C2 RU2291689C2 RU2003131876/15A RU2003131876A RU2291689C2 RU 2291689 C2 RU2291689 C2 RU 2291689C2 RU 2003131876/15 A RU2003131876/15 A RU 2003131876/15A RU 2003131876 A RU2003131876 A RU 2003131876A RU 2291689 C2 RU2291689 C2 RU 2291689C2
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- Prior art keywords
- acetylcysteine
- therapeutic
- acetaminophen
- combination
- pharmaceutically acceptable
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- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
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- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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Landscapes
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| US09/833,228 | 2001-04-11 |
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| WO2013006658A1 (en) * | 2011-07-05 | 2013-01-10 | The Brigham And Women's Hospital, Inc. | Treatment of acetaminophen-induced liver damage by the administration of modulators of nitric oxide |
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| US7662863B2 (en) * | 2003-06-09 | 2010-02-16 | Alan Andrews | Therapeutic agent for the use in reducing alcohol intoxication and reducing or eliminating the negative side effects associated with alcohol ingestion |
| US8778979B2 (en) | 2005-04-05 | 2014-07-15 | Yale University | Glutamate agents in the treatment of mental disorders |
| US8993627B2 (en) | 2005-04-21 | 2015-03-31 | Sentient Lifesciences, Inc. | N-acetylcysteine amide (NAC amide) for the treatment of diseases and conditions associated with oxidative stress |
| US8148356B2 (en) | 2005-08-24 | 2012-04-03 | Cumberland Pharmaceuticals, Inc. | Acetylcysteine composition and uses therefor |
| RU2302236C2 (ru) * | 2005-09-09 | 2007-07-10 | Государственное учреждение научно-исследовательский институт Гриппа Российской академии медицинских наук (ГУ НИИ Гриппа РАМН) | Средство, обладающее антигипоксической и цитопротекторной активностями, используемое для снижения токсичности ремантадина при лечении гриппозной инфекции |
| US20070098790A1 (en) * | 2005-10-31 | 2007-05-03 | David Jiang | Nutritional supplement for the enhancement of the health of the liver |
| US20080139654A1 (en) * | 2006-12-09 | 2008-06-12 | Eric Mott Soderling | Acetaminophen compositions having minimized side effects including reduced hepatotoxicity |
| EP2291182A1 (en) * | 2008-05-13 | 2011-03-09 | Genmedica Therapeutics SL | Salicylate conjugates useful for treating metabolic disorders |
| CA2755069A1 (en) * | 2009-03-16 | 2010-09-23 | Genmedica Therapeutics Sl | Anti-inflammatory and antioxidant conjugates useful for treating metabolic disorders |
| CN102421424A (zh) * | 2009-03-16 | 2012-04-18 | 根梅迪卡治疗公司 | 用于治疗代谢性疾病的组合疗法 |
| WO2010132864A1 (en) * | 2009-05-15 | 2010-11-18 | Intermune, Inc. | Methods of treating hiv patients with anti-fibrotics |
| US20120122787A1 (en) * | 2009-07-10 | 2012-05-17 | Rong Li | Methods for treating polycystic kidney disease (pkd) or other cyst forming diseases |
| EP2453743B1 (en) | 2009-07-15 | 2017-04-12 | The Board of Trustees of The Leland Stanford Junior University | N-acetyl cysteine compositions and their use in improving the therapeutic efficacy of acetaminophen |
| DE102011006425A1 (de) | 2010-03-31 | 2011-10-06 | Awd.Pharma Gmbh & Co. Kg | Pharmazeutische Zubereitung und deren Verwendung |
| US8466197B2 (en) | 2010-12-14 | 2013-06-18 | Genmedica Therapeutics Sl | Thiocarbonates as anti-inflammatory and antioxidant compounds useful for treating metabolic disorders |
| US8747894B2 (en) | 2012-05-08 | 2014-06-10 | Alpex Pharma S.A. | Effervescent compositions containing N-acetylcysteine |
| EP2854798A4 (en) | 2012-05-24 | 2016-05-11 | Mograbi Josef | COMPOSITIONS WITH ISOSILYBIN B FOR THE TREATMENT AND PREVENTION OF ACTIVE-INDUCED TOXICITY |
| PL3639828T3 (pl) | 2013-12-24 | 2022-05-02 | Virginia Commonwealth University | Zastosowanie utlenowanych siarczanów cholesterolu (ocs) w leczeniu ostrej niewydolności wątroby |
| WO2016123223A1 (en) * | 2015-01-27 | 2016-08-04 | Florengale, Llc | Healing topical composition |
| HK1249035A1 (zh) * | 2015-05-27 | 2018-10-26 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | 降低成像後胰腺炎风险的组合物和方法 |
| BR112017025499A2 (pt) | 2015-05-28 | 2018-08-07 | Baylor College Medicine | benefícios da suplementação com n-acetil cisteína e glicina para melhorar os níveis de glutationa |
| EP3402475B1 (en) * | 2016-01-11 | 2021-10-20 | Egetis Therapeutics AB | Methods and formulations for treatment of and/or protection against acute liver failure and other hepatotoxic conditions |
| CA3012837A1 (en) | 2016-02-04 | 2017-08-10 | Czap Research And Development, Llc | Controlled-release and stratified cyclodextrin inclusion complex vehicles |
| DK3554491T3 (en) | 2016-12-15 | 2023-05-15 | Zambon Spa | N-acetylcystein til anvendelse som antibakterielt middel |
| US11040007B2 (en) * | 2017-01-24 | 2021-06-22 | Woosung Pharmaceutical Co., Ltd. | Injection composition containing acetaminophen |
| EP3901620A4 (en) * | 2018-12-21 | 2022-02-16 | FUJIFILM Corporation | PHOTOTOXICITY OR PHOTOALLERGY MEASUREMENT PROCEDURE AND REAGENT FOR USE IN THAT MEASUREMENT |
| US11590090B2 (en) | 2019-09-14 | 2023-02-28 | Anzen Pharmaceuticals, LLC | Acetaminophen formulation with protection against toxic effects of overdose |
| GB2588172B (en) * | 2019-10-11 | 2023-05-24 | Blackhawk Partners Ltd | A pharmaceutical composition comprising cannabinoid |
| CN113288890B (zh) * | 2021-06-21 | 2022-02-22 | 南方医科大学南方医院 | N-乙酰-l-半胱氨酸在制备预防和/或治疗运动损伤的药物中的应用 |
| WO2023010088A1 (en) | 2021-07-28 | 2023-02-02 | Pono Lifestyle Colorado, Llc | Nutraceutical formulations to prevent, treat, and inhibit excess cytokines, sars-cov-2 spike proteins, and mrna vaccine spike proteins |
| EP4238559A1 (en) | 2022-03-04 | 2023-09-06 | Centre Hospitalier Universitaire de Caen Normandie | Combinations of acetaminophen and n-acetyl cysteine for the treatment of pain and fever |
Citations (2)
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|---|---|---|---|---|
| US547457A (en) * | 1895-10-08 | Trolley-track | ||
| US5837729A (en) * | 1996-04-26 | 1998-11-17 | Metatron, Inc. | Methods for treating and preventing HIV infection using acetaminophen and derivatives thereof |
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|---|---|---|---|---|
| IT1141406B (it) * | 1980-04-01 | 1986-10-01 | Dob Far Spa | Sali della cefapirina con aminoacidi |
| FR2519988B1 (fr) * | 1982-01-20 | 1985-06-14 | Refarmed Sa | Derives thioliques de l'erythromycine a activite therapeutique, procede de preparation et produits pharmaceutiques dans lesquels ils apparaissent |
| DE3616923A1 (de) | 1986-05-20 | 1987-11-26 | Nattermann A & Cie | Neue pharmazeutische verwendung von 2-phenyl-1,2-benzisoselenazol-3(2h)-on |
| CA1339256C (en) * | 1989-01-26 | 1997-08-12 | Wulf Droge | Treatment of diseases associated with hiv-infections |
| IT1248995B (it) * | 1990-06-26 | 1995-02-11 | Italfarmaco Spa | Composizioni farmaceutiche a base di sali ferrosi |
| US5474757A (en) * | 1992-10-16 | 1995-12-12 | Rutgers University | Prevention of acetaminophen overdose toxicity with organosulfur compounds |
| US5762922A (en) * | 1994-01-31 | 1998-06-09 | Ludwig Institute For Cancer Research | Antioxidants and intracellular gluthathione raising agents for therapeutic treatments |
| US5475757A (en) * | 1994-06-07 | 1995-12-12 | At&T Corp. | Secure data transmission method |
| WO1996019489A1 (en) * | 1994-12-19 | 1996-06-27 | Russinsky Limited | Compounds |
| US5750493A (en) * | 1995-08-30 | 1998-05-12 | Raymond F. Schinazi | Method to improve the biological and antiviral activity of protease inhibitors |
| FR2744917B1 (fr) | 1996-02-16 | 1998-04-10 | Kouchner Gerard | Composition therapeutique a base d'acetaminophene |
| US5962421A (en) * | 1996-05-16 | 1999-10-05 | Zambon, S.A. | Pharmacological association between N-acetylcysteine and levulose for preventing cellular death and related diseases |
| CA2294247C (en) * | 1997-07-01 | 2004-10-26 | Atherogenics, Inc. | Antioxidant enhancement of therapy for hyperproliferative conditions |
| CA2355859A1 (en) * | 1999-01-04 | 2000-07-13 | Ml Laboratories Plc | Gene therapy-1 |
| IT1312086B1 (it) * | 1999-04-21 | 2002-04-04 | Zambon Spa | Uso della nac per la preparazione di un medicamento adatto allasomministrazione endovenosa per la prevenzione dello stress |
| DE10112325A1 (de) | 2001-03-13 | 2002-10-02 | Fresenius Kabi De Gmbh | Lagerstabile Fertiginfusionslösungen des Paracetamols |
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2001
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- 2002-03-28 NZ NZ528478A patent/NZ528478A/en not_active IP Right Cessation
- 2002-03-28 WO PCT/US2002/009442 patent/WO2002078627A2/en not_active Ceased
- 2002-03-28 CN CNB028077334A patent/CN100464743C/zh not_active Expired - Fee Related
- 2002-03-28 IL IL15818102A patent/IL158181A0/xx unknown
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- 2002-03-28 JP JP2002576895A patent/JP2005508840A/ja active Pending
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US547457A (en) * | 1895-10-08 | Trolley-track | ||
| US5837729A (en) * | 1996-04-26 | 1998-11-17 | Metatron, Inc. | Methods for treating and preventing HIV infection using acetaminophen and derivatives thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013006658A1 (en) * | 2011-07-05 | 2013-01-10 | The Brigham And Women's Hospital, Inc. | Treatment of acetaminophen-induced liver damage by the administration of modulators of nitric oxide |
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| US7723389B2 (en) | 2010-05-25 |
| JP2015078185A (ja) | 2015-04-23 |
| CA2442168C (en) | 2012-05-29 |
| WO2002078627A3 (en) | 2003-09-18 |
| CA2442168A1 (en) | 2002-10-10 |
| CN1507350A (zh) | 2004-06-23 |
| NZ528478A (en) | 2007-08-31 |
| RU2003131876A (ru) | 2005-04-10 |
| AU2002255942B2 (en) | 2007-07-05 |
| IL158181A0 (en) | 2004-03-28 |
| US6566401B2 (en) | 2003-05-20 |
| CN100464743C (zh) | 2009-03-04 |
| JP2011225610A (ja) | 2011-11-10 |
| WO2002078627A2 (en) | 2002-10-10 |
| IL158181A (en) | 2012-04-30 |
| US20020142991A1 (en) | 2002-10-03 |
| EP1379232B1 (en) | 2015-07-29 |
| JP2005508840A (ja) | 2005-04-07 |
| EP1379232A4 (en) | 2008-04-23 |
| ES2550094T3 (es) | 2015-11-04 |
| US20030069311A1 (en) | 2003-04-10 |
| BR0208563A (pt) | 2006-02-21 |
| EP1379232A2 (en) | 2004-01-14 |
| MXPA03008904A (es) | 2005-03-07 |
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| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20170329 |