RU2272034C2 - 2-амино-n-[(1r)-2-[(3r)-3-бензил-3-(n, n', n' -триметилгидразинокарбонил) пиперидин-1-ил]-1-(1h-индол-3-илметил)-2-оксоэтил]-2-метилпропионамид или его фармацевтически приемлемая соль, фармацевтическая композиция на их основе и способ стимулирования высвобождения гормона роста из гипофиза млекопитающего - Google Patents
2-амино-n-[(1r)-2-[(3r)-3-бензил-3-(n, n', n' -триметилгидразинокарбонил) пиперидин-1-ил]-1-(1h-индол-3-илметил)-2-оксоэтил]-2-метилпропионамид или его фармацевтически приемлемая соль, фармацевтическая композиция на их основе и способ стимулирования высвобождения гормона роста из гипофиза млекопитающего Download PDFInfo
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- RU2272034C2 RU2272034C2 RU2002115406/04A RU2002115406A RU2272034C2 RU 2272034 C2 RU2272034 C2 RU 2272034C2 RU 2002115406/04 A RU2002115406/04 A RU 2002115406/04A RU 2002115406 A RU2002115406 A RU 2002115406A RU 2272034 C2 RU2272034 C2 RU 2272034C2
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- Russia
- Prior art keywords
- growth hormone
- compound
- benzyl
- trimethylhydrazinocarbonyl
- indol
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA199901618 | 1999-11-10 | ||
| DKPA199901618 | 1999-11-10 | ||
| US16710199P | 1999-11-23 | 1999-11-23 | |
| PCT/DK2000/000624 WO2001034593A1 (en) | 1999-11-10 | 2000-11-10 | Compound with growth hormone releasing properties |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2002115406A RU2002115406A (ru) | 2003-12-27 |
| RU2272034C2 true RU2272034C2 (ru) | 2006-03-20 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2002115406/04A RU2272034C2 (ru) | 1999-11-10 | 2000-11-10 | 2-амино-n-[(1r)-2-[(3r)-3-бензил-3-(n, n', n' -триметилгидразинокарбонил) пиперидин-1-ил]-1-(1h-индол-3-илметил)-2-оксоэтил]-2-метилпропионамид или его фармацевтически приемлемая соль, фармацевтическая композиция на их основе и способ стимулирования высвобождения гормона роста из гипофиза млекопитающего |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6576648B2 (enExample) |
| EP (1) | EP1230236B1 (enExample) |
| JP (2) | JP2003527338A (enExample) |
| KR (1) | KR100907637B1 (enExample) |
| CN (1) | CN1198818C (enExample) |
| AT (1) | ATE280168T1 (enExample) |
| AU (1) | AU782260B2 (enExample) |
| BR (1) | BR0015407A (enExample) |
| CA (1) | CA2387095C (enExample) |
| CZ (1) | CZ301078B6 (enExample) |
| DE (1) | DE60015173T2 (enExample) |
| DK (1) | DK1230236T3 (enExample) |
| ES (1) | ES2231279T3 (enExample) |
| HU (1) | HU229445B1 (enExample) |
| IL (1) | IL149049A0 (enExample) |
| MX (1) | MXPA02004656A (enExample) |
| NO (1) | NO323910B1 (enExample) |
| PL (1) | PL199989B1 (enExample) |
| PT (1) | PT1230236E (enExample) |
| RU (1) | RU2272034C2 (enExample) |
| UA (1) | UA73530C2 (enExample) |
| WO (1) | WO2001034593A1 (enExample) |
| ZA (1) | ZA200202757B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007531769A (ja) * | 2004-03-30 | 2007-11-08 | サファイア セラピューティクス インコーポレイテッド | 成長ホルモン分泌促進薬を使用したｃ−反応性蛋白質の低減方法 |
| AU2005272074B2 (en) * | 2004-06-29 | 2011-11-24 | Albany Molecular Research, Inc. | Crystal forms of (3r)-1-(2-methylalanyl-d-tryptophyl)-3-(phenylmethyl)-3-piperidinecarboxylic acid 1,2,2-trimethylhydrazide |
| US20130281701A1 (en) * | 2004-06-29 | 2013-10-24 | Helsinn Therapeutics (U.S.), Inc. | Crystal forms of anamorelin |
| CN1976921B (zh) * | 2004-06-29 | 2013-08-21 | 蓝宝石治疗公司 | (3r)-1-(2-甲基丙氨酰-d-色氨酰)-3-(苯甲基)-3-哌啶羧酸1,2,2-三甲基酰肼的晶形 |
| US8039456B2 (en) | 2004-08-12 | 2011-10-18 | Helsinn Therapeutics (U.S.), Inc. | Method of stimulating the motility of the gastrointestinal system using ipamorelin |
| EP1789067B8 (en) * | 2004-08-12 | 2012-08-15 | Helsinn Healthcare S.A. | Use of growth hormone secretagogues for stimulating the motility of the gastrointestinal system |
| WO2008005268A1 (en) * | 2006-06-30 | 2008-01-10 | Schering Corporation | Substituted piperidines that increase p53 activity and the uses thereof |
| CN101686966A (zh) * | 2007-02-13 | 2010-03-31 | 赫尔辛医疗（美国）有限公司 | 使用生长激素促分泌素治疗细胞增生疾病的方法 |
| TWI429436B (zh) * | 2007-04-10 | 2014-03-11 | Helsinn Therapeutics Us Inc | 使用生長激素促泌素治療或預防嘔吐之方法 |
| US8664267B2 (en) * | 2007-04-12 | 2014-03-04 | Academic Pharmaceuticals Incorporated | Parenteral solution containing amiodarone in NNDMA (N,N,-Dimethylacetamide) |
| MX2010008740A (es) | 2008-02-08 | 2010-08-30 | Zeria Pharm Co Ltd | Derivado de 3,8-diaminotetrahidroquinolina. |
| UA105657C2 (uk) * | 2009-02-27 | 2014-06-10 | Хелсінн Терапьютікс (Ю.Ес.), Інк. | Поліпшені способи лікування мігрені на основі анамореліну |
| JO3353B1 (ar) * | 2012-04-20 | 2019-03-13 | Ono Pharmaceutical Co | شكل صلب معزول من أحادي هيدروكلوريد أناموريلين بنسبة مولارية منخفضة من الكلوريد: أناموريلين ومحتوى منخفض من مذيب عضوي متبقي |
| US20150265680A1 (en) | 2012-10-24 | 2015-09-24 | Daiichi Sankyo Company, Limited | Therapeutic agent for amyotrophic lateral sclerosis |
| CN107001323A (zh) * | 2015-10-20 | 2017-08-01 | 江苏恒瑞医药股份有限公司 | 一种阿拉莫林的结晶形式及其制备方法 |
| CN106187865A (zh) * | 2016-07-08 | 2016-12-07 | 武汉工程大学 | (r)‑1‑叔丁氧羰基‑3‑苄基‑3‑甲酸哌啶的合成及手性拆分方法 |
| CN108129357B (zh) * | 2016-12-01 | 2021-12-21 | 上海医药工业研究院 | 阿拉莫林中间体的制备方法 |
| CN108239141A (zh) * | 2016-12-23 | 2018-07-03 | 江苏先声药业有限公司 | 一种阿拉莫林的制备方法 |
| US20220323430A1 (en) * | 2019-08-30 | 2022-10-13 | Helsinn Healthcare Sa | Methods of manufacturing anamorelin tablets having improved stability |
| CN114805305B (zh) * | 2022-04-20 | 2024-04-26 | 成都诺和晟泰生物科技有限公司 | 一种化合物及其应用 |
| CN119792264B (zh) * | 2025-03-14 | 2025-06-10 | 华中科技大学同济医学院附属同济医院 | 丁酰肼在制备预防或治疗copd的药物中的应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5492916A (en) * | 1993-12-23 | 1996-02-20 | Merck & Co., Inc. | Di- and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone |
| US5721250A (en) * | 1993-12-23 | 1998-02-24 | Merck & Co. Inc. | Di-and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4839344A (en) | 1987-06-12 | 1989-06-13 | Eastman Kodak Company | Polypeptide compounds having growth hormone releasing activity |
| ATE122357T1 (de) | 1988-01-28 | 1995-05-15 | Polygen Holding Corp | Polypeptide mit hormonwachstumsbefreiender wirkung. |
| WO1989010933A1 (en) | 1988-05-11 | 1989-11-16 | Eastman Kodak Company | Polypeptide compounds having growth hormone releasing activity |
| IT1240643B (it) | 1990-05-11 | 1993-12-17 | Mediolanum Farmaceutici Spa | Peptidi biologicamente attivi contenenti in catena 2-alchiltriptofano |
| IL98910A0 (en) | 1990-07-24 | 1992-07-15 | Polygen Holding Corp | Polypeptide compounds having growth hormone releasing activity and pharmaceutical compositions containing them |
| US5663146A (en) | 1991-08-22 | 1997-09-02 | Administrators Of The Tulane Educational Fund | Polypeptide analogues having growth hormone releasing activity |
| KR960705808A (ko) * | 1993-11-09 | 1996-11-08 | 조셉 에프. 디프리마 | 성장 호르몬의 방출을 촉진시키는 피페리딘, 피롤리딘 및 헥사하이드로-1H-아제핀(Piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone) |
| EP0730578A4 (en) | 1993-11-24 | 1997-10-08 | Merck & Co Inc | COMPOUNDS CONTAINING INDOLYL GROUPS AND THE USE THEREOF TO PROMOTE THE RELEASE OF GROWTH HORMONES |
| JP4425992B2 (ja) * | 1996-07-22 | 2010-03-03 | サファイア セラピューティクス，インコーポレイティド | 成長ホルモン放出特性を有する化合物 |
| WO1999036431A1 (en) * | 1998-01-16 | 1999-07-22 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| US6303620B1 (en) * | 1998-05-11 | 2001-10-16 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| CA2329881C (en) * | 1998-05-11 | 2010-03-16 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| US20010020012A1 (en) * | 2000-02-01 | 2001-09-06 | Andersen Maibritt Bansholm | Use of compounds for the regulation of food intake |
-
2000
- 2000-10-11 UA UA2002053785A patent/UA73530C2/uk unknown
- 2000-11-10 DE DE60015173T patent/DE60015173T2/de not_active Expired - Lifetime
- 2000-11-10 CN CNB008151458A patent/CN1198818C/zh not_active Expired - Lifetime
- 2000-11-10 JP JP2001536540A patent/JP2003527338A/ja active Pending
- 2000-11-10 PL PL356993A patent/PL199989B1/pl unknown
- 2000-11-10 DK DK00974349T patent/DK1230236T3/da active
- 2000-11-10 WO PCT/DK2000/000624 patent/WO2001034593A1/en not_active Ceased
- 2000-11-10 AU AU12694/01A patent/AU782260B2/en not_active Expired
- 2000-11-10 IL IL14904900A patent/IL149049A0/xx active IP Right Grant
- 2000-11-10 CA CA2387095A patent/CA2387095C/en not_active Expired - Lifetime
- 2000-11-10 HU HU0203844A patent/HU229445B1/hu unknown
- 2000-11-10 ES ES00974349T patent/ES2231279T3/es not_active Expired - Lifetime
- 2000-11-10 KR KR1020027005836A patent/KR100907637B1/ko not_active Expired - Lifetime
- 2000-11-10 MX MXPA02004656A patent/MXPA02004656A/es active IP Right Grant
- 2000-11-10 AT AT00974349T patent/ATE280168T1/de active
- 2000-11-10 RU RU2002115406/04A patent/RU2272034C2/ru active
- 2000-11-10 EP EP00974349A patent/EP1230236B1/en not_active Expired - Lifetime
- 2000-11-10 BR BR0015407-5A patent/BR0015407A/pt not_active Application Discontinuation
- 2000-11-10 CZ CZ20021587A patent/CZ301078B6/cs not_active IP Right Cessation
- 2000-11-10 PT PT00974349T patent/PT1230236E/pt unknown
-
2001
- 2001-03-26 US US09/817,840 patent/US6576648B2/en not_active Expired - Lifetime
-
2002
- 2002-04-09 ZA ZA200202757A patent/ZA200202757B/xx unknown
- 2002-05-08 NO NO20022200A patent/NO323910B1/no not_active IP Right Cessation
-
2008
- 2008-09-04 JP JP2008227447A patent/JP5053960B2/ja not_active Expired - Lifetime
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5492916A (en) * | 1993-12-23 | 1996-02-20 | Merck & Co., Inc. | Di- and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone |
| US5622973A (en) * | 1993-12-23 | 1997-04-22 | Merck & Co., Inc. | Treatment of osteoporosis with substituted piperidines, pyrrolidines and hexahydro-1H-azepines in combination with bisphosphonates |
| US5721250A (en) * | 1993-12-23 | 1998-02-24 | Merck & Co. Inc. | Di-and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone |
Also Published As
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| JP4938708B2 (ja) | 成長ホルモン放出特性を有する化合物 | |
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| PC41 | Official registration of the transfer of exclusive right |
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