RU2261099C2 - Способ поддержания аменореи у женщин, подвергающихся постоянному введению прогестина, и фармацевтическая композиция для его осуществления - Google Patents

Способ поддержания аменореи у женщин, подвергающихся постоянному введению прогестина, и фармацевтическая композиция для его осуществления Download PDF

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RU2261099C2
RU2261099C2 RU2000112650/14A RU2000112650A RU2261099C2 RU 2261099 C2 RU2261099 C2 RU 2261099C2 RU 2000112650/14 A RU2000112650/14 A RU 2000112650/14A RU 2000112650 A RU2000112650 A RU 2000112650A RU 2261099 C2 RU2261099 C2 RU 2261099C2
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Russia
Prior art keywords
progestin
progesterone
amenorrhea
bleeding
administration
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RU2000112650/14A
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English (en)
Russian (ru)
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RU2000112650A (ru
Inventor
ЗЬЕГЛЕ Доминик ДЕ (FR)
ЗЬЕГЛЕ Доминик ДЕ
Виль м Ж. БОЛОНЬЯ (FR)
Вильям Ж. БОЛОНЬЯ
Говард Дж. ЛЕВАЙН (US)
Говард Дж. ЛЕВАЙН
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Колумбия Лабораториз (Бермуда) Лимитед
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
RU2000112650/14A 1997-10-21 1998-10-21 Способ поддержания аменореи у женщин, подвергающихся постоянному введению прогестина, и фармацевтическая композиция для его осуществления RU2261099C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US6348597P 1997-10-21 1997-10-21
US60/063,485 1997-10-21
US09/170,326 US6306914B1 (en) 1997-10-21 1998-10-13 Progestin therapy for maintaining amenorrhea
US09/170,326 1998-10-13

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2005101612/14A Division RU2330667C2 (ru) 1997-10-21 2005-01-21 Прогестинотерапия с регулируемым кровотечением

Publications (2)

Publication Number Publication Date
RU2000112650A RU2000112650A (ru) 2002-05-20
RU2261099C2 true RU2261099C2 (ru) 2005-09-27

Family

ID=26743461

Family Applications (2)

Application Number Title Priority Date Filing Date
RU2000112650/14A RU2261099C2 (ru) 1997-10-21 1998-10-21 Способ поддержания аменореи у женщин, подвергающихся постоянному введению прогестина, и фармацевтическая композиция для его осуществления
RU2005101612/14A RU2330667C2 (ru) 1997-10-21 2005-01-21 Прогестинотерапия с регулируемым кровотечением

Family Applications After (1)

Application Number Title Priority Date Filing Date
RU2005101612/14A RU2330667C2 (ru) 1997-10-21 2005-01-21 Прогестинотерапия с регулируемым кровотечением

Country Status (19)

Country Link
US (3) US6306914B1 (enExample)
EP (1) EP1032399A1 (enExample)
JP (1) JP2003535015A (enExample)
KR (1) KR100581308B1 (enExample)
CN (1) CN1147301C (enExample)
AR (1) AR013981A1 (enExample)
AU (1) AU742166C (enExample)
BR (1) BR9813262A (enExample)
CA (2) CA2307615A1 (enExample)
HU (1) HUP0004133A3 (enExample)
IL (1) IL135742A (enExample)
MX (1) MXPA00003972A (enExample)
MY (1) MY121743A (enExample)
NO (1) NO326856B1 (enExample)
NZ (1) NZ504066A (enExample)
PE (1) PE121799A1 (enExample)
RO (1) RO121319B1 (enExample)
RU (2) RU2261099C2 (enExample)
WO (1) WO1999020282A1 (enExample)

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US20040191276A1 (en) * 1999-11-30 2004-09-30 Cutispharma, Inc. Compositions and kits for compounding pharmaceuticals
US8425892B2 (en) * 2001-10-29 2013-04-23 Columbia Laboratories, Inc. Extended, controlled-release pharmaceutical compositions using charged polymers
MXPA04005445A (es) * 2001-12-05 2005-03-23 Barr Lab Inc Anticonceptivos orales para prevenir el embarazo y disminuir la sintomatologia premenstrual.
EP1513547A4 (en) * 2002-05-23 2009-11-04 Michael F Holick USE OF PEPTIDE ANALOGUES OF PARATHYROID HORMONE FOR THE TREATMENT OF VAGINAL ATROPHY
AU2003297534A1 (en) * 2002-12-24 2004-07-22 Ovion, Inc. Contraceptive device and delivery system
JP2006525358A (ja) * 2003-05-02 2006-11-09 ドゥラメド ファーマシューティカルズ， インコーポレイテッド 長期周期避妊養生法を利用するホルモン治療の方法
JP2007528358A (ja) * 2003-06-25 2007-10-11 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト ジエノゲストを含んでなるホルモン置換療法および抑鬱療法
NZ585546A (en) * 2003-07-16 2011-10-28 Teva Womens Health Inc Methods of hormonal treatment utilizing contraceptive regimens with continuous estrogen administration
US7556150B2 (en) * 2004-06-07 2009-07-07 Duramed Pharmaceuticals, Inc. Dispenser for progestin used for acute and maintenance treatment of DUB
US20070111975A1 (en) 2004-10-07 2007-05-17 Duramed Pharmaceuticals, Inc. Methods of Hormonal Treatment Utilizing Ascending-Dose Extended Cycle Regimens
US8217024B2 (en) * 2005-12-27 2012-07-10 Teva Women's Health, Inc. Conjugated estrogen compositions, applicators, kits, and methods of making and use thereof
US20070264309A1 (en) * 2006-01-20 2007-11-15 Chollet Janet A Method Of Treating Atrophic Vaginitis
US8235047B2 (en) 2006-03-30 2012-08-07 Conceptus, Inc. Methods and devices for deployment into a lumen
KR20090029237A (ko) * 2006-06-02 2009-03-20 피어 트리 파머슈티칼스 인코포레이티드 위축성 질염을 치료하는 방법
GB0616444D0 (en) * 2006-08-18 2006-09-27 Reckitt Benckiser Nv Detergent composition
WO2008091588A1 (en) 2007-01-22 2008-07-31 Targacept, Inc. Intranasal, buccal, and sublingual administration of metanicotine analogs
US8828981B2 (en) 2007-02-06 2014-09-09 George Creasy Progesterone for the treatment or prevention of spontaneous preterm birth
WO2009099586A2 (en) 2008-02-04 2009-08-13 Duramed Pharmaceuticals, Inc. Monolithic intravaginal rings comprising progesterone and methods of making and uses thereof
RS62297B1 (sr) 2011-11-23 2021-09-30 Therapeuticsmd Inc Prirodne kombinovane hormonske supstitucione formulacije i terapije
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
RU2016143081A (ru) 2014-05-22 2018-06-26 Терапьютиксмд, Инк. Натуральные комбинированные гормонозаместительные составы и терапии
EP3174542A4 (en) 2014-07-29 2018-01-03 TherapeuticsMD, Inc. Transdermal cream
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
US9931349B2 (en) 2016-04-01 2018-04-03 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
RU2697369C1 (ru) * 2018-12-21 2019-08-13 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова" Министерства здравоохранения Российской Способ дифференциальной диагностики функциональной гипоталамической аменореи на фоне стресса и энергетического дефицита
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CN113288865B (zh) * 2021-06-28 2022-03-08 浙江仙琚制药股份有限公司 一种黄体酮阴道凝胶剂的制备方法
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Also Published As

Publication number Publication date
WO1999020282A1 (en) 1999-04-29
JP2003535015A (ja) 2003-11-25
CA2649671A1 (en) 1999-04-29
CA2307615A1 (en) 1999-04-29
HUP0004133A2 (hu) 2001-05-28
HUP0004133A3 (en) 2001-09-28
AU742166C (en) 2005-07-14
KR100581308B1 (ko) 2006-05-22
MXPA00003972A (es) 2004-04-21
NO326856B1 (no) 2009-03-02
RU2330667C2 (ru) 2008-08-10
AU1191499A (en) 1999-05-10
NO20002084D0 (no) 2000-04-19
RU2005101612A (ru) 2006-07-10
BR9813262A (pt) 2000-08-22
KR20010031299A (ko) 2001-04-16
RO121319B1 (ro) 2007-03-30
US20010031747A1 (en) 2001-10-18
CN1282250A (zh) 2001-01-31
IL135742A (en) 2004-09-27
PE121799A1 (es) 1999-12-17
CN1147301C (zh) 2004-04-28
US6593317B1 (en) 2003-07-15
NZ504066A (en) 2002-11-26
AU742166B2 (en) 2001-12-20
US6306914B1 (en) 2001-10-23
IL135742A0 (en) 2001-05-20
MY121743A (en) 2006-02-28
EP1032399A1 (en) 2000-09-06
NO20002084L (no) 2000-06-21
AR013981A1 (es) 2001-01-31

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Effective date: 20081022