RO121319B1 - Utilizarea unui progestativ - Google Patents
Utilizarea unui progestativ Download PDFInfo
- Publication number
- RO121319B1 RO121319B1 ROA200000428A RO200000428A RO121319B1 RO 121319 B1 RO121319 B1 RO 121319B1 RO A200000428 A ROA200000428 A RO A200000428A RO 200000428 A RO200000428 A RO 200000428A RO 121319 B1 RO121319 B1 RO 121319B1
- Authority
- RO
- Romania
- Prior art keywords
- progesterone
- bleeding
- progestin
- administration
- water
- Prior art date
Links
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical class C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 title claims abstract description 195
- 239000000583 progesterone congener Substances 0.000 title claims abstract description 53
- 239000000186 progesterone Substances 0.000 claims abstract description 76
- 229960003387 progesterone Drugs 0.000 claims abstract description 76
- 229920000642 polymer Polymers 0.000 claims abstract description 27
- 206010001928 Amenorrhoea Diseases 0.000 claims abstract description 20
- 201000000736 Amenorrhea Diseases 0.000 claims abstract description 19
- 231100000540 amenorrhea Toxicity 0.000 claims abstract description 19
- 239000003814 drug Substances 0.000 claims abstract description 14
- 239000000227 bioadhesive Substances 0.000 claims abstract description 11
- 239000002253 acid Substances 0.000 claims abstract description 6
- 206010051909 Endometrial atrophy Diseases 0.000 claims abstract description 3
- 229940079593 drug Drugs 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 229920006037 cross link polymer Polymers 0.000 claims description 4
- 210000004369 blood Anatomy 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims 1
- 230000000740 bleeding effect Effects 0.000 abstract description 68
- 125000004122 cyclic group Chemical group 0.000 abstract description 11
- 208000034423 Delivery Diseases 0.000 abstract 2
- 230000009677 vaginal delivery Effects 0.000 abstract 2
- 208000032843 Hemorrhage Diseases 0.000 description 68
- 208000034158 bleeding Diseases 0.000 description 68
- 239000000499 gel Substances 0.000 description 27
- 239000000203 mixture Substances 0.000 description 27
- 229940000593 crinone Drugs 0.000 description 20
- 238000011282 treatment Methods 0.000 description 19
- 238000002657 hormone replacement therapy Methods 0.000 description 18
- 239000000262 estrogen Substances 0.000 description 15
- 229940011871 estrogen Drugs 0.000 description 15
- 206010046788 Uterine haemorrhage Diseases 0.000 description 13
- 230000000694 effects Effects 0.000 description 12
- 238000009472 formulation Methods 0.000 description 12
- 238000002560 therapeutic procedure Methods 0.000 description 11
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 229940095055 progestogen systemic hormonal contraceptives Drugs 0.000 description 9
- 230000002357 endometrial effect Effects 0.000 description 8
- 210000004696 endometrium Anatomy 0.000 description 8
- 230000009245 menopause Effects 0.000 description 8
- 238000000034 method Methods 0.000 description 7
- 210000002966 serum Anatomy 0.000 description 7
- 150000003431 steroids Chemical class 0.000 description 7
- 238000002604 ultrasonography Methods 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 230000035587 bioadhesion Effects 0.000 description 6
- 229920002125 Sokalan® Polymers 0.000 description 5
- 230000002159 abnormal effect Effects 0.000 description 5
- 238000011156 evaluation Methods 0.000 description 5
- 230000001788 irregular Effects 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 230000002269 spontaneous effect Effects 0.000 description 5
- 230000003442 weekly effect Effects 0.000 description 5
- MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 description 4
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 4
- 229920000148 Polycarbophil calcium Polymers 0.000 description 4
- 230000002411 adverse Effects 0.000 description 4
- 239000003431 cross linking reagent Substances 0.000 description 4
- 238000012377 drug delivery Methods 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 229960002985 medroxyprogesterone acetate Drugs 0.000 description 4
- PSGAAPLEWMOORI-PEINSRQWSA-N medroxyprogesterone acetate Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2(C)[C@@](OC(C)=O)(C(C)=O)CC[C@H]21 PSGAAPLEWMOORI-PEINSRQWSA-N 0.000 description 4
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 4
- 239000002480 mineral oil Substances 0.000 description 4
- 235000010446 mineral oil Nutrition 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 229950005134 polycarbophil Drugs 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 239000003755 preservative agent Substances 0.000 description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 3
- 235000019482 Palm oil Nutrition 0.000 description 3
- 229960001631 carbomer Drugs 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 229940074117 estraderm Drugs 0.000 description 3
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- KUQWZSZYIQGTHT-UHFFFAOYSA-N hexa-1,5-diene-3,4-diol Chemical compound C=CC(O)C(O)C=C KUQWZSZYIQGTHT-UHFFFAOYSA-N 0.000 description 3
- 239000003906 humectant Substances 0.000 description 3
- 210000004877 mucosa Anatomy 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 239000002540 palm oil Substances 0.000 description 3
- 230000000737 periodic effect Effects 0.000 description 3
- 230000035935 pregnancy Effects 0.000 description 3
- 230000002335 preservative effect Effects 0.000 description 3
- 235000010199 sorbic acid Nutrition 0.000 description 3
- 239000004334 sorbic acid Substances 0.000 description 3
- 229940075582 sorbic acid Drugs 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 239000000829 suppository Substances 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 210000001215 vagina Anatomy 0.000 description 3
- OZAIFHULBGXAKX-UHFFFAOYSA-N 2-(2-cyanopropan-2-yldiazenyl)-2-methylpropanenitrile Chemical compound N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 description 2
- RSEPBGGWRJCQGY-RBRWEJTLSA-N Estradiol valerate Chemical compound C1CC2=CC(O)=CC=C2[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)CCCC)[C@@]1(C)CC2 RSEPBGGWRJCQGY-RBRWEJTLSA-N 0.000 description 2
- 206010000210 abortion Diseases 0.000 description 2
- 231100000176 abortion Toxicity 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 229940035811 conjugated estrogen Drugs 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- 125000005456 glyceride group Chemical group 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 230000003821 menstrual periods Effects 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 229920000609 methyl cellulose Polymers 0.000 description 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 2
- 239000001923 methylcellulose Substances 0.000 description 2
- 229960002216 methylparaben Drugs 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 230000027758 ovulation cycle Effects 0.000 description 2
- 239000006187 pill Substances 0.000 description 2
- 230000036470 plasma concentration Effects 0.000 description 2
- 230000002028 premature Effects 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- 238000011269 treatment regimen Methods 0.000 description 2
- DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 description 1
- DSAYAFZWRDYBQY-UHFFFAOYSA-N 2,5-dimethylhexa-1,5-diene Chemical compound CC(=C)CCC(C)=C DSAYAFZWRDYBQY-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N Benzoic acid Natural products OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
- 239000004342 Benzoyl peroxide Substances 0.000 description 1
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 1
- 206010006242 Breast enlargement Diseases 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 206010013908 Dysfunctional uterine bleeding Diseases 0.000 description 1
- 206010014733 Endometrial cancer Diseases 0.000 description 1
- 206010014759 Endometrial neoplasm Diseases 0.000 description 1
- 201000009273 Endometriosis Diseases 0.000 description 1
- 102000004895 Lipoproteins Human genes 0.000 description 1
- 108090001030 Lipoproteins Proteins 0.000 description 1
- 206010049513 Luteal phase deficiency Diseases 0.000 description 1
- 206010027304 Menopausal symptoms Diseases 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- -1 N-N-dialylacrylamide Chemical compound 0.000 description 1
- 229920002845 Poly(methacrylic acid) Polymers 0.000 description 1
- 241000894106 Trichoderma fertile Species 0.000 description 1
- 206010046910 Vaginal haemorrhage Diseases 0.000 description 1
- 230000037374 absorbed through the skin Effects 0.000 description 1
- 229940094957 androgens and estrogen Drugs 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- WXBLLCUINBKULX-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1.OC(=O)C1=CC=CC=C1 WXBLLCUINBKULX-UHFFFAOYSA-N 0.000 description 1
- 235000019400 benzoyl peroxide Nutrition 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 208000011803 breast fibrocystic disease Diseases 0.000 description 1
- 239000000828 canola oil Substances 0.000 description 1
- 235000019519 canola oil Nutrition 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229940031663 carbomer-974p Drugs 0.000 description 1
- 229940085237 carbomer-980 Drugs 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 230000007211 cardiovascular event Effects 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000000739 chaotic effect Effects 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000002716 delivery method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 230000010339 dilation Effects 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 201000003914 endometrial carcinoma Diseases 0.000 description 1
- 229960004766 estradiol valerate Drugs 0.000 description 1
- 238000009164 estrogen replacement therapy Methods 0.000 description 1
- JKKFKPJIXZFSSB-CBZIJGRNSA-N estrone 3-sulfate Chemical compound OS(=O)(=O)OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 JKKFKPJIXZFSSB-CBZIJGRNSA-N 0.000 description 1
- 230000004720 fertilization Effects 0.000 description 1
- 239000010408 film Substances 0.000 description 1
- 101150023545 gel1 gene Proteins 0.000 description 1
- 230000000762 glandular Effects 0.000 description 1
- 239000003862 glucocorticoid Substances 0.000 description 1
- 208000031169 hemorrhagic disease Diseases 0.000 description 1
- AHAREKHAZNPPMI-UHFFFAOYSA-N hexa-1,3-diene Chemical compound CCC=CC=C AHAREKHAZNPPMI-UHFFFAOYSA-N 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000003999 initiator Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 229940059904 light mineral oil Drugs 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 235000021156 lunch Nutrition 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 210000001161 mammalian embryo Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 229960002900 methylcellulose Drugs 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 210000000754 myometrium Anatomy 0.000 description 1
- 229960004719 nandrolone Drugs 0.000 description 1
- NPAGDVCDWIYMMC-IZPLOLCNSA-N nandrolone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 NPAGDVCDWIYMMC-IZPLOLCNSA-N 0.000 description 1
- 230000002611 ovarian Effects 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 230000003836 peripheral circulation Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 201000011461 pre-eclampsia Diseases 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 229940063238 premarin Drugs 0.000 description 1
- 150000003146 progesterones Chemical class 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 238000010526 radical polymerization reaction Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 150000003839 salts Chemical group 0.000 description 1
- 238000011452 sequencing regimen Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 229940037128 systemic glucocorticoids Drugs 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/34—Gestagens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6348597P | 1997-10-21 | 1997-10-21 | |
| US09/170,326 US6306914B1 (en) | 1997-10-21 | 1998-10-13 | Progestin therapy for maintaining amenorrhea |
| PCT/US1998/022169 WO1999020282A1 (en) | 1997-10-21 | 1998-10-21 | Progestin therapy with controlled bleeding |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RO121319B1 true RO121319B1 (ro) | 2007-03-30 |
Family
ID=26743461
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ROA200000428A RO121319B1 (ro) | 1997-10-21 | 1998-10-21 | Utilizarea unui progestativ |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US6306914B1 (enExample) |
| EP (1) | EP1032399A1 (enExample) |
| JP (1) | JP2003535015A (enExample) |
| KR (1) | KR100581308B1 (enExample) |
| CN (1) | CN1147301C (enExample) |
| AR (1) | AR013981A1 (enExample) |
| AU (1) | AU742166C (enExample) |
| BR (1) | BR9813262A (enExample) |
| CA (2) | CA2307615A1 (enExample) |
| HU (1) | HUP0004133A3 (enExample) |
| IL (1) | IL135742A (enExample) |
| MX (1) | MXPA00003972A (enExample) |
| MY (1) | MY121743A (enExample) |
| NO (1) | NO326856B1 (enExample) |
| NZ (1) | NZ504066A (enExample) |
| PE (1) | PE121799A1 (enExample) |
| RO (1) | RO121319B1 (enExample) |
| RU (2) | RU2261099C2 (enExample) |
| WO (1) | WO1999020282A1 (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL127129A (en) * | 1998-11-18 | 2004-06-01 | Ferring Bv | Method for preparation of progesterone tablets for vaginal delivery and tablets so prepared |
| US20040191276A1 (en) * | 1999-11-30 | 2004-09-30 | Cutispharma, Inc. | Compositions and kits for compounding pharmaceuticals |
| US8425892B2 (en) * | 2001-10-29 | 2013-04-23 | Columbia Laboratories, Inc. | Extended, controlled-release pharmaceutical compositions using charged polymers |
| ES2561491T3 (es) * | 2001-12-05 | 2016-02-26 | Teva Women's Health, Inc. | Anticonceptivos orales para prevenir el embarazo |
| CA2496618A1 (en) * | 2002-05-23 | 2003-12-04 | Michael Holick | Use of a parathyroid hormone peptide analogs for the treatment of vaginal atrophy |
| AU2003297534A1 (en) * | 2002-12-24 | 2004-07-22 | Ovion, Inc. | Contraceptive device and delivery system |
| CA2524474A1 (en) * | 2003-05-02 | 2004-11-18 | Duramed Pharmaceuticals, Inc. | Methods of hormonal treatment utilizing extended cycle contraceptive regimens |
| SI1635843T1 (sl) * | 2003-06-25 | 2009-06-30 | Bayer Schering Pharma Ag | Terapija, ki vsebuje dienogest, za hormonsko nadomestitev in depresijo |
| JP2007534622A (ja) * | 2003-07-16 | 2007-11-29 | デュラメド ファーマシューティカルズ インコーポレーティッド | 連続的エストロゲン投与での避妊薬療法を利用するホルモン処置の方法 |
| EP1761231A1 (en) * | 2004-06-07 | 2007-03-14 | Duramed Pharmaceuticals, Inc. | Dispenser for progestin used for acute and maintenance treatment of dub |
| US20070111975A1 (en) | 2004-10-07 | 2007-05-17 | Duramed Pharmaceuticals, Inc. | Methods of Hormonal Treatment Utilizing Ascending-Dose Extended Cycle Regimens |
| JP2009521533A (ja) * | 2005-12-27 | 2009-06-04 | デュラメド ファーマシューティカルズ インコーポレーティッド | 結合型エストロゲン組成物、アプリケーター、キット、ならびにそれらの作製および使用の方法 |
| CA2637608A1 (en) * | 2006-01-20 | 2007-07-26 | Pear Tree Pharmaceuticals, Inc. | Method of treating atrophic vaginitis |
| US8235047B2 (en) | 2006-03-30 | 2012-08-07 | Conceptus, Inc. | Methods and devices for deployment into a lumen |
| CA2654152A1 (en) * | 2006-06-02 | 2007-12-13 | Pear Tree Women's Health Care | Method of treating atrophic vaginitis |
| GB0616444D0 (en) * | 2006-08-18 | 2006-09-27 | Reckitt Benckiser Nv | Detergent composition |
| WO2008091592A1 (en) | 2007-01-22 | 2008-07-31 | Targacept, Inc. | Intranasal, buccal, and sublingual administration of metanicotine analogs |
| US8828981B2 (en) | 2007-02-06 | 2014-09-09 | George Creasy | Progesterone for the treatment or prevention of spontaneous preterm birth |
| MX337634B (es) | 2008-02-04 | 2016-03-14 | Teva Womens Health Inc | Anillos intravaginales monoliticos que comprenden progesterona y metodos de manufactura y uso de los mismos. |
| BR112014012444B1 (pt) | 2011-11-23 | 2021-12-14 | Therapeuticsmd, Inc | Composição farmacêutica compreendendo estradiol solubilizado, progesterona e um agente de solubilização, bem como usos desta para tratar um sintoma relacionado à menopausa em uma mulher |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| RU2016143081A (ru) | 2014-05-22 | 2018-06-26 | Терапьютиксмд, Инк. | Натуральные комбинированные гормонозаместительные составы и терапии |
| AU2015296609A1 (en) | 2014-07-29 | 2016-12-22 | Therapeuticsmd, Inc. | Transdermal cream |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| KR20180126582A (ko) | 2016-04-01 | 2018-11-27 | 쎄러퓨틱스엠디, 인코퍼레이티드 | 스테로이드 호르몬 약제학적 조성물 |
| WO2017173044A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd Inc. | Steroid hormone compositions in medium chain oils |
| RU2697369C1 (ru) * | 2018-12-21 | 2019-08-13 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова" Министерства здравоохранения Российской | Способ дифференциальной диагностики функциональной гипоталамической аменореи на фоне стресса и энергетического дефицита |
| US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
| CN113288865B (zh) * | 2021-06-28 | 2022-03-08 | 浙江仙琚制药股份有限公司 | 一种黄体酮阴道凝胶剂的制备方法 |
| CN114983929A (zh) * | 2022-05-16 | 2022-09-02 | 安徽万邦医药科技股份有限公司 | 一种稳定的黄体酮缓释凝胶及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0501523B1 (en) | 1983-11-14 | 1997-04-09 | Columbia Laboratories, Inc. | Bioadhesive compositions |
| USD345211S (en) | 1992-04-06 | 1994-03-15 | Columbia Laboratories, Inc. | Dispensing vial for feminine hygiene products |
| US5543150A (en) * | 1993-09-15 | 1996-08-06 | Columbia Laboratories, Inc. | Method of progesterone delivery and affect thereof |
| USD375352S (en) | 1994-03-14 | 1996-11-05 | Columbia Laboratories, Inc. | Dispensing vial for feminine hygiene products |
-
1998
- 1998-10-13 US US09/170,326 patent/US6306914B1/en not_active Expired - Fee Related
- 1998-10-21 MX MXPA00003972A patent/MXPA00003972A/es not_active IP Right Cessation
- 1998-10-21 HU HU0004133A patent/HUP0004133A3/hu unknown
- 1998-10-21 AU AU11914/99A patent/AU742166C/en not_active Ceased
- 1998-10-21 CN CNB988123894A patent/CN1147301C/zh not_active Expired - Fee Related
- 1998-10-21 RU RU2000112650/14A patent/RU2261099C2/ru not_active IP Right Cessation
- 1998-10-21 NZ NZ504066A patent/NZ504066A/xx unknown
- 1998-10-21 JP JP2000516679A patent/JP2003535015A/ja active Pending
- 1998-10-21 BR BR9813262-8A patent/BR9813262A/pt not_active Application Discontinuation
- 1998-10-21 EP EP98955011A patent/EP1032399A1/en not_active Withdrawn
- 1998-10-21 PE PE1998000990A patent/PE121799A1/es not_active Application Discontinuation
- 1998-10-21 CA CA002307615A patent/CA2307615A1/en not_active Abandoned
- 1998-10-21 WO PCT/US1998/022169 patent/WO1999020282A1/en not_active Ceased
- 1998-10-21 KR KR1020007004288A patent/KR100581308B1/ko not_active Expired - Fee Related
- 1998-10-21 RO ROA200000428A patent/RO121319B1/ro unknown
- 1998-10-21 IL IL13574298A patent/IL135742A/en not_active IP Right Cessation
- 1998-10-21 CA CA002649671A patent/CA2649671A1/en not_active Abandoned
- 1998-10-21 MY MYPI98004790A patent/MY121743A/en unknown
- 1998-10-22 AR ARP980105256A patent/AR013981A1/es unknown
-
2000
- 2000-04-19 NO NO20002084A patent/NO326856B1/no not_active IP Right Cessation
- 2000-10-17 US US09/833,259 patent/US6593317B1/en not_active Expired - Fee Related
-
2001
- 2001-04-03 US US09/825,569 patent/US20010031747A1/en active Pending
-
2005
- 2005-01-21 RU RU2005101612/14A patent/RU2330667C2/ru not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR100581308B1 (ko) | 2006-05-22 |
| IL135742A0 (en) | 2001-05-20 |
| AR013981A1 (es) | 2001-01-31 |
| CA2307615A1 (en) | 1999-04-29 |
| MY121743A (en) | 2006-02-28 |
| RU2005101612A (ru) | 2006-07-10 |
| AU1191499A (en) | 1999-05-10 |
| US6306914B1 (en) | 2001-10-23 |
| NO326856B1 (no) | 2009-03-02 |
| AU742166B2 (en) | 2001-12-20 |
| AU742166C (en) | 2005-07-14 |
| EP1032399A1 (en) | 2000-09-06 |
| PE121799A1 (es) | 1999-12-17 |
| BR9813262A (pt) | 2000-08-22 |
| US20010031747A1 (en) | 2001-10-18 |
| NZ504066A (en) | 2002-11-26 |
| CN1147301C (zh) | 2004-04-28 |
| RU2330667C2 (ru) | 2008-08-10 |
| WO1999020282A1 (en) | 1999-04-29 |
| RU2261099C2 (ru) | 2005-09-27 |
| NO20002084L (no) | 2000-06-21 |
| JP2003535015A (ja) | 2003-11-25 |
| US6593317B1 (en) | 2003-07-15 |
| IL135742A (en) | 2004-09-27 |
| KR20010031299A (ko) | 2001-04-16 |
| HUP0004133A3 (en) | 2001-09-28 |
| NO20002084D0 (no) | 2000-04-19 |
| MXPA00003972A (es) | 2004-04-21 |
| HUP0004133A2 (hu) | 2001-05-28 |
| CA2649671A1 (en) | 1999-04-29 |
| CN1282250A (zh) | 2001-01-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RO121319B1 (ro) | Utilizarea unui progestativ | |
| RU2148393C1 (ru) | Новый способ доставки прогестерона и его влияние | |
| US5276022A (en) | Hormone preparation and method | |
| KR101812160B1 (ko) | 연장된 호르몬성 피임제 투약법에서 파탄성 출혈의 관리 | |
| RU2340345C2 (ru) | Схема восполнения эстрогена | |
| BG62383B1 (bg) | Метод за хормонзаместващо лечение | |
| JP5036943B2 (ja) | 新規なホルモン組成物とその利用 | |
| BG65817B1 (bg) | Мезопрогестини (прогестерон рецептор модулатори) за лечение и профилактика на хормонозависими доброкачествени гинекологични заболявания | |
| WO2020247653A1 (en) | Hormonal contraception using a vaginal ring which releases estriol and trimegestone | |
| UA79421C2 (en) | Progestin therapy with regular menstrual bleeding | |
| AU689133C (en) | Novel method of progesterone delivery and affect thereof | |
| Moghadam et al. | Advances in menopausal hormonal therapy delivery systems: a comparative review | |
| Ng et al. | The use of hormonal intrauterine systems in menopausal women | |
| Brincat et al. | Current preparations of HRT: advantages and disadvantages | |
| Verma et al. | LEVONORGESTREL, PHARMACOKINETICS, EFFICACY AND SAFETY |