RU2005101612A - Прогестинотерапия с регулируемым кровотечением - Google Patents
Прогестинотерапия с регулируемым кровотечением Download PDFInfo
- Publication number
- RU2005101612A RU2005101612A RU2005101612/14A RU2005101612A RU2005101612A RU 2005101612 A RU2005101612 A RU 2005101612A RU 2005101612/14 A RU2005101612/14 A RU 2005101612/14A RU 2005101612 A RU2005101612 A RU 2005101612A RU 2005101612 A RU2005101612 A RU 2005101612A
- Authority
- RU
- Russia
- Prior art keywords
- progestin
- site
- delivery system
- cyclic
- drug delivery
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/34—Gestagens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Claims (8)
1. Способ стимулирования регулярного абстинентного кровотечения у женщины, подвергающейся циклическому введению прогестина, включающий ежедневное циклическое вагинальное введение прогестина через систему доставки лекарственного средства к участку действия в количестве, чтобы вызвать секреторную трансформацию эндометрия с целью избежания значительных неблагоприятных побочных эффектов, где система доставки лекарственного средства к участку действия включает водонерастворимый, набухающий в воде сшитый полимер на основе поликарбоновой кислоты и эффективное количество прогестина.
2. Способ по п.1, где полимером является поликарбофил.
3. Способ по п.1, где прогестином является прогестерон.
4. Способ по п.1, где система доставки лекарственного средства к участку действия дополнительно содержит, по крайней мере, одну добавку.
5. Способ по п.1, где систему доставки лекарственного средства к участку действия вводят ежедневно в течение установленной части каждого календарного месяца.
6. Способ по п.1, где женщину также обрабатывают эстрогеном.
7. Фармацевтическая композиция для циклического ежедневного вагинального введения прогестина с целью стимулирования регулярного абстинентного кровотечения, содержащая прогестин вместе с водонерастворимым, однако набухающим в воде, биоадгезивным сшитым полимером на основе поликарбоновой кислоты, где указанная фармацевтическая композиция содержит эффективное количество прогестина.
8. Способ циклического вагинального введения прогестина с целью стимулирования регулярного абстинентного кровотечения, включающий обработку композицией по п.7, содержащей терапевтически эффективное количество прогестина.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6348597P | 1997-10-21 | 1997-10-21 | |
| US60/063,485 | 1997-10-21 | ||
| US09/170,326 US6306914B1 (en) | 1997-10-21 | 1998-10-13 | Progestin therapy for maintaining amenorrhea |
| US09/170,326 | 1998-10-13 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2000112650/14A Division RU2261099C2 (ru) | 1997-10-21 | 1998-10-21 | Способ поддержания аменореи у женщин, подвергающихся постоянному введению прогестина, и фармацевтическая композиция для его осуществления |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2005101612A true RU2005101612A (ru) | 2006-07-10 |
| RU2330667C2 RU2330667C2 (ru) | 2008-08-10 |
Family
ID=26743461
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2000112650/14A RU2261099C2 (ru) | 1997-10-21 | 1998-10-21 | Способ поддержания аменореи у женщин, подвергающихся постоянному введению прогестина, и фармацевтическая композиция для его осуществления |
| RU2005101612/14A RU2330667C2 (ru) | 1997-10-21 | 2005-01-21 | Прогестинотерапия с регулируемым кровотечением |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2000112650/14A RU2261099C2 (ru) | 1997-10-21 | 1998-10-21 | Способ поддержания аменореи у женщин, подвергающихся постоянному введению прогестина, и фармацевтическая композиция для его осуществления |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US6306914B1 (ru) |
| EP (1) | EP1032399A1 (ru) |
| JP (1) | JP2003535015A (ru) |
| KR (1) | KR100581308B1 (ru) |
| CN (1) | CN1147301C (ru) |
| AR (1) | AR013981A1 (ru) |
| AU (1) | AU742166C (ru) |
| BR (1) | BR9813262A (ru) |
| CA (2) | CA2649671A1 (ru) |
| HU (1) | HUP0004133A3 (ru) |
| IL (1) | IL135742A (ru) |
| MX (1) | MXPA00003972A (ru) |
| MY (1) | MY121743A (ru) |
| NO (1) | NO326856B1 (ru) |
| NZ (1) | NZ504066A (ru) |
| PE (1) | PE121799A1 (ru) |
| RO (1) | RO121319B1 (ru) |
| RU (2) | RU2261099C2 (ru) |
| WO (1) | WO1999020282A1 (ru) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8828981B2 (en) | 2007-02-06 | 2014-09-09 | George Creasy | Progesterone for the treatment or prevention of spontaneous preterm birth |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL127129A (en) * | 1998-11-18 | 2004-06-01 | Ferring Bv | Method for preparation of progesterone tablets for vaginal delivery and tablets so prepared |
| US20040191276A1 (en) * | 1999-11-30 | 2004-09-30 | Cutispharma, Inc. | Compositions and kits for compounding pharmaceuticals |
| US8425892B2 (en) * | 2001-10-29 | 2013-04-23 | Columbia Laboratories, Inc. | Extended, controlled-release pharmaceutical compositions using charged polymers |
| SI1453521T1 (sl) * | 2001-12-05 | 2013-11-29 | Teva Women's Health, Inc. | Oralni kontraceptiki za preprečevanje nosečnosti in zmanjševanje predmenstrualne simptomatike |
| CA2496618A1 (en) * | 2002-05-23 | 2003-12-04 | Michael Holick | Use of a parathyroid hormone peptide analogs for the treatment of vaginal atrophy |
| WO2004058110A2 (en) * | 2002-12-24 | 2004-07-15 | Ovion, Inc. | Contraceptive device and delivery system |
| JP2006525358A (ja) * | 2003-05-02 | 2006-11-09 | ドゥラメド ファーマシューティカルズ， インコーポレイテッド | 長期周期避妊養生法を利用するホルモン治療の方法 |
| SI1635843T1 (sl) * | 2003-06-25 | 2009-06-30 | Bayer Schering Pharma Ag | Terapija, ki vsebuje dienogest, za hormonsko nadomestitev in depresijo |
| RU2403046C2 (ru) * | 2003-07-16 | 2010-11-10 | Тева Вимен'С Хелс, Инк. | Способы гормонального лечения с применением контрацептивных режимов с непрерывным введением эстрогена |
| WO2005120432A1 (en) * | 2004-06-07 | 2005-12-22 | Duramed Pharmaceuticals, Inc. | Dispenser for progestin used for acute and maintenance treatment of dub |
| US20070111975A1 (en) | 2004-10-07 | 2007-05-17 | Duramed Pharmaceuticals, Inc. | Methods of Hormonal Treatment Utilizing Ascending-Dose Extended Cycle Regimens |
| EP2289487A1 (en) * | 2005-12-27 | 2011-03-02 | Teva Women's Health, Inc. | Conjugated estrogen compositions, applicators, kits, and methods of making and use thereof |
| CA2637608A1 (en) * | 2006-01-20 | 2007-07-26 | Pear Tree Pharmaceuticals, Inc. | Method of treating atrophic vaginitis |
| US8235047B2 (en) | 2006-03-30 | 2012-08-07 | Conceptus, Inc. | Methods and devices for deployment into a lumen |
| WO2007143607A2 (en) * | 2006-06-02 | 2007-12-13 | Pear Tree Women's Health Care | Method of treating atrophic vaginitis |
| GB0616444D0 (en) * | 2006-08-18 | 2006-09-27 | Reckitt Benckiser Nv | Detergent composition |
| US20100028447A1 (en) | 2007-01-22 | 2010-02-04 | Targacept, Inc. | Intranasal, Buccal, And Sublingual Administration Of Metanicotine Analogs |
| DK2249757T3 (en) * | 2008-02-04 | 2017-10-16 | Ferring Bv | Monolithic vaginal rings comprising progesterone and methods of preparation and use thereof. |
| LT2782584T (lt) | 2011-11-23 | 2021-09-10 | Therapeuticsmd, Inc. | Natūralios kombinuotos pakaitinės hormonų terapijos kompozicijos ir gydymas |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| AU2015264003A1 (en) | 2014-05-22 | 2016-11-17 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| AU2015296609A1 (en) | 2014-07-29 | 2016-12-22 | Therapeuticsmd, Inc. | Transdermal cream |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
| WO2017173071A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
| RU2697369C1 (ru) * | 2018-12-21 | 2019-08-13 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова" Министерства здравоохранения Российской | Способ дифференциальной диагностики функциональной гипоталамической аменореи на фоне стресса и энергетического дефицита |
| US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
| CN113288865B (zh) * | 2021-06-28 | 2022-03-08 | 浙江仙琚制药股份有限公司 | 一种黄体酮阴道凝胶剂的制备方法 |
| CN114983929A (zh) * | 2022-05-16 | 2022-09-02 | 安徽万邦医药科技股份有限公司 | 一种稳定的黄体酮缓释凝胶及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU565354B2 (en) | 1983-11-14 | 1987-09-10 | Bio-Mimetics Inc. | Bioadhesive compositions and methods of treatment therewith |
| USD345211S (en) | 1992-04-06 | 1994-03-15 | Columbia Laboratories, Inc. | Dispensing vial for feminine hygiene products |
| US5543150A (en) * | 1993-09-15 | 1996-08-06 | Columbia Laboratories, Inc. | Method of progesterone delivery and affect thereof |
| USD375352S (en) | 1994-03-14 | 1996-11-05 | Columbia Laboratories, Inc. | Dispensing vial for feminine hygiene products |
-
1998
- 1998-10-13 US US09/170,326 patent/US6306914B1/en not_active Expired - Fee Related
- 1998-10-21 RO ROA200000428A patent/RO121319B1/ro unknown
- 1998-10-21 CA CA002649671A patent/CA2649671A1/en not_active Abandoned
- 1998-10-21 RU RU2000112650/14A patent/RU2261099C2/ru not_active IP Right Cessation
- 1998-10-21 PE PE1998000990A patent/PE121799A1/es not_active Application Discontinuation
- 1998-10-21 WO PCT/US1998/022169 patent/WO1999020282A1/en active IP Right Grant
- 1998-10-21 MY MYPI98004790A patent/MY121743A/en unknown
- 1998-10-21 MX MXPA00003972A patent/MXPA00003972A/es not_active IP Right Cessation
- 1998-10-21 KR KR1020007004288A patent/KR100581308B1/ko not_active IP Right Cessation
- 1998-10-21 NZ NZ504066A patent/NZ504066A/xx unknown
- 1998-10-21 HU HU0004133A patent/HUP0004133A3/hu unknown
- 1998-10-21 BR BR9813262-8A patent/BR9813262A/pt not_active Application Discontinuation
- 1998-10-21 EP EP98955011A patent/EP1032399A1/en not_active Withdrawn
- 1998-10-21 CA CA002307615A patent/CA2307615A1/en not_active Abandoned
- 1998-10-21 JP JP2000516679A patent/JP2003535015A/ja active Pending
- 1998-10-21 AU AU11914/99A patent/AU742166C/en not_active Ceased
- 1998-10-21 IL IL13574298A patent/IL135742A/en not_active IP Right Cessation
- 1998-10-21 CN CNB988123894A patent/CN1147301C/zh not_active Expired - Fee Related
- 1998-10-22 AR ARP980105256A patent/AR013981A1/es unknown
-
2000
- 2000-04-19 NO NO20002084A patent/NO326856B1/no not_active IP Right Cessation
- 2000-10-17 US US09/833,259 patent/US6593317B1/en not_active Expired - Fee Related
-
2001
- 2001-04-03 US US09/825,569 patent/US20010031747A1/en active Pending
-
2005
- 2005-01-21 RU RU2005101612/14A patent/RU2330667C2/ru not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8828981B2 (en) | 2007-02-06 | 2014-09-09 | George Creasy | Progesterone for the treatment or prevention of spontaneous preterm birth |
Also Published As
| Publication number | Publication date |
|---|---|
| IL135742A (en) | 2004-09-27 |
| IL135742A0 (en) | 2001-05-20 |
| US6593317B1 (en) | 2003-07-15 |
| NO326856B1 (no) | 2009-03-02 |
| AR013981A1 (es) | 2001-01-31 |
| JP2003535015A (ja) | 2003-11-25 |
| AU742166B2 (en) | 2001-12-20 |
| CN1147301C (zh) | 2004-04-28 |
| US6306914B1 (en) | 2001-10-23 |
| RO121319B1 (ro) | 2007-03-30 |
| KR100581308B1 (ko) | 2006-05-22 |
| PE121799A1 (es) | 1999-12-17 |
| WO1999020282A1 (en) | 1999-04-29 |
| US20010031747A1 (en) | 2001-10-18 |
| BR9813262A (pt) | 2000-08-22 |
| AU1191499A (en) | 1999-05-10 |
| NO20002084D0 (no) | 2000-04-19 |
| CN1282250A (zh) | 2001-01-31 |
| HUP0004133A2 (hu) | 2001-05-28 |
| MY121743A (en) | 2006-02-28 |
| RU2261099C2 (ru) | 2005-09-27 |
| AU742166C (en) | 2005-07-14 |
| NO20002084L (no) | 2000-06-21 |
| NZ504066A (en) | 2002-11-26 |
| CA2307615A1 (en) | 1999-04-29 |
| RU2330667C2 (ru) | 2008-08-10 |
| EP1032399A1 (en) | 2000-09-06 |
| HUP0004133A3 (en) | 2001-09-28 |
| CA2649671A1 (en) | 1999-04-29 |
| KR20010031299A (ko) | 2001-04-16 |
| MXPA00003972A (es) | 2004-04-21 |
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