RU2229288C2 - Стабильная изотоническая лиофилизированная протеиновая композиция - Google Patents
Стабильная изотоническая лиофилизированная протеиновая композиция Download PDFInfo
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- 230000003612 virological effect Effects 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50801495A | 1995-07-27 | 1995-07-27 | |
| US08/508014 | 1995-07-27 | ||
| US08/615369 | 1996-03-14 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013141049/15A Division RU2013141049A (ru) | 1995-07-27 | 2013-09-06 | Стабильная изотоническая лиофилизированная белковая композиция |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU98103237A RU98103237A (ru) | 2000-01-27 |
| RU2229288C2 true RU2229288C2 (ru) | 2004-05-27 |
Family
ID=24021032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU98103237/15A RU2229288C2 (ru) | 1995-07-27 | 1996-07-23 | Стабильная изотоническая лиофилизированная протеиновая композиция |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0841946B2 (https=) |
| JP (1) | JP4153560B2 (https=) |
| CN (2) | CN101172100A (https=) |
| AR (1) | AR003468A1 (https=) |
| AT (1) | ATE225185T1 (https=) |
| AU (1) | AU715338B2 (https=) |
| CA (1) | CA2226624C (https=) |
| DE (1) | DE69624116T3 (https=) |
| DK (1) | DK0841946T4 (https=) |
| ES (1) | ES2186796T5 (https=) |
| IL (1) | IL122733A (https=) |
| MX (1) | MX9800760A (https=) |
| PT (1) | PT841946E (https=) |
| RU (1) | RU2229288C2 (https=) |
| WO (1) | WO1997004807A1 (https=) |
| ZA (2) | ZA966075B (https=) |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2445115C2 (ru) * | 2006-03-01 | 2012-03-20 | Биосьютикалс Арцнаймиттель Аг | Жидкая композиция g-csf |
| RU2467762C2 (ru) * | 2007-10-26 | 2012-11-27 | Никомед Данмарк Апс | Составы паратиреоидного гормона и их применение |
| RU2476238C2 (ru) * | 2007-12-21 | 2013-02-27 | Ф. Хоффманн-Ля Рош Аг | Препарат антитела |
| RU2481823C2 (ru) * | 2007-12-21 | 2013-05-20 | Инспирейшн Биофармасьютикалс, Инк. | Стабилизированные составы, содержащие фактор ix и трегалозу |
| RU2481824C2 (ru) * | 2008-10-29 | 2013-05-20 | Аблинкс Н.В | Препараты однодоменных антигенсвязывающих молекул |
| US9511122B2 (en) | 2009-12-15 | 2016-12-06 | Ascendis Pharma Growth Disorders Division A/S | Dry growth hormone composition transiently linked to a polymer carrier |
| RU2683823C2 (ru) * | 2013-09-27 | 2019-04-02 | Ханми Фарм. Ко., Лтд. | Препарат гормона роста человека длительного типа |
| US11370835B2 (en) | 2008-10-29 | 2022-06-28 | Ablynx N.V. | Methods for purification of single domain antigen binding molecules |
| US12016903B2 (en) | 2014-11-21 | 2024-06-25 | Ascendis Pharma Endocrinology Division A/S | Long-acting growth hormone treatment |
| US12133883B2 (en) | 2014-11-18 | 2024-11-05 | Ascendis Pharma Endocrinology Division A/S | Polymeric hGH prodrugs |
| US12274737B2 (en) | 2008-04-29 | 2025-04-15 | Ascendis Pharma Endocrinology Division A/S | PEGylated recombinant human growth hormone compounds |
| US12303553B2 (en) | 2019-03-04 | 2025-05-20 | Ascendis Pharma Endocrinology Division A/S | Long-acting growth hormone dosage forms with superior efficacy to daily somatropin |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6685940B2 (en) | 1995-07-27 | 2004-02-03 | Genentech, Inc. | Protein formulation |
| US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
| US6991790B1 (en) | 1997-06-13 | 2006-01-31 | Genentech, Inc. | Antibody formulation |
| US6171586B1 (en) | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
| WO1999045777A1 (en) * | 1998-03-10 | 1999-09-16 | The Children's Hospital Of Philadelphia | Compositions and methods for treatment of asthma |
| US6299875B1 (en) | 1998-06-04 | 2001-10-09 | Panacea Pharmaceuticals, Llc | Methods to block IGE binding to cell surface receptors of mast cells |
| US6913749B2 (en) | 1998-11-02 | 2005-07-05 | Resistentia Pharmaceuticals Ab | Immunogenic polypeptides for inducing anti-self IgE responses |
| AU2002213441B2 (en) * | 2000-10-12 | 2006-10-26 | Genentech, Inc. | Reduced-viscosity concentrated protein formulations |
| US8703126B2 (en) | 2000-10-12 | 2014-04-22 | Genentech, Inc. | Reduced-viscosity concentrated protein formulations |
| WO2004041863A2 (en) | 2002-11-08 | 2004-05-21 | Ablynx N.V. | Single domain antibodies directed against interferon- gamma and uses therefor |
| EP1558645B1 (en) | 2002-11-08 | 2011-07-27 | Ablynx N.V. | Stabilized single domain antibodies in pharmaceutical composition adapted for inhalation |
| EP1900753B1 (en) | 2002-11-08 | 2017-08-09 | Ablynx N.V. | Method of administering therapeutic polypeptides, and polypeptides therefor |
| JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
| CA2676843A1 (en) * | 2007-01-29 | 2008-08-07 | Valtion Teknillinen Tutkimuskeskus | Method for producing novel ige based reagents |
| AR065368A1 (es) | 2007-02-15 | 2009-06-03 | Astrazeneca Ab | Anticuerpos para moleculas de ige |
| ES2993140T3 (en) | 2010-04-02 | 2024-12-23 | Amunix Pharmaceuticals Inc | Binding fusion proteins, binding fusion protein-drug conjugates, xten-drug conjugates and methods of making and using same |
| CN102533704A (zh) * | 2010-12-30 | 2012-07-04 | 上海雅心生物技术有限公司 | 即配即用型的胰蛋白酶制剂 |
| PT2691112T (pt) * | 2011-03-31 | 2018-07-10 | Merck Sharp & Dohme | Formulações estáveis de anticorpos para o recetor pd-1 humano de morte programada e tratamentos relacionados |
| CN107233569B (zh) * | 2011-10-25 | 2021-08-31 | 普罗西纳生物科学有限公司 | 抗体制剂和方法 |
| CN104707146B (zh) * | 2013-12-16 | 2019-04-16 | 浙江海正药业股份有限公司 | 一种含有阿达木单抗的药物组合物 |
| GB201610198D0 (en) | 2016-06-10 | 2016-07-27 | Ucb Biopharma Sprl | Anti-ige antibodies |
| JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
| JP7382232B2 (ja) | 2017-05-02 | 2023-11-16 | メルク・シャープ・アンド・ドーム・エルエルシー | 抗ｌａｇ３抗体の製剤および抗ｌａｇ３抗体と抗ｐｄ－１抗体との共製剤 |
| WO2019019998A1 (zh) * | 2017-07-25 | 2019-01-31 | 江苏恒瑞医药股份有限公司 | 一种il-15蛋白复合物药物组合物及其用途 |
| KR20220098056A (ko) * | 2018-02-09 | 2022-07-08 | 제넨테크, 인크. | 비만 세포 매개 염증성 질환에 대한 치료 및 진단 방법 |
| CN110732023B (zh) * | 2018-07-18 | 2023-06-16 | 江苏恒瑞医药股份有限公司 | 一种her2抗体药物组合物及其用途 |
| MX2021004928A (es) | 2018-10-31 | 2021-06-08 | Merck Sharp & Dohme Llc | Cristales de anticuerpo anti-pd-1 humano y metodos de uso de los mismos. |
| CN113827717A (zh) * | 2020-06-23 | 2021-12-24 | 三生国健药业（上海）股份有限公司 | 抗her2单克隆抗体冻干制剂及制备方法 |
| CA3185192A1 (en) | 2020-07-10 | 2022-01-13 | Sujun DENG | Anti-ige engineered antibody and application thereof |
| TW202409078A (zh) * | 2022-07-18 | 2024-03-01 | 中國大陸商蘇州創勝醫藥集團有限公司 | 穩定之包含抗gremlin1抗體的藥物製劑 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5011676A (en) * | 1990-03-27 | 1991-04-30 | Thomas Jefferson University | Method to directly radiolabel antibodies for diagnostic imaging and therapy |
| US5290764A (en) * | 1992-01-14 | 1994-03-01 | The Dupont Merck Pharmaceutical Company | Stabilization of active plasminogen activator inhibitor-1 |
| EP0661060A2 (de) * | 1993-12-28 | 1995-07-05 | IMMUNO Aktiengesellschaft | Hochkonzentriertes Immunglobulin-Präparat und Verfahren zu seiner Herstellung |
| RU95107153A (ru) * | 1994-05-04 | 1997-11-27 | Санофи | Стабилизированная протеинсодержащая лиофилизированная композиция |
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| DE3729863A1 (de) * | 1987-09-05 | 1989-03-16 | Boehringer Mannheim Gmbh | Stabilisierte erythropoietin-lyophilisate |
| AU616916B2 (en) * | 1987-11-20 | 1991-11-14 | Kissei Pharmaceutical Co. Ltd. | 4h-quinolizin-4-one compounds exhibiting therapeutic activities |
| AU618317B2 (en) * | 1987-12-31 | 1991-12-19 | Tanox Biosystems, Inc. | Unique antigenic epitopes on ige-bearing b lymphocytes |
| EP0651819A1 (en) * | 1992-03-20 | 1995-05-10 | Immunet | Methods for human monoclonal antibody production |
| JPH07118168A (ja) * | 1993-10-19 | 1995-05-09 | Tomoyasu Ra | ＩｇＥ産生抑制剤 |
| ES2219640T3 (es) * | 1992-09-24 | 2004-12-01 | Novartis Ag | Anticuerpos monoclonales reformados contra un isotopo de inmunoglobulina. |
| FR2719479B1 (fr) * | 1994-05-04 | 1996-07-26 | Sanofi Elf | Formulation stable lyophilisée comprenant une protéine: kit de dosage. |
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1996
- 1996-07-17 ZA ZA9606075A patent/ZA966075B/xx unknown
- 1996-07-23 ZA ZA9606240A patent/ZA966240B/xx unknown
- 1996-07-23 RU RU98103237/15A patent/RU2229288C2/ru not_active IP Right Cessation
- 1996-07-23 CN CNA2007101928120A patent/CN101172100A/zh active Pending
- 1996-07-23 CN CN2007101928065A patent/CN101172099B/zh not_active Expired - Lifetime
- 1996-07-24 IL IL12273396A patent/IL122733A/en not_active IP Right Cessation
- 1996-07-24 WO PCT/US1996/012275 patent/WO1997004807A1/en not_active Ceased
- 1996-07-24 JP JP50775897A patent/JP4153560B2/ja not_active Expired - Lifetime
- 1996-07-24 MX MX9800760A patent/MX9800760A/es active IP Right Grant
- 1996-07-24 ES ES96926134T patent/ES2186796T5/es not_active Expired - Lifetime
- 1996-07-24 EP EP96926134A patent/EP0841946B2/en not_active Expired - Lifetime
- 1996-07-24 AU AU66381/96A patent/AU715338B2/en not_active Expired
- 1996-07-24 PT PT96926134T patent/PT841946E/pt unknown
- 1996-07-24 CA CA2226624A patent/CA2226624C/en not_active Expired - Lifetime
- 1996-07-24 AT AT96926134T patent/ATE225185T1/de active
- 1996-07-24 DK DK96926134T patent/DK0841946T4/da active
- 1996-07-24 DE DE69624116T patent/DE69624116T3/de not_active Expired - Lifetime
- 1996-07-25 AR ARP960103741A patent/AR003468A1/es unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5011676A (en) * | 1990-03-27 | 1991-04-30 | Thomas Jefferson University | Method to directly radiolabel antibodies for diagnostic imaging and therapy |
| US5290764A (en) * | 1992-01-14 | 1994-03-01 | The Dupont Merck Pharmaceutical Company | Stabilization of active plasminogen activator inhibitor-1 |
| EP0661060A2 (de) * | 1993-12-28 | 1995-07-05 | IMMUNO Aktiengesellschaft | Hochkonzentriertes Immunglobulin-Präparat und Verfahren zu seiner Herstellung |
| RU95107153A (ru) * | 1994-05-04 | 1997-11-27 | Санофи | Стабилизированная протеинсодержащая лиофилизированная композиция |
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2445115C2 (ru) * | 2006-03-01 | 2012-03-20 | Биосьютикалс Арцнаймиттель Аг | Жидкая композиция g-csf |
| RU2467762C2 (ru) * | 2007-10-26 | 2012-11-27 | Никомед Данмарк Апс | Составы паратиреоидного гормона и их применение |
| RU2476238C2 (ru) * | 2007-12-21 | 2013-02-27 | Ф. Хоффманн-Ля Рош Аг | Препарат антитела |
| RU2481823C2 (ru) * | 2007-12-21 | 2013-05-20 | Инспирейшн Биофармасьютикалс, Инк. | Стабилизированные составы, содержащие фактор ix и трегалозу |
| US12274737B2 (en) | 2008-04-29 | 2025-04-15 | Ascendis Pharma Endocrinology Division A/S | PEGylated recombinant human growth hormone compounds |
| RU2481824C2 (ru) * | 2008-10-29 | 2013-05-20 | Аблинкс Н.В | Препараты однодоменных антигенсвязывающих молекул |
| RU2683861C2 (ru) * | 2008-10-29 | 2019-04-02 | Аблинкс Н.В. | Препараты однодоменных антигенсвязывающих молекул |
| US11370835B2 (en) | 2008-10-29 | 2022-06-28 | Ablynx N.V. | Methods for purification of single domain antigen binding molecules |
| US12226457B2 (en) | 2009-12-15 | 2025-02-18 | Ascendis Pharma Endocrinology Division A/S | Dry growth hormone composition transiently linked to a polymer carrier |
| US9511122B2 (en) | 2009-12-15 | 2016-12-06 | Ascendis Pharma Growth Disorders Division A/S | Dry growth hormone composition transiently linked to a polymer carrier |
| US9919033B2 (en) | 2009-12-15 | 2018-03-20 | Ascendis Pharma Endocrinology Division A/S | Dry growth hormone composition transiently linked to a polymer carrier |
| US10682395B2 (en) | 2009-12-15 | 2020-06-16 | Ascendis Pharma Endocrinology Division A/S | Dry growth hormone composition transiently linked to a polymer carrier |
| RU2683823C2 (ru) * | 2013-09-27 | 2019-04-02 | Ханми Фарм. Ко., Лтд. | Препарат гормона роста человека длительного типа |
| US10987425B2 (en) | 2013-09-27 | 2021-04-27 | Hanmi Pharm. Co., Ltd. | Liquid formulation of long-acting human growth hormone immunoglobulin conjugate |
| US12133883B2 (en) | 2014-11-18 | 2024-11-05 | Ascendis Pharma Endocrinology Division A/S | Polymeric hGH prodrugs |
| US12016903B2 (en) | 2014-11-21 | 2024-06-25 | Ascendis Pharma Endocrinology Division A/S | Long-acting growth hormone treatment |
| US12303553B2 (en) | 2019-03-04 | 2025-05-20 | Ascendis Pharma Endocrinology Division A/S | Long-acting growth hormone dosage forms with superior efficacy to daily somatropin |
Also Published As
| Publication number | Publication date |
|---|---|
| DE69624116T3 (de) | 2009-07-09 |
| AU6638196A (en) | 1997-02-26 |
| EP0841946B1 (en) | 2002-10-02 |
| DE69624116T2 (de) | 2003-06-18 |
| CN101172099B (zh) | 2012-02-15 |
| JP4153560B2 (ja) | 2008-09-24 |
| AU715338B2 (en) | 2000-01-20 |
| CN101172099A (zh) | 2008-05-07 |
| ES2186796T3 (es) | 2003-05-16 |
| ES2186796T5 (es) | 2009-04-01 |
| IL122733A0 (en) | 1998-08-16 |
| CA2226624A1 (en) | 1997-02-13 |
| DE69624116D1 (de) | 2002-11-07 |
| IL122733A (en) | 2001-09-13 |
| EP0841946A1 (en) | 1998-05-20 |
| EP0841946B2 (en) | 2008-10-15 |
| DK0841946T3 (da) | 2003-02-10 |
| DK0841946T4 (da) | 2009-02-16 |
| AR003468A1 (es) | 1998-08-05 |
| MX9800760A (es) | 1998-04-30 |
| ZA966075B (en) | 1998-01-19 |
| CA2226624C (en) | 2013-07-16 |
| PT841946E (pt) | 2003-02-28 |
| JPH11510172A (ja) | 1999-09-07 |
| CN101172100A (zh) | 2008-05-07 |
| WO1997004807A1 (en) | 1997-02-13 |
| ZA966240B (en) | 1998-01-23 |
| ATE225185T1 (de) | 2002-10-15 |
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