RU2221456C1 - Biologically active substance, biologically active supplement to food, pharmaceutical preparation, biologically active supplement for feeding animal, veterinary preparation, fertilizer, activator of microbiological process, oral nutrition, perfume-cosmetic agent, hygienic agent, dairy foodstuff, confectionery, baked goods, butter-fat foodstuff, sauce, alcohol drink, nonalcoholic beverage, piscine foodstuff, meat foodstuff, macaroni article, chewing gum, beer - Google Patents

Abstract

FIELD: food, biotechnological and medicinal industries. SUBSTANCE: invention relates to field for preparing biologically active substances. Biologically active substance represents protein hydrolyzate prepared by acid hydrolysis that is carried out up to negative reaction for protein and the following neutralization of peptide-containing raw taken among the following row: animal or fish carcasses, albumin, animal or fish blood, animal or fish meat. Then method involves filtration and preparing hydrolyzate and precipitate followed by drying hydrolyzate. The ready product comprises peptides with molecular mass above 3 000 Da with content 25 wt.-%, not above; optical activity α $\genfrac{}{}{0ex}{}{\text{20}}{\text{D}}$ of the end product is 5-15, the ratio amine nitrogen : fatty acids : carbohydrates = (10-30) : (0.2-2) : (0.4-5), respectively, and product contains also sodium, chrome, nickel, cobalt, selenium, calcium, potassium, sulfur, phosphorus, chlorine, iron, zinc, copper, manganese. Prepared biologically active substance is used in producing biologically active nutrient supplement, pharmaceutical preparation, biologically active supplement for feeding animals, veterinary preparation, fertilizer, activator of microbiological processes, oral nutrition, perfume- cosmetic agent, hygienic agent, dairy foodstuff, confectionery, baked good, butterfat foodstuff, sauce, alcoholic drink, nonalcoholic beverage, piscine foodstuff, meat foodstuff, macaroni articles, chewing gum and beer. This allows preparing the universal biologically active substance due to broad spectrum of its application and wasteless process for it preparing. Also, chemical composition of biologically active substance shows the close affinity at cellular level with human, animals and plants cells that is provided due to molecular peptide mass and optical density value of biologically active substance. Also, except for physical-chemical indices providing biological activity this substance in its addition to other foodstuffs confers high technological properties to ready foodstuffs, for example: prolonged time storage of ready foodstuffs, enhanced stability of foodstuff, structural- rheological properties in combination with high moisture-retaining capacity. Invention can be used in chemical- pharmaceutical industry, agriculture, in part, in plant growing and animal husbandry, in different branches of food industry and perfume-cosmetic industry. EFFECT: valuable properties of substance. 72 cl

Description

 The group of inventions relates to the food, biotechnological and medical industries, in particular to the field of biologically active products, and can be used in the pharmaceutical industry, agriculture, in particular plant growing and livestock, in various sectors of the food industry and perfumery and cosmetics.

 Deteriorating environmental conditions, social conditions of people’s life, as well as a decrease in the diet of substances that are especially valuable for the body, such as vitamins, macro- and micronutrients, dietary fiber, proteins, etc., contribute to reducing the average life expectancy of people and worsening health status population.

 To solve these problems, scientists suggest introducing complexes of biologically active substances from natural sources into the human diet, both in the form of separate concentrates and in the form of food products enriched with biologically active substances.

 This is a new direction, bordering on a number of related sciences: nutrition science, pharmacology, animal husbandry.

 As the analysis of the prior art has shown, recently the direction of processing natural raw materials has been very actively developing to obtain biologically active complexes. Peptide-containing animal raw materials (waste from the processing of animal raw materials, animal blood), mountain ore containing mummy-like substances, microorganisms, vegetables, etc. are used as natural raw materials.

The prior art mineral-organic substrate having the property of a biological stimulant, which is a protein hydrolyzate obtained by grinding the feedstock (protein-containing waste products of animal products), acid hydrolysis of the feedstock in 5-20% sulfuric acid for 5-15 hours at a temperature 90-110 ^o C, subsequent filtration of the acid hydrolyzate is then carried out an alkaline hydrolysis of the residue, insoluble in acid, calcium oxide at 95-105 ^o C for 3-5 hours, by mixing and stirring m of acid and alkaline hydrolysates, pH correction (if necessary), filtration and freeze-drying of the final solution (MOS), while it has the following composition, wt.%: amino acids 65-67 including amino acids free: aspartic 7.32, threonine 0.69, serine 1.38, glutamine 3.88, valine 1.73, proline 5.22, methionine 0.89, alanine 2.39, leucine 1.13, isoleucine 0.56, histidine 22.16, phenylalanine 0.61, arginine 1.56, lysine 1.28, fats 18-20, lipids other than fats 2-2.5, carbohydrates 8-11, organic and inorganic salts 0.5-2, macronutrients 0.2 -2, including mg / g: calcium 5.72, potassium 7.1 3, sulfur 24.09, phosphorus 19.15, chlorine 2.0, trace elements 0.0005-0.009, including μg / g: iron 67.79, zinc 33.22, copper 8.50, manganese 5, 35 (RF patent 2016510).

There is also a method of obtaining a food semi-finished product, in which the whole blood of slaughtered animals is mixed with sugar and water in a ratio of 1: (3-4): (0.1-0.6) and the mixture is sterilized at 105-110 ^o C for 2- 3 min (USSR copyright certificate 1729387, class A 23 J 1/06, 1992).

 The disadvantages of the method are to obtain a product with insufficiently high consumer qualities and biological value.

Also known is a method of producing a food semi-finished product from the blood of slaughtered animals, where the blood cells previously hemolized with a solution of hydrochloric acid with a concentration of 0.20-0.25 mol / dm ³ in the ratio: 1: 1, for 3-5 minutes, are mixed with sugar and the mixture is evaporated to a solids content of 58-62%, then molasses, a mixture of edible bone fat and vegetable oil are introduced, and then heat treatment is carried out at 75-80 ^o C for 8-12 minutes, followed by cooling to 38-42 ^o C, and after cooling make food additives: honey, ascorbin acid and flavor in the following ratio of ingredients, wt.%: hemolyzed blood cells - 40-45, a mixture of edible bone fat and vegetable oil - 4-5, sugar - 45-50, molasses - 3-4, honey - 2- 3, ascorbic acid - 0.04-0.05, flavoring - 0.02-0.03 (RF patent 2126215).

 A bioprotective food substance is also known, which is a biologically active extract from mountain ore containing mummy-like substances obtained by water extraction of pre-ground mountain ore with subsequent decantation, filtration, purification from heavy elements, concentration and / or drying, and a substance with the following chemical composition, wt.%: mono-, di-, tripeptides - 25-30, including conjugated amino acids, mg amino acids per 100 g of concentrate: aspartic acid lots - 200-500, threonine - 70-150, serine - 80-140, glutamic acid - 250-4700, glycerin - 2500-4300, alanine - 350-1400, cystine - 100-120, isoleucine - 30-100, leucine - 50-140, histidine - 150-270, lysine - 80-110, arginine - 150-570, valine - 30-40, methionine - 10-18, phenylalanine - 40-95, tyrosine - 30-50, proline - 1200 -1500, Y-aminobutyric acid - up to 1.0, including free amino acids, mg amino acids per 100 g of concentrate: aspartic acid - 10-100, oxyproline - 70-75, glutamic acid - 4.5-5.0, glycine - 1000-40000, alanine - 20-30, valine - 10-20, isoleucine - 2-3, leucine - 5-6, tyrosine - 7-8, P-alanine - 10-11, phenylalanine - 4-5, Y-Amino Oil Kitty lots - up to 1, histidine - 2-3, arginine - up to 1.0, minerals - 30-50, including micro, macrocells, micrograms per 1 g of concentrate: aluminum - 3-43, boron - 12-190 barium - 10-42, beryllium - 0.02-0.20, calcium - 1600-18000, cadmium - 0.1-1.0, cobalt - 2-3, chromium - not more than 0.001, copper - 1-15 , iron - 12-240, mercury - traces, potassium - 1000-6300, lithium - 0.3-3.0, magnesium - 1300-22400, manganese - 53.0-58.3, molybdenum - 0.02-2 , 0, sodium - 2400-73000, nickel - 0.1-5.0, phosphorus - 20-193, tin - traces, antimony - traces, selenium - traces, silicon - 13-145, lead - 0.1-0 , 8, strontium - 20-162, titanium - 0.2-2.5, sulfur - 10-1000, reducing substances - 2-4, organic acids - 2-3, volatile and non-volatile aromatic substances - not more than 4, brown pigments, polyphenols - 6, melanoidins - not more than 10 (RF patent 2111680).

 Known biologically active pharmaceutical product of natural nature, which contains an acid hydrolyzate from Mytilus species containing amino acids, melanoidins and traces of elements from Mytilus edulis and Mytilus galloprovincialis (DE 19934309339, 19930317, A 61 K 35/56). Additionally, the invention includes various uses for this product. In particular, it is used as a prophylactic, therapeutic radiopharmaceutical for humans and animals, has an antipyretic effect, stimulates recovery processes after surgery, and blood production, especially in radio and chemotherapy. The product has a proven effect under psychological and / or physical stress, as well as a geroprotector.

 The use of peptides as a stimulator of mineral absorption and for the prevention of hyperlipidemia and hypercholesterolemia is known (patent EP 0791357, 1997,08.27). Vegetable peptides, in particular excess peptides that have a molecular weight of 200 to 6000 and which contain at least 20 moles or more acidic ammo acids, are used in the manufacture of medicines to stimulate intestinal absorption of minerals such as calcium or iron, or for prevention or treatment hyperlipidemia and hypercholesterolemia. Peptides are obtained by enzymatic hydrolysis of vegetable proteins (19930317, A 61 K 35/56).

 As shown by the analysis of the above sources of information, the range of practical use of known biologically active substances is limited.

 Since a biologically active substance, in accordance with the invention, relates to substances of animal origin, further analysis of the prior art is carried out taking into account this direction.

 The group of inventions relates to biologically active substances, biologically active food additives for humans and animals, and pharmaceutical and veterinary preparations, various food products, cosmetic and hygiene products containing biologically active substances that are used to normalize the physiological state of the body. And also a group of inventions relates to fertilizer and activator of microbiological processes, the growth of plants and plant cells containing a biologically active substance.

 The closest technical solution, in relation to a biologically active substance, will be a biologically active agent (ALS) having an immunomodulating property, which is obtained by grinding and homogenizing raw materials from animal tissue, then a precipitate containing cell membranes is isolated from the homogenate, from which cell components are obtained after resuspension membranes, animal tissue modified during embryogenesis and / or proliferation and / or cell differentiation processes and / or of theology preceding and / or concomitant tissue regeneration and / or repair, the homogenate of which is cleaned of undamaged tissue elements by filtration and / or centrifugation at an acceleration of 150-250 g for 10-15 minutes and a precipitate containing cell membranes is isolated, which is subjected to hydrolysis, hydrolysis products are filtered and / or centrifuged with acceleration of more than 1500 g for 20-40 minutes with the release of the supernatant of hydrolysis products containing cell membrane components as the target product (RF patent 2041717). ALS contains organic compounds: peptides, amino acids, carbohydrates, lipids, nucleotides and other organic compounds in certain proportions by weight. The obtained biologically active agent in an amount of 0.001-85.0 wt.% Used to obtain the drug to normalize the physiological state of the human body and animals. The preparation also contains a filler (physiological solution of sodium chloride, and / or saline buffer solution, and / or carbohydrate compounds, and / or fats of mineral, animal, vegetable or synthetic origin and mixtures thereof), and may also contain a preservative.

Regarding a biologically active food supplement, the closest technical solution is a protein food supplement, which is obtained by freezing and grinding raw materials of animal origin, extraction of biologically active substances with a water-salt solution, where 1-2.5% is used as a water-salt solution sodium carbonate solution with a ratio of the volume of raw materials and sodium carbonate solution in the range from 1: 8 to 1: 20, and the extraction is carried out at a pH of 10.4-10.8 for 2-4 hours in the presence of magnesium chloride in an amount e 0.1-0.5%, after which the extract is acidified to a pH of 3,8-5,5, then removed ballast substances carried precipitate washing with organic solvents and dried at temperature not higher than 55 ^o C, the molecular weight of the incoming in addition to the nucleoprotein components is in the range of 10000-90000 Yes (RF patent 2075944).

 The disadvantages of the known technical solutions are low biological value and a narrow range of applications in the food industry.

 Known pharmaceutical composition for the prevention and treatment of cancer, includes at least three active compounds present in the circulatory system: at least one amino acid, at least one vitamin, and at least one component selected from the group consisting of adenine , 2-deoxyribose, D-mannose, D-glucosamine, malic acid, oxaloacetic acid, adenosine triphosphate and / or their pharmaceutically acceptable salts, given that if the composition contains, in addition to the amino acid, only malic acid and vitamin OTU, the vitamin may be ascorbic acid (RF Patent 2138257).

 The closest technical solution, in relation to a pharmaceutical preparation, will be a drug for the prevention and / or treatment of diseases containing an active principle and a pharmaceutically acceptable carrier, wherein the active principle contains an effective amount of the L-Lys-L-Glu dipeptide or its chemical modifications in in the form of salts (RF patent 2139085).

 As shown by the analysis of the prior art, in relation to biologically active additives for feeding animals, this direction has become very widespread.

 Thus, a feed additive is known from the prior art, including choline and methionine, threonine, while all components are added to a ration balanced in all nutrients and active substances in the following ratio,% of the diet: choline - 0.08-0.12, methionine - 0 , 13-0.16, threonine - 0.13-0.16 (RF patent 2131678).

Known feed additive with biological activity obtained by extraction of biogens in one solution of metal salts under heating and high pressure and subsequent heat treatment at a temperature of at least 450 ^o C for at least 20 minutes (RF patent 2151521, 2000).

 Known prophylactic feed bioconcentrate, which contains a preparation of bifidobacteria and acidophilus bacillus, lactulose syrup in the following ratio of components, wt.%: Preparation of bifidobacteria and acidophilus bacillus - 1.2-92.3, lactulose syrup - the rest, while it may additionally contain vitamins, for example A, and / or group D, and / or E, and / or K, and / or group B, and / or C, and / or H in an amount of 0.0001-12 wt.%, trace elements in an amount of 0.001- 0.8 wt. %, amino acids, for example methionine, in an amount of 0.6-20.0 wt.% (RF patent 2123346).

 The prior art additive for animal feed consisting of copper sulfate, zinc sulfate, magnesium sulfate, selenium sulfate, germanium sulfate, rare earth composition and amino acids, which are subjected to special processing (CN, 1101799, 04/26/1985).

 A food supplement for pets and game, which consists of amino acids extracted from bristles, human hair and feathers, powder from pine needles and Chinese medicine materials, which are mixed and further processed (CN, 1173292, 02/18/1998).

 The disadvantages of these feed additives is that they can only be used as an additive to a balanced diet.

 Known methods for producing protein feed additives from keratin and collagen-containing raw materials by its enzymatic hydrolysis by proteolytic enzymes (see SU, ed. St. 1517005, 1989; SU, ed. St. 1554173, RF patent 2133097).

The disadvantages of the known technologies are the high energy intensity and duration of the hydrolysis process, as well as the use of scarce enzyme systems
The closest technical solution to the claimed biologically active additive for animal feeding will be a biologically active preparation for horses, including a species-specific protein, as which it contains cultivation products of induced lymphoid cells of horses, proteins, amino acids, salts of mineral acids and additionally fatty acids, sugars, ascorbic acid acid, water in the following ratio of components, wt. %: proteins 5.0-60.0, amino acids 1.6-5.0, fatty acids 0.10-12.0, sugars 2.0-20.0, ascorbic acid 0.6-10.0, water 1.0-5.0, salts of mineral acids - the rest (RF patent 2034570).

 The disadvantage of this additive is the narrow range of use.

 The feed additive is known in the art, which in its composition relates to veterinary preparations containing a biologically active component of natural origin, characterized in that it additionally contains an antibiotic, a biosorbent based on yeast of table and champagne wines is used as a biologically active component of natural origin. the surface of the additive particles has an electrokinetic potential of at least 10 mV, while the antibiotic content is 5-50 g per 1 kg of the finished additive, and achestve antibiotic tetracycline derivatives used (RF Patent 2131677).

 Also known from the prior art is a food product for pets, mainly for cats and cats, consisting of edible particles and an edible shell, while the particles consist of a mixture of bicarbonates, proteins, fats, fibers and minerals, and may also contain veterinary medicines, vitamins , trace elements, amino acid preservatives, antioxidants and flavorings (DE 19610389, 07/10/1997).

 Peptides are known that consist of several amino acid molecules and have a molecular weight of from 2500 to 10,000 daltons and an isoelectric point between pH 8-11; they are obtained by extraction from marine invertebrates, in particular from marine anemones. These peptides are used as hypotensively active compounds in veterinary medicine and for human treatment (DE 3325689, 01/17/1985). This veterinary drug is accepted as the closest analogue for the claimed veterinary drug.

 A disadvantage of the known technical solution is a narrow spectrum of action.

 Known activator of microbiological processes, growth of plants and plant cells, containing a mixture of three chemical compounds belonging to the group of ammonium salts of aryl acetic acids, taken in the ratio 0.1: 10.0 0.1: 10.0: 0.1: 10 with a total the amount of the mixture is 1x10-10, 1x10-1 g per 1 g of biomass produced or processed (RU, 2092547). This activator is accepted as the closest analogue in relation to the activator of microbiological processes, the growth of plants and plant cells.

The closest technical solution, in relation to fertilizer, will be fertilizer, which is obtained by mixing algae and animal (from aquatic organisms) raw materials with additional plant components, after which the mixture is fermented at 20-38 ^o C for 28-48 hours, the fermented mass is boiled at 75-85 ^o C for 5-15 minutes, boiled mass is pressed out to obtain a liquid fraction and pulp, fat is separated from the liquid fraction, spent vegetable oil is added to the fat in an amount of 10-90% of the total mass, heated at 50-90 and ^o C. yderzhivayut 30 minutes and the skim milk portion of the liquid fraction is added a preservative, cooled and frozen pulp is dried to a residual mass fraction of water 10% (RF Patent 2095005, 1995).

 The disadvantage of this solution is that the resulting product is not ready for direct use.

 It is widely known that deficiencies in the structure and quality of nutrition are accompanied by the inability of the corresponding protective systems of the body to adequately respond to adverse environmental influences, which sharply increases the risk of many diseases. Therefore, the restoration of the nutrition structure, improving its quality and safety is currently one of the most important and priority tasks.

 So known food mixture for adaptation of the body in a stressful situation, which is obtained by mixing glucose, fructose, oligo - and polysaccharides, amino acid ligand, potassium chloride and water or fruit juice (US patent, 5270297, class A 23 L 3 / 08, 1993).

 The disadvantages are the receipt of a product with a short shelf life and the inability to use it for adaptation in conditions of airtight isolation of the body from the external environment due to the stimulation of urine formation and intestinal motility.

 Known nutritional composition for pediatrics, containing specific amino acids and having a balanced composition suitable for children (US, 4368204, 01/11/1983).

 The closest technical solution for oral nutrition will be an acceptable basic nutritional formula that is suitable for people with specific dietary requirements (US, 6245803, June 12, 2001). A way to support nutrition for a person suffering from food protein allergens involves the use of a composition as the only nutrition source consisting of: a carbohydrate component in an amount of 38-56% cal. from the general content; fat component in an amount of 38-50% cal; free amino acid components in an amount of 10-20% cal. Moreover, the composition may additionally contain vitamins, micro and macro elements.

 The disadvantage of this product is that it has a low biological value.

 It is widely known in the prior art to introduce various biologically active components in the composition of cosmetic preparations, which contribute to increasing skin turgor, smoothing small wrinkles, giving the skin freshness and velvety [author. St. N 822824, 1979, ed. St. N 822825, 1979, ed. St. 1335288, 1985].

 Also widely used are cosmetics containing substances isolated from various organs and tissues of mammals.

 Known cream containing simple and complex lipids of animal origin, amino acids, cocoa butter, glycerin, emulsifier, mineral salts, vitamins, preservative and water [RF patent 2013088, 1994].

 Known cosmetic preparations containing polypeptides from collagen and elastin [US patent 4585797, 1986].

 Known cosmetic product containing a cosmetic base suitable for external use in the form of a lotion, gel, cream or ointment, and a biologically active substance obtained from organs and tissues of animals, a complex of polypeptides with mol. m. 1000-10000 Yes, in an amount sufficient for the manifestation of its biological activity and comprising 0.1-2.0% of the cosmetic base [RF patent 2161974]. This tool is taken as the closest analogue in relation to cosmetic products.

 The disadvantage of this product is its low biological activity.

 Currently, the composition of hygiene products, for example: shampoos containing surfactants, widely includes various components that create favorable conditions for hair growth and normal functioning of the skin.

 Known means for washing hair containing lactic acid, oily extracts from the low-melting fraction of mink fat, calamus rhizomes, fruits of capsicum, chamomile flowers and St. John's wort (ed. St. SSSR 1130347).

 The disadvantage of this known detergent is: the use of expensive lactic acid and the need for the preparation of shampoo using an additional component to reduce the acidity of the shampoo.

 The closest technical solution, in relation to hygiene products, will be a detergent containing a deproteinized whey concentrate and additionally sulfoethoxylates, glycerin, formalin, ethyl alcohol (ed. St. USSR 1342503).

 The disadvantage of this well-known detergent is: the use of a concentrate of deproteinized whey, free of healthy protein, which does not sufficiently contribute to maintaining skin and hair in good condition.

 The closest technical solution for a bakery product is bakery products obtained by kneading dough from flour, water, yeast, a protein fortifier, which is used as a lipid-protein complex from peas in an amount of 2.5-4.5% on a dry matter basis to the mass of flour in the dough, and other components provided by the recipe (RF patent 2098966).

 A confectionery product is known - chocolate, which contains cocoa liquor, cocoa butter, soybean phosphatide concentrate and powdered sugar, powdered soy milk and Nazir balm (RF patent 2128445). In this case, soy milk powder is introduced as a valuable source of protein and essential amino acids.

 In relation to a confectionery product, the closest technical solution is a protein-containing confectionery product, including a protein fortifier, which is used as a protein hydrolyzate from gelatin, a sweetening component, milk powder, flavoring, contains lecithin, alcohol extract of Eleutherococcus with a solids content of 5%, food deodorized vegetable oil and water (RF patent 2043731).

 The disadvantage of this confectionery is the low biological value.

Famous mayonnaise, which includes vegetable protein, skimmed milk powder, sodium alginate, mustard powder, baking soda, salt, sugar, vegetable oil and water. To obtain such mayonnaise, a water-protein mixture is separately prepared, for which 3.0-3.5% of vegetable protein is mixed with water at 35-40 ^o C in a ratio of 1: 7. The mixture is stirred vigorously for 2-5 minutes. Then, 0.3-0.5% sodium alginate and water are added to the suspension in a ratio of 1: (10-15), after which it is pasteurized at 60-65 ^o C with constant stirring for 15-20 minutes and cooled to 30- 35 ^o C. the resulting suspension is introduced into mayonnaise in an amount of 24-28% of the total mass. At the same time, milk mustard paste is prepared. For its preparation, 1.0-1.5% mustard powder and 2.5-3.0% skimmed milk powder are mixed with water at 35-40 ^o C in the ratio 1: (3.5-4.0), add 0 , 05% drinking soda, 2.5-3.0% sugar and 1.0-1.5% sodium chloride. Milk mustard paste is pasteurized at 90-95 ^o C for 15-20 minutes and then cooled to 35-40 ^o C. Cooled milk mustard paste and water-protein suspension are mixed and gradually added to the resulting mixture at 20-25 ^o C 30-40% deodorized vegetable oil and 12-14% acetic acid solution of 6% concentration. Next, the emulsion is homogenized at a pressure of 1.05-2.0 MPa and packaged (USSR copyright certificate 11194370, 1984).

 The disadvantages of this mayonnaise are the need to introduce a large amount of vegetable protein, which gives the product an off-flavor mealy and grayish tint, multi-stage process and the duration of its production, due to the separate preparation of two mixtures and their separate pasteurization.

There is mayonnaise containing vegetable oil, egg and mustard powders, whey powder or whey protein concentrate, sodium alginate, glucose-fructose syrup or sucrose, baking soda, acetic acid, salt. To prepare it, take (0.3-1.0)% sodium alginate and (1.5-2.2)% sucrose, which are dissolved in water at 35-40 ^o C. Then, 1.6- 4.0% dry cheese whey, 0.03-0.05% drinking soda, 1.0-1.5% salt, 3.0-5.0% egg and 0.25-0.75% mustard powders. The resulting mixture was pasteurized at 60-65 ^o C for 20-25 minutes The paste is cooled to 30-35 ^o C and 35-47% of vegetable oil and 0.55-0.75% of acetic acid of 80% concentration are successively introduced into it. The resulting emulsion is homogenized at a pressure of 2.5-5.0 MPa and packaged (USSR copyright certificate 1287833, 1987).

 The disadvantage of this mayonnaise is the need for strict adherence to the input sequence of the components in predetermined proportions, since otherwise the finished product acquires a consistency not characteristic of mayonnaise.

 The closest to the proposed invention in terms of technical essence and the achieved result, with respect to the object - sauce, is a mayonnaise-type sauce, in which, along with skimmed milk powder, whey protein concentrate is introduced in the following ratio of components, wt.%: Vegetable oil 30-65 40, egg powder 0.01-4.50, skimmed milk powder 0.01-6.55, whey protein concentrate 0.50-7.00, dry mustard 0.25-2.50, granulated sugar 0 , 26-3.50, salt 0.90-2.00, drinking soda 0.04-0.10, acetic or citric acid 0.65-1.25, flavoring and fillers 0.001-50.00, water - the rest (USSR copyright certificate 1243687, 1983).

Mayonnaise sauce is prepared as follows. Mustard powder is fed into the container and it is poured with water at 80-100 ^o С, stirred and kept for 1-24 hours. Then the upper layer of water is drained and water, dry whey protein concentrate, egg powder, skimmed milk powder are added to the mustard mass. , baking soda, table salt, granulated sugar and heated to 85-90 ^o C, keeping the mixture at this temperature for 15-20 minutes In cases where the mayonnaise contains egg powder, the mixture is heated to 60 ^o C to prevent protein denaturation. After pasteurization and dissolution of all components, the mixture is cooled to 25-30 ^o C and with constant stirring with a thin stream of deodorized vegetable oil is introduced. Then, after obtaining a homogeneous stable emulsion, a solution of acetic or citric acid, flavoring agents and fillers are introduced. Everything is thoroughly mixed for 5-7 minutes, homogenized at a pressure of 1.0-3.0 MPa and packaged.

 The disadvantages of this mayonnaise are: mandatory joint input of skimmed milk powder and whey protein concentrate; significant consumption of skimmed milk powder (up to 6.55%) and whey protein concentrate (up to 7.0%); low biological value; insufficiently satisfactory rheological indicators of mayonnaise and its storage stability.

 As shown by the analysis of the prior art, amino acids are widely used in beverages.

 So known composition for drinks, having the desired color and having no undesirable taste, while it contains 5-100%, preferably 25-35% USRDI (daily intake) of iron, and the said iron is iron, chelated with amino acids, or encapsulated ferrous sulfate, 5-100% USRDI zinc, preferably in the form of zinc gluconate, 0.001-0.05% coloring agent, preferably selected from the group consisting of Lake Yellow # 6, Lake Red # 40, Lake Blue # 1, riboflavin, beta-k rotin and mixtures thereof, if desired, up to 98%, preferably 10-98% sweetener, preferably sugar, 0.001-10%, preferably 3-5% flavoring agent, said flavoring agent selected from fruit or botanical flavoring agents or mixtures thereof, preferably from the group consisting of flavors "Jamaica", "mango", "orange", "lemon-lime", "strawberry", "peach", "lemon", "lime" and mixtures thereof, and 1-50% food an acid, preferably selected from the group consisting of citric acid, malic acid, tartaric acid, lactic acid, and mixtures thereof (application RF 98109944).

 The closest technical solution, in respect of a non-alcoholic drink, will be a non-alcoholic drink with a rehabilitative effect, containing fruit juice, mono- and / or disaccharides, mineral-organic substrate Lenkin (RF patent 2090107).

 The disadvantage of the product is the inconsistent composition of the mineral-organic substrate lenkin, because the raw material for its production is a mummy-like water-soluble substance that forms in the bowels of the earth's crust and is mined as ore from rock masses.

 Regarding an alcoholic beverage, the closest technical solution will be the special “Polisky Souvenir” vodka, which includes 1000 dal of the finished drink: bee honey - 30 kg, aromatic alcohol of rye malt - 500 l and water-alcohol liquid. The ratio of dry rye malt to rectified ethyl alcohol in the preparation of rye malt aromatic alcohol is / 0.18-0.22 /: 1, which makes it possible to enrich vodka with amylolytic enzymes and amino acids that would facilitate the breakdown of starch in the human body to easily digestible dextrins and maltose thereby improving digestion and vital activity of the human body (RF patent 2112796).

 The disadvantage is the low organoleptic quality of the resulting product.

The closest technical solution in relation to the oil-fat product will be margarine containing solid fat, vegetable oil, emulsifier, dye, dairy product, flavorings and water, as solid fat it contains edible salomas with a melting point of 31-47 ^o C and hardness 160-1000 g / cm or a mixture of edible oil with a melting point of 31-37 ^o C and a hardness of 160-600 g / cm and a melting point of 37-47 ^o C and a hardness of 600-1000 g / cm, and as a dairy product milk powder and / or whey powder and / or whey roto-protein concentrate, and / or dried cream, and / or "BK-lact" (RF patent 2110184).

 The disadvantage is the low biological value.

 An enriched fish product is known from the prior art, which is obtained by treating fish raw materials or semi-finished products with an activator, enrichment, stabilizer or their carriers, and an ambassador of fish raw materials, while carbohydrates, hydrocarbons, nitrogen-containing and mineral substances are used as activators, enrichment, stabilizers, and their derivatives or mixtures (RF patent 2054875). This product is accepted as the closest analogue in relation to the fish product.

 The disadvantage is the low biological value.

In relation to a meat product, the closest technical solution will be a meat product in the form of a paste for therapeutic and prophylactic products, obtained by pretreatment at a temperature of 60-65 ^o C for 2 hours and grinding the meat raw material, making meat, followed by the addition of a protein component, blood plasma, onion, salt, sugar, ground black or white pepper, coriander, filling the shells, cooking the loaves and cooling them, while second-grade beef and meat-and-meat are used as meat raw materials oh deboning (MMD) of pigs, and as the protein component - lentil flour, presoaked in blood plasma in the ratio 1: 1 during 1.5-2.0 hours at a temperature of 20-22 ^o C, at the stage of making further minced powder pumpkin and milk semi-finished product (PTMP), hydrated in water in a ratio of 1: 1 at a temperature of 20-22 ^o C until a homogeneous consistency is achieved (RF patent 2137403). The presence in the composition of blood plasma enriches it with a soluble, easily digestible protein.

 The disadvantage of this product is the low organoleptic properties.

 BACKGROUND OF THE INVENTION Instant pasta products containing flour, a liquid phase, table salt and seasonings, biologically active flavoring additives, and / or preservatives, and / or vitamins are known in the art, the liquid phase being a protein-white aqueous solution, while being protein-white-containing the solution uses a broth of meat and / or chicken concentrates, and / or egg powder or egg proteins, and / or milk powder and a starch-containing element (RF application 97104449). This tool is taken as the closest analogue in relation to pasta.

 The disadvantage is that the added protein-white additives do not provide a product with high organoleptic characteristics.

 The closest technical solution, in relation to chewing gum, will be chewing gum containing flavoring, flavoring, chewing base and food acid (patent US 4931293, 11/14/1988).

 The disadvantage is the low biological activity.

 A beer type beverage is known in which wort is obtained from glucose syrup based on starch, soluble protein material, water and hops, wherein starch glucose syrup is obtained from wheat, potato, corn, sorghum, barley, rice or tapioca, and soluble protein the material contains at least one of the amino acids selected from the following group: glutamine, aspartic acid, asparagine, glutamic acid, series, threonine, lysine and arginine, and in which the composition and concentration of amino acids are sufficient for the implementation of the fermentation process using brewer's yeast (RF application 2000115726). This drink is accepted as the closest analogue in relation to beer.

 The disadvantage of this product is its low biological value.

 The main objective of the present invention is the development of a biologically active substance that is stable and can be easily incorporated into pharmaceutical or veterinary preparations, dietary supplements for humans and animals, as well as in food products and cosmetic preparations, both in solid form and in the form of any convenient solution.

This is achieved by obtaining a biologically active substance (BAS), which can be used as a biologically active food supplement and is a protein hydrolyzate obtained by acid hydrolysis and subsequent neutralization of peptide-containing animal raw materials selected from the following: carcasses of animals or fish, albumin, blood of animals or fish, meat of animals or fish, protein-containing waste in the manufacture of products from animals or fish, filtration to obtain a hydrolyzate and sediment, followed by drying of the hydro isate, while the finished product contains peptides with a molecular weight above 3000 daltons not more than 25 wt.%, optical activity α $\genfrac{}{}{0ex}{}{\text{20}}{\text{D}}$ the finished product is 5-15, the ratio of nitrogen amine: fatty acids: carbohydrates is (10-30) :( 0.2-2) :( 0.4-5), and also contains sodium, chromium, nickel, cobalt, selenium , calcium, potassium, sulfur, phosphorus, chlorine, iron, zinc, copper, manganese.

 Also, a biologically active food supplement can be obtained on the basis of the obtained biologically active substance and a component selected from the series: carbohydrates, lipids, vitamins, vitamin-like substances, mineral components, alkaloids, homeopathic remedies, glycosides, immunoglobulin preparations, lactoferrin, phenolic compounds, organic acids, enzymes, terpenoids, hormones and hormone-like substances, cytokines, plant products, microbial products, beekeeping products, products animal origin, mineral substances of natural origin, detoxicants, processing aids, or mixtures thereof, in the following ratio of components, wt.%: BAS - 10-90, component or mixture of components - the rest.

 In this case, carbohydrates are selected from the series: glucose, fructose, lactose, starch, sucrose, maltose, deoxyribose, soluble and insoluble dietary fiber, inulin, ribose.

 Lipids are selected from the series: triglycerides, phospholipids, sterols, sterols, microbial lipids.

 Vitamins are selected from the range: Vitamin A, Vitamin D, Vitamin E, Vitamin K, Vitamin B1, Vitamin B2, Niacin, Vitamin PP, Nicotinic Acid, Pantothenic Acid, Pyridoxine, Folic Acid, Folacin, Cyanocobalamin, Vitamin C, and Vitamin-Like Substances from the series: biotin, bioflavonoids, orotic acid, pangamic acid, para-aminobenzoic acid PABA, choline, inositol, vitamin T, carnitine, vitamin U, lipoic acid, α-lipoic acid, thioctic acid.

 Mineral components are selected from the series: calcium, phosphorus, magnesium, sodium, potassium, sulfur, chlorine, iron, copper, selenium, iodine, chromium, zinc, fluorine, manganese, cobalt, molybdenum, silicon, bromine, silver, boron, vanadium, germanium.

 The alkaloids are selected from the series: pyrrolidine derivatives, piperidine derivatives, pyridine derivatives, quinoline derivatives, isoquinoline derivatives, indole derivatives, imidazole derivatives, purine derivatives, diterpeno alkaloids, steroid alkaloids, glycoalkaloids, acyclic and peptide.

 Glycosides are selected from the series: saponins, antraglycosides, bitter glycosides, thioglycosides.

 Phenolic compounds are selected from the series: simple phenols, phenolospiets, phenolic acids, coumarins, chromones, lignans, flavonoids, isoflavonoids, flavonones, flavones, rotenoids, tannins, lignin, melanins, humic acids.

 A biologically active food supplement contains enzymes selected from the range: one-component enzymes, two-component enzymes.

 Terpenoids are selected from the series: monoterpenes and their derivatives, sesquiterpenes, diterpenes, sesquiterpenic lactones, triterpene saponins, tetraterpenes and their derivatives.

 A biologically active food supplement contains products of plant origin selected from the range: higher plants, fractionation components of higher plants, lower plants, fractionation components. Moreover, the components of fractionation of products of plant origin can be in the form of infusions, extracts, decoctions, squeezed, powder, and can also be obtained by extraction with various extractants.

 Products of microbial origin are selected from a number of: bifidobacteria, lactobacilli, Escherichia coli, yeast, acidophilus bacilli.

 Technological additives can be selected from a number of: technological components for tabletting, flavoring agents, flavorings, sweeteners, preservatives, colorants, liquids.

 A pharmaceutical preparation contains a biologically active substance and a pharmaceutical base selected from the series: homeopathic remedies, non-narcotic analgesics, sclerotics, remedies for correcting disorders in alcoholism, toxic and drug addictions, regenerants, currants, vegetotropic remedies, hematotropic agents, hormones and their antagonists, immunotropic drugs, intermediates, neurotropic drugs, organotropic drugs, antimicrobial agents, anthelmintic drugs, antitumor drugs, tech biological additives, or their mixture, in the following ratio of components, wt.%: BAS - 0.0001-50, the pharmaceutical base - the rest.

 At the same time, vegetotropic drugs are selected from the series: adrenolytic drugs, adrenomimetic drugs, anticholinergic drugs, cholinomimetic drugs.

 Hematotropic drugs are selected from the series: antiplatelet agents, anticoagulants, substitutes for plasma and other blood components, fibrinolysis inhibitors, coagulants, blood coagulation factors, hemostatic agents, hematopoiesis stimulants, fibrinolytics.

 Hormones and their antagonists are selected from the series: androgens, antiandrogens, glucagon and its analogues, hypothalamic hormones, pituitary glands, gonadotropins and their antagonists, thyroid hormones, their analogues and antagonists, antithyroid drugs, insulins, corticosteroids, estrogens, their progestogens and gestagens antagonists.

 Immunotropic drugs are selected from the series: immunoglobulins, immunosuppressants, immunomodulators.

 Intermediates are selected from the series: adenosinergic agents, angiotensin II receptor antagonists AT1-subtype, histaminergic agents, dopaminomimetics, prostaglandins and their antagonists, thromboxanes and their antagonists, leukotrienes and their antagonists, serotonergic agents.

 Metabolics are selected from a number of: anabolics, antihypoxants and antioxidants, vitamins and vitamin-like drugs, hypoglycemic synthetic and other drugs, lipid-lowering drugs, detoxifying agents, antidotes, correctors of bone and cartilage tissue metabolism, macro- and micronutrients, rehydrants, regulators of water-electrolyte balance and KShchS, means that affect the metabolism of uric acid, agents for enteral and parenteral nutrition, enzymes and antifermenta, agents that prevent the formation and contribute to ra the creation of calculi.

 Neurotropic drugs are selected from the series: anxiolytics, sedatives and hypnotics, antidepressants, antipsychotics and lithium preparations, general tonic, general strengthening drugs and adaptogens, opioids and their analogs and antagonists, antiparkinsonian drugs, antiepileptic drugs, psychostimulants and neuroprotective drugs, .

 Organotropic drugs are selected from the series: dermatotropic drugs, gastrointestinal drugs, respiratory drugs, cardiovascular drugs, myotropic antispasmodics, drugs that regulate the function of the genitourinary system and reproduction.

 Antimicrobial agents are selected from the series: antibiotics, antiviral agents, antifungal agents, antimicrobial agents in combinations, synthetic antibacterial agents.

 Antineoplastic agents are selected from the series: alkylating agents, antimetabolites, antitumor antibiotics, antitumor hormones and hormone antagonists, antitumor drugs of plant origin, including alkaloids.

 Non-narcotic analgesics are selected from the series: non-steroidal drugs, anti-inflammatory drugs.

 Technological additives are selected from the series: technological components for tabletting, flavoring agents, aromatic additives, sweeteners, liquids, suppository base, film base, gel base, hydrophilic base, powder base, lipophilic base, diphilic base, ointment base .

 A dietary supplement for feeding animals contains a biologically active substance and a component selected from the range: carbohydrates, lipids, vitamins, vitamin-like substances, mineral components, alkaloids, homeopathic remedies, glycosides, immunoglobulin preparations, phenolic compounds, organic acids, enzymes, terpenoids, hormones and hormone-like substances, cytokines, plant products, microbial products, beekeeping products, animal products, mineral-containing substances of natural origin, detoxifiers, processing aids, or mixtures thereof, in the following ratio of components, wt.%: BAS - 10-90, component or mixture of components - the rest.

 Carbohydrates are selected from the range: glucose, fructose, lactose, starch, sucrose, maltose, deoxyribose, soluble and insoluble dietary fiber, inulin, ribose.

 Lipids are selected from the series: triglycerides, phospholipids, sterols, sterols, microbial lipids.

 Vitamins are selected from the series: Vitamin A, Vitamin D, Vitamin E Vitamin K, Vitamin B1, Vitamin B2, Niacin, Vitamin PP, Nicotinic Acid, Pantothenic Acid, Pyridoxine, Folic Acid, Folacin, Cyanocobalamin, Vitamin C.

 Vitamin-like substances are selected from the series: biotin, bioflavonoids, orotic acid, pangamic acid, para-aminobenzoic acid PABA, choline, inositol, vitamin T, carnitine, vitamin U, lipoic acid, α-lipoic acid, thioctic acid.

 Mineral components are selected from the series: calcium, phosphorus, magnesium, sodium, potassium, sulfur, chlorine, iron, copper, selenium, iodine, chromium, zinc, fluorine, manganese, cobalt, molybdenum, silicon, bromine, silver, boron, vanadium, germanium.

 The alkaloids are selected from the series: pyrrolidine derivatives, piperidine derivatives, pyridine derivatives, quinoline derivatives, isoquinoline derivatives, indole derivatives, imidazole derivatives, purine derivatives, diterpeno alkaloids, steroid alkaloids, glycoalkaloids, acyclic and peptide.

 Glycosides are selected from the series: saponins, antraglycosides, bitter glycosides, thioglycosides.

 Phenolic compounds are selected from the series: simple phenols, phenolospiets, phenolic acids, coumarins, chromones, lignans, flavonoids, isoflavonoids, flavonones, flavones, rotenoids, tannins, lignin, melanins, humic acids.

 Enzymes are selected from the series: one-component enzymes, two-component enzymes.

 Terpenoids are selected from the series: monoterpenes and their derivatives, sesquiterpenes, diterpenes, sesquiterpenic lactones, triterpene saponins, tetraterpenes and their derivatives.

 Plant products are selected from the series: higher plants, components of fractionation of higher plants, lower plants, components of fractionation of lower plants.

 Products of microbial origin are selected from the series: bifidobacteria, lactobacilli, Escherichia coli, yeast acidophilus coli.

 Technological additives are selected from the range: technological components for tabletting, flavoring agents, flavorings, sweeteners, preservatives, colorants, liquids.

 The veterinary preparation contains a biologically active substance and a pharmaceutical base selected from the range of: homeopathic remedies, non-narcotic analgesics, sclerotics, remedies for correcting disorders in alcoholism, toxic and drug addictions, regenerants, currants, vegetotropic agents, hematotropic drugs, hormones and their antagonists, immunotropic drugs , intermediates, neurotropic agents, organotropic drugs, antimicrobial agents, anthelmintic agents, antitumor agents, processing aids, or mixtures thereof , With the following ratio of components, wt%: BAS - 0,0001-50 pharmaceutical basis - the rest..

 Vegetotropic drugs are selected from the range: adrenolytic drugs, adrenomimetic drugs, anticholinergic drugs, anticholinergic drugs.

 Hematotropic drugs are selected from the series: antiplatelet agents, anticoagulants, substitutes for plasma and other blood components, fibrinolysis inhibitors, coagulants, blood coagulation factors, hemostatic agents, hematopoiesis stimulants, fibrinolytics.

 Hormones and their antagonists are selected from the series: androgens, antiandrogens, glucagon and its analogues, hypothalamic hormones, pituitary glands, gonadotropins and their antagonists, thyroid hormones, their analogues and antagonists, antithyroid drugs, insulins, corticosteroids, estrogens, their progestogens and gestagens antagonists.

 Immunotropic drugs are selected from the series: immunoglobulins, immunosuppressants, immunomodulators.

 Intermediates are selected from the series: adenosinergic agents, angiotensin II receptor antagonists AT1-subtype, histaminergic agents, dopaminomimetics, prostaglandins and their antagonists, thromboxanes and their antagonists, leukotrienes and their antagonists, serotonergic agents.

 Metabolics are selected from a number of: anabolics, antihypoxants and antioxidants, vitamins and vitamin-like drugs, hypoglycemic synthetic and other drugs, lipid-lowering drugs, detoxifying agents, antidotes, correctors of bone and cartilage tissue metabolism, macro- and micronutrients, rehydrants, regulators of water-electrolyte balance and KShchS, means that affect the metabolism of uric acid, agents for enteral and parenteral nutrition, enzymes and antifermenta, agents that prevent the formation and contribute to ra the creation of calculi.

 Neurotropic drugs are selected from the series: anxiolytics, sedatives and hypnotics, antidepressants, antipsychotics and lithium preparations, general tonic, general strengthening drugs and adaptogens, opioids and their analogs and antagonists, antiparkinsonian drugs, antiepileptic drugs, psychostimulants and neuroprotective drugs, .

 Organotropic drugs are selected from the series: dermatotropic drugs, gastrointestinal drugs, respiratory drugs, cardiovascular drugs, myotropic antispasmodics, drugs that regulate the function of the genitourinary system and reproduction.

 Antimicrobial agents are selected from the series: antibiotics, antiviral agents, antifungal agents, antimicrobial agents in combinations, synthetic antibacterial agents.

 Antineoplastic agents are selected from the series: alkylating agents, antimetabolites, antitumor antibiotics, antitumor hormones and hormone antagonists, antitumor drugs of plant origin, including alkaloids.

 Non-narcotic analgesics are selected from the series: non-steroidal drugs, anti-inflammatory drugs.

 Technological additives are selected from the series: technological components for tabletting, flavoring agents, aromatic additives, sweeteners, liquids, suppository base, gel base, film base, powder base, hydrophilic base, lipophilic base, diphilic base, ointment base .

 Upon receipt of a biologically active substance, a precipitate is obtained at the filtration stage, which is used as a fertilizer.

The activator of microbiological processes, plant growth and plant cells is a solution of biologically active substances with a concentration of 1 • 10 ^-1 -1 • 10 ^-12 %.

 Oral nutrition contains a BAS and an acceptable food base, with the following ratio of components, wt.%: BAS - 0.001-50, an acceptable food base - the rest.

 Perfume and cosmetic product contains a biologically active substance and a perfume and cosmetic acceptable base for external use, selected from the following: fat-based module, emulsion-based module, gel-based module, water-alcohol-based module, in the following ratio of components, wt.% : BAS - up to 20, perfume and cosmetic base - the rest.

 The hygienic product contains a biologically active substance and a hygienically acceptable base for external use, selected from the range: module for toothpaste, module for shampoo, module for liquid soap, module for soap, foam base, wt.%: Biologically active substance - up to 20, perfumery and cosmetic base - the rest.

 The milk product contains a biologically active substance and a milk base selected from the series: milk module, cottage cheese module, sour-milk module, with the following ratio of components, wt.%: Biologically active substance - up to 25, milk basis - the rest.

 The confectionery product contains a biologically active substance and a base selected from the range: module for sweets, module for jelly products, module for marmalade, module for soufflé, module for fudge, module for chocolate, module for oriental sweets, module for sorbet, in the following ratio of components, wt.%: biologically active substances - up to 25, the basis - the rest.

 A bakery product contains a biologically active substance and a base selected from the series: module for gingerbread, module for cakes, module for cookies, module for wafers, module for bread, module for bakery products, in the following ratio of components, wt.%: Dietary supplement to food - up to 40, the basis - the rest.

 The oil-fat product contains a biologically active substance and a base selected from the range: margarine, butter, vegetable oil, combination oil, oil substitute, fat, in the following ratio, wt.%: Biologically active substance - up to 15, the base - the rest.

 Sauce, a biologically active food supplement, obtained according to claim 1, and a base selected from the series: module for mayonnaise, module for ketchup, module for dressing, module for adjika, soybean module, seasoning module, horseradish, mustard, in the following the ratio of components, wt. %: BAS - up to 25, basis - the rest.

 An alcoholic beverage contains a biologically active substance and a water-alcohol base, in the following ratio of components, wt. %: BAS - up to 35, water-alcohol base - the rest.

 A soft drink contains a biologically active substance and a base selected from the series: drinking water, mineral water, juice, nectar, fruit drinks, lemonade, mineralized water, non-alcoholic beer, kvass, in the following ratio of components, wt. %: BAS - up to 15, the basis - the rest.

 The fish product contains a biologically active substance and a fish base, with the following ratio of components, wt.%: Biologically active substances - up to 40, fish base - the rest.

 The meat product contains a biologically active substance and a base selected from the range: module for cooked sausage, module for cooked smoked sausage, module for smoked sausage, module for meat products, module for minced meat, module for raw smoked sausage, module for sausages, module for sausages sausages, in the following ratio of components, wt.%: biologically active substances - up to 40, the base - the rest.

 Pasta contains biologically active substances and a test base, with the following ratio of components, wt.%: Biologically active substances - up to 35, test basis - the rest.

 Chewing gum contains a biologically active substance and a module for chewing gum, in the following ratio, wt. %: BAS - up to 25, the module for chewing gum - the rest.

 Beer contains biologically active substances and a beer base, with the following ratio of components, wt.%: Biologically active substances - up to 40, beer base - the rest.

 The biologically active substance contains the following amino acids: lysine, histidine, arginine, aspartic acid, threonine, serine, glutamic acid, proline, glycine, alanine, cystine, valine, methionine, isoleucine, leucine, tyrosine, phenylalanine.

 The technical result of the claimed invention is the versatility of the use of biologically active substances due to the wide range of its application and non-waste process for its production. And also the chemical composition of biologically active substances has a close affinity at the cellular level with human, animal and plant cells, which is ensured by the molecular weight of peptides and the optical density of biologically active substances. In addition to the physical and chemical parameters providing biological activity, this substance, when introduced into other products, gives the finished products high technological properties, for example: increase the shelf life of finished products, increase product stability (beer, soft drinks, sauces, hygiene products, oil and fat products and dairy products), structural and rheological properties with high water-holding capacity (meat products, bakery products, confectionery and pasta).

 Human nutrition is one of the most important environmental factors and affects the human body throughout life. Nutrients, being transformed in the process of metabolism into structural and functional elements of cells, provide physical and mental performance, determine the health and life expectancy of a person. Eating disorders always lead to one or another negative consequences. Therefore, rational nutrition adequate to age, professional activity, and health status is considered as the most important factor in the prevention of most human diseases, including cardiovascular (atherosclerosis, myocardial infarction, stroke, hypertension, etc.), oncological, gastrointestinal, and metabolism (obesity, osteochondrosis) (T. L. Pilate and others. "Biologically active food additives", M., 2002, p.11).

 To do this, it is necessary to optimize human nutrition in order to improve health, reduce the risk of developing diseases, prevent and treat diseases as part of nutritional measures by replenishing the complex of biologically active substances that our body lacks due to a sharp change in the structure of nutrition; compensation of additional loads on the human body arising from the development of diseases and man-made civilization (urbanization).

 Optimization of human nutrition can be achieved both by the direct use of biologically active food additives, and by consuming food products containing complexes of biologically active substances in the form of functional ingredients.

 Therefore, this invention is directed not only to the creation of a biologically active substance and a biologically active food supplement, but also to the production of food products with high biological and organoleptic properties.

 In the present invention, the terms “module” and “base” should be understood as the classic composition acceptable for this type of product.

 Studies have shown that biologically active substance has hematocorrective activity. Its use contributes to a more rapid restoration of hematopoiesis after the use of the cytostatic cyclophosphamide or total gamma radiation. The most effective is the course (5-10-day) application. BAS is active both with parenteral administration and with the introduction into the stomach. The equal effectiveness of the use of biologically active substances in doses of 100 and 1000 mg / kg allows us to judge the large breadth of therapeutic doses of the drug. This allows us to recommend BAS for study in the clinic as a hematocorrector.

 Based on the biologically active substance and technological additives, a biologically active food supplement was obtained. Tests of the obtained dietary supplement allowed us to attribute it to substances of the energy-plastic and activating metabolic type of action. Dietary supplement has a stimulating effect on the sympatho-adrenaline system of the body, optimizing on the psychophysiological functions and adaptation processes, normalizing the effect on the person’s reserve capabilities, mental and physical performance, and the state of night sleep, helps to reduce the recovery time of psychophysiological shifts after work. It was also found that the use of dietary supplements is more effective than control to increase the stability of the human operator while ensuring operability in extreme conditions. Compared with the control, a pronounced bioprotective effect was found to increase the natural resistance of the human body both in the period preceding activities in special and extreme conditions, and directly during its implementation, as well as in the recovery period.

 A bioprotective and optimizing effect of dietary supplements on body functions and operator activity indicators was identified when working under adverse factors and operating conditions (the effects of noise, high and low ambient temperatures, high static load, psycho-emotional stress, orthostatic loads, high level functional stress).

 It has been established that dietary supplements are an additional, important means of maintaining performance and accelerating the restoration of functional changes in athletes and specialists working in adverse environmental conditions. The use of dietary supplements can serve as a means of improving adaptability, prevention of professional fatigue, prenosological functional changes, and prevent chronic depletion of the body's functional reserves.

 A two-month intake of dietary supplements contributed to a decrease in the biological aging rate of testers and an increase in energy capabilities in comparison with the results of background studies. These preliminary experimental data substantiate the possibility of using dietary supplements in order to extend the professional longevity of various contingents.

 The use of biologically active substances in the experiment showed that the drug increases the body's resistance and has protective properties when damaged by cyclophosphamide and radiation, contributes to a more rapid restoration of the hematopoietic system, and has a stimulating effect on the phagocytic activity of neutrophils. The use of biologically active substances in the study of the laws of chemical carcinogenesis of the gastrointestinal tract in the experiment showed a decrease in the incidence of tumors by 10-12%, which indicates the antitumor effect of the drug. The use of the claimed pharmaceutical preparation in the form of an ointment for skin damage contributed to a reduction in the healing time by 1/3. A pharmaceutical preparation can be introduced into the body by intramuscular injection, inhalation, suppository, sublingual administration, vomiting, intraoral administration in pills, intranasal administration, or by application to mucous or wound surfaces in the form of compresses, powders, ointments and gels.

 An acceptable perfume and cosmetic base for external use can be aqueous solutions of alcohols, all types of emulsions, gels and a greasy base. The use of one specific base selected from the group of the above substances and a biologically active substance makes it possible to compose various types of perfumes and cosmetics in accordance with the invention, such as tonic, creams, balms, milk for cleansing the skin, nail cream, massage cream, lipstick, mascara, makeup base, etc. for everyday body care. A particularly good effect when using new cosmetic compositions is observed when herbal extracts are also present in the composition. The selection of a suitable herbal extract is based on the well-known usual use of such extracts in cosmetics with a change in the activity of drugs and thereby allowing the content of cosmetic preparations to be adapted to the requirements and needs of a person.

 Also, with the use of biologically active substances, various hygiene products can be obtained: shampoos, hair balms, foaming agents for baths, soaps, toothpastes, elixirs, etc., which also have high biological properties.

 Wastes from the production of biologically active substances at the filtration stage are widely used as fertilizers. Studies have shown that the resulting fertilizer is optimally balanced for a set of macro- and microelements.

 When using biologically active additives for feeding animals, it was shown that the biologically active components of biologically active substances are in the optimal ratio. Therefore, when using food containing dietary supplements, the biotonus of the body of animals and birds increases, the metabolism normalizes, which leads to an increase in the working capacity and productivity of animals and birds.

Example 1: Biologically active substance (BAS)
Fish meat is ground and acid hydrolyzed in 15% sulfuric acid until a negative reaction is obtained on the protein, then it is neutralized and filtered to obtain a hydrolyzate and a precipitate, the resulting hydrolyzate is spray dried, and the finished product contains peptides with a molecular weight of above 3000 daltons 15 wt. %, optical activity α $\genfrac{}{}{0ex}{}{\text{20}}{\text{D}}$ the finished product is 8, the ratio of nitrogen amine: fatty acids: carbohydrates is 15: 1.3: 2.8 and contains sodium, chromium, nickel, cobalt, selenium, calcium, potassium, sulfur, phosphorus, chlorine, iron, zinc, copper, manganese.

Example 2: Dietary Supplement
A dietary supplement in the form of a tablet contains:
BAS - 0.3 g
Immunoglobulin fraction of human serum - 0.1 g
Bifidobacteria - 0.007 g
Vitamin A - 1650 ME
Vitamin E - 0.005 g
Vitamin C - 0.05 g
Skimmed milk powder - 0.1 g
Fragrance - 0.001 g
Calcium Stearate - 0.01 g
CMC - Up to a tablet weight of 0.55 g
The resulting biologically active food supplement has high biological value.

Example 3: Pharmaceutical Preparation
A pharmaceutical preparation in the form of a tablet contains:
BAS - 0.2 g
Emoxipin - 0.2 g
Starch - 0.05 g
Talc - 0.05 g
Sugar - 0.5 g
In the narcological hospital, the use of the obtained drug was tested in the clinic for the relief of withdrawal symptoms of hangover.

 The drug was taken in 2 groups of 10 people each. The first group included patients with mild signs of withdrawal symptoms without pronounced intoxication manifestations with short drinking periods, reduced alcohol intake while maintaining hemodynamics and a relatively calm state of health. Taking the drug allowed to stop the disorder without the use of tranquilizers, vitamin therapy and other detoxification agents.

 The second group also selected 10 people with severe withdrawal symptoms of vegetative, somato-vegetative type with mood changes, increased blood pressure, with long periods of binge and with a high degree of tolerance. Taking the drug in a dose of 2 tablets 2 times a day for 7 days allowed, together with detoxification therapy, vitamin therapy, to normalize hemodynamic disturbances, remove somatic and autonomic disorders, and create a favorable mood background. In some cases, taking the drug was accompanied by the introduction of haloperidol at night.

 Thus, the use of the drug in the practice of treating alcoholism is quite effective and requires further use for the treatment of exacerbation of alcoholism.

Example 4: Pharmaceutical Preparation
A pharmaceutical preparation in the form of a tablet contains:
BAS - 0.2 g
Human immunoglobulin G - 0.2 g
Interferon-α - 0.02 g
Fragrance - 0.005
Magnesium Stearate - To tablet weight 0.5 g
Example 3: Pharmaceutical Preparation
A pharmaceutical preparation in the form of a suppository contains:
BAS - 0.1 g
Human immunoglobulin G - 0.05 g
Chamomile Flower Extract - 0.02 g
Suppository polyethylene base - Up to 1.4 g suppository mass
Example 5: Pharmaceutical Preparation
A pharmaceutical preparation in the form of an ointment contains:
BAS - 5.0 g
Streptocide - 5.0 g
Oil-fat base - 90.0 g
The resulting ointment contributes to the rapid healing of wounds.

Example 6: Dietary supplement for animal feed
Dietary supplement for feeding animals contains (per 1 kg):
BAS - 500 g.

 Vitamin and mineral premix - 500 g.

In horse breeding, dietary supplements are used in a mixture with porridge once a day at a dose of 80 mg / kg body weight. As the tests showed, in horses treated with dietary supplements, the power reserve is maintained throughout the entire running distance. They did not lose their pace at the end of the race, which happened in the horses of the control group
Example 7: Veterinary drug
A veterinary preparation in the form of a powder contains:
BAS - 10 wt.%
Phthacin - 90 wt.%
The resulting veterinary drug is used to treat calves with gastroenterocolitis. The drug is used orally 30 minutes before feeding with warm water at a dose of 150-350 mg per 1 kg of animal weight 1-2 times a day
Example 8: Fertilizer
The blood of animals is subjected to acid hydrolysis in 19% sulfuric acid to a negative reaction to protein, then they are neutralized and filtered to obtain a hydrolyzate and a precipitate, the resulting precipitate is used as fertilizer.

Example 9: Activator of microbiological processes, plant growth and plant cells
The influence of biologically active substances on the processes of callus formation and regeneration in cereal plants was studied. Biologically active substances at a concentration of 10 ^-5 were added to the nutrient media of Linsmeier and Skoog (when cultivating wheat tissue) and Gamborg B5 (when cultivating barley tissue). As a control, we studied the tissue cultivation of these cultures in the presence of traditional stimulants (6-BAP, kinetics, and IAA, when studying the effect on regeneration). As the analysis showed, the number of regenerated plants with the addition of biologically active substances in the nutrient medium in wheat is 2 times higher than in control, and in barley 2.5 times. It should be noted that when using biologically active substances in other quantities, the positive effect is observed to a lesser extent.

 Thus, the addition of biologically active substances to the nutrient medium as a stimulant leads to a substantial increase in the frequency of callus formation and regeneration.

Example 10: Oral Nutrition
The components are prepared for mixing, while all bulk products are inspected, sieved and passed through a magnetic trap. Next, prepare the mixture by sequential introduction into the mixer of bulk components and biologically active substances. Stirred and the mixture thus obtained is Packed in airtight packaging and stored until use. The shelf life of the mixture without changing consumer properties is at least 2 years. Before use, the mixture is diluted with boiled or disinfected water. The reconstituted mixture is an opaque liquid that does not contain a solid phase and is suitable for consumption through a water intake system. The mixture is prepared from pre-prepared glucose, freeze-dried juice, potassium chloride, citric acid, dry biologically active substances, in a ratio of 1: 6: 2.

 Thus, the obtained nutrient mixture of long-term storage has adaptogenic and radioprotective properties.

Example 11: Cosmetic
A fat-based cream containing: biologically active substance - 0.1, paraffin - 7-11, beeswax - 5-9, ceresin - 4-8, oil extracts of nettle, St. John's wort, chamomile, calendula - 5-10, olive oil - 10-20, perfume oil - up to 100.

 The resulting cream is easily and evenly applied to the skin, quickly absorbed without leaving a film. It has a beneficial effect on the skin, which is associated with the inclusion of a biologically active additive, natural fatty components in its composition. In particular, prolonged exposure to the cream improves the water-holding properties of the skin by 15.1% / according to moisture measurement /. The elasticity of the skin increases in terms of elastometry by 17%.

 The skin after regular use of the cream becomes smooth, elastic, the feeling of tightening is removed after washing, the phenomenon of irritation, peeling.

Example 12: Cosmetic
Face gel containing: biologically active substance 0.5, carbopol 0.2-0.6, hydroxyethyl cellulose 0.1-1.0, propylene glycol 1-5, triethanolamine 0.1-0.6, alcohol water-glycerin extracts of calendula, chamomile, nettle - 1-4, water - up to 100. The tool is prepared as follows.

A biologically active substance in an amount of 0.5% of the cosmetic base is obtained by the method described in example 1. The components are fed into the reactor through dispensers. The components are sequentially introduced into the reactor and mixed. The gel-forming components are dispersed in water at 150 ^o C. After swelling and uniform distribution, i.e. the formation of a dispersion, the homogeneous mass is neutralized and cooled, with stirring, to room temperature. Then, with stirring, the biologically active substance is added. Then filtering and packaging.

 The inventive tool increases the body's resistance to damaging effects. The use of a prescription product enhances skin elasticity and strengthens the contours of the face, prevents the destruction of the structure of the fibers of the skin of the face and neck, restores the skin surface and enhances skin elasticity.

Example 13: Hygiene Product
To obtain shampoo, a quantity of 7.8 kg of water is loaded into the digester and heated to 70 ^° C. When the stirrer is on and heating is on, pre-molten monoethanolamides in the amount of 0.5 kg are fed. After their complete dissolution, slowly, in portions, with constant stirring, ethoxylated sodium lauryl sulfate in the amount of 2.0 kg is supplied. Then add calendula hydrophytoconcentrate in an amount of 0.005 kg, previously dissolved in a small amount of water. The mass is cooled and at 45-50 ^o C served citric acid in an amount of 0.001 kg resorcinol 0.05 kg, 0.13 kg of a perfume, a biologically active agent in an amount of 0.5 kg, a colorant 0.00025 kg salt 0.5 kg After cooling the entire mass, the shampoo is ready.

 The resulting shampoo is stable during storage and has a high biological activity.

Example 14: Dairy Product
The dairy product in the form of a paste contains, wt.%:
BAS - 3
Curd 9% fat - 80
Whole milk - 8
60% sugar syrup - 5%
Water - Else
The resulting product has high structural and rheological properties and high biological activity.

Example 15: Confectionery
To obtain chocolate, a mixture is prepared from grated cocoa, powdered soy milk and powdered sugar with 26% of the prescribed amount of cocoa butter. Mixing is carried out at a temperature of 60 ^o C for 8 minutes The resulting mixture is ground in a five-roll mill, and then mixed with the remaining amount of cocoa butter at a temperature of 50 ^o C to achieve a viscosity of 130 p mass. At the end of mixing add BAS and flavor. The finished chocolate mass is sent to the casting of the tiles.

 The components of chocolate are taken in the following ratio, wt.%: Cocoa mass - 40.1; cocoa butter - 9.1; BAS - 0.5; milk powder - 10.8; icing sugar - the rest.

 The resulting product has a taste of dark chocolate and has a pronounced biological effect.

 Example 16: Bakery product.

 The dough is prepared from 100 g of wheat flour 1 s., 3 g of pressed baker's yeast, 1.3 g of salt, 10 g of biologically active substances, 0.08 g of citric acid, 0.04 g of acetic acid. The kneaded dough is subjected to fermentation for 30 minutes, cutting, proofing and baking.

 The resulting product has high organoleptic and biological characteristics.

Example 17: Oil-fat product
Margarine composition,%: edible salomas with trm 36 ^o C, hardness 550 g / cm - 25, sunflower oil - 54.5, emulsifier - 0.40, dye - 0.15, flavorings - 0.50, milk powder - 1,0, BAS - 1,0, water - the rest, total - 100. The resulting margarine is packaged in PVC glasses, has a finely divided structure with a pronounced milk flavor and a shelf life of about 90 days at a storage temperature of 0 to +5 ^o C.

Example 18: Mayonnaise
In the mixer in accordance with the recipe serves water with a temperature of 35-40 ^o C and dry components: granulated sugar, salt, egg powder, mustard powder, baking soda, biologically active substances. The prepared mixture is heated to a temperature of 45-50 ^o C and incubated for 20-25 minutes The resulting mass is cooled to 30 ^o With and injected with vegetable oil and a solution of acetic or citric acid. The resulting emulsion is homogenized at a pressure of 2.0-5.0 MPa.

In the following ratio of components included in the formulation, wt.%:
Vegetable oil - 30.00-65.40
Egg Powder - 0.01-4.00
Biologically active substance - 1.5-10
Dry mustard - 0.50-1.20
Sugar - 0.80-2.50
Salt - 0.1-1.6
Drinking soda - 0.03-0.10
Acetic or citric acid - 0.10-0.47
Flavoring additives and fillers - 0.001-50.00
Water - Else
The use of biologically active substances can improve the quality and biological value of mayonnaise due to its multifaceted action, which improves the organoleptic and rheological properties of the final product.

 The high quality and biological value of the proposed mayonnaise is due to the content in the biologically active substance of protein nitrogen compounds, carbohydrates, immune proteins, mineral salts, trace elements, as well as water and fat-soluble vitamins.

Example 19: Alcoholic Drink
Vodka contains: a filtrate of a water-alcohol infusion of biologically active substances with a strength of 40% - 10 wt. %; aqueous-alcoholic liquid from rectified ethyl alcohol - the rest.

 The resulting vodka tastes good.

Example 20: Soft Drink
To obtain 100 l of the drink take the components in the following ratio (kg): BAS 0.4; sugar 33.0; plum juice rest.

 The drink has a sufficiently high biological activity, increases the immunity of patients with drug addiction and chronic alcoholism.

Example 21: Fish product
To obtain fish cakes, the following components are fed into the mixer, kg:
Mackerel - 15
BAS - 15
Saline in an amount of 10 l
Black pepper spices - 1
Coriander - 0.15 g
Sugar - 0.1
Pollock - Rest
The resulting fish cakes are frozen. The resulting product has a pleasant taste and high biological properties.

Example 22: Meat Product
To obtain the stuffing, the mixer is fed in the following sequence and quantities, kg:
Cutlet beef - 52
Pork meat - 22
Saline in an amount of 13.6 l
BAS - 12
Spices black pepper - 0.1
Coriander - 0.15 g
Sugar - 0.1
Mixing is carried out until a homogeneous mass. The prepared meat is subjected to grinding on a top with a diameter of the holes of the lattice 3 mm Molded convenience foods are frozen and packaged.

Example 23: Pasta
To obtain instant pasta, dough is prepared by mixing flour, salt, food additives, preservatives, biologically active substances and fats with water, a semi-finished product is formed and processed with steam, portioned, moisture removed, cooled, packed and packaged, in the following ratio of components, wt .%: flour - 75, salt - 10, food additives - 0.02, preservatives - 0.002, biologically active substances - 1, fats - 2, water - the rest.

 The resulting pasta have high organoleptic characteristics and have high biological activity.

Example 24: Chewing Gum
Chewing gum contains: a base comprising a modified resin, a plasticizer, a flavoring agent, a sweetener and a biologically active substance in the following ratio of components, wt.%:
BAS - 5
Modified Resin - Up to 80
Plasticizer - 10
Flavoring additives:
Sweetener Flavoring - Other
The resulting chewing gum has a pleasant taste and high biological properties.

Example 25: Beer
A method of preparing a beer-type beverage involves the following steps: mixing glucose syrup rich in fermentable sugars and biologically active substances in an amount of 20% of the amount of syrup, to obtain a wort composition, boiling the wort with hops for flavoring, clarification, cooling the wort and aeration, introduction brewer's yeast into wort, wort fermentation to convert sugar to ethanol and carbon dioxide to produce immature or young beer, ripening or aging of the fermented wort, usually by means of a second fermentation, and filter radios, pasteurization and bottling of beer.

 Due to the content of nutrient and stimulating components in it, a biologically active substance has a healing effect on the human body and mammals, therefore, bioactive compositions obtained from peptide-containing animal raw materials contain biological substances in proportions characteristic of living organisms; this can be considered as an explanation of the beneficial effects of food, cosmetic, hygienic and pharmaceutical preparations containing bioactive compositions obtained from peptide-containing animal raw materials.

 The claimed group of inventions is united by a single inventive concept, which is aimed at providing a person with nutrients necessary for the body, through the introduction into the diet and use of various products containing biologically active substances.

Claims (72)

1. Biologically active substance (BAS), characterized in that it is a protein hydrolyzate obtained by acid hydrolysis and subsequent neutralization of peptide-containing animal raw materials selected from the following: carcasses of animals or fish, albumin, blood of animals or fish, meat of animals or fish , protein-containing waste in the production of products from animals or fish, filtration to obtain a hydrolyzate and sediment, followed by drying of the hydrolyzate, while the finished product contains peptides with a molecular weight above 3000 Alton not more than 25 wt.%, the optical activity of α $\genfrac{}{}{0ex}{}{\text{20}}{\text{D}}$ the finished product is 5-15, the ratio of nitrogen amine: fatty acids: carbohydrates is (10-30) :( 0.2-2) :( 0.4-5), and also contains sodium, chromium, nickel, cobalt, selenium , calcium, potassium, sulfur, phosphorus, chlorine, iron, zinc, copper, manganese. 2. A biologically active food supplement, characterized in that it contains a biologically active substance (BAS), obtained according to claim 1, and a component selected from the series: carbohydrates, lipids, vitamins, vitamin-like substances, mineral components, alkaloids, homeopathic remedies, glycosides, immunoglobulin preparations, phenolic compounds, organic acids, enzymes, terpenoids, hormones and hormone-like substances, cytokines, herbal products, microbial products, beekeeping products, fat products otnogo origin, mineral bearing substances of natural origin, detoxicants, processing aids, or mixtures thereof, with the following component ratio, wt.%: Biologically active substance for food 10-90 Component or mixture of components Else 3. The biologically active food supplement according to claim 2, characterized in that the carbohydrates are selected from the series: glucose, fructose, lactose, starch, sucrose, maltose, deoxyribose, soluble and insoluble dietary fiber, inulin, ribose. 4. A biologically active food supplement according to claim 2, characterized in that the lipids are selected from the series: triglycerides, phospholipids, sterols, sterols, microbial lipids. 5. The biologically active food supplement according to claim 2, characterized in that the vitamins are selected from the series: vitamin A, vitamin D, vitamin E, vitamin K, vitamin B1, vitamin B2, niacin, vitamin PP, nicotinic acid, pantothenic acid, pyridoxine, folic acid, folacin, cyanocobalamin, vitamin C. 6. The biologically active food supplement according to claim 2, characterized in that the vitamin-like substances are selected from the series: biotin, bioflavonoids, orotic acid, pangamic acid, para-aminobenzoic acid PABA, choline, inositol, vitamin T, carnitine, vitamin U, lipoic acid , α-lipoic acid, thioctic acid. 7. A biologically active food supplement according to claim 2, characterized in that the mineral components are selected from the series: calcium, phosphorus, magnesium, sodium, potassium, sulfur, chlorine, iron, copper, selenium, iodine, chromium, zinc, fluorine, manganese, cobalt, molybdenum, silicon, bromine, silver, boron, vanadium, germanium. 8. The biologically active food supplement according to claim 2, characterized in that the alkaloids are selected from the series: pyrrolidine derivatives, piperidine derivatives, pyridine derivatives, quinoline derivatives, isoquinoline derivatives, indole derivatives, imidazole derivatives, purine derivatives, diterpeno structure alkaloids, steroid alkaloids, glycoalkaloids, acyclic and peptide alkaloids containing sulfur, urea derivatives. 9. A biologically active food supplement according to claim 2, characterized in that the glycosides are selected from the series: saponins, antraglycosides, bitter glycosides, thioglycosides. 10. The biologically active food supplement according to claim 2, characterized in that the phenolic compounds are selected from the series: simple phenols, phenolospiets, phenolic acids, coumarins, chromones, lignans, flavonoids, isoflavonoids, flavonones, flavones, rotenoids, tannins, lignin, melanins, humic acids. 11. A biologically active food supplement according to claim 2, characterized in that the enzymes are selected from the series: one-component enzymes, two-component enzymes. 12. Biologically active food supplement according to claim 2, characterized in that terpenoids are selected from the series: monoterpenes and their derivatives, sesquiterpenes, diterpenes, sesquiterpenic lactones, triterpene saponins, tetraterpenes and their derivatives. 13. Biologically active food supplement according to claim 2, characterized in that the products of plant origin are selected from the series: higher plants, components of fractionation of higher plants, lower plants, components of fractionation of lower plants. 14. The biologically active food supplement according to claim 2, characterized in that the products of microbial origin are selected from the series: bifidobacteria, lactobacilli, Escherichia coli, yeast, acidophilus bacilli. 15. Biologically active food supplement according to claim 2, characterized in that the technological additives are selected from the following: technological components for tabletting, flavoring additives, flavorings, sweeteners, preservatives, colorants, liquids. 16. A pharmaceutical preparation containing a biologically active substance (BAS), obtained according to claim 1, and a pharmaceutical base selected from the series: homeopathic remedies, non-narcotic analgesics, sclerosing agents, remedies for correcting disorders in alcoholism, toxic and drug addiction, regenerants, currants, vegetotropic drugs, hematotropic drugs, hormones and their antagonists, immunotropic drugs, intermediates, neurotropic drugs, organotropic drugs, antimicrobial agents, anthelmintic, anti neoplastic agents, technological additives, or their mixture in the following ratio of components, wt.%: Active ingredient 0.0001-50 Pharmaceutical base 17. The pharmaceutical preparation according to clause 16, wherein the vegetotropic drugs are selected from the series: adrenolytic drugs, adrenomimetic drugs, anticholinergic drugs, anticholinergic drugs. 18. The pharmaceutical preparation according to clause 16, wherein the hematotropic agents are selected from the series: antiplatelet agents, anticoagulants, plasma and other blood component substitutes, fibrinolysis inhibitors, coagulants, blood coagulation factors, hemostatic agents, hematopoiesis stimulants, fibrinolytics. 19. The pharmaceutical preparation according to clause 16, wherein the hormones and their antagonists are selected from the series: androgens, antiandrogens, glucagon and its analogues, hypothalamic hormones, pituitary glands, gonadotropins and their antagonists, thyroid hormones, their analogues and antagonists, antithyroid drugs, insulins, corticosteroids, estrogens, progestogens, their homologs and antagonists. 20. The pharmaceutical preparation according to clause 16, wherein the immunotropic drugs are selected from the series: immunoglobulins, immunosuppressants, immunomodulators. 21. The pharmaceutical preparation according to claim 16, characterized in that the intermediates are selected from the series: adenosynergics, angiotensin II receptor antagonists AT1 subtype, histaminergics, dopaminomimetics, prostaglandins and their antagonists, thromboxanes and their antagonists, leukotrienes and their antagonists, facilities. 22. The pharmaceutical preparation according to claim 16, characterized in that the metabolites are selected from the series: anabolics, antihypoxants and antioxidants, vitamins and vitamin-like agents, hypoglycemic, synthetic and other agents, lipid-lowering agents, detoxifying agents, antidotes, correctors of bone and cartilage tissue metabolism. , macro- and microelements, rehydrants, regulators of water-electrolyte balance and KHS, means that affect the metabolism of uric acid, agents for enteral and parenteral nutrition, enzymes and antienzymes, agents that prevent the formation and promote the dissolution of calculi. 23. The pharmaceutical preparation according to claim 16, characterized in that the neurotropic drugs are selected from the series: anxiolytics, sedatives and hypnotics, antidepressants, antipsychotics and lithium preparations, general tonic, general strengthening agents and adaptogens, opioids and their analogues and antagonists, antiparkinsonian drugs, antiepileptic drugs, psychostimulants and nootropics, drugs that affect neuromuscular transmission. 24. The pharmaceutical preparation according to clause 16, wherein the organotropic drugs are selected from the series: dermatotropic drugs, gastrointestinal drugs, respiratory drugs, cardiovascular drugs, myotropic antispasmodics, drugs that regulate the function of the genitourinary system and reproduction. 25. The pharmaceutical preparation according to clause 16, wherein the antimicrobial agents are selected from the series: antibiotics, antiviral agents, antifungal agents, antimicrobial agents in combinations, synthetic antibacterial agents. 26. The pharmaceutical preparation according to clause 16, wherein the antitumor agents are selected from the series: alkylating agents, antimetabolites, antitumor antibiotics, antitumor hormonal agents and hormone antagonists, antitumor agents of plant origin, including alkaloids. 27. The pharmaceutical preparation according to clause 16, wherein the non-narcotic analgesics are selected from the series: non-steroidal drugs, anti-inflammatory drugs. 28. The pharmaceutical preparation according to clause 16, characterized in that the technological additives are selected from the following: technological components for tabletting, flavoring agents, aromatic additives, sweeteners, liquids, base for suppositories, base for films, base for gels, base for powder, hydrophilic base, lipophilic base, diphilic base, ointment base. 29. A dietary supplement for feeding animals, characterized in that it contains a biologically active substance (BAS), obtained according to claim 1, and a component selected from the series: carbohydrates, lipids, vitamins, vitamin-like substances, mineral components, alkaloids, homeopathic remedies , glycosides, immunoglobulin preparations, phenolic compounds, organic acids, enzymes, terpenoids, hormones and hormone-like substances, cytokines, herbal products, microbial products, beekeeper products animals, products of animal origin, mineral-containing substances of natural origin, detoxicants, processing aids, or mixtures thereof in the following ratio of components, wt.%: Biologically active substance 10-90 Component or mixture of components Else 30. The dietary supplement for feeding animals according to clause 29, wherein the carbohydrates are selected from the series: glucose, fructose, lactose, starch, sucrose, maltose, deoxyribose, soluble and insoluble dietary fiber, inulin, ribose. 31. The dietary supplement for feeding animals according to clause 29, wherein the lipids are selected from the series: triglycerides, phospholipids, sterols, sterols, microbial lipids. 32. The dietary supplement for feeding animals according to clause 29, wherein the vitamins are selected from the series: vitamin A, vitamin D, vitamin E, vitamin K, vitamin B1, vitamin B2, niacin, vitamin PP, nicotinic acid, pantothenic acid , pyridoxine, folic acid, folacin, cyanocobalamin, vitamin C. 33. The dietary supplement for feeding animals according to clause 29, wherein the vitamin-like substances are selected from the series: biotin, bioflavonoids, orotic acid, pangamic acid, para-aminobenzoic acid PABA, choline, inositol, vitamin T, carnitine, vitamin U, lipoic acid, α-lipoic acid, thioctic acid. 34. The dietary supplement for feeding animals according to clause 29, wherein the mineral components are selected from the series: calcium, phosphorus, magnesium, sodium, potassium, sulfur, chlorine, iron, copper, selenium, iodine, chromium, zinc, fluorine , manganese, cobalt, molybdenum, silicon, bromine, silver, boron, vanadium, germanium. 35. The dietary supplement for feeding animals according to clause 29, wherein the alkaloids are selected from the series: pyrrolidine derivatives, piperidine derivatives, pyridine derivatives, quinoline derivatives, isoquinoline derivatives, indole derivatives, imidazole derivatives, purine derivatives, diterpene alkaloids, steroidal alkaloids, glycoalkaloids, acyclic and peptide alkaloids containing sulfur, urea derivatives. 36. The dietary supplement for feeding animals according to clause 29, wherein the glycosides are selected from the series: saponins, antraglycosides, bitter glycosides, thioglycosides. 37. The dietary supplement for feeding animals according to clause 29, wherein the phenolic compounds are selected from the series: simple phenols, phenolospiets, phenolic acids, coumarins, chromones, lignans, flavonoids, isoflavonoids, flavonones, flavones, rotenoids, tannins, lignin , melanins, humic acids. 38. The dietary supplement for feeding animals according to clause 29, wherein the enzymes are selected from the series: one-component enzymes, two-component enzymes. 39. The dietary supplement for feeding animals according to clause 29, wherein the terpenoids are selected from the series: monoterpenes and their derivatives, sesquiterpenes, diterpenes, sesquiterpenic lactones, triterpene saponins, tetraterpenes and their derivatives. 40. The dietary supplement for feeding animals according to clause 29, wherein the products of plant origin are selected from the series: higher plants, fractionation components of higher plants, lower plants, fractionation components of lower plants. 41. The dietary supplement for feeding animals according to clause 29, wherein the products of microbial origin are selected from the series: bifidobacteria, lactobacilli, Escherichia coli, yeast, acidophilus bacilli. 42. The dietary supplement for feeding animals according to clause 29, wherein the technological additives are selected from the series: technological components for tabletting, flavoring agents, flavorings, sweeteners, preservatives, colorants, liquids. 43. A veterinary preparation, characterized in that it contains a biologically active substance (BAS), obtained according to claim 1, and a pharmaceutical base selected from the following: homeopathic remedies, non-narcotic analgesics, sclerotics, remedies for correcting disorders of alcoholism, toxic and addictions, regenerants, repertoires, vegetotropic drugs, hematotropic drugs, hormones and their antagonists, immunotropic drugs, intermediates, neurotropic drugs, organotropic drugs, antimicrobial agents fixed agents, antitumor agents, technological additives, or their mixture in the following ratio of components, wt.%: Active ingredient 0.0001-50 Pharmaceutical base 44. The veterinary preparation according to item 43, wherein the vegetotropic drugs are selected from the series: adrenolytic drugs, adrenomimetic drugs, anticholinergic drugs, cholinomimetic drugs. 45. The veterinary preparation according to item 43, wherein the hematotropic drugs are selected from the series: antiplatelet agents, anticoagulants, substitutes for plasma and other blood components, fibrinolysis inhibitors, coagulants, blood coagulation factors, hemostatic agents, hematopoiesis stimulants, fibrinolytics. 46. The veterinary preparation according to item 43, wherein the hormones and their antagonists are selected from the series: androgens, antiandrogens, glucagon and its analogues, hormones of the hypothalamus, pituitary, gonadotropins and their antagonists, thyroid hormones, their analogues and antagonists, antithyroid drugs, insulins, corticosteroids, estrogens, progestogens, their homologs and antagonists. 47. The veterinary preparation according to item 43, wherein the immunotropic drugs are selected from the series: immunoglobulins, immunosuppressants, immunomodulators. 48. The veterinary preparation according to item 43, wherein the intermediates are selected from the series: adenosinergic agents, angiotensin II receptor antagonists AT1-subtype, histaminergic agents, dopaminomimetics, prostaglandins and their antagonists, thromboxanes and their antagonists, leukotriergens and their antagonists and their antagonists facilities. 49. The veterinary preparation according to item 43, wherein the metabolites are selected from the series: anabolics, antihypoxants and antioxidants, vitamins and vitamin-like agents, synthetic hypoglycemic and other drugs, lipid-lowering drugs, detoxifying agents, antidotes, corrector of bone and cartilage tissue metabolism, macro- and micronutrients, rehydrates, regulators of water-electrolyte balance and KShchS., means affecting the metabolism of uric acid, means for enteral and parenteral nutrition, enzymes and antienzymes, medium CTBA impeding formation and promote dissolution concrements. 50. The veterinary preparation according to item 43, wherein the neurotropic drugs are selected from the series: anxiolytics, sedatives and hypnotics, antidepressants, antipsychotics and lithium preparations, general tonic, general strengthening agents and adaptogens, opioids and their analogues and antagonists, antiparkinsonian drugs, antiepileptic drugs, psychostimulants and nootropics, drugs that affect neuromuscular transmission. 51. The veterinary preparation according to item 43, wherein the organotropic drugs are selected from the series: dermatotropic drugs, gastrointestinal drugs, respiratory drugs, cardiovascular drugs, myotropic antispasmodics, drugs that regulate the function of the genitourinary system and reproduction. 52. The veterinary preparation according to item 43, wherein the antimicrobial agents are selected from the series: antibiotics, antiviral agents, antifungal agents, antimicrobial agents in combinations, synthetic antibacterial agents. 53. The veterinary preparation according to item 43, wherein the antitumor agents are selected from the series: alkylating agents, antimetabolites, antitumor antibiotics, antitumor hormonal agents and hormone antagonists, antitumor agents of plant origin, including alkaloids. 54. Veterinary preparation according to item 43, wherein the non-narcotic analgesics are selected from the series: non-steroidal drugs, anti-inflammatory drugs. 55. The veterinary preparation according to item 43, wherein the technological additives are selected from the series: technological components for tabletting, flavorings, aromatic additives, sweeteners, liquids, base for suppositories, base for gels, base for films, base for powder, hydrophilic base, lipophilic base, diphilic base, ointment base. 56. Fertilizer, characterized in that it is a precipitate obtained according to claim 1. 57. An activator of microbiological processes, growth of plants and plant cells, characterized in that it is a solution of a biologically active substance (BAS), obtained according to claim 1, with a concentration of 1 · 10 ^-1 -1 · 10 ^-12 . 58. Oral nutrition, characterized in that it contains a biologically active substance (BAS), obtained according to claim 1, and an acceptable food base in the following ratio of components wt.%: Active ingredient 0.001-50 Nutritional Acceptable Basis Else 59. Perfume and cosmetic product, characterized in that it contains a biologically active substance (BAS), obtained according to claim 1, and a perfume and cosmetic acceptable base for external use, selected from the series: fat-based module, emulsion-based module, module on a gel basis, a module on a water-alcohol basis, in the following ratio of components, wt.%: Biologically active substance Up to 20 Perfume and cosmetic base 60. A hygienic product, characterized in that it contains a biologically active substance (BAS), obtained according to claim 1, and a hygienically acceptable basis for external use, selected from the following: module for toothpaste, module for shampoo, module for liquid soap, module for soap, a foaming base, in the following ratio of components, wt.%: Biologically active substance Up to 25 Hygienically acceptable base 61. A dairy product, characterized in that it contains a biologically active substance (BAS), obtained according to claim 1, and a milk base selected from the series: milk module, cottage cheese module, sour-milk module, in the following ratio of components, wt.%: Biologically active substance Up to 25 Milk base Else 62. A confectionery product, characterized in that it contains a biologically active substance (BAS), obtained according to claim 1, and a base selected from the series: module for sweets, module for jelly products, module for marmalade, module for soufflé, module for fudge , module for chocolate, module for oriental sweets, module for sorbet, in the following ratio of components, wt.%: Biologically active substance Up to 25 Basis Else 63. A bakery product, characterized in that it contains a biologically active substance (BAS), obtained according to claim 1, and a base selected from the series: module for gingerbread, module for cakes, module for cookies, module for waffles, module for bread, module for bakery products, in the following ratio of components, wt.%: Biologically active substance Up to 40 Basis Else 64. Fat-and-oil product, characterized in that it contains a biologically active substance (BAS), obtained according to claim 1, and a base selected from the series: margarine, butter, vegetable oil, combination oil, oil substitute, fat, in the following ratio of components , wt.%: Biologically active substance Up to 15 Basis Else 65. A sauce characterized in that it contains a biologically active substance (BAS) obtained according to claim 1, and a base selected from the series: module for mayonnaise, module for ketchup, module for dressing, module for adjika, soy module, module for seasoning, horseradish, mustard, in the following ratio of components, wt.%: Biologically active substance Up to 25 Basis Else 66. An alcoholic beverage, characterized in that it contains a biologically active substance (BAS), obtained according to claim 1, and a water-alcohol base in the following ratio of components, wt.%: Biologically active substance Up to 35 Water-alcohol base 67. Non-alcoholic drink, characterized in that it contains a biologically active substance (BAS), obtained according to claim 1, and a base selected from the series: drinking water, mineralized water, mineral water, juice, nectar, fruit drinks, lemonade, non-alcoholic beer, kvass, in the following ratio of components, wt.%: Biologically active substance Up to 15 Basis Else 68. Fish product, characterized in that it contains a biologically active substance (BAS), obtained according to claim 1, and a fish base in the following ratio of components, wt.%: Biologically active substance Up to 40 Fish base Else 69. A meat product, characterized in that it contains a biologically active substance (BAS), obtained according to claim 1, and a base selected from the series: module for cooked sausage, module for cooked smoked sausage, module for smoked sausage, module for meat products, module for minced meat, module for smoked sausage, module for sausages, module for sausages, in the following ratio of components, wt.%: Biologically active substance Up to 40 Basis Else 70. Pasta, characterized in that it contains a biologically active substance (BAS), obtained according to claim 1, and a test base in the following ratio of components, wt.%: Biologically active substance Up to 35 Test Base Else 71. Chewing gum, characterized in that it contains a biologically active substance (BAS), obtained according to claim 1, and a module for chewing gum in the following ratio of components, wt.%: Biologically active substance Up to 25 Chewing gum module 72. Beer, characterized in that it contains a biologically active substance (BAS), obtained according to claim 1, and a beer base in the following ratio of components, wt.%: Biologically active substance Up to 40 Beer base Else