RU2805542C1 - Mineral complex for use in cosmetics - Google Patents

Abstract

FIELD: cosmetics.

SUBSTANCE: mineral complex for cosmetics. The mineral complex contains a copper compound: copper glycinate, copper lysinate, copper malonate or copper salt of pyrrolidone-carboxylic acid - 0.5-10 wt.%, selenium compound: selenopyran, selenocysteine or sodium selenite - 0.02-0.05 wt.% or selenium yeast selenomethionine - 3-6 wt.%, manganese compound: manganese picolinate, manganese chloride or manganese chloride - 0.06-0.2 wt.%, zinc compound: zinc sulfate, zinc lactate, zinc malonate, zinc gluconate , zinc chloride or zinc salt of pyrrolidonecarboxylic acid - 10-20 wt.%, silicon compound: stabilized orthosilicic acid or methylsilanol mannuronate - 5-30 wt.%, magnesium compound: magnesium sulfate, magnesium chloride or magnesium salt of pyrrolidonecarboxylic acid - 10-74 wt.%, excipient - the rest.

EFFECT: increase in the dermatological efficacy of the finished product and the preservation of organoleptic properties, stability and tolerability of the finished product.

3 cl, 3 tbl, 5 ex

Description

The proposed invention relates to the field of the cosmetic industry, namely to a mineral complex containing analogues of dermatologically active fractions of four medicinal salts from the sources “Liz” Vichy, “La Roche Pose”, “RAPAN” and the Dead Sea, and can be used as raw materials in medicinal cosmetics.

In any medicinal salts, one can identify mineral compounds that can be called “ballast” in dermatological terms (there is no proven dermatological effectiveness), but the vast majority of them are in the composition of salts: potassium, sodium, calcium. There are also dermatologically active mineral compounds for which there is a scientific evidence base for a significant positive effect on the physiology of the skin - these are silicon, selenium, copper, zinc, the synergistic complex copper - zinc - manganese and, to a lesser extent, magnesium.

Currently, there are several problems with the use of natural medicinal salts in the cosmetic industry.

The first problem is that the high concentration of “ballast” mineral salts in the composition of natural medicinal salts does not allow the introduction of natural salts into the composition of the finished product in such a concentration that the content of dermatologically active components is equal to that in the corresponding medicinal water, since “ballast” mineral salts, being strong electrolytes, significantly destabilize cosmetic emulsions and unexpectedly reduce the effectiveness of gelling agents.

The second problem with using natural medicinal salts is that there is no “ideal” source for the composition of dermatologically active components. Selenium in therapeutic doses was found only in "Vichy" (source "Liz") and salt "RAPAN", in the water of the springs "La Roche Posay" it is already 15 - 20 times less, in other medicinal salts - trace amounts, silicon - only in “La Roche Pose” and “Vichy” (source “Liz”), the zinc-copper-manganese complex is in “RAPAN” salt, manganese separately is in “Vichy”, magnesium (the least dermatologically useful of the active minerals) is most in Dead Sea, bischofite, less in ordinary sea salt and even less in thermal water salts.

Thus, a cosmetic lithocomplex is known from the prior art as a preventive and therapeutic-cosmetic skin care product. It contains zeolite in the amount of 0.1-79.0, bentonite 0.1-60.0, table salt and/or sea salt and/or lake salt 0.1-79.0, Dead Sea salt 0.1 -79.0, sodium sulfate 0.1-79.0, potassium sulfate 0.1-50.0, zinc oxide 0.1-1.0, copper sulfate 0.1-1.0 and distilled water 30.0 -99.7 wt. % (RU 2612026 dated 12/09/2015).

The disadvantages of this technical solution include the absence of a number of dermatologically active mineral compounds inherent in natural sources of medicinal salts “Liz” Vichy and “La Roche Pose” and salt “RAPAN”. At the same time, high concentrations of sodium salt negatively affect sensitive, dry and atopic skin. In addition, the known solution is inconvenient to use as a raw material in various cosmetics.

The closest to the patented solution is a mineral complex for use in a cosmetic product, which includes “Dead Sea minerals”, Calcium (Ca2+): 35,000 - 40,000 mg/l; Chloride (Cl-): 320000 - 370000 mg/l; Magnesium (Mg+2): 92000 - 95000 mg/l; Sodium (Na+): 2400 - 3200 mg/l; Potassium (K+): 2500 mg/l and Bromide (Br-): 10000 - 12000 mg/l (see US 2022296641 dated 09/22/2022).

The main disadvantages of the prototype, as in the previous case, include low dermatological effectiveness due to the lack of a number of dermatologically active mineral compounds inherent in natural sources of medicinal salts “Liz” Vichy, “La Roche Pose” and salt “RAPAN”, and high concentrations of potassium, sodium, calcium - “ballast” mineral compounds. The skin-irritating and dehydrating effect of the salts of the main “ballast” mineral, sodium, due to hyperosmosis, does not allow the use of current concentrations of medicinal salts in products for sensitive, dry and atopic skin. In addition, salts of “ballast minerals” are strong electrolytes and have an extremely destabilizing effect on emulsion products and can also lead to an unpredictable drop in the viscosity of the finished cosmetic product.

The technical problem to be solved by the proposed invention is the creation of a mineral complex that can be used as a raw material for the preparation of various types of cosmetic and medicinal products, including dermatologically active minerals of medicinal salts of the four most effective balneological resorts for dermatological problems (sources "Liz" Vichy, La Roche Posay, RAPAN and Dead Sea salts), while the minerals are used in forms that ensure their bioavailability - the ability to penetrate through intact skin, manufacturability when introduced into the formulations of finished cosmetic products, and, in the case of selenium, also reducing toxicity.

The technical result achieved in this case is to ensure that in any finished cosmetic product it is possible to achieve the same concentration of dermatologically active minerals as in the medicinal salts of the most effective balneological centers for dermatological problems: the sources of “Liz” Vichy, “La Roche Posay”, salt “RAPAN” and the Dead Sea, thereby increasing the dermatological effectiveness of the finished product, while maintaining the organoleptic properties, stability and tolerability of the finished product.

The technical result is achieved due to the fact that the mineral complex for use in cosmetics contains:

a copper compound selected from the group: copper glycinate or copper lysinate or copper malonate or copper salt of pyrrolidone carboxylic acid in an amount equal to from 0.5 to 10.0 wt. % in terms of the entire complex,

a selenium compound selected from the group: selenopyran or sodium selenite in an amount equal to from 0.02 to 0.05 wt. % in terms of the entire complex, or selenomethionine in the composition of selenium yeast in an amount equal to from 3.0 to 6.0 wt. % in terms of the entire complex,

a manganese compound selected from the group: manganese picolinate or manganese chloride dihydrate or tetrahydrate in an amount equal to from 0.06 to 0.20 wt. % in terms of the entire complex,

a zinc compound selected from the group: zinc sulfate or zinc lactate or zinc malonate or zinc gluconate or zinc chloride or zinc salt of pyrrolidone carboxylic acid in an amount equal to from 10.0 to 20.0 wt. % in terms of the entire complex,

a silicon compound selected from the group: stabilized orthosilicic acid or methylsilanol mannuronate in an amount of from 5.0 to 30.0 wt. % in terms of the entire complex,

a magnesium compound selected from the group: magnesium sulfate or magnesium chloride or magnesium salt of pyrrolidone carboxylic acid in an amount equal to from 10.0 to 74.0 wt. % in terms of the entire complex,

excipient - the rest.

In particular, the excipient - filler is selected from the group: maltodextrin, beta-cyclodextrin, sorbitol, carboxymethylcellulose, xanthan gum, tara gum, carrageenan, sodium alginate, deltagluconolactone.

In particular, the mineral complex may additionally contain an anti-caking agent, namely hydrophilic aerosil.

The presence in the mineral complex of a substance from the group: copper glycinate or copper lysinate or copper malonate or copper salt of pyrrolidone-carboxylic acid in an amount equal to 0.5 to 10.0 wt.% in terms of the entire complex, together with the substance from the group : zinc sulfate or zinc lactate or zinc malonate or zinc gluconate or zinc chloride or zinc salt of pyrrolidone carboxylic acid in an amount equal to 10.0 to 20.0 wt.% in terms of the entire complex, enhances the synthesis of elastin and collagen, which slows down aging skin cells, promotes regeneration and increased elasticity of mature skin.

The presence in the mineral complex of a set of substances taken from the following groups: substances from the group: zinc sulfate or zinc lactate or zinc malonate or zinc gluconate or zinc chloride or zinc salt of pyrrolidone carboxylic acid in an amount equal to 10.0 to 20.0 wt.% in terms of the entire complex, substances from the group: copper glycinate or copper lysinate or copper malonate or copper salt of pyrrolidone-carboxylic acid in an amount equal to 0.5 to 10.0 wt. % in terms of the entire complex, as well as substances from the group: manganese picolinate or manganese chloride dihydrate or tetrahydrate in an amount equal to 0.06 to 0.20 wt. % in terms of the entire complex, provides acceleration of skin regeneration, increasing its elasticity, as well as reducing hypersensitivity for atopic skin.

The presence in the mineral complex of a substance from the group: selenopyran or sodium selenite in an amount equal to from 0.02 to 0.05 wt. % in terms of the entire complex, or selenomethionine in the composition of selenium yeast in an amount equal to from 3.0 to 6.0 wt. % in terms of the entire complex, accelerates the onset of remission and lengthens periods of remission in the treatment of psoriasis, neurodermatitis, eczema, and also increases the skin’s ability to resist photoaging.

The presence in the mineral complex of a substance from the group: stabilized orthosilicic acid or methylsilanol mannuronate in an amount ranging from 5.0 to 30.0 wt. % in terms of the entire complex, provides stimulation of the synthesis of hyaluronic acid (stimulation of the expression of type 2 hyaluron synthase), elastin and type 1 collagen, which leads to improved skin hydration and slowdown of aging.

The presence in the mineral complex of a substance from the group: magnesium sulfate or magnesium chloride or magnesium salt of pyrrolidone carboxylic acid in an amount equal to 10.0 to 74.0 wt.% in terms of the entire complex, improves the condition of the epidermal skin barrier, and also has a beneficial effect for atopic skin.

Thus, by mixing the indicated components of the mixture, it becomes possible in any finished cosmetic product to achieve the same concentration of dermatologically active minerals as in the medicinal salts of the most famous and effective balneological centers. At the same time, due to the absence of “ballast” mineral salts of potassium, sodium and calcium, which are strong electrolytes and have an extremely destabilizing effect on emulsion products, as well as the given ratio of copper, selenium, manganese, zinc, silicon and magnesium, the stability of the finished cosmetic product is maintained. Also, due to the absence of a hyperosmotic environment for potassium and sodium ions, skin dehydration is not provoked, there is no skin-irritating effect characteristic of high sodium concentrations, which makes it possible to use the products for hypersensitive and atopic skin. Due to the absence of a significant concentration of electrolytes, there is no need to use electrolyte-resistant gelling agents, which are characterized by the formation of a dense film that is noticeable on the skin and gives the effect of “tightening” and stickiness; you can use gelling agents that provide a comfortable sensory experience, including polyacrylates. There is also no need to use electrolyte-resistant emulsifiers, which are characterized by a destabilizing effect on skin cell membranes and are not recommended for products intended for sensitive and atopic skin.

The simultaneous inclusion of these components in the complex has a synergistic effect, i.e. the components provide and enhance the effect of each other, and the quantitative content of each of them is designed to achieve the greatest therapeutic effect.

To prepare the composition, the following components are used:

- copper glycinate Cu(NH2CH2COO)2 - a salt of copper and the amino acid glycine, blue crystals, soluble in water, acceptable classifications of the component are pure, analytical grade, food, pharmaceutical;

- copper lysinate Cu(C6H14N2O2)2 - a salt of copper and the amino acid lysine, blue crystals, soluble in water, acceptable classifications of the component are pure, analytical grade, food, pharmaceutical;

- copper malonate CuC3H2O2*4H2O - a salt of copper and malonic (methanedicarboxylic) acid, is blue-green crystals, soluble in water (7.1 g/l), acceptable classifications of the component are pure, analytical grade, food, pharmaceutical;

- copper salt of pyrrolidone-carboxylic acid C5H6NCuO3 - salt of copper and pyrrolidone-carboxylic acid, is greenish crystals, dissolves in water, acceptable classifications of the component are pure, analytical grade, food, pharmaceutical;

- selenopyran C19H22Se - an organic compound of selenium and xanthene, is a light beige powder, dispersible in water, soluble in fats, acceptable classifications of the component are pure, chemical, food, pharmaceutical;

- sodium selenite Na2SeO3, a salt of sodium and selenous acid, is colorless crystals, soluble in water, acceptable classifications of the component are pure, analytical grade, pharmaceutical grade;

- selenomethionine in selenium yeast C5H11NO2Se, a compound of selenium and the amino acid methionine, in its pure form is a white crystalline powder. Obtained by fermentation of Saccharomyces cerevisiae in a medium rich in selenium, standard selenium content 2000 mg per 1 kg of selenium yeast, well dispersible, partially water soluble. Acceptable classifications of the component h, hd, food, pharmaceutical;.

- manganese picolinate C12H8N2O4Mn, a compound of manganese and picolinic acid, pale pink crystals, soluble in water, acceptable classifications of the component are pure, analytical grade, pharmaceutical;

- manganese (IV) chloride dihydrate, MnCl4*2(H2O), reddish-brown crystals, highly soluble in water, acceptable classifications of the component are pure, analytical grade, pharmaceutical grade;

- manganese (II) chloride tetrahydrate, MnCl2*4(H2O), reddish-brown crystals, highly soluble in water, acceptable classifications of the component are pure, analytical grade, pharmaceutical grade;

- zinc sulfate, ZnSO4, zinc salt of sulfuric acid, colorless crystals, soluble in water, permissible classifications of the component, chemical grade, pharmaceutical grade;

- zinc lactate C6H10ZnO6, zinc salt of lactic acid, colorless crystals, soluble in water, permissible classifications of the component, chemical grade, chemical grade, food, pharmaceutical;

- zinc malonate C3H2O4Zn, salt of zinc and malonic acid, colorless crystals, soluble in water, acceptable classifications of the component, chemical grade, pharmaceutical grade;

- zinc gluconate C12H22O14Zn, salt of zinc and gluconic acid, soluble in water, acceptable classifications of the component are pure, analytical grade, pharmaceutical;

- zinc chloride ZnCl2, salt of zinc and hydrochloric acid, soluble in water, acceptable classifications of the component are pure, analytical grade, pharmaceutical;

- zinc salt of pyrrolidone-carboxylic acid C5H6NZnO3 - salt of zinc and pyrrolidone-carboxylic acid, is colorless crystals, dissolves in water, acceptable classifications of the component are pure, chemical, food, pharmaceutical;

- stabilized orthosilicic acid H4SiO4, obtained by the interaction of soluble silicates with acids, soluble in water, during storage the molecular solution turns into a sol, which then turns into a gel, which, at the concentrations used in the finished product, does not spoil the organoleptic properties of liquid, gel-like or emulsion products, acceptable classifications component h, hd, food, pharmaceutical;

- methylsilanol mannuronate C7H11NaO7Si, complex of organic silicon and mannuronic acid, colorless crystals, soluble in water, acceptable classifications of the component: pure, chemical grade, food, pharmaceutical;

- magnesium sulfate MgSO4, salt of magnesium and sulfuric acid, colorless crystals, soluble in water, permissible classifications of the component: pure, chemical, food, pharmaceutical;

- magnesium chloride MgCl2, salt of magnesium and hydrochloric acid, soluble in water, acceptable classifications of the component are pure, chemical, food, pharmaceutical;

- magnesium salt of pyrrolidone carboxylic acid C5H6NMgO3 - salt of magnesium and pyrrolidone carboxylic acid, is colorless crystals, dissolves in water, acceptable classifications of the component are pure, analytical grade, food, pharmaceutical;

- maltodextrin C6nH(10n+2)O(5n+1) (maltose molasses), a product of partial hydrolysis of starch, is a white to light beige powder, hygroscopic, used as an anti-caking agent and filler in the food and pharmaceutical industries, permissible classification of food, pharmaceutical components;

- beta-cyclodextrin C54H94O35 is a cyclic oligomer of glucose, obtained enzymatically from starch, is a white to light beige powder, hygroscopic, used as an anti-caking agent and filler in the food and pharmaceutical industries, as a stabilizer, filler and masker of unpleasant odors in cosmetics industry, acceptable classifications of food, pharmaceutical components;

- sorbitol C6H14O, hexahydric alcohol obtained from glucose, soluble in water, used as a filler and sweetener in the food and pharmaceutical industries, filler, humectant in the cosmetic industry, permissible classifications of food and pharmaceutical components;

- carboxymethylcellulose [C6H7O2(OH)3-x(OCH2COOH)x]n, cellulose-glycolic acid, light beige powder, hygroscopic, used as a thickener, stabilizer in the food, pharmaceutical, cosmetic industries, permissible classifications of food, pharmaceutical components;

- xanthan gum (C35H49O29)n, white to light beige powder, hygroscopic, microbiologically obtained thickener, stabilizer, emulsifier and gelling agent in the food, pharmaceutical and cosmetic industries, acceptable classifications of food and pharmaceutical components;

- tara gum, seed resin from the Peruvian carob tree, a polysaccharide of galactose and mannose residues in a ratio of 1:3, is a white to yellow powder, hygroscopic, used as a stabilizer, thickener and gelling agent in the food, pharmaceutical and cosmetic industries , acceptable classifications of food, pharmaceutical components;

- carrageenan, a sulfated heteropolysaccharide of red seaweed, consisting of subunits of galactose and anhydrogalactose, is a white to light beige powder, hygroscopic, used as a stabilizer, thickener and gelling agent in the food, pharmaceutical and cosmetic industries, permissible classifications of food components ., pharma;

- sodium alginate (C6H7O6Na)n, a polysaccharide from brown seaweed, consisting of a residue of mannuric and guluric acids, is a powder from white to light beige or light brown, hygroscopic, used as a stabilizer, thickener and gelling agent in food , pharmaceutical and cosmetic industries, as an enterosorbent for poisoning with heavy metals and radionuclides in the pharmaceutical industry, acceptable classifications of food, pharmaceutical components;

- deltagluconolactone C6H10O6, a derivative of gluconic acid, white powder, soluble in water, used as a moisture-retaining component in the food, pharmaceutical and cosmetic industries, as a soft peeling component in the cosmetic industry, permissible classifications of the component are pure, chemical, food, pharmaceutical;

- hydrophilic aerosil SiO2, highly dispersed pyrogenic silicon dioxide, white powder, dispersed in water to form stable sols, used in the food, pharmaceutical and cosmetic industries as an anti-caking agent, stabilizer, structure former, sorbent, permissible classifications of the component are pure, analytical grade, pharmaceutical.

The mineral complex is obtained as follows.

The mineral complex can be obtained by mechanically mixing the components, with the addition of fillers and an anti-caking agent. Mixing is carried out in a drum mixer, with the mandatory use of personal protective equipment when mixing dust-producing components (respirators with a degree of protection of at least FFP2, safety glasses, disposable gowns). Components whose concentration in the finished mixture is less than 5% are first thoroughly mixed with an equivalent amount of filler or other components to ensure uniform distribution; if the mass of the resulting mixture is less than 10% of the finished mixture, then an equivalent amount of filler or other components is again added to it and thoroughly knead, the process is repeated until the mass of the mixture becomes more than 10% of the finished mixture. After this, the resulting mixture is mixed with the main mass. The mixing time for the mixture containing all components is at least 40 minutes.

Due to the good solubility or dispersibility of the components of the complex in water, it is possible to introduce it into any type of cosmetic products that contain an aqueous phase, including hygiene products with a high surfactant content: creams and gels of any viscosity, tonics, toners, liquid shampoos, shower gels, liquid soap, facial cleansers.

Incorporation into dry powder and solid cosmetic products is also possible.

The complex is introduced into emulsion products by adding it after emulsification, having previously dissolved it in a small amount of water, the input temperature is no more than 75°C.

In products that are cosmetic gels, the product is added to the mass before the introduction of gelling agents.

In its original dry form, the complex can be added to any dry powder cosmetic products.

When introducing the complex into solid products (solid soap, solid shampoos), if there is at least 4% aqueous phase in the product, the product is dispersed in the aqueous phase.

In the absence of an aqueous phase: for products obtained by dosing the molten mass into molds, the complex is dispersed in the melt; for products obtained by pressing components, the complex is mixed with dry ingredients.

The complex is introduced into anhydrous oil products by careful dispersion in the mass; to avoid precipitation of the complex components, it is necessary to increase the viscosity of the product.

The invention is further explained with the help of examples.

Complex input rates: from 1.0 to 3.0 wt%.

In the examples of mixtures, columns No. 2 of tables indicate a substance from the group, No. 3 - its % content in the mixture according to the example of mixture No. 1, columns No. 4 and No. 5 indicate the concentration of ions of the corresponding elements in 1 kg of the finished cosmetic product (GCP) at lower and upper recommended limits for introducing the complex into the finished product (1% and 3% by weight, respectively), column No. 6 shows an example of mixture No. 1.1 of the same composition, but with a different % content of the substance from column No. 2 (% content is outside the declared intervals).

Example of mixture No. 1 and mixture No. 1.1.

1 2 3 4 5 6 Element Connection name % wt. In mixture No. 1 mg of element in 1 kg of GCP when adding 1% mixture No. 1 mg of element in 1 kg of GCP when adding 3% mixture No. 1 % wt. In mixture No. 1.1 Selenium Selenopyran 0.05 1.2 3.6 0.06 Silicon Orthosilicic acid 30.00 531.3 1593.8 33.00 Copper Copper glycinate 10.00 275.1 825.3 11.00 Zinc Zinc lactate 20.00 535.0 1604.9 23.00 Manganese Manganese chloride *2H2O 0.20 6.8 20.5 0.30 Magnesium Magnesium sulfate 10.00 200.0 600.0 9.00 Auxiliary Maltodextrin 29.55 - - 23.44 Auxiliary Hydrophilic Aerosil 0.20 - - 0.20

Example of mixture No. 2.

1 2 3 4 5 Element Connection name % wt. In mixture No. 2 mg of element in 1 kg of GCP when adding 1% mixture No. 2 mg of element in 1 kg of GCP when adding 3% mixture No. 2 Selenium Selenium yeast (2000 mg/kg) 4.50 0.9 2.7 Silicon Methylsilanol mannuronate 17.5 120.4 361.3 Copper Copper salt of pyrrolidone carboxylic acid (copper PCA) 10.00 198.7 596.2 Zinc Zinc salt of pyrrolidone carboxylic acid (zinc PCA) 20.00 407.5 1222.6 Manganese Manganese chloride *4H2O 0.13 3.6 10.9 Magnesium Magnesium salt of pyrrolidone carboxylic acid (magnesium PCA) 42.00 362.6 1087.8 Auxiliary Beta-cyclodextrin 5.67 - - Auxiliary Hydrophilic Aerosil 0.20 - -

Example of mixture No. 3 and mixture No. 3.1.

1 2 3 4 5 6 Element Connection name % wt. In mixture No. 3 mg of element in 1 kg of GCP when adding 1% mixture No. 3 mg of element in 1 kg of GCP when adding 3% mixture No. 3 % wt. In mixture No. 3.1 Selenium Sodium Selenite 0.05 2.3 6.9 0.10 Silicon Orthosilicic acid 17.5 309.9 929.7 3.0 Copper Copper lysinate 10.00 178.5 535.4 12.00 Zinc Zinc chloride 20.00 955.9 2867.6 22.00 Manganese Manganese chloride *2H2O 0.13 2.0 6.1 0.05 Magnesium Magnesium sulfate 42.00 840.0 2520.0 9.00 Auxiliary Maltodextrin 10.12 - - 53.65 Auxiliary Hydrophilic Aerosil 0.20 - - 0.20

Example of mixture No. 4.

1 2 3 4 5 Element Connection name % wt. In mixture No. 4 mg of element in 1 kg of GCP when adding 1% mixture No. 4 mg of element in 1 kg of GCP when adding 3% mixture No. 4 Selenium Sodium selenite 0.035 1.6 4.8 Silicon Methylsilanol mannuronate 30.0 206.5 619.4 Copper Copper malonate 5.25 178.8 538.4 Zinc Zinc sulfate*7H2O 15.00 338.5 1015.6 Manganese Manganese picolinate 0.13 2.4 7.2 Magnesium Magnesium chloride 42.00 1061.1 3183.2 Auxiliary Sorbitol 7,385 - - Auxiliary Hydrophilic Aerosil 0.20 - -

Example of mixture No. 5.

1 2 3 4 5 Element Connection name % wt. In mixture No. 5 mg of element in 1 kg of GCP when adding 1% mixture No. 5 mg of element in 1 kg of GCP when adding 3% mixture No. 5 Selenium Sodium selenite 0.02 0.9 2.8 Silicon Methylsilanol mannuronate 5.00 34.4 103.2 Copper Copper lysinate 0.50 8.9 26.8 Zinc Zinc chloride 15.00 716.9 2150.7 Manganese Manganese chloride*2H2O 0.13 4.4 13.3 Magnesium Magnesium chloride 74.00 1869.5 5608.4 Auxiliary Carboxymethylcellulose 1.00 - - Auxiliary Maltodextrin 4.15 - - Auxiliary Hydrophilic Aerosil 0.20 - -

Example of mixture No. 6 and mixture No. 6.1.

1 2 3 4 5 6 Element Connection name % wt. In mixture No. 6 mg of element in 1 kg of GCP when adding 1% mixture No. 6 mg of element in 1 kg of GCP when adding 3% mixture No. 6 % wt. In mixture No. 6.1 Selenium Selenopyran 0.02 0.5 1.4 0.01 Silicon Orthosilicic acid 5.00 88.5 265.6 4.00 Copper Copper malonate 10.00 340.5 1021.6 11.00 Zinc Zinc malonate 15.00 515.9 1547.6 7.00 Manganese Manganese picolinate 0.06 1.1 3.3 0.30 Magnesium Magnesium chloride 10.00 252.6 757.9 77.00 Auxiliary Maltodextrin 59.72 - - 0.49 Auxiliary Hydrophilic Aerosil 0.20 - - 0.2

Example of mixture No. 7 and mixture No. 7.1.

1 2 3 4 5 6 Element Connection name % wt. In mixture No. 7 mg of element in 1 kg of GCP when adding 1% mixture No. 7 mg of element in 1 kg of GCP when adding 3% mixture No. 7 % wt. In mixture No. 7.1 Selenium Selenopyran 0.035 0.8 2.5 0.01 Silicon Orthosilicic acid 5.00 88.5 265.6 3.00 Copper Copper lysinate 5.25 93.7 281.1 0.40 Zinc Zinc sulfate*7H2O 10.00 225.7 677.1 7.00 Manganese Manganese chloride*4H2O 0.06 1.7 5.0 0.05 Magnesium Magnesium sulfate 74.00 1480.0 4440.0 78.00 Auxiliary Xanthan gum 1.00 - - 1.00 Auxiliary Sorbitol 4.455 - - 10.34 Auxiliary Hydrophilic Aerosil 0.20 - - 0.20

Example of mixture No. 8.

1 2 3 4 5 Element Connection name % wt. In mixture No. 8 mg of element in 1 kg of GCP when adding 1% mixture No. 8 mg of element in 1 kg of GCP when adding 3% mixture No. 8 Selenium Selenium yeast (2000 mg/kg) 3.00 0.6 1.8 Silicon Orthosilicic acid 5.00 88.5 265.6 Copper Copper glycinate 0.50 13.8 41.3 Zinc Zinc malonate 10.00 343.9 1031.7 Manganese Manganese picolinate 0.20 3.7 11.0 Magnesium Magnesium salt of pyrrolidone carboxylic acid (magnesium PCA) 74.00 638.8 1916.5 Auxiliary Tara gum 1.10 - - Auxiliary Beta-cyclodextrin 6.00 - - Auxiliary Hydrophilic Aerosil 0.20 - -

Example of mixture No. 9.

1 2 3 4 5 Element Connection name % wt. In mixture No. 9 mg of element in 1 kg of GCP when adding 1% mixture No. 9 mg of element in 1 kg of GCP when adding 3% mixture No. 9 Selenium Selenium yeast (2000 mg/kg) 6.00 1.2 3.6 Silicon Orthosilicic acid 5.00 88.5 265.6 Copper Copper glycinate 5.25 144.4 433.3 Zinc Zinc sulfate *7H2O 20.00 451.4 1354.2 Manganese Manganese chloride*4H2O 0.20 5.6 16.8 Magnesium Magnesium salt of pyrrolidone carboxylic acid (magnesium PCA) 10.00 86.3 259.0 Auxiliary Maltodextrin 52.05 - - Auxiliary Carrageenan 1.30 - - Auxiliary Hydrophilic Aerosil 0.20 - -

Example of mixture No. 10.

1 2 3 4 5 Element Connection name % wt. In mixture No. 10 mg of element in 1 kg of GCP when adding 1% mixture No. 10 mg of element in 1 kg of GCP when adding 3% mixture No. 10 Selenium Sodium selenite 0.035 1.6 4.8 Silicon Orthosilicic acid 17.50 309.0 929.7 Copper Copper malonate 0.50 17.0 51.1 Zinc Zinc lactate 15.00 401.2 1203.7 Manganese Manganese chloride*2H2O 0.13 4.4 13.3 Magnesium Magnesium sulfate 42.00 840.0 2520.0 Auxiliary Sorbitol 23,635 - - Auxiliary Sodium alginate 1.00 - - Auxiliary Hydrophilic Aerosil 0.20 - -

Example of mixture No. 11.

1 2 3 4 5 Element Connection name % wt. In mixture No. 11 mg of element in 1 kg of GCP when adding 1% mixture No. 11 mg of element in 1 kg of GCP when adding 3% mixture No. 11 Selenium Sodium Selenite 0.035 1.6 4.8 Silicon Orthosilicic acid 17.50 309.0 929.7 Copper Copper salt of pyrrolidone carboxylic acid (copper PCA) 0.50 9.9 29.8 Zinc Zinc malonate 20.00 687.8 2063.5 Manganese Manganese chloride*2H2O 0.13 4.4 13.3 Magnesium Magnesium sulfate 42.00 840.0 2520.0 Auxiliary Deltagluconolactone 19,635 - - Auxiliary Hydrophilic Aerosil 0.20 - -

Example of mixture No. 12.

1 2 3 4 5 Element Connection name % wt. In mixture No. 12 mg of element in 1 kg of GCP when adding 1% mixture No. 12 mg of element in 1 kg of GCP when adding 3% mixture No. 12 Selenium Sodium Selenite 0.035 1.6 4.8 Silicon Orthosilicic acid 17.50 309.0 929.7 Copper Copper salt of pyrrolidone carboxylic acid (copper PCA) 5.25 104.3 313.0 Zinc Zinc lactate 10.00 267.5 802.5 Manganese Manganese chloride*2H2O 0.13 4.4 13.3 Magnesium Magnesium sulfate 42.00 840.0 2520.0 Auxiliary Maltodextrin 24,885 - - Auxiliary Hydrophilic Aerosil 0.20 - -

Example of mixture No. 13 and mixture No. 13.1.

1 2 3 4 5 6 Element Connection name % wt. In mixture No. 13 mg of element in 1 kg of GCP when adding 1% mixture No. 13 mg of element in 1 kg of GCP when adding 3% mixture No. 13 % wt. In mixture No. 13.1 Selenium Sodium selenite 0.035 1.6 4.8 0.06 Silicon Orthosilicic acid 17.50 309.0 929.7 32 Copper Copper glycinate 5.25 144.4 433.3 0.40 Zinc Zinc chloride 10.00 477.9 1433.8 25.00 Manganese Manganese chloride*2H2O 0.13 4.4 13.3 0.21 Magnesium Magnesium sulfate 42.00 840.0 2520.0 9.00 Auxiliary Maltodextrin 24,885 - - 33.13 Auxiliary Hydrophilic Aerosil 0.20 - - 0.20

Example of mixture No. 14.

1 2 3 4 5 Element Connection name % wt. In mixture No. 14 mg of element in 1 kg of GCP when adding 1% mixture No. 14 mg of element in 1 kg of GCP when adding 3% mixture No. 14 Selenium Sodium selenite 0.035 1.6 4.8 Silicon Orthosilicic acid 17.50 309.0 929.7 Copper Copper glycinate 5.25 144.4 433.3 Zinc Zinc salt of pyrrolidone carboxylic acid (zinc PCA) 10.00 203.8 611.3 Manganese Manganese chloride*2H2O 0.13 4.4 13.3 Magnesium Magnesium sulfate 42.00 840.0 2520.0 Auxiliary Maltodextrin 24,885 - - Auxiliary Hydrophilic Aerosil 0.20 - -

Example of mixture No. 15.

1 2 3 4 5 Element Connection name % wt. In mixture No. 15 mg of element in 1 kg of GCP when adding 1% mixture No. 15 mg of element in 1 kg of GCP when adding 3% mixture No. 15 Selenium Sodium selenite 0.035 1.6 4.8 Silicon Orthosilicic acid 17.50 309.0 929.7 Copper Copper glycinate 5.25 144.4 433.3 Zinc Zinc salt of pyrrolidone carboxylic acid (zinc PCA) 15.00 305.6 916.9 Manganese Manganese chloride*2H2O 0.13 4.4 13.3 Magnesium Magnesium sulfate 42.00 840.0 2520.0 Auxiliary Maltodextrin 19,885 - - Auxiliary Hydrophilic Aerosil 0.20 - -

Example of mixture No. 16.

1 2 3 4 5 Element Connection name % wt. In mixture No. 16 mg of element in 1 kg of GCP when adding 1% mixture No. 16 mg of element in 1 kg of GCP when adding 3% mixture No. 16 Selenium Sodium selenite 0.035 1.6 4.8 Silicon Orthosilicic acid 17.50 309.0 929.7 Copper Copper glycinate 5.25 144.4 433.3 Zinc Zinc gluconate 10.00 142.5 427.6 Manganese Manganese chloride*2H2O 0.13 4.4 13.3 Magnesium Magnesium sulfate 47.00 840.0 2520.0 Auxiliary Maltodextrin 20,085 - -

Example of mixture No. 17.

1 2 3 4 5 Element Connection name % wt. In mixture No. 17 mg of element in 1 kg of GCP when adding 1% mixture No. 17 mg of element in 1 kg of GCP when adding 3% mixture No. 17 Selenium Sodium selenite 0.035 1.6 4.8 Silicon Orthosilicic acid 17.50 309.0 929.7 Copper Copper glycinate 5.25 144.4 433.3 Zinc Zinc gluconate 20.00 203.8 611.3 Manganese Manganese chloride*2H2O 0.13 4.4 13.3 Magnesium Magnesium chloride 10.00 252.6 757.9 Auxiliary Maltodextrin 46,885 - - Auxiliary Hydrophilic Aerosil 0.20 - -

The complexes were tested in different types of finished cosmetic products. The technological convenience of introducing the complex into the formulation, the organoleptic properties of the finished product depending on its type, the stability of the finished product, tolerability and effectiveness were assessed. To test the technological convenience of introducing a mineral complex into finished products, its influence on the consumer characteristics of finished products and dermatological effectiveness, reference (without a mineral complex), prototype samples of products (using a mixture of a mineral complex of the declared composition) and samples of products (using a mixture of a mineral complex) were made complex, the components of which are outside the declared ranges) from different categories: liquid cosmetic product (facial toner), gel product (facial serum), emulsion product (face cream), product with a high surfactant content (shower gel) , anhydrous product (sugar body scrub).

Example No. 1. Anti-aging facial toner.

Recipe for 100 kg excluding losses.

name of raw materials % by weight in the finished product Unit measurements Purified water 69.41 kg Melissa hydrolate 20.30 kg Methylsulfonylmethane (MSM) 1.98 kg Propylene glycol 1.91 kg Mineral complex at the RC “Mixture No. 3” 1.00 kg Panthenol 0.99 kg Hydrolyzed oat protein 0.99 kg Preservative Nipagard SCE (sorbitan caprylate, propanediol, benzoic acid) 0.50 kg Polyglyceryl 6-laurate 0.49 kg Glycine 0.40 kg Ascorbic acid 0.40 kg Sorbitol 0.40 kg Delta-gluconolactone 0.30 kg Sodium lactate 0.30 kg Lavender blend 0.25 kg Sodium citrate 0.20 kg Sodium hydroxide 0.16 kg Nut tannin extract 0.02 kg TOTAL 100.00

Three samples of tonic were made: an experimental product according to the given recipe from example No. 1 using mixture No. 3, an experimental product according to the given recipe from example No. 1 using mixture No. 3.1 and a reference product with an identical recipe, but without the mineral complex (instead of which there was an equivalent amount of water has been added).

The mineral complex according to the recipe for mixture No. 3 was introduced into the product at the initial stage of production by adding it to water along with the rest of the ingredients, except for the preservative and flavoring, at a temperature of 50 ° C and prolonged stirring. After cooling to 42 °C, the preservative and flavor were added, the total mixing time was 1.5 hours. Stability testing was carried out by accelerated storage in an oven at 42°C for four weeks, which corresponds to approximately 9 months of storage at room temperature. During the entire period of accelerated storage, the mass remained transparent and stable. The introduction of the mineral complex was technologically convenient; the complex did not affect the organoleptic properties of the product (color, smell, consistency), which were identical to a similar tonic without the mineral complex.

The mineral complex according to the recipe from example No. 1 using mixture No. 3.1 was introduced into the product at the initial stage of production in a similar way. Checking the stability of the finished product showed that after accelerated storage in a heating cabinet at a temperature of 42 ° C for two weeks (equivalent to storage at room temperature for 20 weeks), a sediment of beige agglomerates formed in the tonic, which disappeared with vigorous shaking, but within appeared again within a day or two. That is, the finished product turned out to be unstable and its further testing was impossible.

Example No. 2. Anti-aging gel serum for face.

Per 100 kg excluding losses

name of raw materials % by weight in the finished product Unit measurements Water 77.10 kg Mineral complex at the RC “Mixture No. 1” 3.00 kg Panthenol 3.00 kg Vitamin F 2.00 kg Olive squalane 2.00 kg Sodium pyrrolidone carboxylic acid (NaPCA) 2.00 kg Glycerol 1.50 kg Sodium lactate 1.00 kg Vitamin E 1.00 kg Sorbitol 1.00 kg Niacinamide 1.00 kg Lactic acid 1.00 kg Lecigel 0.80 kg Preservative Sensicare C1000 (phenoxyethanol, glyceryl laurate) 0.80 kg Allantoin 0.50 kg Betaine 0.50 kg Glucosamine 0.30 kg Burdock root extract 0.20 kg Arginine 0.20 kg Lysine 0.20 kg Proline 0.20 kg Serin 0.20 kg Methionine 0.10 kg Cysteine 0.10 kg Food flavoring 0.10 kg Blue Spirulina Extract 0.10 kg Oligohyaluronic acid 0.05 kg Disodium salt EDTA 0.05 kg TOTAL 100.00

Three whey samples were prepared: an experimental product according to the given recipe from example No. 2 using mixture No. 1, an experimental product according to the given recipe from example No. 2 using mixture No. 1.1 and a reference product with an identical recipe, but without the mineral complex (instead of which there was an equivalent amount of water has been added).

First, a gel was formed by adding lecigel dispersion in water in a mixture of glycerin and fat-soluble components (squalane and vitamin F), then adding a mineral complex according to the recipe for mixture No. 3 and the remaining components, except for the preservative and flavoring, at a temperature of 45 ° C and long stirring. After cooling to 42°C, the preservative and flavor were added for a total production time of 3.0 hours. Stability testing was carried out by accelerated storage in an oven at 42°C for four weeks, which corresponds to approximately 9 months of storage at room temperature. The mass remained stable throughout the accelerated storage period. The introduction of the mineral complex was technologically convenient; the complex did not affect the organoleptic properties of the product (color, smell, consistency), which were identical to a similar gel serum without the mineral complex.

The mineral complex according to the recipe for mixture No. 1.1 was introduced into the product in a similar way. Checking the stability of the finished product showed that after 3 weeks of storage in a heating cabinet at a temperature of 42 ° C, the finished product began to liquefy, and a more liquid fraction peeled off in the lower part of the container (probable effect of an increased dose of zinc lactate). Further testing of the product was not possible.

Example No. 3. Anti-aging face cream.

Per 100 kg excluding losses

name of raw materials % by weight in the finished product Unit measurements Water 67.35 kg Hemp oil 5.00 kg Rice bran oil 5.00 kg Polyglyceryl-3-methylglucose distearate 4.00 kg Mineral complex at the RC “Mixture No. 13” 3.00 kg Vitamin F 2.00 kg Sorbitol 2.00 kg Blend of tocopherols 1.50 kg Wheat germ oil 1.00 kg Black cumin oil 1.00 kg Sodium PCA (sodium pyrrolidone carboxylic acid) 1.00 kg Phytokeratin (hydrolyzed soy and rice protein) 1.00 kg Glycine 1.00 kg Panthenol 1.00 kg Preservative Sharomix 708 (benzyl alcohol, benzoic acid, sorbic acid, glycerin) 0.80 kg Red root extract, dry 0.70 kg Kuril tea extract, dry 0.70 kg Licorice root extract, dry 0.70 kg Ascorbic acid 0.50 kg Lactic acid 0.50 kg Food flavoring 0.20 kg Retinol acetate 0.05 kg TOTAL 100.00

Three samples of face cream were made: an experimental product according to the given recipe from example No. 3 using mixture No. 13, an experimental product according to the given recipe from example No. 3 using mixture No. 13.1 and a reference product with an identical recipe, but without the mineral complex (instead of to which an equivalent mass of water has been added).

The mineral complex according to the recipe for mixture No. 13 was introduced into the aqueous phase before emulsification. Stability testing was carried out by distilling the finished cream in a centrifuge (5000 rpm for 5 minutes); as a result of testing, the cream showed good stability (1 drop separated from the standard sample, which is acceptable). Accelerated storage was also carried out in an oven at 37 °C for four weeks, which corresponds to approximately 8 months of storage at room temperature. The mass remained stable throughout the accelerated storage period. The introduction of the mineral complex was technologically convenient; the complex did not affect the organoleptic properties of the product (color, smell, consistency, stability), which were identical to a similar cream without the mineral complex.

The mineral complex according to the recipe for mixture No. 13.1 was introduced into the product in a similar way. When checking the stability of the finished product in a centrifuge, 3 drops of the exfoliated oil phase separated from the standard sample, which is not allowed by GOST 31460-2012 “Cosmetic creams”, as it indicates insufficient stability of the emulsion and a significant probability of its destabilization after several months of storage. Further testing of the sample was not possible.

Example No. 4. Shower gel for dry and sensitive skin without sulfates.

Per 100 kg excluding losses

name of raw materials % by weight in the finished product Unit measurements Water 71.80 kg Decyl glucoside 9.00 kg Lauryl glucoside 9.00 kg Sorbitol 3.00 kg Mineral complex at the RC “Mixture No. 7” 1.00 kg Panthenol 1.00 kg Sodium alginate 1.00 kg Seed extract 1.00 kg Preservative Nipagard SCE (sorbitan caprylate, propanediol, benzoic acid) 0.80 kg Natural Vitamin E 0.50 kg Blue chamomile essential oil 0.40 kg Lactic acid 0.10 kg Lemon acid 0.10 kg succinic acid 0.10 kg Ascorbic acid 0.10 kg Rosemary extract 0.10 kg TOTAL 100.00

Three samples of shower gel were made: an experimental product according to the given recipe from example No. 4 using mixture No. 7, an experimental product according to the given recipe from example No. 4 using mixture No. 7.1 and a reference product with an identical recipe, but without the mineral complex (instead of to which an equivalent amount of water by weight was added) and the amount of gelling agents reduced by 15%.

The mineral complex according to the recipe for mixture No. 7 was introduced at the beginning of production before adding surfactants and gelling agents. After cooling to 42°C, the preservative and flavor were added for a total production time of 3.0 hours. It was experimentally found that in order for the viscosity of the product to match the standard, an increase in the amount of gelling agents by approximately 15% is required. Stability testing was carried out by accelerated storage in an oven at 42°C for four weeks, which corresponds to approximately 9 months of storage at room temperature. The mass remained stable throughout the accelerated storage period. The introduction of the mineral complex was technologically convenient; the complex did not affect the organoleptic properties of the product (color, smell, foam), which were identical to a similar shower gel without the mineral complex. The introduction of a mineral complex into a product with a high surfactant content led to a slight decrease in viscosity, which is easily compensated by a corresponding increase in gelling agents (by 15% relative to the initial addition), while the stability of the product is completely preserved.

The mineral complex according to the recipe for mixture No. 7.1 was introduced into the product in a similar way. When checking the stability of the finished product in a heating cabinet at a temperature of 42 °C, after 2.5 weeks of control storage, a slight delamination of the product occurred; in the lower part of the mass, the less viscous fraction peeled off, which indicates a loss of gel stability. Further testing of the sample was impossible.

Example No. 5. Sugar body scrub for dry and sensitive skin.

Per 100 kg excluding losses

name of raw materials % by weight in the finished product Unit measurements Sugar 45.69 kg Sunflower oil 22.60 kg Glycerol 20.00 kg Polyglyceryl-4-caprate 4.00 kg Silicon dioxide (silica) 3.00 kg Mineral complex according to the RC “Example No. 6” 2.00 kg Natural flavor 1.20 kg Vitamin E 0.50 kg Freeze-dried raspberries 0.50 kg Phenoxyethanol 0.30 kg Vitamin F 0.10 kg Sodium ascorbate 0.10 kg Natural dye Carmine 0.01 kg TOTAL 100.00

Three samples of body scrub were made: an experimental product according to the given recipe from example No. 5 using mixture No. 6, an experimental product according to the given recipe from example No. 5 using mixture No. 6.1 and a reference product with an identical recipe, but without the mineral complex (instead of to which an equivalent mass of water has been added).

The mineral complex according to the recipe for mixture No. 6 was introduced at the initial stage of production by thoroughly dispersing it in a mixture of sunflower oil and polyglyceryl-4-caprate using an UPES homogenizer (installation for the production of emulsions and suspensions) at a speed of 3000 rpm for 10 minutes. Then the remaining components, a thickener (silica) and an abrasive (sugar), were added. Accelerated storage of the product was carried out in an oven at 37°C for four weeks, which approximately corresponds to 8 months of storage at room temperature. Throughout the accelerated storage period, the mass maintained stability and viscosity identical to the reference scrub. The introduction of the mineral complex was technologically convenient; the complex did not affect the organoleptic properties of the product (color, smell, consistency, stability), which were identical to a similar body scrub without the mineral complex.

The mineral complex according to the recipe for mixture No. 6.1 was introduced into the product in a similar way. When checking the stability of the finished product in a heating cabinet at a temperature of 42 °C, after a week a small part of the fat fraction peeled off, which indicates a decrease in the effectiveness of the structure former and thickener (aerosil). Further testing of the sample was impossible.

Finished cosmetic products according to examples No. 1-5 were subjected to comparative clinical trials with reference products without the addition of a mineral complex. The duration of the tests was 4 weeks. Cosmetic products according to examples No. 1-3 (tonic, serum, face cream) are sequential stages of standard skin care, so the tests of these products were carried out in combination. The reference and experimental samples differed in labeling, which was selected in such a way that reference products were used on one side of the face (right), and experimental products with the addition of a mineral complex were used on the other (left). Subjects did not know which type of labeling applied to reference and experimental products. The age of the subjects ranged from 24 to 47 years, the number was 20 people, the gender composition was 100% women. A preliminary questionnaire was conducted to determine the type and condition of the subjects’ facial skin, as well as an instrumental determination of skin hydration (bioelectric impedance analysis, Lifetrons ST-100AS-WH1 Digital Skin Monitor ST-100AS device). Cosmetic products were used 2 times a day, morning and evening, on cleansed skin. First, the skin was wiped with tonic, after 2-3 minutes the serum was applied, after the serum was absorbed, the cream was applied. The subjects were instructed on the scheme and amount of application of cosmetics. The results were recorded using a questionnaire, and skin hydration was determined instrumentally. The evaluation criteria were as follows:

Tonic: skin irritation effect upon application, feeling of tightness after application, stickiness after application, skin comfort after application. Facial serum: ease of distribution on the skin, speed of absorption, feeling of tightness after application, discomfort/burning upon application. Face cream: ease of distribution on the skin, speed of absorption, lack of heaviness/stickiness after absorption, skin irritation effect. The care complex as a whole: skin hydration (subjective assessment), skin hydration (instrumental assessment 10 - 15 minutes after cleansing the skin without applying any skin care products), skin softening, elasticity and firmness (pinch test), micro-relief smoothing and lifting effect, stress test (the level of skin discomfort 10 minutes after washing with baby soap without applying any skincare products allows one to judge the state of the epidermal barrier and the skin’s ability to compensate for external stress). The results are presented in Table 1 (analysis of skin irritation effect and organoleptic properties) and Table 2 (efficacy of application). Test data show that the tonic, serum and cream do not have a skin irritating effect, and in terms of ease of use they are not inferior to standard products without a mineral complex. The experimental products are comfortable to apply, absorb easily and quickly, do not cause tightness, burning, discomfort, and do not leave a feeling of heaviness or grease on the skin. In terms of effectiveness, the experimental products showed better results than their standards - prototypes: in terms of the level of skin hydration, an instrumental improvement of 87% was recorded compared to the beginning of the study, which is 85% higher than the effectiveness of the prototypes (improvement by 47%). In terms of elasticity and firmness, the experimental products showed 69% higher efficiency compared to the prototypes; also, according to the visual assessment of women, the smoothing of the microrelief (lifting effect) with the experimental products was 49% better than the prototype products.

Cosmetic products according to examples No. 4-5 also underwent clinical testing in comparison with reference prototypes for a general assessment of consumer characteristics. The duration of the tests was 4 weeks. Shower gel was used daily once a day, body scrub was used every other day. In the case of products according to examples Nos. 4-5, the subjects knew which product was the reference product and which was the experimental one. The purpose of the tests was to directly compare the consumer characteristics of experimental products with reference ones. The criteria for evaluating the shower gel were: foaminess, skin hydration 10 - 15 minutes after the shower (subjective assessment), lack of skin irritation effect during use. The criteria for evaluating the body scrub were: comfort of application, lack of skin irritation during use, skin hydration after use, softening of the skin after use. The results are shown in Table No. 3. The data indicate that the experimental products are comfortable to use, the introduction of the mineral complex did not worsen the sensory characteristics, the condition of the skin of the subjects after using the experimental products was significantly better: greater hydration, softness and elasticity as assessed by the majority of the subjects.

By analogy, experiments were carried out with mineral complexes from examples of mixtures Nos. 2, 4, 5, 8 - 17. They were used to prepare different types of finished products. The results turned out to be similar (as for mineral complexes from examples of mixtures No. 1, 3, 6, 7 and 13).

Finished products using mineral complexes from examples of mixtures Nos. 2, 4, 5, 8 - 17 remained uniform and stable during accelerated storage or, in the case of emulsion products, centrifugation. The introduction of each of the above-mentioned mineral complexes was technologically convenient; the mineral complex did not affect the organoleptic properties of the product (color, smell, consistency), which were identical to similar products without the mineral complex. Also, finished products using mineral complexes from examples of mixtures No. 2, 4, 5, 8 - 17 showed similar results in terms of dermatological effectiveness. Tests were also conducted on women aged 24 to 47 years, the number of people in each group was 20. The duration of the tests was 4 weeks. In terms of effectiveness, the experimental products showed better results than the standards - prototypes: in terms of the level of skin hydration, an instrumental improvement of 87% was recorded compared to the beginning of the study, which is 85% higher than the effectiveness of the prototypes (improvement by 47%). In terms of elasticity and firmness, the experimental products showed 69% higher efficiency compared to the prototypes; also, according to the visual assessment of women, the smoothing of the microrelief (lifting effect) with the experimental products was 49% better than the prototype products.

When mineral complexes with the composition of components from examples of mixtures No. 2, 4, 5, 8 - 17 were used in finished products, but outside the declared ranges of components, the stability of the finished products was not ensured and the organoleptic properties deteriorated, so further testing was not possible.

Thus, it is possible to achieve in any finished cosmetic product the same concentration of dermatologically active minerals as in the medicinal salts of the most effective balneological centers for dermatological problems: the “Liz” Vichy springs, “La Roche Posay”, “RAPAN” salt and the Dead Sea , while increasing the dermatological effectiveness of the finished product and maintaining the organoleptic properties, stability and tolerability of the finished product.

Claims (10)

1. Mineral complex for use in cosmetics, containing: a copper compound selected from the group: copper glycinate or copper lysinate or copper malonate or copper salt of pyrrolidone carboxylic acid in an amount equal to from 0.5 to 10 wt.%; a selenium compound selected from the group: selenopyran or selenocysteine or sodium selenite in an amount equal to from 0.02 to 0.05 wt.%, or selenomethionine of selenium yeast in an amount equal to from 3.0 to 6.0 wt.%; a manganese compound selected from the group: manganese picolinate, or manganese chloride, or manganese chloride in an amount equal to from 0.06 to 0.20 wt.%; a zinc compound selected from the group: zinc sulfate, or zinc lactate, or zinc malonate, or zinc gluconate, or zinc chloride, or zinc salt of pyrrolidone carboxylic acid in an amount equal to 10 to 20% by weight; a silicon compound selected from the group: stabilized orthosilicic acid or methylsilanol mannuronate in an amount of from 5 to 30% by weight; a magnesium compound selected from the group: magnesium sulfate, or magnesium chloride, or magnesium salt of pyrrolidone carboxylic acid in an amount equal to from 10 to 74 wt.%; excipient - the rest. 2. Mineral complex according to claim 1, characterized in that it additionally contains an anti-caking agent - hydrophilic aerosil. 3. The mineral complex according to claim 1, characterized in that the excipient is a substance selected from the group: maltodextrin, beta-cyclodextrin, sorbitol, carboxymethylcellulose, xanthan gum, tara gum, carrageenan, sodium alginate, deltagluconolactone.