JP2009067718A - Skin preparation for external use containing phenolic compound in sap of plant of aceraceae - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a skin preparation for external use such as a cosmetic, etc., preventing or improving skin aging such as spots and wrinkles. <P>SOLUTION: This skin preparation for external use contains a phenolic compound having active oxygen dismutase-like (SOD-like) activity, obtained by separating/collecting from the sap of a plant of Aceraceae, or a fraction containing the compound. The (+)catechin and syringareginol separated as the phenolic compound have high SOD-like activity, and it is extremely advantageous to blend either one or both of them with the preparation. By blending the sap of the plant of Aceraceae, the moistness, etc., of the skin are improved. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to an external preparation for skin that is effective for preventing skin aging, moisturizing skin, and the like. More specifically, it is contained in the sap of a maple plant and is effective in eliminating active oxygen (SOD-like) action that is effective in preventing skin aging. The present invention relates to an external preparation for skin comprising a phenolic compound having an active ingredient as an active ingredient.

  As people age, the skin develops aging symptoms such as wrinkles and blemishes and reduced elasticity. In recent years, it has become clear that the progression of aging symptoms is promoted not only by aging but also by various stresses existing in the environment such as heat, ultraviolet rays, various chemical substances, etc. Attempts have been made to prevent skin aging using agents and active oxygen scavengers. Attempts have also been made to use antioxidants. For example, vitamin E and vitamin C are known to be free radical scavenging antioxidants in vivo. Furthermore, synthetic antioxidants such as BHT and BHA are also known as antioxidants.

However, it cannot be said that the antioxidant ability (free radical scavenging ability) of these substances is sufficient, and there is a suspicion of carcinogenicity in BHT and BHA. As natural antioxidants, for example, various materials such as basidiomycetous extracts (Patent Documents 1 to 3) have been reported, but their effects are not sufficient, and practically high antioxidant function. What has is desired.
On the other hand, in order to maintain and improve the health and aesthetics of the skin regardless of age or gender, various cosmetics such as lotions, cosmetic liquids, creams, milks, jelly, etc. are used on a daily basis. Since these cosmetics are used on a daily basis for a long period of time, it is necessary that the cosmetics have high safety and exhibit a stable effect.

The inventors of the present invention have been researching and developing quality improvement and effective use of maple sap, which is a maple sap, for many years. To date, the nutritional enriched maple syrup beverage (Patent Document 4), A patent for a bioactive phenolic compound and a food containing the same (Patent Document 5) has been filed.
JP-A-5-317016 JP-A-6-65575 JP 59-124984 A JP 2003-70448 A JP 2006-8523 A

  Further development of the topical skin preparation for maintaining and improving the health and aesthetics of the skin is desired from the viewpoint of functionality and safety. In particular, there is a demand for the development of cosmetics that have the effect of preventing the generation of wrinkles and blemishes associated with aging and the reduction of elasticity and improving symptoms.

  Therefore, the present inventors focused on maple sap as a plant material from the viewpoint of safety, and tried to use this as a cosmetic ingredient, and it was found that the skin moisturizing effect was good. It was. On the other hand, as a result of diligent research to search for effective components for preventing skin aging from maple sap, we succeeded in separating several phenolic compounds that have active oxygen scavenging (superoxide dismutase (SOD) -like) action. did. Maple sap represented by maple syrup easily rots when left at room temperature for about 12 hours due to the presence of nutrients such as sugars. Therefore, heat treatment is generally performed in order to provide storability. However, it has also been found that phenolic compounds with high SOD-like activity cannot be obtained from such heat-treated sap. As a result of further research, it was noted that the SOD-like activity of the two phenolic compounds (+) catechin and syringarezinol isolated from untreated maple sap was particularly high. It was. The present invention has been completed as a result of further studies based on these findings.

That is, the present invention

1) a topical skin preparation characterized by containing as an active ingredient a phenolic compound isolated from the sap of a maple plant and having a reactive oxygen scavenging (SOD-like) action or a fraction containing the compound,
2) (+) catechin and / or syringaresinol or at least one of them as a phenolic compound having an active oxygen scavenging (SOD-like) action, separated from the sap of a maple plant and the sap of a maple plant 1) or 2) above, wherein the external preparation for skin according to 1) above, and 3) the use form for external skin is cosmetic. Topical skin preparations,
It is.

  The maple sap contains a phenolic compound having SOD-like activity. However, simply adding the sap itself to cosmetics, for example, can exert SOD-like activity that contributes to the prevention of skin aging. Can not. The topical skin preparation of the present invention can prevent skin aging by separating a phenolic compound having an active oxygen scavenging (SOD-like) action from a maple sap and blending it in cosmetics or the like. . Moreover, if the maple sap itself is blended at the same time, effects such as moisturizing the skin can be imparted. This moisturizing effect is thought to be due to the action of sugars in the maple sap. Among the phenolic compounds, (+) catechin and syringarezinol isolated from maple sap not subjected to heat treatment have high SOD-like activity, and either or both of them are used in skins such as cosmetics. It becomes very advantageous to mix | blend with an external preparation.

The best mode of the present invention will be described below.
As the maple family referred to in the present invention, red maple (Red maple: Acer rubrum), silver maple (Silver Maple: Acer saccharum), Manitoba Maple (Manitoba Maple: Acer negrundo), black maple (Black maple: accernigrum), Norway Examples include Maple (Acer platanoides), Sycamore Maple (Acer pseudoplatanus), Canyon Maple (Acer grandidentatum), and Bigleaf Maple (Acer macreophyllum). Among these, silver maple and black maple are particularly useful as a source for obtaining a phenolic compound having an active oxygen scavenging (SOD-like) action or a fraction containing the same.
A phenolic compound having SOD activity or a fraction containing it can be obtained from maple plant sap as follows.

  The sap collected from the above-mentioned maple family plant is passed through column chromatography packed with a reverse phase chromatographic carrier, for example, Toyopearl HW-40, which is a porous filler, without heat treatment at a high temperature, When the column is eluted with water, monosaccharides and some oligosaccharides are eluted in the elution fraction. A mixture of saccharide and phenolic compound is eluted from the fraction eluted with 5% methanol aqueous solution or 5% isopropyl alcohol aqueous solution. Then, a fraction of a desired phenolic compound is obtained from the fraction eluted with 50% methanol or 50% isopropyl alcohol aqueous solution. Also present in this fraction are (+) catechin and syringaredinol.

  A phenolic compound fraction containing an SOD-like action can also be obtained from a concentrate of a maple plant sap. The sap of a maple plant is heated and concentrated at a temperature not reaching 100 ° C., and the obtained syrup is adsorbed to column chromatography packed with Toyopearl HW-40, which is a porous filler, in the same manner as described above. Then, when the column is eluted with water, monosaccharides and some oligosaccharides are eluted in the eluted fraction. A mixture of saccharide and phenolic compound is eluted from the fraction eluted with 5% methanol aqueous solution or 5% isopropyl alcohol aqueous solution. Then, a fraction of a desired phenolic compound is obtained from the fraction eluted with 50% methanol or 50% isopropyl alcohol aqueous solution. In this case, S + -like activity of (+) catechin and syringaredinol is lost when heating and concentrating at a high temperature exceeding 100 ° C. Therefore, it is necessary to avoid such high-temperature heating when obtaining these two compounds. It is.

  The fraction containing the phenolic compound of the maple sap can be used as the skin external preparation of the present invention as it is or by adding it to an external preparation base. If necessary, the diluted, concentrated, and dried solid may be dissolved again in water or a polar solvent, or after purification treatment such as decolorization, deodorization, and desalting, may be blended with the external preparation base. Further, in order to improve the storage stability, it is preferable to use after lyophilization after purification and dissolving in a solvent before use.

  The compounding amount of the phenolic compound having an active oxygen scavenging (SOD-like) action in the external preparation for skin of the present invention is the separated fraction obtained by adsorbing to a reverse phase chromatographic carrier, extracting with hydrous alcohol, and drying. In this state, it is appropriate to be about 0.001 to 10% by weight, more preferably about 0.001 to 5% by weight. In addition, when a maple sap is blended with the external preparation for skin of the present invention, for example, it is appropriate to blend 5 to 30% by weight, preferably 3 to 10% by weight of a sugar concentration of 1% by weight.

In addition, phenolic compounds derived from parts other than sap, such as leaves and xylem, may be added to the maple plant at the same time, and even if it is a phenolic compound that does not have SOD-like activity, its formulation is particularly limited. It is not something.
In addition to the above essential components, the external preparation for skin of the present invention is a component usually used in external preparations for skin such as cosmetics and pharmaceuticals, for example, whitening agents, moisturizers, antioxidants, oily components, ultraviolet absorbers, surfactants. , Thickeners, alcohols, powder components, color materials, aqueous components, water, various skin nutrients, and the like can be appropriately blended as necessary.

  Others, disodium edetate, trisodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate, sequestering agents such as gluconic acid, caffeine, tannin, verapamil, tranexamic acid and its derivatives, licorice extract, grabrizine , Hot water extract of fire thorn fruit, various herbal medicines, drugs such as tocopherol acetate, glycyrrhizic acid and its derivatives or salts thereof, vitamin C, magnesium ascorbate phosphate, glucoside ascorbate, arbutin, kojic acid, etc. Whitening agents, sugars such as glucose, fructose, mannose, sucrose, trehalose and the like can be appropriately blended.

  The external preparation for skin of the present invention is used in the form of cosmetics, quasi-drugs, etc., and can be particularly preferably widely applied to cosmetics. A wide range of dosage forms such as a system, an emulsion system, a powder system, an oil liquid system, a gel system, an ointment system, an aerosol system, a water-oil two-layer system, and a water-oil-powder three-layer system can be adopted. That is, if it is a basic cosmetic, it can be widely applied in the above-mentioned various dosage forms in the form of face wash, lotion, milky lotion, cream, gel, essence (beauty liquid), pack, mask and the like. In addition, makeup cosmetics can be widely applied to foundations and the like, and toiletries such as body soaps and soaps. Furthermore, if it is a quasi-drug, it can be widely applied to various ointment forms. However, the form which can take the skin external preparation of this invention is not limited to these dosage forms and forms.

The present invention will be described more specifically with reference to the following examples. In the following description, “%” means “% by weight” unless otherwise specified.
First, the test method regarding the antioxidant action of the phenolic compound fraction from the maple plant sap in the present invention will be described.
An active oxygen scavenging enzyme (SOD active enzyme) is produced in animals and plants, and has a function of removing active oxygen (superoxide) with a metal-containing enzyme. Typical diseases caused by active oxygen include cancer, leukemia, cerebral overflow, cerebral infarction, myocardial infarction, etc., and it is one of the causes of skin aging, wrinkles, tensioning, and spots due to aging. Substances having the ability to scavenge active oxygen are expected to have these preventive and therapeutic effects. SOD activity can be measured according to the method of MW Sutherland et al. (Free Rad. Res., 27, 283 (1997)).

(1) Preparation of phenolic compound fraction 1 L of silver maple (Acer saccharum) sap is subjected to column chromatography (300 mL) of reverse phase packing material, Cosmosil C18, and first eluted with 2 L of water. After removing the water-eluted fraction, it is eluted with 50% aqueous methanol. The eluted fractions were collected and concentrated under reduced pressure to obtain 3 g of the desired phenolic compound fraction (MS-C6,8).

(2) Results of HPLC analysis of this fraction (MS-C6,8) Analysis conditions: Column: Unison UK-Phenyl 100x4.6 (manufactured by Imtakt), solvent: CH ₃ CN: 5% AcOH = 13: 87 , flow rate 0.95 mL / min, detection: UV 235 nm, scopoletin (Retention time, 6.10) was used as a standard substance. As a result, 11 types of phenolic compounds 1, 4, 5, 8, 10, 11, 12, 13, 15, 16, and 17 were detected, identified, and confirmed. The chemical structural formulas of these 11 compounds are shown below. In this structural formula, compound 10 represents (+) catechin, and compound 12 represents syringaredinol. In the formula, Me represents a methyl group.

(3) SOD activity evaluation results
The activity was measured according to the method of MW Sutherland et al. (Free Rad. Res., 27, 283 (1997)), and the activity was expressed as IC50 (μM) using ascorbic acid as a standard substance. The measurement results of the SOD activity of the phenolic compounds 1, 4, 10, 12, and 15 and the 11 phenolic compound fractions are shown below.

Compound 1: 85.3
Compound 4: 45.0
Compound 10: 5.4
Compound 12: 30.4
Compound 15: 15.8
Phenolic compound fraction (MS-C6,8): 10.0
Ascorbic acid: 71.0
As described above, it was confirmed that the maple sap phenolic compound used in the present invention significantly suppressed the generation of active oxygen and had an active oxygen scavenging action. Apart from Compound 1, it shows that the SOD-like activity is very high compared to the control substance ascorbic acid.

Formulation examples of the external preparation for skin of the present invention are shown below.
Example 1
(Example of cream formulation)
Component A: cyclomethicone 10.0%, cetyl octanoate 5.0%, squalane 10.0%, meadowfoam 3.0%, tetrahydrotetramethylcyclotetrasiloxane 5.0%, dimethicone polyol 3.0%, Quotanium-18 hectorite 2.0%, fragrance appropriate amount.

  B component: Edetate 0.1%, Polyethylene glycol 6000 1.0%, Glycerol 5.0%, Dipropylene glycol 5.0%, Tranexamic acid 0.5%, Ascorbic acid magnesium alginate 0.1%, Sodium hyaluronate 0.01%, L-arginic acid salt 0.01%, phenolic compound fraction of maple sap (MS-C6,8) 0.5%, methylparaben 0.2%, ion-exchanged water residue.

A cream is prepared by dispersing a B component dissolved at room temperature into an oil phase part in which the A component is uniformly dispersed, while gradually adding the component.
Example 2
(Prescription example of wrinkle prevention cream)
Stearic acid 2.0%, stearyl alcohol 7.0%, hydrogenated lanolin 2.0%, squalane 5.0%, 2-octyldodecyl alcohol 6.0%, polyoxyethylene (25 mol) cetyl alcohol ether 3. 0%, glycerin monostearate ester 2.0%, propylene glycol 5.0%, phenolic compound fraction of maple sap (MS-C6,8) 0.2%, sodium bisulfite 0.03%, ethyl paraben 0.3%, proper amount of fragrance, ion-exchanged water remaining.

Production method: Propylene glycol is added to ion-exchanged water and heated to 70 ° C. (aqueous phase). The other ingredients are mixed, dissolved by heating and kept at 70 ° C. (oil phase). An oil phase is added to the aqueous phase, pre-emulsified, and uniformly emulsified with a homomixer, and then cooled to 30 ° C. while stirring well to prepare a wrinkle prevention cream.
Example 3
(Example of cream formulation)
Solid paraffin 5.0%, Beeswax 10.0%, Petrolatum 15.0%, Liquid paraffin 41.0%, Glycerol monostearate 2.0%, Polyoxyethylene (20 mol) sorbitan monolaurate 2 0.0%, soap powder 0.1%, borax 0.2%, phenolic compound fraction of maple sap (MS-C6,8) 0.2%, sodium bisulfite 0.03%, ethylparaben 0.3 %. Perfume appropriate amount, ion-exchanged water remaining.

Production method: Soap powder and borax are added to ion-exchanged water, dissolved by heating and kept at 70 ° C. (aqueous phase). The other ingredients are mixed, heated and melted, and kept at 70 ° C. (oil phase). The reaction is gradually added while stirring the oil phase in the aqueous phase. After completion of the reaction, the mixture is uniformly emulsified with a homomixer, and cooled to 30 ° C. while stirring well after the emulsification to prepare a cream.
Example 4
(Emulsion formulation example)
Stearic acid 2.5%, petrolatum 5.0%, liquid paraffin 10.0%, polyoxyethylene (10 mol) monooleate 2.0%, polyethylene glycol 1500 3.0%, triethanolamine 1.0 %, Carboxyvinyl polymer 0.05 (trade name: Carbopol 941, BF Goodrich Chemical company), phenolic compound fraction of maple sap (MS-C6,8) 0.1%, sodium hydrogen sulfite 0.01%, ethyl Paraben 0.3%, proper amount of perfume, ion-exchanged water remaining.
Production method: A carboxyvinyl polymer is dissolved in a small amount of ion-exchanged water (phase A). Polyethylene glycol 1500 and triethanolamine are added to the remaining ion-exchanged water, dissolved by heating and maintained at 70 ° C. (aqueous phase). The other ingredients are mixed, heated and melted, and kept at 70 ° C. (oil phase). Add the oil phase to the water phase, preliminarily emulsify, add the A phase and uniformly emulsify with a homomixer.

Example 5
(Emulsion formulation example)
Phase A: Squalane 5.0%, oleyl oleate 3.0%, petrolatum 2.0%, sorbitan sesquioleate 0.8%, polyoxyethylene oleyl ether (2OEO) 1.2%, evening primrose oil 0.5 %, Preservative appropriate amount, perfume appropriate amount.

  Phase B: 1,3-butylene glycol 4.5%, Melissa ethanol extract 1.5%, Cascon 99.5% Ethanol extract 1.0%, Ethanol 3.0%, Carboxyvinyl polymer 0.2%, Potassium hydroxide 0.1 L-arginine L-aspartate 0.01%, phenolic compound fraction of maple sap (MS-C6,8) 1.0%, 3-butylene glycol extract 10.0%, erythritol 0.5%, sodium hexametaphosphate 0.05%, ion-exchanged water remaining.

Production method: The oil phase part of A and the aqueous phase part of B are each heated to 70 ° C. and completely dissolved. Add Phase A to Phase B and emulsify with an emulsifier. The emulsion is cooled using a heat exchanger to prepare an emulsion.
Example 6
(Example of jelly formulation)
95% ethyl alcohol 10.0%, dipropylene glycol 15.0%, polyoxyethylene (50 mol) oleyl alcohol ether 2.0%, carboxyvinyl polymer 1.0% (trade name: Carbopol 940, BF Goodrich Chemical company ), Caustic soda 0.15 L-arginine 0.1%, phenolic compound fraction of maple sap (MS-C6,8) 3.0%, sodium 2-hydroxy-4-methoxybenzophenone sulfonate 0.05%, ethylenediamine Tetraacetate ・ 3sodium ・ 2 water 0.05%, methylparaben 0.2%, perfume appropriate amount, ion exchange water remaining.

Production method: Carbopol 940 is uniformly dissolved in ion-exchanged water. On the other hand, an extract of Merrilot 50% aqueous ethanol and polyoxyethylene (50 mol) oleyl alcohol ether are dissolved in 95% ethanol and added to the aqueous phase. Next, after adding other components, the mixture is neutralized with caustic soda and L-arginine and thickened to prepare a jelly.
Example 7
(Prescription example of serum)
Phase A: ethyl alcohol (95%) 10.0%, polyoxyethylene (20 mol) octyldodecanol 1.0%, pantotenyl ethyl ether 0.1%, phenolic compound fraction of maple sap (MS-C6 8) 1.0%, methyl paraben 0.15%.

Phase B: Potassium hydroxide 0.1%
Phase C: glycerin 5.0%, dipropylene glycol 10.0%, sodium bisulfite 0.03%, carboxyvinyl polymer 0.2% (trade name: Carbopol 940, BF Goodrich Chemical company), purified water residue.
Production method: A phase and C phase are uniformly dissolved, and A phase is added to C phase to solubilize. Subsequently, after adding B phase, it fills and prepares a cosmetic liquid.

Example 8
(Pack prescription example)
Phase A: Dipropylene glycol 5.0%, polyoxyethylene (60 mol) hydrogenated castor oil 5.0%.
Phase B: phenolic compound fraction of maple sap (MS-C6,8) 0.5%, olive oil 5.0%, tocopherol acetate 0.2%, ethyl paraben 0.2%, fragrance 0.2%.

Phase C: sodium bisulfite 0.03%, polyvinyl alcohol 13.0% (saponification degree 90, polymerization degree 2,000), ethanol 7.0%, purified water residue.
Production method: A phase, B phase, and C phase are uniformly dissolved, and B phase is added to A phase to solubilize. This is then added to phase C and then filled to prepare a pack.
Example 9
(Prescription example of lotion)
Phase A: ethanol 5.0%, POE oleyl alcohol ether 2.0%, oleyl alcohol 0.12%, ethylhexyl-P-dimethylaminobenzoate 0.18%, perfume appropriate amount.

Phase B: 1,3-butylene glycol 9.5%, glycerin 2.0%, sodium pyrrolidonecarboxylate 0.5%, nicotinamide 0.1%, phenolic compound fraction of maple sap (MS-C6, 8) 1.0%, β-cyclodextrin 1.0%, erythritol 0.05%, residual ion-exchanged water.
Production method: An alcohol phase of A is added to an aqueous phase of B and solubilized to prepare a lotion.

Example 10
(Prescription example of solid foundation)
Talc 43.1%, kaolin 15.0%, sericite 10.0%, zinc white 7.0% titanium dioxide 3.8%, PMMA spherical powder 5.0%, yellow iron oxide 2.9%, red oxidation Iron 1.0%, black iron oxide 0.2%, squalane 8.0%, isostearic acid 4.0%, monooleic acid POE sorbitan 3.0%, isocetyl octanoate 2.0%, phenolic of maple sap Compound fraction 1.0%, preservative proper amount, perfume proper amount.

Production method: Thoroughly blend the powder components of talc to black iron oxide with a blender, add the oil component of squalane to isocetyl octanoate, onionis ethanol extract, preservative, and fragrance, knead well, then fill the container and mold A solid foundation is prepared.
Example 11
(Emulsion foundation cream type formulation example)
Powder part: titanium dioxide 10.3%, sericite 5.4%, kaolin 3.0%, yellow iron oxide 0.8%, bengara 0.3%, black iron oxide 0.2%.

Oil phase: Decamethylcyclopentasiloxane 11.5%, liquid paraffin 4.5%, polyoxyethylene-modified dimethylpolysiloxane 4.0%.
Aqueous phase: Purified water 50.01%, 3-butylene glycol 4.5%, phenolic compound fraction of maple sap (MS-C6,8) 1.0%, sorbitan sesquioleate 3.0% , Preservative appropriate amount, perfume appropriate amount.

Production method: After heating and stirring the aqueous phase part, a powder part sufficiently mixed and pulverized is added and homomixed. Furthermore, after adding the heat-mixed oil phase part and carrying out a homomixer process, a fragrance | flavor is added with stirring, it cools to room temperature, and an emulsion type foundation (cream type) is prepared.
Example 12
(Prescription example of lotion)
Phase A: Ethanol 5.0%, POE oleyl alcohol ether 2.0%, oleyl alcohol 0.12%, ethylhexyl-P-dimethylaminobenzoate 0.18%, perfume appropriate amount.

Phase B: 1,3-butylene glycol 9.5%, glycerin 2.0%, sodium pyrrolidonecarboxylate 0.5%, nicotinamide 0.1%, β-cyclodextrin 1.0%, erythritol 0.05 %, Maple sap (sugar content 5%) 60.0%, residual ion-exchanged water.
Production method: A phase (alcohol phase) is added to B phase (water phase) and solubilized to obtain a lotion.

Example 13
(Prescription example of lotion)
Phase A: Ethanol 5.0%, POE oleyl alcohol ether 2.0%, oleyl alcohol 0.12%, ethylhexyl-P-dimethylaminobenzoate 0.18%, perfume appropriate amount.

Phase B: 1,3-butylene glycol 9.5%, glycerin 2.0%, sodium pyrrolidonecarboxylate 0.5%, nicotinamide 0.1%, phenolic compound fraction of maple sap (MS-C6, 8) 1.0%, β-cyclodextrin 1.0%, erythritol 0.05%, maple sap (sugar content 2%) 60.0%, ion-exchanged water remaining.
Production method: A phase (alcohol phase) is added to B phase (water phase) and solubilized to obtain a lotion.

Example 14
(Prescription example of serum)
Phase A: Ethyl alcohol (95%) 10.0%, polyoxyethylene (20 mol) octyldodecanol 1.0%, pantotenyl ethyl ether 0.1%, phenolic compound fraction of maple sap (MS-C6 8) 1.0%, methyl paraben 0.15%.

Phase B: Potassium hydroxide 0.1%
Phase C: glycerin 5.0%, dipropylene glycol 10.0%, sodium hydrogen sulfite 0.03%, carboxyvinyl polymer 0.2% (trade name: Carbopol 940, BF Goodrich Chemical company) Maple sap (sugar content 5% ) 20.0%, ion-exchanged water remaining.
Production method: A phase and C phase are uniformly dissolved, and A phase is added to C phase to solubilize. Next, a phase B is added to prepare a cosmetic liquid.

Example 15
(Prescription example of emulsified foundation-cream type)
Powder part: titanium dioxide 10.3%, sericite 5.4%, kaolin 3.0%, yellow iron oxide 0.8%, bengara 0.3%, black iron oxide 0.2%.
Oil phase: Decamethylcyclopentasiloxane 11.5%, liquid paraffin 4.5%, polyoxyethylene-modified dimethylpolysiloxane 4.0%.

Aqueous phase: Maple sap (sugar content 5%) 50.0%, 1,3-butylene glycol 4.5%, phenolic compound fraction of maple sap (MS-C6,8) 1.0%, sorbitan sesquiolein Acid ester 3.0%, preservative appropriate amount, perfume appropriate amount.
Manufacturing method: After heating and stirring the aqueous phase, a sufficiently mixed and pulverized powder part is added and homomixed. Furthermore, after adding the heat-mixed oil phase and carrying out a homomixer process, a fragrance | flavor is added with stirring and it cools to room temperature.

    As described above, the skin external preparation of the present invention has an excellent SOD action, and has an excellent effect on skin function deterioration such as wrinkling, sagging, and hardening due to aging and light stimulation. At the same time, it is possible to maintain an elastic, youthful and healthy skin state, which is useful as a cosmetic.

Claims (3)

  A topical skin preparation characterized by comprising a phenolic compound isolated from a sap of a maple plant and having a reactive oxygen scavenging (SOD-like) action or a fraction containing the compound as an active ingredient.   Separation of maple plant sap, and (+) catechin and / or syringaredinol or at least one of them as a phenolic compound having an active oxygen scavenging (SOD-like) action isolated from the maple plant sap The skin external preparation according to claim 1, comprising a fraction.   The external preparation for skin according to claim 1 or 2, wherein the external use form is a cosmetic.