RU2205184C2 - Производные к-252а - Google Patents

Производные к-252а Download PDF

Info

Publication number
RU2205184C2
RU2205184C2 RU99100050/04A RU99100050A RU2205184C2 RU 2205184 C2 RU2205184 C2 RU 2205184C2 RU 99100050/04 A RU99100050/04 A RU 99100050/04A RU 99100050 A RU99100050 A RU 99100050A RU 2205184 C2 RU2205184 C2 RU 2205184C2
Authority
RU
Russia
Prior art keywords
hydrogen
lower alkyl
group
same meanings
compound
Prior art date
Application number
RU99100050/04A
Other languages
English (en)
Russian (ru)
Other versions
RU99100050A (ru
Inventor
Роберт Л. ХАДКИНЗ (US)
Роберт Л. Хадкинз
Джон П. МАЛЛАМО (US)
Джон П. Малламо
Масами ХАМАНО (JP)
Масами Хамано
Рейко ТАНАКА (JP)
Рейко Танака
Тикара МУРАКАТА (JP)
Тикара Мураката
Original Assignee
Сефалон, Инк.
Киова Хакко Когио Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сефалон, Инк., Киова Хакко Когио Ко., Лтд. filed Critical Сефалон, Инк.
Publication of RU99100050A publication Critical patent/RU99100050A/ru
Application granted granted Critical
Publication of RU2205184C2 publication Critical patent/RU2205184C2/ru

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
RU99100050/04A 1996-06-03 1997-06-02 Производные к-252а RU2205184C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65736696A 1996-06-03 1996-06-03
US08/657,366 1996-06-03
US08/657.366 1996-06-03

Publications (2)

Publication Number Publication Date
RU99100050A RU99100050A (ru) 2000-12-27
RU2205184C2 true RU2205184C2 (ru) 2003-05-27

Family

ID=24636859

Family Applications (1)

Application Number Title Priority Date Filing Date
RU99100050/04A RU2205184C2 (ru) 1996-06-03 1997-06-02 Производные к-252а

Country Status (17)

Country Link
US (1) US6306849B1 (https=)
EP (1) EP0918777B1 (https=)
JP (1) JP2000511902A (https=)
CN (1) CN1198827C (https=)
AT (1) ATE222912T1 (https=)
AU (1) AU716656B2 (https=)
BR (1) BR9711093A (https=)
CA (1) CA2256633C (https=)
DE (1) DE69715010T2 (https=)
DK (1) DK0918777T3 (https=)
ES (1) ES2183184T3 (https=)
NO (1) NO312464B1 (https=)
NZ (2) NZ333018A (https=)
PT (1) PT918777E (https=)
RU (1) RU2205184C2 (https=)
UA (1) UA67725C2 (https=)
WO (1) WO1997046565A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2532341C2 (ru) * 2008-12-22 2014-11-10 Креабилис С.А. Синтез полимерных конъюгатов индолокарбазольных соединений

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7795246B2 (en) 1998-08-06 2010-09-14 Cephalon, Inc. Particle-forming compositions containing fused pyrrolocarbazoles
US6200968B1 (en) 1998-08-06 2001-03-13 Cephalon, Inc. Particle-forming compositions containing fused pyrrolocarbazoles
WO2000018407A1 (en) 1998-09-25 2000-04-06 Cephalon, Inc. Methods for preventing/treating damage to sensory hair cells and cochlear neurons
US7129250B2 (en) 2000-05-19 2006-10-31 Aegera Therapeutics Inc. Neuroprotective and anti-proliferative compounds
US7018999B2 (en) 2001-05-16 2006-03-28 Cephalon, Inc. Methods for the treatment and prevention of pain
AU2003259846A1 (en) * 2002-08-16 2004-03-03 The General Hospital Corporation Non-invasive functional imaging of peripheral nervous system activation in humans and animals
EP1545615A4 (en) * 2002-10-04 2006-03-01 Rinat Neuroscience Corp METHODS OF TREATING CARDIAC ARRHYTHMIA AND PREVENTING DEATH OF CARDIAC ARRHYTHMIA USING NGF ANTAGONISTS
ZA200502612B (en) 2002-10-08 2007-07-25 Rinat Neuroscience Corp Methods for treating post-surgical pain by administering a nerve crowth factor antagonist and compositions containing the same
US7255860B2 (en) * 2002-10-08 2007-08-14 Rinat Neuroscience Corp. Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist antibody
UA80447C2 (en) 2002-10-08 2007-09-25 Methods for treating pain by administering nerve growth factor antagonist and opioid analgesic
CN101014364B (zh) * 2002-12-24 2012-01-18 里纳特神经系统学公司 抗ngf抗体及其使用方法
US7569364B2 (en) 2002-12-24 2009-08-04 Pfizer Inc. Anti-NGF antibodies and methods using same
US9498530B2 (en) 2002-12-24 2016-11-22 Rinat Neuroscience Corp. Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions containing the same
EP2191846A1 (en) 2003-02-19 2010-06-02 Rinat Neuroscience Corp. Method for treating pain by administering a nerve growth factor antagonist and an NSAID and composition containing the same
US20060014165A1 (en) * 2003-07-14 2006-01-19 Decode Genetics Ehf. Methods of diagnosis and treatment for asthma and other respiratory diseases based on haplotype association
JP5301152B2 (ja) * 2004-04-07 2013-09-25 ライナット ニューロサイエンス コーポレイション 神経成長因子アンタゴニストを投与することによって骨癌の疼痛を処置するための方法
MX2007001155A (es) * 2004-07-29 2007-08-14 Creabilis Therapeutics Spa Uso de inhibidores de k-252a y de quinasa para la prevencion o el tratamiento de patologias asociadas con hmgb1.
US20080021013A1 (en) * 2006-07-21 2008-01-24 Cephalon, Inc. JAK inhibitors for treatment of myeloproliferative disorders

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0370236A1 (de) * 1988-10-21 1990-05-30 Gödecke Aktiengesellschaft Indolocarbazol-Derivate, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
EP0630898A1 (en) * 1992-09-21 1994-12-28 Kyowa Hakko Kogyo Kabushiki Kaisha Thrombocytopenia remedy
RU2039035C1 (ru) * 1991-01-22 1995-07-09 Американ Хоум Продактс Корпорейшн Производные {[2- (амино -3,4- диоксо -1- циклобутен -1-ил) амино] алкиловых}кислот
US5468872A (en) * 1993-09-16 1995-11-21 Cephalon, Inc. K-252a functional derivatives potentiate neurotrophin-3 for the treatment of neurological disorders

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554402A (en) 1983-12-23 1985-11-19 Aluminum Company Of America Vibration damper for overhead conductor
JPS62120388A (ja) 1985-11-19 1987-06-01 Meiji Seika Kaisha Ltd Ｓｆ−２３７０物質ハロゲン化誘導体とその製造法
JPS62155284A (ja) 1985-12-27 1987-07-10 Kyowa Hakko Kogyo Co Ltd 生理活性物質ｋ−２５２の誘導体
JPS62155285A (ja) 1985-12-27 1987-07-10 Kyowa Hakko Kogyo Co Ltd 生理活性物質ｋ−２５２の誘導体
JPS62220196A (ja) 1986-03-20 1987-09-28 Kyowa Hakko Kogyo Co Ltd 新規物質ｕｃｎ―０１
US4816450A (en) 1986-09-15 1989-03-28 Duke University Inhibition of protein kinase C by long-chain bases
JPH0826037B2 (ja) 1987-01-22 1996-03-13 協和醗酵工業株式会社 生理活性物質ｋ−２５２の誘導体
JPH0826036B2 (ja) 1987-01-22 1996-03-13 協和醗酵工業株式会社 生理活性物質ｋ−２５２の誘導体
US4735939A (en) 1987-02-27 1988-04-05 The Dow Chemical Company Insecticidal activity of staurosporine
DE3752123T2 (de) 1987-03-09 1998-05-14 Kyowa Hakko Kogyo Kk Derivate des physiologisch aktiven mittels k-252
IL86632A0 (en) 1987-06-15 1988-11-30 Ciba Geigy Ag Derivatives substituted at methyl-amino nitrogen
US5093330A (en) 1987-06-15 1992-03-03 Ciba-Geigy Corporation Staurosporine derivatives substituted at methylamino nitrogen
JPH07113027B2 (ja) 1987-12-24 1995-12-06 協和醗酵工業株式会社 Ｋ−２５２誘導体
WO1989007105A1 (fr) 1988-02-04 1989-08-10 Kyowa Hakko Kogyo Co., Ltd. Derives de staurosporine
DE3924538A1 (de) 1989-07-25 1991-01-31 Goedecke Ag Indolocarbazol und dessen verwendung
WO1991009034A1 (en) 1989-12-14 1991-06-27 Schering Corporation Indolocarbazoles from saccharothrix aerocolonigenes subsp. copiosa subsp. nov. scc 1951 atcc 53856
JPH0586068A (ja) 1991-03-04 1993-04-06 Rikagaku Kenkyusho 新規抗生物質ｒｋ−１４０９、その製造法並びに抗腫瘍剤及び抗炎症剤
WO1993008809A1 (en) 1991-11-08 1993-05-13 The University Of Southern California Compositions containing k-252 compounds for potentiation of neurotrophin activity
JP2593021B2 (ja) 1991-12-13 1997-03-19 伊藤ハム株式会社 ウシ胚の性の識別方法
US6271242B1 (en) 1992-02-10 2001-08-07 Bristol-Myers Squibb Co. Method for treating cancer using a tyrosine protein kinase inhibitor
JPH05247055A (ja) 1992-03-03 1993-09-24 Meiji Seika Kaisha Ltd スタウロスポリン誘導体及びそれを含有する抗腫瘍効果増強剤
DE69326388T2 (de) 1992-06-22 1999-12-30 Kyowa Hakko Kogyo Co., Ltd. Verfahren zur Herstellung von Staurosporin-Derivaten
JPH0673063A (ja) 1992-06-22 1994-03-15 Kyowa Hakko Kogyo Co Ltd Ｕｃｎ−０１誘導体
US5461146A (en) 1992-07-24 1995-10-24 Cephalon, Inc. Selected protein kinase inhibitors for the treatment of neurological disorders
US5621100A (en) 1992-07-24 1997-04-15 Cephalon, Inc. K-252a derivatives for treatment of neurological disorders
DE69409641T2 (de) 1993-05-28 1998-11-26 Cephalon, Inc., West Chester, Pa. Anwendung von indolocarbazol-derivaten zur behandlung von prostataerkrankungen
AU7000094A (en) 1993-06-17 1995-01-17 Ciba-Geigy Ag Indolocarbazole compound useful as proteinkinase c inhibitor

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0370236A1 (de) * 1988-10-21 1990-05-30 Gödecke Aktiengesellschaft Indolocarbazol-Derivate, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
RU2039035C1 (ru) * 1991-01-22 1995-07-09 Американ Хоум Продактс Корпорейшн Производные {[2- (амино -3,4- диоксо -1- циклобутен -1-ил) амино] алкиловых}кислот
EP0630898A1 (en) * 1992-09-21 1994-12-28 Kyowa Hakko Kogyo Kabushiki Kaisha Thrombocytopenia remedy
US5468872A (en) * 1993-09-16 1995-11-21 Cephalon, Inc. K-252a functional derivatives potentiate neurotrophin-3 for the treatment of neurological disorders

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2532341C2 (ru) * 2008-12-22 2014-11-10 Креабилис С.А. Синтез полимерных конъюгатов индолокарбазольных соединений

Also Published As

Publication number Publication date
CN1198827C (zh) 2005-04-27
US6306849B1 (en) 2001-10-23
PT918777E (pt) 2003-01-31
DE69715010T2 (de) 2003-04-03
AU3225397A (en) 1998-01-05
WO1997046565A1 (en) 1997-12-11
EP0918777B1 (en) 2002-08-28
NZ504097A (en) 2005-06-24
NO985622D0 (no) 1998-12-02
EP0918777A1 (en) 1999-06-02
CA2256633A1 (en) 1997-12-11
AU716656B2 (en) 2000-03-02
CN1226893A (zh) 1999-08-25
CA2256633C (en) 2009-04-07
ES2183184T3 (es) 2003-03-16
ATE222912T1 (de) 2002-09-15
DE69715010D1 (de) 2002-10-02
DK0918777T3 (da) 2002-12-30
NO985622L (no) 1999-02-02
BR9711093A (pt) 1999-08-17
NO312464B1 (no) 2002-05-13
JP2000511902A (ja) 2000-09-12
HK1018703A1 (en) 1999-12-30
UA67725C2 (en) 2004-07-15
NZ333018A (en) 2000-05-26

Similar Documents

Publication Publication Date Title
RU2205184C2 (ru) Производные к-252а
Biard et al. Lepadiformine, a new marine cytotoxic alkaloid from Clavelina lepadiformis Müller
US5118677A (en) Amide esters of rapamycin
JP7427812B2 (ja) 血漿カリクレインの阻害剤およびその使用
RU99100050A (ru) Некоторые производные к-252а
EP0176956B1 (de) Neue Diarylverbindungen
FR2595245A1 (fr) Compositions tinctoriales pour fibres keratiniques a base de derives d'indole et composes nouveaux
DE1056725T1 (de) Hemmung von raf-kinase unter verwendung von aryl- und heteroarylsubstituierten heterocyclischen harnstoffen
CN107151250B (zh) 嘧啶类七元环化合物、其制备方法、药用组合物及其应用
US4578394A (en) Cholinergic function increasing 3-[N-(pyridyl) carbamoyl]-1,4-dihydropyridines
KR100414810B1 (ko) 리포좀형성uv흡수제
CN114507235A (zh) 一种具有降解btk激酶的化合物及其制备方法和药学上的应用
EP0185964A2 (de) Dihydropyridin-carbonsäureamide, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln
NL8301949A (nl) Amidines en werkwijze voor het bereiden daarvan.
SE452615B (sv) Piperazinderivat och forfaranden for framstellning derav
EP0209701A2 (de) Neue 1,4-Dihydropyridine, Verfahren zur Herstellung und ihre Verwendung in Arzneimitteln
US4642310A (en) Circulation-active tetrahydrothienopyridines
JPH02502543A (ja) 新規６置換マイトマイシン類似体
NO943652L (no) Fremgangsmåte for fremstilling av 3-aminopyridiner fra 3-nitropyridiner
Pop et al. Improved anticonvulsant activity of phenytoin by a redox brain delivery system I: Synthesis and some properties of the dihydropyridine derivatives
DE1932384A1 (de) Derivate des 2-Oxo-1,2-dihydro-chinolins
DE4107439A1 (de) Kosmetische mittel, die 2-(1'-cyano-2'-arylvinyl)benzimidazol-derivate enthalten, neue 2-(1'-cyano-2'-arylvinyl)benzimidazol-derivate, verfahren zu ihrer herstellung und ihre verwendung
KR890016018A (ko) 6-옥소-피리다진 유도체류, 이들 화합물의 제조방법과 그 함유 의약품
WO1987006579A1 (fr) Amines et ethers nouveaux
TW202327575A (zh) 葡糖腦苷脂酶活性的小分子調節劑及其用途

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20120603