RU2205184C2 - Производные к-252а - Google Patents

Производные к-252а Download PDF

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Publication number
RU2205184C2
RU2205184C2 RU99100050/04A RU99100050A RU2205184C2 RU 2205184 C2 RU2205184 C2 RU 2205184C2 RU 99100050/04 A RU99100050/04 A RU 99100050/04A RU 99100050 A RU99100050 A RU 99100050A RU 2205184 C2 RU2205184 C2 RU 2205184C2
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RU
Russia
Prior art keywords
hydrogen
lower alkyl
group
same meanings
compound
Prior art date
Application number
RU99100050/04A
Other languages
English (en)
Russian (ru)
Other versions
RU99100050A (ru
Inventor
Роберт Л. ХАДКИНЗ (US)
Роберт Л. Хадкинз
Джон П. МАЛЛАМО (US)
Джон П. Малламо
Масами ХАМАНО (JP)
Масами Хамано
Рейко ТАНАКА (JP)
Рейко Танака
Тикара МУРАКАТА (JP)
Тикара Мураката
Original Assignee
Сефалон, Инк.
Киова Хакко Когио Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Сефалон, Инк., Киова Хакко Когио Ко., Лтд. filed Critical Сефалон, Инк.
Publication of RU99100050A publication Critical patent/RU99100050A/ru
Application granted granted Critical
Publication of RU2205184C2 publication Critical patent/RU2205184C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
RU99100050/04A 1996-06-03 1997-06-02 Производные к-252а RU2205184C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65736696A 1996-06-03 1996-06-03
US08/657,366 1996-06-03
US08/657.366 1996-06-03

Publications (2)

Publication Number Publication Date
RU99100050A RU99100050A (ru) 2000-12-27
RU2205184C2 true RU2205184C2 (ru) 2003-05-27

Family

ID=24636859

Family Applications (1)

Application Number Title Priority Date Filing Date
RU99100050/04A RU2205184C2 (ru) 1996-06-03 1997-06-02 Производные к-252а

Country Status (17)

Country Link
US (1) US6306849B1 (enExample)
EP (1) EP0918777B1 (enExample)
JP (1) JP2000511902A (enExample)
CN (1) CN1198827C (enExample)
AT (1) ATE222912T1 (enExample)
AU (1) AU716656B2 (enExample)
BR (1) BR9711093A (enExample)
CA (1) CA2256633C (enExample)
DE (1) DE69715010T2 (enExample)
DK (1) DK0918777T3 (enExample)
ES (1) ES2183184T3 (enExample)
NO (1) NO312464B1 (enExample)
NZ (2) NZ333018A (enExample)
PT (1) PT918777E (enExample)
RU (1) RU2205184C2 (enExample)
UA (1) UA67725C2 (enExample)
WO (1) WO1997046565A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2532341C2 (ru) * 2008-12-22 2014-11-10 Креабилис С.А. Синтез полимерных конъюгатов индолокарбазольных соединений

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US7795246B2 (en) 1998-08-06 2010-09-14 Cephalon, Inc. Particle-forming compositions containing fused pyrrolocarbazoles
US6200968B1 (en) 1998-08-06 2001-03-13 Cephalon, Inc. Particle-forming compositions containing fused pyrrolocarbazoles
WO2000018407A1 (en) 1998-09-25 2000-04-06 Cephalon, Inc. Methods for preventing/treating damage to sensory hair cells and cochlear neurons
US7129250B2 (en) 2000-05-19 2006-10-31 Aegera Therapeutics Inc. Neuroprotective and anti-proliferative compounds
AR035971A1 (es) 2001-05-16 2004-07-28 Cephalon Inc Metodos para el tratamiento y la prevencion del dolor
WO2004016167A1 (en) * 2002-08-16 2004-02-26 The General Hospital Corporation Non-invasive functional imaging of peripheral nervous system activation in humans and animals
EP1545615A4 (en) * 2002-10-04 2006-03-01 Rinat Neuroscience Corp METHODS OF TREATING CARDIAC ARRHYTHMIA AND PREVENTING DEATH OF CARDIAC ARRHYTHMIA USING NGF ANTAGONISTS
WO2004032870A2 (en) * 2002-10-08 2004-04-22 Rinat Neuroscience Corp. Methods for treating post-surgical pain by admisnistering a nerve growth factor antagonist and compositions containing the same
UA80447C2 (en) 2002-10-08 2007-09-25 Methods for treating pain by administering nerve growth factor antagonist and opioid analgesic
US7255860B2 (en) * 2002-10-08 2007-08-14 Rinat Neuroscience Corp. Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist antibody
US7569364B2 (en) * 2002-12-24 2009-08-04 Pfizer Inc. Anti-NGF antibodies and methods using same
SI2270048T1 (sl) * 2002-12-24 2016-01-29 Rinat Neuroscience Corp. Protitelesa proti NGF-ju in postopki uporabe le-teh
US9498530B2 (en) 2002-12-24 2016-11-22 Rinat Neuroscience Corp. Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions containing the same
US7655231B2 (en) * 2003-02-19 2010-02-02 Pfizer Inc. Methods for treating pain by administering a nerve growth factor antagonist and an NSAID
US20060014165A1 (en) * 2003-07-14 2006-01-19 Decode Genetics Ehf. Methods of diagnosis and treatment for asthma and other respiratory diseases based on haplotype association
SG152226A1 (en) * 2004-04-07 2009-05-29 Rinat Neuroscience Corp Methods for treating bone cancer pain by administering a nerve growth factor antagonist
MX2007001155A (es) * 2004-07-29 2007-08-14 Creabilis Therapeutics Spa Uso de inhibidores de k-252a y de quinasa para la prevencion o el tratamiento de patologias asociadas con hmgb1.
US20080021013A1 (en) * 2006-07-21 2008-01-24 Cephalon, Inc. JAK inhibitors for treatment of myeloproliferative disorders

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Publication number Priority date Publication date Assignee Title
EP0370236A1 (de) * 1988-10-21 1990-05-30 Gödecke Aktiengesellschaft Indolocarbazol-Derivate, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
EP0630898A1 (en) * 1992-09-21 1994-12-28 Kyowa Hakko Kogyo Kabushiki Kaisha Thrombocytopenia remedy
RU2039035C1 (ru) * 1991-01-22 1995-07-09 Американ Хоум Продактс Корпорейшн Производные {[2- (амино -3,4- диоксо -1- циклобутен -1-ил) амино] алкиловых}кислот
US5468872A (en) * 1993-09-16 1995-11-21 Cephalon, Inc. K-252a functional derivatives potentiate neurotrophin-3 for the treatment of neurological disorders

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JPS62120388A (ja) 1985-11-19 1987-06-01 Meiji Seika Kaisha Ltd Ｓｆ−２３７０物質ハロゲン化誘導体とその製造法
JPS62155284A (ja) 1985-12-27 1987-07-10 Kyowa Hakko Kogyo Co Ltd 生理活性物質ｋ−２５２の誘導体
JPS62155285A (ja) 1985-12-27 1987-07-10 Kyowa Hakko Kogyo Co Ltd 生理活性物質ｋ−２５２の誘導体
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US4816450A (en) 1986-09-15 1989-03-28 Duke University Inhibition of protein kinase C by long-chain bases
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JPH0826036B2 (ja) * 1987-01-22 1996-03-13 協和醗酵工業株式会社 生理活性物質ｋ−２５２の誘導体
US4735939A (en) 1987-02-27 1988-04-05 The Dow Chemical Company Insecticidal activity of staurosporine
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CA2123096A1 (en) 1991-11-08 1993-05-13 Beat J. Knusel Compositions containing k-252 compounds for potentiation of neurotrophin activity
JP2593021B2 (ja) 1991-12-13 1997-03-19 伊藤ハム株式会社 ウシ胚の性の識別方法
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Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0370236A1 (de) * 1988-10-21 1990-05-30 Gödecke Aktiengesellschaft Indolocarbazol-Derivate, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
RU2039035C1 (ru) * 1991-01-22 1995-07-09 Американ Хоум Продактс Корпорейшн Производные {[2- (амино -3,4- диоксо -1- циклобутен -1-ил) амино] алкиловых}кислот
EP0630898A1 (en) * 1992-09-21 1994-12-28 Kyowa Hakko Kogyo Kabushiki Kaisha Thrombocytopenia remedy
US5468872A (en) * 1993-09-16 1995-11-21 Cephalon, Inc. K-252a functional derivatives potentiate neurotrophin-3 for the treatment of neurological disorders

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2532341C2 (ru) * 2008-12-22 2014-11-10 Креабилис С.А. Синтез полимерных конъюгатов индолокарбазольных соединений

Also Published As

Publication number Publication date
BR9711093A (pt) 1999-08-17
ES2183184T3 (es) 2003-03-16
EP0918777A1 (en) 1999-06-02
DK0918777T3 (da) 2002-12-30
PT918777E (pt) 2003-01-31
NZ333018A (en) 2000-05-26
CA2256633A1 (en) 1997-12-11
JP2000511902A (ja) 2000-09-12
UA67725C2 (en) 2004-07-15
NO312464B1 (no) 2002-05-13
NO985622L (no) 1999-02-02
AU716656B2 (en) 2000-03-02
NO985622D0 (no) 1998-12-02
DE69715010D1 (de) 2002-10-02
HK1018703A1 (en) 1999-12-30
WO1997046565A1 (en) 1997-12-11
ATE222912T1 (de) 2002-09-15
CA2256633C (en) 2009-04-07
NZ504097A (en) 2005-06-24
CN1198827C (zh) 2005-04-27
AU3225397A (en) 1998-01-05
CN1226893A (zh) 1999-08-25
DE69715010T2 (de) 2003-04-03
EP0918777B1 (en) 2002-08-28
US6306849B1 (en) 2001-10-23

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Effective date: 20120603