BR9711093A - Derivados selecionados de k-252a - Google Patents
Derivados selecionados de k-252aInfo
- Publication number
- BR9711093A BR9711093A BR9711093A BR9711093A BR9711093A BR 9711093 A BR9711093 A BR 9711093A BR 9711093 A BR9711093 A BR 9711093A BR 9711093 A BR9711093 A BR 9711093A BR 9711093 A BR9711093 A BR 9711093A
- Authority
- BR
- Brazil
- Prior art keywords
- selected derivatives
- survival
- enhancing
- compounds
- represented
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
- VVVPGLRKXQSQSZ-UHFFFAOYSA-N indolo[3,2-c]carbazole Chemical class C1=CC=CC2=NC3=C4C5=CC=CC=C5N=C4C=CC3=C21 VVVPGLRKXQSQSZ-UHFFFAOYSA-N 0.000 abstract 1
- 230000004073 interleukin-2 production Effects 0.000 abstract 1
- 230000004083 survival effect Effects 0.000 abstract 1
- 230000001228 trophic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65736696A | 1996-06-03 | 1996-06-03 | |
| PCT/US1997/009448 WO1997046565A1 (en) | 1996-06-03 | 1997-06-02 | SELECTED DERIVATIVES OF K-252a |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9711093A true BR9711093A (pt) | 1999-08-17 |
Family
ID=24636859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9711093A BR9711093A (pt) | 1996-06-03 | 1997-06-02 | Derivados selecionados de k-252a |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6306849B1 (enExample) |
| EP (1) | EP0918777B1 (enExample) |
| JP (1) | JP2000511902A (enExample) |
| CN (1) | CN1198827C (enExample) |
| AT (1) | ATE222912T1 (enExample) |
| AU (1) | AU716656B2 (enExample) |
| BR (1) | BR9711093A (enExample) |
| CA (1) | CA2256633C (enExample) |
| DE (1) | DE69715010T2 (enExample) |
| DK (1) | DK0918777T3 (enExample) |
| ES (1) | ES2183184T3 (enExample) |
| NO (1) | NO312464B1 (enExample) |
| NZ (2) | NZ333018A (enExample) |
| PT (1) | PT918777E (enExample) |
| RU (1) | RU2205184C2 (enExample) |
| UA (1) | UA67725C2 (enExample) |
| WO (1) | WO1997046565A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7795246B2 (en) | 1998-08-06 | 2010-09-14 | Cephalon, Inc. | Particle-forming compositions containing fused pyrrolocarbazoles |
| US6200968B1 (en) | 1998-08-06 | 2001-03-13 | Cephalon, Inc. | Particle-forming compositions containing fused pyrrolocarbazoles |
| WO2000018407A1 (en) | 1998-09-25 | 2000-04-06 | Cephalon, Inc. | Methods for preventing/treating damage to sensory hair cells and cochlear neurons |
| US7129250B2 (en) | 2000-05-19 | 2006-10-31 | Aegera Therapeutics Inc. | Neuroprotective and anti-proliferative compounds |
| AR035971A1 (es) | 2001-05-16 | 2004-07-28 | Cephalon Inc | Metodos para el tratamiento y la prevencion del dolor |
| WO2004016167A1 (en) * | 2002-08-16 | 2004-02-26 | The General Hospital Corporation | Non-invasive functional imaging of peripheral nervous system activation in humans and animals |
| EP1545615A4 (en) * | 2002-10-04 | 2006-03-01 | Rinat Neuroscience Corp | METHODS OF TREATING CARDIAC ARRHYTHMIA AND PREVENTING DEATH OF CARDIAC ARRHYTHMIA USING NGF ANTAGONISTS |
| WO2004032870A2 (en) * | 2002-10-08 | 2004-04-22 | Rinat Neuroscience Corp. | Methods for treating post-surgical pain by admisnistering a nerve growth factor antagonist and compositions containing the same |
| UA80447C2 (en) | 2002-10-08 | 2007-09-25 | Methods for treating pain by administering nerve growth factor antagonist and opioid analgesic | |
| US7255860B2 (en) * | 2002-10-08 | 2007-08-14 | Rinat Neuroscience Corp. | Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist antibody |
| US7569364B2 (en) * | 2002-12-24 | 2009-08-04 | Pfizer Inc. | Anti-NGF antibodies and methods using same |
| SI2270048T1 (sl) * | 2002-12-24 | 2016-01-29 | Rinat Neuroscience Corp. | Protitelesa proti NGF-ju in postopki uporabe le-teh |
| US9498530B2 (en) | 2002-12-24 | 2016-11-22 | Rinat Neuroscience Corp. | Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions containing the same |
| US7655231B2 (en) * | 2003-02-19 | 2010-02-02 | Pfizer Inc. | Methods for treating pain by administering a nerve growth factor antagonist and an NSAID |
| US20060014165A1 (en) * | 2003-07-14 | 2006-01-19 | Decode Genetics Ehf. | Methods of diagnosis and treatment for asthma and other respiratory diseases based on haplotype association |
| SG152226A1 (en) * | 2004-04-07 | 2009-05-29 | Rinat Neuroscience Corp | Methods for treating bone cancer pain by administering a nerve growth factor antagonist |
| MX2007001155A (es) * | 2004-07-29 | 2007-08-14 | Creabilis Therapeutics Spa | Uso de inhibidores de k-252a y de quinasa para la prevencion o el tratamiento de patologias asociadas con hmgb1. |
| US20080021013A1 (en) * | 2006-07-21 | 2008-01-24 | Cephalon, Inc. | JAK inhibitors for treatment of myeloproliferative disorders |
| KR101431165B1 (ko) * | 2008-12-22 | 2014-08-18 | 크레아빌리스 에스.에이. | 인돌로카르바졸 화합물의 중합체 컨쥬케이트의 합성 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4554402A (en) | 1983-12-23 | 1985-11-19 | Aluminum Company Of America | Vibration damper for overhead conductor |
| JPS62120388A (ja) | 1985-11-19 | 1987-06-01 | Meiji Seika Kaisha Ltd | Ｓｆ−２３７０物質ハロゲン化誘導体とその製造法 |
| JPS62155284A (ja) | 1985-12-27 | 1987-07-10 | Kyowa Hakko Kogyo Co Ltd | 生理活性物質ｋ−２５２の誘導体 |
| JPS62155285A (ja) | 1985-12-27 | 1987-07-10 | Kyowa Hakko Kogyo Co Ltd | 生理活性物質ｋ−２５２の誘導体 |
| JPS62220196A (ja) | 1986-03-20 | 1987-09-28 | Kyowa Hakko Kogyo Co Ltd | 新規物質ｕｃｎ―０１ |
| US4816450A (en) | 1986-09-15 | 1989-03-28 | Duke University | Inhibition of protein kinase C by long-chain bases |
| JPH0826037B2 (ja) | 1987-01-22 | 1996-03-13 | 協和醗酵工業株式会社 | 生理活性物質ｋ−２５２の誘導体 |
| JPH0826036B2 (ja) * | 1987-01-22 | 1996-03-13 | 協和醗酵工業株式会社 | 生理活性物質ｋ−２５２の誘導体 |
| US4735939A (en) | 1987-02-27 | 1988-04-05 | The Dow Chemical Company | Insecticidal activity of staurosporine |
| EP0303697B1 (en) | 1987-03-09 | 1997-10-01 | Kyowa Hakko Kogyo Co., Ltd. | Derivatives of physiologically active substance k-252 |
| IL86632A0 (en) | 1987-06-15 | 1988-11-30 | Ciba Geigy Ag | Derivatives substituted at methyl-amino nitrogen |
| US5093330A (en) | 1987-06-15 | 1992-03-03 | Ciba-Geigy Corporation | Staurosporine derivatives substituted at methylamino nitrogen |
| JPH07113027B2 (ja) | 1987-12-24 | 1995-12-06 | 協和醗酵工業株式会社 | Ｋ−２５２誘導体 |
| JP2766360B2 (ja) | 1988-02-04 | 1998-06-18 | 協和醗酵工業株式会社 | スタウロスポリン誘導体 |
| DE3835842A1 (de) * | 1988-10-21 | 1990-04-26 | Goedecke Ag | Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel |
| DE3924538A1 (de) | 1989-07-25 | 1991-01-31 | Goedecke Ag | Indolocarbazol und dessen verwendung |
| WO1991009034A1 (en) | 1989-12-14 | 1991-06-27 | Schering Corporation | Indolocarbazoles from saccharothrix aerocolonigenes subsp. copiosa subsp. nov. scc 1951 atcc 53856 |
| US5168103A (en) * | 1991-01-22 | 1992-12-01 | American Home Products Corporation | [[2-(amino-3,4-dioxo-1-cyclobuten-1-yl) amino]alkyl]-acid derivatives |
| JPH0586068A (ja) | 1991-03-04 | 1993-04-06 | Rikagaku Kenkyusho | 新規抗生物質ｒｋ−１４０９、その製造法並びに抗腫瘍剤及び抗炎症剤 |
| CA2123096A1 (en) | 1991-11-08 | 1993-05-13 | Beat J. Knusel | Compositions containing k-252 compounds for potentiation of neurotrophin activity |
| JP2593021B2 (ja) | 1991-12-13 | 1997-03-19 | 伊藤ハム株式会社 | ウシ胚の性の識別方法 |
| US6271242B1 (en) | 1992-02-10 | 2001-08-07 | Bristol-Myers Squibb Co. | Method for treating cancer using a tyrosine protein kinase inhibitor |
| JPH05247055A (ja) | 1992-03-03 | 1993-09-24 | Meiji Seika Kaisha Ltd | スタウロスポリン誘導体及びそれを含有する抗腫瘍効果増強剤 |
| ES2136103T3 (es) | 1992-06-22 | 1999-11-16 | Kyowa Hakko Kogyo Kk | Procedimiento para la preparacion de derivados de estaurosporina. |
| JPH0673063A (ja) | 1992-06-22 | 1994-03-15 | Kyowa Hakko Kogyo Co Ltd | Ｕｃｎ−０１誘導体 |
| US5461146A (en) | 1992-07-24 | 1995-10-24 | Cephalon, Inc. | Selected protein kinase inhibitors for the treatment of neurological disorders |
| US5621100A (en) | 1992-07-24 | 1997-04-15 | Cephalon, Inc. | K-252a derivatives for treatment of neurological disorders |
| CA2123895A1 (en) * | 1992-09-21 | 1994-03-31 | Tatsuya Tamaoki | A therapeutic agent for thrombocytopenia |
| DE69409641T2 (de) | 1993-05-28 | 1998-11-26 | Cephalon, Inc., West Chester, Pa. | Anwendung von indolocarbazol-derivaten zur behandlung von prostataerkrankungen |
| WO1995000520A1 (en) | 1993-06-17 | 1995-01-05 | Ciba-Geigy Ag | Indolocarbazole compound useful as proteinkinase c inhibitor |
| US5468872A (en) | 1993-09-16 | 1995-11-21 | Cephalon, Inc. | K-252a functional derivatives potentiate neurotrophin-3 for the treatment of neurological disorders |
-
1997
- 1997-02-06 UA UA98126949A patent/UA67725C2/uk unknown
- 1997-06-02 BR BR9711093A patent/BR9711093A/pt active Search and Examination
- 1997-06-02 CA CA002256633A patent/CA2256633C/en not_active Expired - Fee Related
- 1997-06-02 DE DE69715010T patent/DE69715010T2/de not_active Expired - Lifetime
- 1997-06-02 RU RU99100050/04A patent/RU2205184C2/ru not_active IP Right Cessation
- 1997-06-02 AT AT97927906T patent/ATE222912T1/de not_active IP Right Cessation
- 1997-06-02 DK DK97927906T patent/DK0918777T3/da active
- 1997-06-02 AU AU32253/97A patent/AU716656B2/en not_active Ceased
- 1997-06-02 JP JP10500751A patent/JP2000511902A/ja active Pending
- 1997-06-02 CN CNB97196985XA patent/CN1198827C/zh not_active Expired - Fee Related
- 1997-06-02 ES ES97927906T patent/ES2183184T3/es not_active Expired - Lifetime
- 1997-06-02 PT PT97927906T patent/PT918777E/pt unknown
- 1997-06-02 EP EP97927906A patent/EP0918777B1/en not_active Expired - Lifetime
- 1997-06-02 NZ NZ333018A patent/NZ333018A/xx not_active IP Right Cessation
- 1997-06-02 WO PCT/US1997/009448 patent/WO1997046565A1/en not_active Ceased
- 1997-06-02 US US08/867,084 patent/US6306849B1/en not_active Expired - Fee Related
-
1998
- 1998-12-02 NO NO19985622A patent/NO312464B1/no not_active IP Right Cessation
-
2000
- 2000-04-19 NZ NZ504097A patent/NZ504097A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2183184T3 (es) | 2003-03-16 |
| EP0918777A1 (en) | 1999-06-02 |
| DK0918777T3 (da) | 2002-12-30 |
| PT918777E (pt) | 2003-01-31 |
| NZ333018A (en) | 2000-05-26 |
| CA2256633A1 (en) | 1997-12-11 |
| JP2000511902A (ja) | 2000-09-12 |
| UA67725C2 (en) | 2004-07-15 |
| NO312464B1 (no) | 2002-05-13 |
| NO985622L (no) | 1999-02-02 |
| AU716656B2 (en) | 2000-03-02 |
| NO985622D0 (no) | 1998-12-02 |
| DE69715010D1 (de) | 2002-10-02 |
| HK1018703A1 (en) | 1999-12-30 |
| WO1997046565A1 (en) | 1997-12-11 |
| ATE222912T1 (de) | 2002-09-15 |
| CA2256633C (en) | 2009-04-07 |
| NZ504097A (en) | 2005-06-24 |
| RU2205184C2 (ru) | 2003-05-27 |
| CN1198827C (zh) | 2005-04-27 |
| AU3225397A (en) | 1998-01-05 |
| CN1226893A (zh) | 1999-08-25 |
| DE69715010T2 (de) | 2003-04-03 |
| EP0918777B1 (en) | 2002-08-28 |
| US6306849B1 (en) | 2001-10-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR9711093A (pt) | Derivados selecionados de k-252a | |
| AU1676200A (en) | Polyhydroxylated heterocyclic derivatives as anti-coagulants | |
| MX9702682A (es) | Pirrolocarbazoles fusionados. | |
| MY126559A (en) | Fungicidal 2-methoxybenzophenones | |
| ES2187660T3 (es) | Derivados de rapamicina. | |
| EP0630898A4 (en) | MEDICINE FOR THROMBOZYTOPENIA. | |
| SE8204817L (sv) | Tetrazinderivat | |
| ATE289810T1 (de) | Ecteinascidinderivate | |
| AU7707094A (en) | Novel tetracyclic compound | |
| IE780922L (en) | 1,3,5-s-HEXAHYDROSUBSTITUTED TRIAZINES | |
| DE69727305D1 (de) | Verwendung neurogen-entzuendungshemmender verbindungen und zusammensetzungen | |
| SE9604582D0 (sv) | Novel compounds | |
| ATE234308T1 (de) | 3'-epi k-252a derivate | |
| AU4733185A (en) | Proline derivatives | |
| DE69703115D1 (de) | Zwischenprodukte um 2-imidazolin-5onederivate herzustellen. | |
| AU7020996A (en) | UCK14 compounds | |
| IL86665A0 (en) | Mitomycin analogs | |
| GB9911556D0 (en) | Immunosuppressant tricyclic compounds | |
| CA2201219A1 (en) | Process for the preparation of substituted pyrimidines | |
| DK0566557T3 (da) | 2- og 3-amino- og azidoderivater af 1,5- iminosukkere som antivirale forbindelser | |
| SU1746666A1 (ru) | Замещенные 3-аминометиленпирролидин-2,4-дионы, обладающие противосудорожной активностью |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFERIMENTO DO PRESENTE PEDIDO COM BASE NOS ARTIGOS 10(VIII), 24 E 25 DA LEI 9.279/96 |
|
| B12B | Appeal against refusal [chapter 12.2 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B11D | Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time |