RU2201919C2 - Стирилсульфоновые соединения, фармацевтические композиции на их основе, способ ингибирования роста опухолевых клеток, способ индукции апоптоза опухолевых клеток и способ лечения - Google Patents
Стирилсульфоновые соединения, фармацевтические композиции на их основе, способ ингибирования роста опухолевых клеток, способ индукции апоптоза опухолевых клеток и способ лечения Download PDFInfo
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- RU2201919C2 RU2201919C2 RU2000111513/04A RU2000111513A RU2201919C2 RU 2201919 C2 RU2201919 C2 RU 2201919C2 RU 2000111513/04 A RU2000111513/04 A RU 2000111513/04A RU 2000111513 A RU2000111513 A RU 2000111513A RU 2201919 C2 RU2201919 C2 RU 2201919C2
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- C—CHEMISTRY; METALLURGY
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| JP4596651B2 (ja) * | 1999-04-02 | 2010-12-08 | テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション | （ｅ）−スチリルスルホン抗癌剤 |
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| EP1841420B1 (en) * | 2005-01-05 | 2011-12-07 | Temple University - Of The Commonwealth System of Higher Education | Treatment of drug-resistant proliferative disorders |
| AU2006216544B2 (en) * | 2005-02-25 | 2012-04-05 | Onconova Therapeutics, Inc. | Unsaturated sulfides, sulfones, sulfoxides and sulfonamides synthesis |
| JP5278968B2 (ja) | 2006-08-30 | 2013-09-04 | テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション | 骨髄異形性症候群及び急性骨髄性白血病の治療のための組成物及び方法 |
| CA2663375A1 (en) * | 2006-09-15 | 2008-03-20 | Onconova Therapeutics, Inc. | Activated cytotoxic compounds for attachment to targeting molecules for the treatment of mammalian disease conditions |
| WO2008076270A2 (en) * | 2006-12-13 | 2008-06-26 | Temple University-Of The Commonwealth System Of Higher Education | Sulfide, sulfoxide and sulfone chalcone analogues, derivatives thereof and therapeutic uses thereof |
| CN110776447A (zh) | 2012-09-20 | 2020-02-11 | 坦普尔大学 | 取代的烷基二芳基衍生物、制备方法和用途 |
| US10576050B2 (en) | 2012-12-07 | 2020-03-03 | Onconova Therapeutics, Inc. | Methods and compositions for treatment of cancer |
| US10383831B2 (en) | 2015-08-03 | 2019-08-20 | Temple University—Of the Commonwealth System of Higher Education | 2,4,6-trialkoxystryl aryl sulfones, sulfonamides and carboxamides, and methods of preparation and use |
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| US4937388A (en) * | 1985-08-09 | 1990-06-26 | Imperial Chemical Industries Plc | Insecticidal ethers |
| EP0398818A1 (fr) * | 1989-04-10 | 1990-11-22 | Rhone-Poulenc Agrochimie | Sulfones herbicides dihalogénées |
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| US3185743A (en) | 1960-08-24 | 1965-05-25 | Union Carbide Corp | Production of olefinic compounds from allyl sulfones |
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| US3514386A (en) | 1967-12-11 | 1970-05-26 | Exxon Research Engineering Co | Stereoselective addition of thiols to acetylenic compounds |
| US3917714A (en) | 1972-09-06 | 1975-11-04 | American Cyanamid Co | Bis(alkylsulfonyl)vinylbenzenes |
| US4161407A (en) | 1977-10-06 | 1979-07-17 | Eastman Kodak Company | Crosslinkable polymers having vinylsulfonyl groups or styrylsulfonyl groups and their use as hardeners for gelatin |
| US4386221A (en) | 1981-10-28 | 1983-05-31 | Eastman Kodak Company | Process for the preparation of aryl alkyl sulfones and aryl vinyl sulfones |
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| US5700823A (en) * | 1994-01-07 | 1997-12-23 | Sugen, Inc. | Treatment of platelet derived growth factor related disorders such as cancers |
| US5659087A (en) | 1995-06-07 | 1997-08-19 | Eli Lilly And Company | Diarylvinyl sulfoxides |
| AU6112896A (en) * | 1995-06-07 | 1996-12-30 | Sugen, Inc. | Tyrphostin-like compounds for the treatment of cell prolifer ative disorders or cell differentiation disorders |
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- 1998-10-01 CZ CZ20001174A patent/CZ299718B6/cs not_active IP Right Cessation
- 1998-10-01 EP EP98949680A patent/EP1027330B1/en not_active Expired - Lifetime
- 1998-10-01 RU RU2000111513/04A patent/RU2201919C2/ru not_active IP Right Cessation
- 1998-10-01 JP JP2000514880A patent/JP4294217B2/ja not_active Expired - Fee Related
- 1998-10-01 WO PCT/US1998/020580 patent/WO1999018068A1/en not_active Ceased
- 1998-10-01 IL IL13543898A patent/IL135438A/xx not_active IP Right Cessation
- 1998-10-01 CN CNB988098199A patent/CN1163480C/zh not_active Expired - Fee Related
- 1998-10-01 AU AU95954/98A patent/AU741042B2/en not_active Ceased
- 1998-10-01 AT AT98949680T patent/ATE284386T1/de not_active IP Right Cessation
- 1998-10-01 KR KR1020007003554A patent/KR100579355B1/ko not_active Expired - Fee Related
- 1998-10-01 DE DE69828079T patent/DE69828079T2/de not_active Expired - Lifetime
- 1998-10-01 NZ NZ503479A patent/NZ503479A/xx not_active IP Right Cessation
- 1998-10-01 BR BRPI9814059-0A patent/BR9814059B1/pt not_active IP Right Cessation
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US4937388A (en) * | 1985-08-09 | 1990-06-26 | Imperial Chemical Industries Plc | Insecticidal ethers |
| EP0398818A1 (fr) * | 1989-04-10 | 1990-11-22 | Rhone-Poulenc Agrochimie | Sulfones herbicides dihalogénées |
Also Published As
| Publication number | Publication date |
|---|---|
| ATE284386T1 (de) | 2004-12-15 |
| DE69828079T2 (de) | 2005-12-22 |
| CN1163480C (zh) | 2004-08-25 |
| WO1999018068A1 (en) | 1999-04-15 |
| EP1027330A4 (en) | 2003-09-10 |
| HK1031373A1 (en) | 2001-06-15 |
| EP1027330A1 (en) | 2000-08-16 |
| KR20010015689A (ko) | 2001-02-26 |
| US6359013B1 (en) | 2002-03-19 |
| CZ20001174A3 (cs) | 2000-09-13 |
| IL135438A0 (en) | 2001-05-20 |
| JP4294217B2 (ja) | 2009-07-08 |
| NZ503479A (en) | 2002-08-28 |
| DE69828079D1 (de) | 2005-01-13 |
| CZ299718B6 (cs) | 2008-10-29 |
| BR9814059B1 (pt) | 2010-08-24 |
| KR100579355B1 (ko) | 2006-05-12 |
| CN1273580A (zh) | 2000-11-15 |
| CA2305790C (en) | 2008-09-23 |
| AU741042B2 (en) | 2001-11-22 |
| IL135438A (en) | 2005-12-18 |
| BR9814059A (pt) | 2000-09-26 |
| CA2305790A1 (en) | 1999-04-15 |
| EP1027330B1 (en) | 2004-12-08 |
| JP2001519326A (ja) | 2001-10-23 |
| AU9595498A (en) | 1999-04-27 |
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| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20161002 |