BR9814059B1 - composto e composiÇço farmacÉutica. - Google Patents
composto e composiÇço farmacÉutica.Info
- Publication number
- BR9814059B1 BR9814059B1 BRPI9814059-0A BR9814059A BR9814059B1 BR 9814059 B1 BR9814059 B1 BR 9814059B1 BR 9814059 A BR9814059 A BR 9814059A BR 9814059 B1 BR9814059 B1 BR 9814059B1
- Authority
- BR
- Brazil
- Prior art keywords
- hydrogen
- group
- fluorine
- bromine
- chlorine
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000001257 hydrogen Substances 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 229910052731 fluorine Inorganic materials 0.000 abstract 5
- 239000011737 fluorine Chemical group 0.000 abstract 5
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 4
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 4
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 4
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 4
- 229910052794 bromium Chemical group 0.000 abstract 4
- 229910052801 chlorine Inorganic materials 0.000 abstract 4
- 239000000460 chlorine Chemical group 0.000 abstract 4
- 150000002431 hydrogen Chemical group 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 210000004881 tumor cell Anatomy 0.000 abstract 2
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 abstract 1
- -1 2-nitrophenyl Chemical group 0.000 abstract 1
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- XJNHONCWGODPIZ-PHEQNACWSA-N [(e)-2-[(e)-2-phenylethenyl]sulfonylethenyl]benzene Chemical class C=1C=CC=CC=1/C=C/S(=O)(=O)\C=C\C1=CC=CC=C1 XJNHONCWGODPIZ-PHEQNACWSA-N 0.000 abstract 1
- 230000006907 apoptotic process Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/12—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/02—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms
- C07C317/10—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/14—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Graft Or Block Polymers (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6093397P | 1997-10-03 | 1997-10-03 | |
| PCT/US1998/020580 WO1999018068A1 (en) | 1997-10-03 | 1998-10-01 | Styryl sulfone anticancer agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR9814059A BR9814059A (pt) | 2000-09-26 |
| BR9814059B1 true BR9814059B1 (pt) | 2010-08-24 |
Family
ID=22032642
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9814059-0A BR9814059B1 (pt) | 1997-10-03 | 1998-10-01 | composto e composiÇço farmacÉutica. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6359013B1 (enExample) |
| EP (1) | EP1027330B1 (enExample) |
| JP (1) | JP4294217B2 (enExample) |
| KR (1) | KR100579355B1 (enExample) |
| CN (1) | CN1163480C (enExample) |
| AT (1) | ATE284386T1 (enExample) |
| AU (1) | AU741042B2 (enExample) |
| BR (1) | BR9814059B1 (enExample) |
| CA (1) | CA2305790C (enExample) |
| CZ (1) | CZ299718B6 (enExample) |
| DE (1) | DE69828079T2 (enExample) |
| IL (1) | IL135438A (enExample) |
| NZ (1) | NZ503479A (enExample) |
| RU (1) | RU2201919C2 (enExample) |
| WO (1) | WO1999018068A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6548553B2 (en) | 1997-10-03 | 2003-04-15 | Temple University-Of The Commonwealth System Of Higher Education | Styryl sulfone anticancer agents |
| US6762207B1 (en) * | 1999-04-02 | 2004-07-13 | Temple University - Of The Commonwealth System Of Higher Education | (E)-styryl sulfone anticancer agents |
| JP4596651B2 (ja) * | 1999-04-02 | 2010-12-08 | テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション | （ｅ）−スチリルスルホン抗癌剤 |
| WO2000077169A2 (en) | 1999-06-16 | 2000-12-21 | Temple University - Of The Commonwealth System Of Higher Education | (z)-styryl acetoxyphenyl sulfides as cyclooxygenase inhibitors |
| US6767926B1 (en) | 1999-10-12 | 2004-07-27 | Temple University - Of The Commonwealth System Of Higher Education | Method for protecting normal cells from cytotoxicity of chemotherapeutic agents |
| AU780844B2 (en) * | 1999-10-12 | 2005-04-21 | Temple University-Of The Commonwealth System Of Higher Education | Method for protecting normal cells from cytotoxicity of chemotherapeutic agents |
| US6486210B2 (en) * | 2000-04-14 | 2002-11-26 | Temple University—Of the Commonwealth System of Higher Education | Substituted styryl benzylsulfones for treating proliferative disorders |
| US6541475B2 (en) * | 2000-04-14 | 2003-04-01 | Temple University - Of The Commonwealth System Of Higher Education | α, β-unsaturated sulfones for treating proliferative disorders |
| WO2002028828A1 (en) * | 2000-10-05 | 2002-04-11 | Temple University - Of The Commonwealth System Of Higher Education | Substituted (e)-styryl benzylsulfones for treating proliferative disorders |
| US6833480B2 (en) | 2001-02-27 | 2004-12-21 | Temple University - Of The Commonwealth System Of Higher Education | (Z)-styrylbenzylsulfones and pharmaceutical uses thereof |
| JP4302986B2 (ja) * | 2001-02-28 | 2009-07-29 | テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション | 細胞及び組織をα，β不飽和アリールスルホンにより電離放射線から防護する方法 |
| MXPA04008356A (es) * | 2002-02-28 | 2005-09-12 | Univ Temple | (e)-2,6-dialcoxiestiril bencilsulfonas sustituidas con un grupo amino y en la posicion 4 para tratar trastornos poliferativos. |
| IL163608A0 (en) * | 2002-02-28 | 2005-12-18 | Univ Temple | Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders |
| US7012100B1 (en) | 2002-06-04 | 2006-03-14 | Avolix Pharmaceuticals, Inc. | Cell migration inhibiting compositions and methods and compositions for treating cancer |
| US7744889B2 (en) * | 2003-11-14 | 2010-06-29 | Temple University - Of The Commonwealth System Of Higher Education | Alpha, beta-unsaturated sulfoxides for treating proliferative disorders |
| EP1740530B8 (en) | 2004-03-16 | 2017-03-01 | Temple University - Of The Commonwealth System of Higher Education | Substituted phenoxy- and phenylthio-derivatives for treating proliferative disorders |
| EP1773310B9 (en) | 2004-06-24 | 2012-04-25 | Temple University - Of The Commonwealth System of Higher Education | Alpha, beta-unsaturated sulfones, sulfoxides, sulfonimides, sulfinimides, acylsulfonamides and acylsulfinamides and therapeutic uses thereof |
| EP1841420B1 (en) * | 2005-01-05 | 2011-12-07 | Temple University - Of The Commonwealth System of Higher Education | Treatment of drug-resistant proliferative disorders |
| AU2006216544B2 (en) * | 2005-02-25 | 2012-04-05 | Onconova Therapeutics, Inc. | Unsaturated sulfides, sulfones, sulfoxides and sulfonamides synthesis |
| JP5278968B2 (ja) | 2006-08-30 | 2013-09-04 | テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション | 骨髄異形性症候群及び急性骨髄性白血病の治療のための組成物及び方法 |
| CA2663375A1 (en) * | 2006-09-15 | 2008-03-20 | Onconova Therapeutics, Inc. | Activated cytotoxic compounds for attachment to targeting molecules for the treatment of mammalian disease conditions |
| WO2008076270A2 (en) * | 2006-12-13 | 2008-06-26 | Temple University-Of The Commonwealth System Of Higher Education | Sulfide, sulfoxide and sulfone chalcone analogues, derivatives thereof and therapeutic uses thereof |
| CN110776447A (zh) | 2012-09-20 | 2020-02-11 | 坦普尔大学 | 取代的烷基二芳基衍生物、制备方法和用途 |
| US10576050B2 (en) | 2012-12-07 | 2020-03-03 | Onconova Therapeutics, Inc. | Methods and compositions for treatment of cancer |
| US10383831B2 (en) | 2015-08-03 | 2019-08-20 | Temple University—Of the Commonwealth System of Higher Education | 2,4,6-trialkoxystryl aryl sulfones, sulfonamides and carboxamides, and methods of preparation and use |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2532612A (en) | 1945-08-29 | 1950-12-05 | Union Oil Co | Preparation of unsaturated thio-ethers |
| US3185743A (en) | 1960-08-24 | 1965-05-25 | Union Carbide Corp | Production of olefinic compounds from allyl sulfones |
| US3418101A (en) | 1965-12-15 | 1968-12-24 | Pennsalt Chemicals Corp | Process for plant desiccation |
| US3514386A (en) | 1967-12-11 | 1970-05-26 | Exxon Research Engineering Co | Stereoselective addition of thiols to acetylenic compounds |
| US3917714A (en) | 1972-09-06 | 1975-11-04 | American Cyanamid Co | Bis(alkylsulfonyl)vinylbenzenes |
| US4161407A (en) | 1977-10-06 | 1979-07-17 | Eastman Kodak Company | Crosslinkable polymers having vinylsulfonyl groups or styrylsulfonyl groups and their use as hardeners for gelatin |
| US4386221A (en) | 1981-10-28 | 1983-05-31 | Eastman Kodak Company | Process for the preparation of aryl alkyl sulfones and aryl vinyl sulfones |
| US4937388A (en) * | 1985-08-09 | 1990-06-26 | Imperial Chemical Industries Plc | Insecticidal ethers |
| FR2645536B1 (fr) * | 1989-04-10 | 1991-05-31 | Rhone Poulenc Agrochimie | Composes herbicides et les compositions les contenant |
| US6177401B1 (en) * | 1992-11-13 | 2001-01-23 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften | Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis |
| US5700823A (en) * | 1994-01-07 | 1997-12-23 | Sugen, Inc. | Treatment of platelet derived growth factor related disorders such as cancers |
| US5659087A (en) | 1995-06-07 | 1997-08-19 | Eli Lilly And Company | Diarylvinyl sulfoxides |
| AU6112896A (en) * | 1995-06-07 | 1996-12-30 | Sugen, Inc. | Tyrphostin-like compounds for the treatment of cell prolifer ative disorders or cell differentiation disorders |
-
1998
- 1998-10-01 CZ CZ20001174A patent/CZ299718B6/cs not_active IP Right Cessation
- 1998-10-01 EP EP98949680A patent/EP1027330B1/en not_active Expired - Lifetime
- 1998-10-01 RU RU2000111513/04A patent/RU2201919C2/ru not_active IP Right Cessation
- 1998-10-01 JP JP2000514880A patent/JP4294217B2/ja not_active Expired - Fee Related
- 1998-10-01 WO PCT/US1998/020580 patent/WO1999018068A1/en not_active Ceased
- 1998-10-01 IL IL13543898A patent/IL135438A/xx not_active IP Right Cessation
- 1998-10-01 CN CNB988098199A patent/CN1163480C/zh not_active Expired - Fee Related
- 1998-10-01 AU AU95954/98A patent/AU741042B2/en not_active Ceased
- 1998-10-01 AT AT98949680T patent/ATE284386T1/de not_active IP Right Cessation
- 1998-10-01 KR KR1020007003554A patent/KR100579355B1/ko not_active Expired - Fee Related
- 1998-10-01 DE DE69828079T patent/DE69828079T2/de not_active Expired - Lifetime
- 1998-10-01 NZ NZ503479A patent/NZ503479A/xx not_active IP Right Cessation
- 1998-10-01 BR BRPI9814059-0A patent/BR9814059B1/pt not_active IP Right Cessation
- 1998-10-01 US US09/509,227 patent/US6359013B1/en not_active Expired - Lifetime
- 1998-10-01 CA CA002305790A patent/CA2305790C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE284386T1 (de) | 2004-12-15 |
| DE69828079T2 (de) | 2005-12-22 |
| CN1163480C (zh) | 2004-08-25 |
| WO1999018068A1 (en) | 1999-04-15 |
| EP1027330A4 (en) | 2003-09-10 |
| HK1031373A1 (en) | 2001-06-15 |
| EP1027330A1 (en) | 2000-08-16 |
| KR20010015689A (ko) | 2001-02-26 |
| US6359013B1 (en) | 2002-03-19 |
| CZ20001174A3 (cs) | 2000-09-13 |
| IL135438A0 (en) | 2001-05-20 |
| RU2201919C2 (ru) | 2003-04-10 |
| JP4294217B2 (ja) | 2009-07-08 |
| NZ503479A (en) | 2002-08-28 |
| DE69828079D1 (de) | 2005-01-13 |
| CZ299718B6 (cs) | 2008-10-29 |
| KR100579355B1 (ko) | 2006-05-12 |
| CN1273580A (zh) | 2000-11-15 |
| CA2305790C (en) | 2008-09-23 |
| AU741042B2 (en) | 2001-11-22 |
| IL135438A (en) | 2005-12-18 |
| BR9814059A (pt) | 2000-09-26 |
| CA2305790A1 (en) | 1999-04-15 |
| EP1027330B1 (en) | 2004-12-08 |
| JP2001519326A (ja) | 2001-10-23 |
| AU9595498A (en) | 1999-04-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 24/08/2010, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time | ||
| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |