CA2305790C - Styryl sulfone anticancer agents - Google Patents
Styryl sulfone anticancer agents Download PDFInfo
- Publication number
- CA2305790C CA2305790C CA002305790A CA2305790A CA2305790C CA 2305790 C CA2305790 C CA 2305790C CA 002305790 A CA002305790 A CA 002305790A CA 2305790 A CA2305790 A CA 2305790A CA 2305790 C CA2305790 C CA 2305790C
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- Prior art keywords
- compound
- sulfone
- composition according
- cells
- hydrogen
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/12—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/02—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms
- C07C317/10—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/14—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Graft Or Block Polymers (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (3)
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|---|---|---|---|
| US6093397P | 1997-10-03 | 1997-10-03 | |
| US60/060,933 | 1997-10-03 | ||
| PCT/US1998/020580 WO1999018068A1 (en) | 1997-10-03 | 1998-10-01 | Styryl sulfone anticancer agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2305790A1 CA2305790A1 (en) | 1999-04-15 |
| CA2305790C true CA2305790C (en) | 2008-09-23 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002305790A Expired - Fee Related CA2305790C (en) | 1997-10-03 | 1998-10-01 | Styryl sulfone anticancer agents |
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|---|---|
| US (1) | US6359013B1 (enExample) |
| EP (1) | EP1027330B1 (enExample) |
| JP (1) | JP4294217B2 (enExample) |
| KR (1) | KR100579355B1 (enExample) |
| CN (1) | CN1163480C (enExample) |
| AT (1) | ATE284386T1 (enExample) |
| AU (1) | AU741042B2 (enExample) |
| BR (1) | BR9814059B1 (enExample) |
| CA (1) | CA2305790C (enExample) |
| CZ (1) | CZ299718B6 (enExample) |
| DE (1) | DE69828079T2 (enExample) |
| IL (1) | IL135438A (enExample) |
| NZ (1) | NZ503479A (enExample) |
| RU (1) | RU2201919C2 (enExample) |
| WO (1) | WO1999018068A1 (enExample) |
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| US6548553B2 (en) | 1997-10-03 | 2003-04-15 | Temple University-Of The Commonwealth System Of Higher Education | Styryl sulfone anticancer agents |
| US6762207B1 (en) | 1999-04-02 | 2004-07-13 | Temple University - Of The Commonwealth System Of Higher Education | (E)-styryl sulfone anticancer agents |
| CA2366750C (en) * | 1999-04-02 | 2010-06-01 | Temple University - Of The Commonwealth System Of Higher Education | (e)-styryl sulfone anticancer agents |
| AU778825B2 (en) | 1999-06-16 | 2004-12-23 | Temple University - Of The Commonwealth System Of Higher Education | (Z)-styryl acetoxyphenyl sulfides as cyclooxygenase inhibitors |
| EP1223923B1 (en) * | 1999-10-12 | 2010-03-31 | Temple University of the Commonwealth System of Higher Education | Unsaturated aryl sulfones for protecting normal cells from cytotoxicity of chemotherapeutic agents |
| US6767926B1 (en) | 1999-10-12 | 2004-07-27 | Temple University - Of The Commonwealth System Of Higher Education | Method for protecting normal cells from cytotoxicity of chemotherapeutic agents |
| US6541475B2 (en) * | 2000-04-14 | 2003-04-01 | Temple University - Of The Commonwealth System Of Higher Education | α, β-unsaturated sulfones for treating proliferative disorders |
| US6486210B2 (en) * | 2000-04-14 | 2002-11-26 | Temple University—Of the Commonwealth System of Higher Education | Substituted styryl benzylsulfones for treating proliferative disorders |
| JP2004510761A (ja) * | 2000-10-05 | 2004-04-08 | テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション | 増殖性疾病を治療するための置換（ｅ）−スチリルベンジルスルホン |
| US6833480B2 (en) * | 2001-02-27 | 2004-12-21 | Temple University - Of The Commonwealth System Of Higher Education | (Z)-styrylbenzylsulfones and pharmaceutical uses thereof |
| WO2002069892A2 (en) * | 2001-02-28 | 2002-09-12 | Temple University Of The Commonwealth System Of Higher Education | METHOD FOR PROTECTING CELLS AND TISSUES FROM IONIZING RADIATION TOXICITY WITH α, β UNSATURATED ARYL SULFONES |
| EP1534284B1 (en) * | 2002-02-28 | 2011-07-27 | Temple University - Of The Commonwealth System of Higher Education | Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders |
| ES2373945T3 (es) * | 2002-02-28 | 2012-02-10 | Temple University - Of The Commonwealth System Of Higher Education | Bencilsulfonas de (e)-2,6-dialcoxiestirilo amino sustituido sustituidas en 4 para tratar trastornos proliferativos. |
| US7012100B1 (en) | 2002-06-04 | 2006-03-14 | Avolix Pharmaceuticals, Inc. | Cell migration inhibiting compositions and methods and compositions for treating cancer |
| CA2546495C (en) * | 2003-11-14 | 2012-10-09 | Temple University - Of The Commonwealth System Of Higher Education | Alpha, beta-unsaturated sulfoxides for treating proliferative disorders |
| WO2005089269A2 (en) | 2004-03-16 | 2005-09-29 | Temple University - Of The Commonwealth System Of Higher Education | Substituted phenoxy- and phenylthio- derivatives for treating proliferative disorders |
| WO2006025924A2 (en) | 2004-06-24 | 2006-03-09 | Temple University Of The Commonwealth System Of Higher Education | Alpha, beta-unsaturated sulfones, sulfoxides, sulfonimides, sulfinimides, acylsulfonamides and acylsulfinamides and therapeutic uses thereof |
| CA2593523C (en) * | 2005-01-05 | 2014-04-08 | Temple University - Of The Commonwealth System Of Higher Education | Treatment of drug-resistant proliferative disorders |
| PT1896401E (pt) * | 2005-02-25 | 2013-07-17 | Univ Temple | Síntese de sulfuretos, sulfonas, sulfóxidos e sulfonamidas não saturados |
| JP5278968B2 (ja) | 2006-08-30 | 2013-09-04 | テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション | 骨髄異形性症候群及び急性骨髄性白血病の治療のための組成物及び方法 |
| CA2663375A1 (en) * | 2006-09-15 | 2008-03-20 | Onconova Therapeutics, Inc. | Activated cytotoxic compounds for attachment to targeting molecules for the treatment of mammalian disease conditions |
| EP2091527B1 (en) * | 2006-12-13 | 2016-03-23 | Temple University - Of The Commonwealth System of Higher Education | Sulfide, sulfoxide and sulfone chalcone analogues, derivatives thereof and therapeutic uses thereof |
| ES2863538T3 (es) | 2012-09-20 | 2021-10-11 | Univ Temple | Derivados de alquil diarilo sustituidos, métodos de preparación y usos |
| ES2864681T3 (es) | 2012-12-07 | 2021-10-14 | Onconova Therapeutics Inc | Tratamiento del cáncer hematológico refractario a un agente contra el cáncer |
| WO2017023912A1 (en) | 2015-08-03 | 2017-02-09 | Temple University - Of The Commonwealth System Of Higher Education | 2,4,6-trialkoxystryl aryl sulfones, sulfonamides and carboxamides, and methods of preparation and use |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2532612A (en) | 1945-08-29 | 1950-12-05 | Union Oil Co | Preparation of unsaturated thio-ethers |
| US3185743A (en) | 1960-08-24 | 1965-05-25 | Union Carbide Corp | Production of olefinic compounds from allyl sulfones |
| US3418101A (en) | 1965-12-15 | 1968-12-24 | Pennsalt Chemicals Corp | Process for plant desiccation |
| US3514386A (en) | 1967-12-11 | 1970-05-26 | Exxon Research Engineering Co | Stereoselective addition of thiols to acetylenic compounds |
| US3917714A (en) | 1972-09-06 | 1975-11-04 | American Cyanamid Co | Bis(alkylsulfonyl)vinylbenzenes |
| US4161407A (en) | 1977-10-06 | 1979-07-17 | Eastman Kodak Company | Crosslinkable polymers having vinylsulfonyl groups or styrylsulfonyl groups and their use as hardeners for gelatin |
| US4386221A (en) | 1981-10-28 | 1983-05-31 | Eastman Kodak Company | Process for the preparation of aryl alkyl sulfones and aryl vinyl sulfones |
| US4937388A (en) * | 1985-08-09 | 1990-06-26 | Imperial Chemical Industries Plc | Insecticidal ethers |
| FR2645536B1 (fr) * | 1989-04-10 | 1991-05-31 | Rhone Poulenc Agrochimie | Composes herbicides et les compositions les contenant |
| US6177401B1 (en) * | 1992-11-13 | 2001-01-23 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften | Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis |
| US5700823A (en) * | 1994-01-07 | 1997-12-23 | Sugen, Inc. | Treatment of platelet derived growth factor related disorders such as cancers |
| US5659087A (en) | 1995-06-07 | 1997-08-19 | Eli Lilly And Company | Diarylvinyl sulfoxides |
| WO1996040629A1 (en) * | 1995-06-07 | 1996-12-19 | Sugen, Inc. | Tyrphostin-like compounds for the treatment of cell proliferative disorders or cell differentiation disorders |
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- 1998-10-01 CN CNB988098199A patent/CN1163480C/zh not_active Expired - Fee Related
- 1998-10-01 WO PCT/US1998/020580 patent/WO1999018068A1/en not_active Ceased
- 1998-10-01 CA CA002305790A patent/CA2305790C/en not_active Expired - Fee Related
- 1998-10-01 KR KR1020007003554A patent/KR100579355B1/ko not_active Expired - Fee Related
- 1998-10-01 US US09/509,227 patent/US6359013B1/en not_active Expired - Lifetime
- 1998-10-01 DE DE69828079T patent/DE69828079T2/de not_active Expired - Lifetime
- 1998-10-01 RU RU2000111513/04A patent/RU2201919C2/ru not_active IP Right Cessation
- 1998-10-01 BR BRPI9814059-0A patent/BR9814059B1/pt not_active IP Right Cessation
- 1998-10-01 EP EP98949680A patent/EP1027330B1/en not_active Expired - Lifetime
- 1998-10-01 AT AT98949680T patent/ATE284386T1/de not_active IP Right Cessation
- 1998-10-01 AU AU95954/98A patent/AU741042B2/en not_active Ceased
- 1998-10-01 JP JP2000514880A patent/JP4294217B2/ja not_active Expired - Fee Related
- 1998-10-01 NZ NZ503479A patent/NZ503479A/xx not_active IP Right Cessation
- 1998-10-01 CZ CZ20001174A patent/CZ299718B6/cs not_active IP Right Cessation
Also Published As
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|---|---|
| BR9814059B1 (pt) | 2010-08-24 |
| HK1031373A1 (en) | 2001-06-15 |
| CZ20001174A3 (cs) | 2000-09-13 |
| EP1027330A1 (en) | 2000-08-16 |
| CZ299718B6 (cs) | 2008-10-29 |
| EP1027330B1 (en) | 2004-12-08 |
| KR100579355B1 (ko) | 2006-05-12 |
| JP4294217B2 (ja) | 2009-07-08 |
| WO1999018068A1 (en) | 1999-04-15 |
| CA2305790A1 (en) | 1999-04-15 |
| CN1273580A (zh) | 2000-11-15 |
| IL135438A0 (en) | 2001-05-20 |
| EP1027330A4 (en) | 2003-09-10 |
| DE69828079D1 (de) | 2005-01-13 |
| NZ503479A (en) | 2002-08-28 |
| RU2201919C2 (ru) | 2003-04-10 |
| BR9814059A (pt) | 2000-09-26 |
| AU9595498A (en) | 1999-04-27 |
| DE69828079T2 (de) | 2005-12-22 |
| ATE284386T1 (de) | 2004-12-15 |
| KR20010015689A (ko) | 2001-02-26 |
| IL135438A (en) | 2005-12-18 |
| US6359013B1 (en) | 2002-03-19 |
| AU741042B2 (en) | 2001-11-22 |
| JP2001519326A (ja) | 2001-10-23 |
| CN1163480C (zh) | 2004-08-25 |
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