KR100579355B1 - 스티릴 설폰 항암제 - Google Patents

스티릴 설폰 항암제 Download PDF

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Publication number
KR100579355B1
KR100579355B1 KR1020007003554A KR20007003554A KR100579355B1 KR 100579355 B1 KR100579355 B1 KR 100579355B1 KR 1020007003554 A KR1020007003554 A KR 1020007003554A KR 20007003554 A KR20007003554 A KR 20007003554A KR 100579355 B1 KR100579355 B1 KR 100579355B1
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South Korea
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sulfone
hydrogen
cells
fluorine
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English (en)
Korean (ko)
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KR20010015689A (ko
Inventor
프렘쿠마 이. 레디
라마나 엠. 브이. 레디
Original Assignee
템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션
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Application filed by 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 filed Critical 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션
Publication of KR20010015689A publication Critical patent/KR20010015689A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/12—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/02—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms
    • C07C317/10—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/14—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Graft Or Block Polymers (AREA)
KR1020007003554A 1997-10-03 1998-10-01 스티릴 설폰 항암제 Expired - Fee Related KR100579355B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6093397P 1997-10-03 1997-10-03
US60/060,933 1997-10-03
PCT/US1998/020580 WO1999018068A1 (en) 1997-10-03 1998-10-01 Styryl sulfone anticancer agents

Publications (2)

Publication Number Publication Date
KR20010015689A KR20010015689A (ko) 2001-02-26
KR100579355B1 true KR100579355B1 (ko) 2006-05-12

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020007003554A Expired - Fee Related KR100579355B1 (ko) 1997-10-03 1998-10-01 스티릴 설폰 항암제

Country Status (15)

Country Link
US (1) US6359013B1 (enExample)
EP (1) EP1027330B1 (enExample)
JP (1) JP4294217B2 (enExample)
KR (1) KR100579355B1 (enExample)
CN (1) CN1163480C (enExample)
AT (1) ATE284386T1 (enExample)
AU (1) AU741042B2 (enExample)
BR (1) BR9814059B1 (enExample)
CA (1) CA2305790C (enExample)
CZ (1) CZ299718B6 (enExample)
DE (1) DE69828079T2 (enExample)
IL (1) IL135438A (enExample)
NZ (1) NZ503479A (enExample)
RU (1) RU2201919C2 (enExample)
WO (1) WO1999018068A1 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6548553B2 (en) 1997-10-03 2003-04-15 Temple University-Of The Commonwealth System Of Higher Education Styryl sulfone anticancer agents
US6762207B1 (en) * 1999-04-02 2004-07-13 Temple University - Of The Commonwealth System Of Higher Education (E)-styryl sulfone anticancer agents
JP4596651B2 (ja) * 1999-04-02 2010-12-08 テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション （ｅ）−スチリルスルホン抗癌剤
WO2000077169A2 (en) 1999-06-16 2000-12-21 Temple University - Of The Commonwealth System Of Higher Education (z)-styryl acetoxyphenyl sulfides as cyclooxygenase inhibitors
US6767926B1 (en) 1999-10-12 2004-07-27 Temple University - Of The Commonwealth System Of Higher Education Method for protecting normal cells from cytotoxicity of chemotherapeutic agents
AU780844B2 (en) * 1999-10-12 2005-04-21 Temple University-Of The Commonwealth System Of Higher Education Method for protecting normal cells from cytotoxicity of chemotherapeutic agents
US6486210B2 (en) * 2000-04-14 2002-11-26 Temple University—Of the Commonwealth System of Higher Education Substituted styryl benzylsulfones for treating proliferative disorders
US6541475B2 (en) * 2000-04-14 2003-04-01 Temple University - Of The Commonwealth System Of Higher Education α, β-unsaturated sulfones for treating proliferative disorders
WO2002028828A1 (en) * 2000-10-05 2002-04-11 Temple University - Of The Commonwealth System Of Higher Education Substituted (e)-styryl benzylsulfones for treating proliferative disorders
US6833480B2 (en) 2001-02-27 2004-12-21 Temple University - Of The Commonwealth System Of Higher Education (Z)-styrylbenzylsulfones and pharmaceutical uses thereof
JP4302986B2 (ja) * 2001-02-28 2009-07-29 テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション 細胞及び組織をα，β不飽和アリールスルホンにより電離放射線から防護する方法
MXPA04008356A (es) * 2002-02-28 2005-09-12 Univ Temple (e)-2,6-dialcoxiestiril bencilsulfonas sustituidas con un grupo amino y en la posicion 4 para tratar trastornos poliferativos.
IL163608A0 (en) * 2002-02-28 2005-12-18 Univ Temple Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders
US7012100B1 (en) 2002-06-04 2006-03-14 Avolix Pharmaceuticals, Inc. Cell migration inhibiting compositions and methods and compositions for treating cancer
US7744889B2 (en) * 2003-11-14 2010-06-29 Temple University - Of The Commonwealth System Of Higher Education Alpha, beta-unsaturated sulfoxides for treating proliferative disorders
EP1740530B8 (en) 2004-03-16 2017-03-01 Temple University - Of The Commonwealth System of Higher Education Substituted phenoxy- and phenylthio-derivatives for treating proliferative disorders
EP1773310B9 (en) 2004-06-24 2012-04-25 Temple University - Of The Commonwealth System of Higher Education Alpha, beta-unsaturated sulfones, sulfoxides, sulfonimides, sulfinimides, acylsulfonamides and acylsulfinamides and therapeutic uses thereof
EP1841420B1 (en) * 2005-01-05 2011-12-07 Temple University - Of The Commonwealth System of Higher Education Treatment of drug-resistant proliferative disorders
AU2006216544B2 (en) * 2005-02-25 2012-04-05 Onconova Therapeutics, Inc. Unsaturated sulfides, sulfones, sulfoxides and sulfonamides synthesis
JP5278968B2 (ja) 2006-08-30 2013-09-04 テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション 骨髄異形性症候群及び急性骨髄性白血病の治療のための組成物及び方法
CA2663375A1 (en) * 2006-09-15 2008-03-20 Onconova Therapeutics, Inc. Activated cytotoxic compounds for attachment to targeting molecules for the treatment of mammalian disease conditions
WO2008076270A2 (en) * 2006-12-13 2008-06-26 Temple University-Of The Commonwealth System Of Higher Education Sulfide, sulfoxide and sulfone chalcone analogues, derivatives thereof and therapeutic uses thereof
CN110776447A (zh) 2012-09-20 2020-02-11 坦普尔大学 取代的烷基二芳基衍生物、制备方法和用途
US10576050B2 (en) 2012-12-07 2020-03-03 Onconova Therapeutics, Inc. Methods and compositions for treatment of cancer
US10383831B2 (en) 2015-08-03 2019-08-20 Temple University—Of the Commonwealth System of Higher Education 2,4,6-trialkoxystryl aryl sulfones, sulfonamides and carboxamides, and methods of preparation and use

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2532612A (en) 1945-08-29 1950-12-05 Union Oil Co Preparation of unsaturated thio-ethers
US3185743A (en) 1960-08-24 1965-05-25 Union Carbide Corp Production of olefinic compounds from allyl sulfones
US3418101A (en) 1965-12-15 1968-12-24 Pennsalt Chemicals Corp Process for plant desiccation
US3514386A (en) 1967-12-11 1970-05-26 Exxon Research Engineering Co Stereoselective addition of thiols to acetylenic compounds
US3917714A (en) 1972-09-06 1975-11-04 American Cyanamid Co Bis(alkylsulfonyl)vinylbenzenes
US4161407A (en) 1977-10-06 1979-07-17 Eastman Kodak Company Crosslinkable polymers having vinylsulfonyl groups or styrylsulfonyl groups and their use as hardeners for gelatin
US4386221A (en) 1981-10-28 1983-05-31 Eastman Kodak Company Process for the preparation of aryl alkyl sulfones and aryl vinyl sulfones
US4937388A (en) * 1985-08-09 1990-06-26 Imperial Chemical Industries Plc Insecticidal ethers
FR2645536B1 (fr) * 1989-04-10 1991-05-31 Rhone Poulenc Agrochimie Composes herbicides et les compositions les contenant
US6177401B1 (en) * 1992-11-13 2001-01-23 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis
US5700823A (en) * 1994-01-07 1997-12-23 Sugen, Inc. Treatment of platelet derived growth factor related disorders such as cancers
US5659087A (en) 1995-06-07 1997-08-19 Eli Lilly And Company Diarylvinyl sulfoxides
AU6112896A (en) * 1995-06-07 1996-12-30 Sugen, Inc. Tyrphostin-like compounds for the treatment of cell prolifer ative disorders or cell differentiation disorders

Also Published As

Publication number Publication date
ATE284386T1 (de) 2004-12-15
DE69828079T2 (de) 2005-12-22
CN1163480C (zh) 2004-08-25
WO1999018068A1 (en) 1999-04-15
EP1027330A4 (en) 2003-09-10
HK1031373A1 (en) 2001-06-15
EP1027330A1 (en) 2000-08-16
KR20010015689A (ko) 2001-02-26
US6359013B1 (en) 2002-03-19
CZ20001174A3 (cs) 2000-09-13
IL135438A0 (en) 2001-05-20
RU2201919C2 (ru) 2003-04-10
JP4294217B2 (ja) 2009-07-08
NZ503479A (en) 2002-08-28
DE69828079D1 (de) 2005-01-13
CZ299718B6 (cs) 2008-10-29
BR9814059B1 (pt) 2010-08-24
CN1273580A (zh) 2000-11-15
CA2305790C (en) 2008-09-23
AU741042B2 (en) 2001-11-22
IL135438A (en) 2005-12-18
BR9814059A (pt) 2000-09-26
CA2305790A1 (en) 1999-04-15
EP1027330B1 (en) 2004-12-08
JP2001519326A (ja) 2001-10-23
AU9595498A (en) 1999-04-27

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KR100579355B1 (ko) 스티릴 설폰 항암제
US6548553B2 (en) Styryl sulfone anticancer agents
US6201154B1 (en) Z-styryl sulfone anticancer agents
US6642410B2 (en) Substituted benzylthioacetic acids and esters
US7056953B2 (en) (E)-styryl sulfone anticancer agents
AU2001251614B2 (en) Alpha,beta-unsaturated sulfones for treating proliferative disorders
EP1173160B1 (en) (e)-styryl sulfone anticancer agents
WO2000059494A1 (en) Styryl sulfone anticancer agents
HK1031373B (en) Styryl sulfone anticancer agents

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