RU2201765C2 - Гибридные матричные имплантаты и эксплантаты - Google Patents
Гибридные матричные имплантаты и эксплантаты Download PDFInfo
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- RU2201765C2 RU2201765C2 RU98109891/14A RU98109891A RU2201765C2 RU 2201765 C2 RU2201765 C2 RU 2201765C2 RU 98109891/14 A RU98109891/14 A RU 98109891/14A RU 98109891 A RU98109891 A RU 98109891A RU 2201765 C2 RU2201765 C2 RU 2201765C2
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
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- A—HUMAN NECESSITIES
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- C—CHEMISTRY; METALLURGY
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
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- A—HUMAN NECESSITIES
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/426—Immunomodulating agents, i.e. cytokines, interleukins, interferons
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/428—Vitamins, e.g. tocopherol, riboflavin
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/64—Animal cells
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
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- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Prostheses (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/548.002 | 1995-10-25 | ||
| US08/548,002 US5965125A (en) | 1995-10-25 | 1995-10-25 | Hybrid matrix implants and explants |
| US08/548,002 | 1995-10-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU98109891A RU98109891A (ru) | 2000-03-27 |
| RU2201765C2 true RU2201765C2 (ru) | 2003-04-10 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU98109891/14A RU2201765C2 (ru) | 1995-10-25 | 1996-10-25 | Гибридные матричные имплантаты и эксплантаты |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US5965125A (enExample) |
| EP (1) | EP0917428A4 (enExample) |
| JP (1) | JP2000501299A (enExample) |
| CN (1) | CN1199567C (enExample) |
| AU (1) | AU706563B2 (enExample) |
| BR (1) | BR9611248A (enExample) |
| NO (1) | NO326107B1 (enExample) |
| NZ (1) | NZ321417A (enExample) |
| RU (1) | RU2201765C2 (enExample) |
| WO (1) | WO1997015195A1 (enExample) |
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Families Citing this family (109)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050186673A1 (en) * | 1995-02-22 | 2005-08-25 | Ed. Geistlich Soehne Ag Fuer Chemistrie Industrie | Collagen carrier of therapeutic genetic material, and method |
| GB9721585D0 (en) * | 1997-10-10 | 1997-12-10 | Geistlich Soehne Ag | Chemical product |
| US7112320B1 (en) | 1995-06-07 | 2006-09-26 | Andre Beaulieu | Solid wound healing formulations containing fibronectin |
| US6528483B2 (en) | 1995-06-07 | 2003-03-04 | André Beaulieu | Method of producing concentrated non-buffered solutions of fibronectin |
| US6419920B1 (en) | 1995-10-25 | 2002-07-16 | Trans Karyotic Therapies, Inc. | Hybrid matrix implants and explants |
| IL118376A0 (en) * | 1996-05-22 | 1996-09-12 | Univ Ben Gurion | Polysaccharide sponges for cell culture and transplantation |
| US6150164A (en) * | 1996-09-30 | 2000-11-21 | The Regents Of The University Of Michigan | Methods and compositions of a bioartificial kidney suitable for use in vivo or ex vivo |
| US7899511B2 (en) | 2004-07-13 | 2011-03-01 | Dexcom, Inc. | Low oxygen in vivo analyte sensor |
| US20050033132A1 (en) | 1997-03-04 | 2005-02-10 | Shults Mark C. | Analyte measuring device |
| US9155496B2 (en) | 1997-03-04 | 2015-10-13 | Dexcom, Inc. | Low oxygen in vivo analyte sensor |
| US20010007673A1 (en) * | 1999-11-12 | 2001-07-12 | Merrill Seymour Goldenberg | Sustained-release delayed gels |
| TW586934B (en) * | 1997-05-19 | 2004-05-11 | Sumitomo Pharma | Immunopotentiating composition |
| GB9718415D0 (en) * | 1997-08-29 | 1997-11-05 | Smithkline Beecham Plc | Formulation |
| US20050186283A1 (en) * | 1997-10-10 | 2005-08-25 | Ed. Geistlich Soehne Ag Fuer Chemistrie Industrie | Collagen carrier of therapeutic genetic material, and method |
| US6886568B2 (en) * | 1998-04-08 | 2005-05-03 | The Johns Hopkins University | Method for fabricating cell-containing implants |
| US6378527B1 (en) * | 1998-04-08 | 2002-04-30 | Chondros, Inc. | Cell-culture and polymer constructs |
| US7427602B1 (en) * | 1998-05-13 | 2008-09-23 | The Regents Of The University Of Michigan | Sustained DNA delivery from structural matrices |
| JP2002526508A (ja) * | 1998-09-21 | 2002-08-20 | イシス・イノベイシヨン・リミテツド | フィブリル |
| DK1163018T3 (da) * | 1999-03-19 | 2003-09-29 | Univ Michigan Technology Man W | Mineralisering og cellulær mønstring på biomaterialeoverflader |
| US6767928B1 (en) | 1999-03-19 | 2004-07-27 | The Regents Of The University Of Michigan | Mineralization and biological modification of biomaterial surfaces |
| US6662805B2 (en) * | 1999-03-24 | 2003-12-16 | The Johns Hopkins University | Method for composite cell-based implants |
| US6372494B1 (en) | 1999-05-14 | 2002-04-16 | Advanced Tissue Sciences, Inc. | Methods of making conditioned cell culture medium compositions |
| US6287340B1 (en) * | 1999-05-14 | 2001-09-11 | Trustees Of Tufts College | Bioengineered anterior cruciate ligament |
| ATE284674T1 (de) * | 1999-10-05 | 2005-01-15 | Transkaryotic Therapies Inc | Hybride matrizen und gemische davon |
| EP1099443A1 (en) | 1999-11-11 | 2001-05-16 | Sulzer Orthopedics Ltd. | Transplant/implant device and method for its production |
| WO2001065936A1 (en) * | 2000-03-06 | 2001-09-13 | Shah Kumarpal A | Method for immune switching |
| RU2180241C2 (ru) * | 2000-04-18 | 2002-03-10 | Государственное унитарное предприятие "Иммунопрепарат" | Ранозаживляющее средство |
| US7144729B2 (en) | 2000-09-01 | 2006-12-05 | Dfb Pharmaceuticals, Inc. | Methods and compositions for tissue regeneration |
| AR034262A1 (es) * | 2000-09-14 | 2004-02-18 | Transkaryotic Therapies Inc | Una composicion para proporcionar una mezcla fluida inyectable, un equipo, un metodo para preparacion de una mezcla de dicho equipo, un aparato para la introduccion de una mezcla en un paciente |
| US6538010B1 (en) * | 2000-11-08 | 2003-03-25 | Research Triangle Institute | Compounds and methods for promoting smoking cessation |
| US6444222B1 (en) * | 2001-05-08 | 2002-09-03 | Verigen Transplantation Services International Ag | Reinforced matrices |
| CA2388723C (en) * | 2001-06-06 | 2012-10-23 | Becton, Dickinson & Company | Method of providing a substrate with a ready-to-use, uniformly distributed extracellular matrix |
| EP1406573A4 (en) * | 2001-06-07 | 2005-03-30 | Skinmedica Inc | CONDITIONED CELL CULTURE MEDIA AND ITS USES |
| EP1416874A4 (en) * | 2001-07-16 | 2007-04-18 | Depuy Products Inc | BIOLOGICAL / SYNTHETIC POROUS EXTRACELLULAR HYBRID MATRIX SCUFF |
| JP4197160B2 (ja) * | 2001-07-16 | 2008-12-17 | デピュイ・プロダクツ・インコーポレイテッド | 軟骨修復および再生用の支持骨格材料および方法 |
| US8337537B2 (en) * | 2001-07-16 | 2012-12-25 | Depuy Products, Inc. | Device from naturally occurring biologically derived materials |
| AU2002320517B2 (en) * | 2001-07-16 | 2008-03-13 | Depuy Products, Inc. | Hybrid biologic-synthetic bioabsorable scaffolds |
| US6867189B2 (en) * | 2001-07-26 | 2005-03-15 | Genset S.A. | Use of adipsin/complement factor D in the treatment of metabolic related disorders |
| US7217570B2 (en) * | 2001-08-23 | 2007-05-15 | The Wistar Institute Of Anatomy And Biology | Organotypic intestinal culture and methods of use thereof |
| US7332330B2 (en) * | 2001-09-11 | 2008-02-19 | Renamed Biologics, Inc. | Device for maintaining vascularization near an implant |
| US20040031067A1 (en) * | 2001-10-11 | 2004-02-12 | Meenhard Herlyn | Regulation of human skin healing |
| US20030166274A1 (en) * | 2001-11-15 | 2003-09-04 | Hewitt Charles W. | Three-dimensional matrix for producing living tissue equivalents |
| US6902932B2 (en) * | 2001-11-16 | 2005-06-07 | Tissue Regeneration, Inc. | Helically organized silk fibroin fiber bundles for matrices in tissue engineering |
| RU2210352C1 (ru) * | 2001-12-07 | 2003-08-20 | Глинских Нина Поликарповна | Композиция для лечения воспалительных заболеваний пародонта на основе клеточных культур |
| RU2210341C1 (ru) * | 2001-12-07 | 2003-08-20 | Глинских Нина Поликарповна | Способ получения трансплантатов для заполнения костных дефектов при хирургическом лечении воспалительных заболеваний пародонта |
| US7803393B2 (en) * | 2002-03-08 | 2010-09-28 | Board Of Regents, The University Of Texas System | Preparing an implant by gas-plasma treatment of a substrate to couple cells |
| US7442546B2 (en) * | 2002-03-15 | 2008-10-28 | The Regents Of The University Of Michigan | Method of modulating inflammatory response |
| US7431922B2 (en) * | 2002-03-29 | 2008-10-07 | Tissuegene, Inc. | Bioadhesive directed somatic cell therapy |
| US20040219659A1 (en) * | 2002-04-22 | 2004-11-04 | Altman Gregory H. | Multi-dimensional strain bioreactor |
| US7459152B2 (en) * | 2003-04-23 | 2008-12-02 | Rush University Medical Center | Erythropoietin administration to improve graft survival |
| US7651596B2 (en) | 2005-04-08 | 2010-01-26 | Dexcom, Inc. | Cellulosic-based interference domain for an analyte sensor |
| US7591801B2 (en) | 2004-02-26 | 2009-09-22 | Dexcom, Inc. | Integrated delivery device for continuous glucose sensor |
| US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
| US8257963B2 (en) | 2007-06-01 | 2012-09-04 | Depuy Mitek, Inc. | Chondrocyte container and method of use |
| US7897384B2 (en) * | 2003-09-08 | 2011-03-01 | Ethicon, Inc. | Chondrocyte therapeutic delivery system |
| US7927599B2 (en) * | 2003-09-08 | 2011-04-19 | Ethicon, Inc. | Chondrocyte therapeutic delivery system |
| AU2004276316A1 (en) * | 2003-09-24 | 2005-04-07 | The Board Of Trustees Of The Leland Stanford Junior University | IGF-1 instructs multipotent adult CNS neural stem cells to an oligodendroglial lineage |
| US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
| US11633133B2 (en) | 2003-12-05 | 2023-04-25 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| US8423114B2 (en) | 2006-10-04 | 2013-04-16 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| EP2239566B1 (en) | 2003-12-05 | 2014-04-23 | DexCom, Inc. | Calibration techniques for a continuous analyte sensor |
| US8808228B2 (en) | 2004-02-26 | 2014-08-19 | Dexcom, Inc. | Integrated medicament delivery device for use with continuous analyte sensor |
| RU2268738C1 (ru) * | 2004-06-18 | 2006-01-27 | Владимир Никитич Ярыгин | Способ восстановления гиалинового хряща суставов |
| US7310544B2 (en) | 2004-07-13 | 2007-12-18 | Dexcom, Inc. | Methods and systems for inserting a transcutaneous analyte sensor |
| US20070045902A1 (en) | 2004-07-13 | 2007-03-01 | Brauker James H | Analyte sensor |
| ES2432556T3 (es) | 2004-08-04 | 2013-12-04 | Evonik Corporation | Métodos para fabricar dispositivos de suministro y sus dispositivos |
| WO2006073514A2 (en) * | 2004-08-25 | 2006-07-13 | Tufts University | Compositions, methods and kits for repressing virulence in gram positive bacteria |
| US8744546B2 (en) | 2005-05-05 | 2014-06-03 | Dexcom, Inc. | Cellulosic-based resistance domain for an analyte sensor |
| US9107917B2 (en) * | 2005-05-13 | 2015-08-18 | The Feinstein Institute For Medical Research | Treatment of sepsis and inflammation with alpha2A adrenergic antagonists |
| JP2009508596A (ja) | 2005-09-19 | 2009-03-05 | ヒストジェニックス コーポレイション | 細胞支持基材及びその調製方法 |
| US20070148144A1 (en) * | 2005-10-27 | 2007-06-28 | Mason James M | Gene-enhanced tissue engineering |
| US9757061B2 (en) | 2006-01-17 | 2017-09-12 | Dexcom, Inc. | Low oxygen in vivo analyte sensor |
| US8679809B2 (en) | 2006-05-19 | 2014-03-25 | The University Of Hong Kong | Cell-matrix microspheres, methods for preparation and applications |
| EP2032149A4 (en) * | 2006-06-13 | 2010-09-01 | Fmc Biopolymer As | METHOD AND SYSTEMS FOR THE USE OF BIOPOLYMER-BASED BEADS AND HYDROGELS |
| KR100803576B1 (ko) | 2006-06-14 | 2008-02-15 | 주식회사 인피트론 | 지방줄기세포 및 지방세포를 포함한 이식용 조성물 |
| KR20070122316A (ko) * | 2006-06-26 | 2007-12-31 | (주) 에스바이오메딕스 | 주사용 인체 연조직 충전제 및 이의 제조 방법 |
| KR20070122315A (ko) * | 2006-06-26 | 2007-12-31 | (주) 에스바이오메딕스 | 자가 진피 세포 및 히알루론산을 함유하는 주사용 인체연조직 충전제 조성물 |
| US8735154B2 (en) * | 2006-10-30 | 2014-05-27 | The University Of Kansas | Templated islet cells and small islet cell clusters for diabetes treatment |
| US20080306444A1 (en) | 2007-06-08 | 2008-12-11 | Dexcom, Inc. | Integrated medicament delivery device for use with continuous analyte sensor |
| EP2175978B1 (en) * | 2007-07-06 | 2019-02-20 | The University of Hong Kong | Collagen-based microspheres and methods of preparation and use thereof |
| US9452258B2 (en) | 2007-10-09 | 2016-09-27 | Dexcom, Inc. | Integrated insulin delivery system with continuous glucose sensor |
| KR100956267B1 (ko) * | 2007-12-12 | 2010-05-07 | 주식회사 에이프로테크놀로지 | 엘라스틴을 안정화제로서 함유하는 반유동성 이식용 조성물 |
| WO2009078022A2 (en) * | 2007-12-17 | 2009-06-25 | Izun Pharmaceuticals Corporation | Synergistic combinations of growth factors with herbal compositions for the enhancement of tissue repair |
| US8728528B2 (en) | 2007-12-20 | 2014-05-20 | Evonik Corporation | Process for preparing microparticles having a low residual solvent volume |
| US9402724B2 (en) * | 2008-05-12 | 2016-08-02 | Mo-Sci Corporation | Dynamic bioactive nanofiber scaffolding |
| KR102018475B1 (ko) | 2008-09-15 | 2019-09-04 | 제넨테크, 인크. | 세포 오스몰농도를 조절하기 위한 조성물 및 방법 |
| US9889230B2 (en) * | 2008-10-17 | 2018-02-13 | Covidien Lp | Hemostatic implant |
| US9308070B2 (en) | 2008-12-15 | 2016-04-12 | Allergan, Inc. | Pliable silk medical device |
| GB0912399D0 (en) * | 2009-07-16 | 2009-08-26 | Ucl Business Plc | Polymeric collagen biomaterials |
| US8597948B2 (en) | 2011-03-10 | 2013-12-03 | First Principles, Inc. | Cloned biological material medical device and method thereof |
| WO2012145594A2 (en) * | 2011-04-20 | 2012-10-26 | Trustees Of Tufts College | Molded regenerated silk geometries using temperature control and mechanical processing |
| KR101327630B1 (ko) * | 2012-03-05 | 2013-11-13 | 울산대학교 산학협력단 | 아텔로콜라겐을 이용한 췌도세포 이식용 담체의 제조방법 그리고 이를 이용하여 제조된 인공췌장 |
| AU2014262670B2 (en) * | 2013-05-08 | 2020-07-09 | ProKidney IPCo, LLC | Organoids comprising isolated renal cells and uses thereof |
| US11229789B2 (en) | 2013-05-30 | 2022-01-25 | Neurostim Oab, Inc. | Neuro activator with controller |
| US10016600B2 (en) | 2013-05-30 | 2018-07-10 | Neurostim Solutions, Llc | Topical neurological stimulation |
| US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
| US9238090B1 (en) | 2014-12-24 | 2016-01-19 | Fettech, Llc | Tissue-based compositions |
| US11077301B2 (en) | 2015-02-21 | 2021-08-03 | NeurostimOAB, Inc. | Topical nerve stimulator and sensor for bladder control |
| US10973956B2 (en) | 2017-01-05 | 2021-04-13 | The Regents Of The University Of Michigan | Microporous hydrogel scaffolds for cell transplantation |
| US20190117131A1 (en) | 2017-10-24 | 2019-04-25 | Dexcom, Inc. | Pre-connected analyte sensors |
| US11331022B2 (en) | 2017-10-24 | 2022-05-17 | Dexcom, Inc. | Pre-connected analyte sensors |
| WO2019094365A1 (en) | 2017-11-07 | 2019-05-16 | Neurostim Oab, Inc. | Non-invasive nerve activator with adaptive circuit |
| US20200399594A1 (en) * | 2018-02-22 | 2020-12-24 | Uvic Industry Partnerships Inc. | Morphogenic compound-releasing microspheres and use in bioink |
| CN108690205A (zh) * | 2018-05-28 | 2018-10-23 | 深圳市第二人民医院 | 一种ⅱ型胶原和聚丙烯酰胺复合水凝胶及其制备和应用 |
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| WO2021126921A1 (en) | 2019-12-16 | 2021-06-24 | Neurostim Solutions, Llc | Non-invasive nerve activator with boosted charge delivery |
| CN111203115B (zh) * | 2020-01-07 | 2022-02-11 | 天津市第三中心医院 | 一种氧化多糖抗凝涂层血液透析膜材料及其制备方法 |
| WO2021210026A1 (en) * | 2020-04-17 | 2021-10-21 | Vasanthi Palanivel | A cell-free growth factor concentrate, method of preparing the same and a kit thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2014359C1 (ru) * | 1992-02-12 | 1994-06-15 | Радюхин Виктор Алексеевич | Трехмерный биоактивный носитель для культивирования животных клеток и тканей |
| RU2037317C1 (ru) * | 1988-07-11 | 1995-06-19 | Пердью Рисерч Фаундейшн | Тканевый трансплантат |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55501130A (enExample) * | 1978-12-26 | 1980-12-18 | ||
| US4485096A (en) * | 1982-02-26 | 1984-11-27 | Massachusetts Institute Of Technology | Tissue-equivalent and method for preparation thereof |
| US4686098A (en) * | 1984-05-14 | 1987-08-11 | Merck & Co., Inc. | Encapsulated mouse cells transformed with avian retrovirus-bovine growth hormone DNA, and a method of administering BGH in vivo |
| US4604346A (en) * | 1984-10-09 | 1986-08-05 | Massachusetts Institute Of Technology | Skin-equivalent prepared by the use of punch biopsy |
| US4997753A (en) * | 1985-04-04 | 1991-03-05 | Verax Corporation | Weighted collagen microsponge for immobilizing bioactive material |
| US4863856A (en) * | 1985-04-04 | 1989-09-05 | Verax Corporation | Weighted collagen microsponge for immobilizing bioactive materials |
| US4861714A (en) * | 1985-04-04 | 1989-08-29 | Verax Corporation | Weighted collagen microsponge for immobilizing bioactive material |
| US5100783A (en) * | 1985-05-10 | 1992-03-31 | Verax Corporation | Weighted microsponge for immobilizing bioactive material |
| US5266480A (en) * | 1986-04-18 | 1993-11-30 | Advanced Tissue Sciences, Inc. | Three-dimensional skin culture system |
| US4963489A (en) * | 1987-04-14 | 1990-10-16 | Marrow-Tech, Inc. | Three-dimensional cell and tissue culture system |
| US5032508A (en) * | 1988-09-08 | 1991-07-16 | Marrow-Tech, Inc. | Three-dimensional cell and tissue culture system |
| EP0338716A3 (en) * | 1988-04-21 | 1990-04-11 | Berlex Laboratories, Inc. | Method and system for the production of non-degraded proteins from mammalian cells |
| US4837379A (en) * | 1988-06-02 | 1989-06-06 | Organogenesis Inc. | Fibrin-collagen tissue equivalents and methods for preparation thereof |
| IL90690A0 (en) * | 1988-09-30 | 1990-01-18 | Organogenesis Inc | Tissue equivalents and their preparation |
| US5106949A (en) * | 1989-09-15 | 1992-04-21 | Organogenesis, Inc. | Collagen compositions and methods for preparation thereof |
| IL95429A (en) * | 1989-09-15 | 1997-09-30 | Organogenesis | Living tissue equivalents comprising hydrated collagen lattice and a collagen gel and their production |
| US5032550A (en) | 1989-10-13 | 1991-07-16 | Aluminum Company Of America | High impact resistant ceramic composite |
| US5256418A (en) * | 1990-04-06 | 1993-10-26 | Organogenesis, Inc. | Collagen constructs |
| US5270192A (en) * | 1991-02-07 | 1993-12-14 | Monsanto Company | Biological artificial liver |
| PT101031B (pt) * | 1991-11-05 | 2002-07-31 | Transkaryotic Therapies Inc | Processo para o fornecimento de proteinas por terapia genetica |
| EP0674497B1 (en) * | 1992-11-16 | 2002-07-24 | Brown University Research Foundation | Microporous macrocapsules |
| TW402639B (en) * | 1992-12-03 | 2000-08-21 | Transkaryotic Therapies Inc | Protein production and protein delivery |
| FR2704236B1 (fr) * | 1993-04-21 | 1995-06-23 | Pasteur Institut | Vecteur rétroviral pour la préparation de cellules recombinantes susceptibles d'être implantées in vivo dans un but thérapeutique. |
| FR2708202B1 (fr) * | 1993-07-26 | 1996-03-29 | Pasteur Institut | Implant biocompatible pour l'expression chez l'homme ou chez l'animal de substances déterminées. |
| DK0702723T3 (da) * | 1993-04-21 | 2003-01-13 | Pasteur Institut | Biokompatibelt implantat til ekspression og udskillelse af terapeutisk forbindelse in vivo |
| DE69533437T2 (de) * | 1994-01-13 | 2005-09-15 | The Rogosin Institute | Makroeingekapselte sekretorische zellen |
| JPH10501706A (ja) * | 1994-04-04 | 1998-02-17 | コラーゲン コーポレイション | 細胞−ゲル |
-
1995
- 1995-10-25 US US08/548,002 patent/US5965125A/en not_active Expired - Fee Related
-
1996
- 1996-10-25 BR BR9611248-4A patent/BR9611248A/pt not_active Application Discontinuation
- 1996-10-25 WO PCT/US1996/017114 patent/WO1997015195A1/en not_active Ceased
- 1996-10-25 RU RU98109891/14A patent/RU2201765C2/ru not_active IP Right Cessation
- 1996-10-25 AU AU74744/96A patent/AU706563B2/en not_active Ceased
- 1996-10-25 CN CNB961993243A patent/CN1199567C/zh not_active Expired - Fee Related
- 1996-10-25 NZ NZ321417A patent/NZ321417A/xx unknown
- 1996-10-25 JP JP9516803A patent/JP2000501299A/ja active Pending
- 1996-10-25 EP EP96936960A patent/EP0917428A4/en not_active Withdrawn
-
1998
- 1998-04-24 NO NO19981859A patent/NO326107B1/no not_active IP Right Cessation
-
1999
- 1999-05-14 US US09/312,246 patent/US6472181B1/en not_active Expired - Fee Related
-
2002
- 2002-07-02 US US10/188,628 patent/US6582391B2/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2037317C1 (ru) * | 1988-07-11 | 1995-06-19 | Пердью Рисерч Фаундейшн | Тканевый трансплантат |
| RU2014359C1 (ru) * | 1992-02-12 | 1994-06-15 | Радюхин Виктор Алексеевич | Трехмерный биоактивный носитель для культивирования животных клеток и тканей |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2249462C1 (ru) * | 2003-08-21 | 2005-04-10 | Севастьянов Виктор Иванович | Универсальный гетерогенный коллагеновый матрикс для имплантации и способ его получения |
| RU2422172C2 (ru) * | 2005-01-06 | 2011-06-27 | Бакстер Интернэшнл Инк. | Дополненные матриксы для лечения переломов костей |
| RU2449799C2 (ru) * | 2009-10-30 | 2012-05-10 | Федеральное Государственное Учреждение "Российский кардиологический научно-производственный комплекс Федерального агентства по высокотехнологичной медицинской помощи" | Средство для осуществления терапевтического ангиогенеза и способ его осуществления |
| RU2545331C2 (ru) * | 2010-03-17 | 2015-03-27 | Амсилк Гмбх | Способ получения полимерсодержащих волокон |
| RU2722744C1 (ru) * | 2019-03-26 | 2020-06-03 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр реабилитации и курортологии" Министерства здравоохранения Российской Федерации (ФГБУ НМИЦ РК Минздрава России) | Органоспецифический биопластический материал на основе растворимой формы стабилизированного внеклеточного матрикса |
Also Published As
| Publication number | Publication date |
|---|---|
| NO981859D0 (no) | 1998-04-24 |
| CN1199567C (zh) | 2005-05-04 |
| US20030077260A1 (en) | 2003-04-24 |
| NO981859L (no) | 1998-06-24 |
| EP0917428A1 (en) | 1999-05-26 |
| JP2000501299A (ja) | 2000-02-08 |
| CN1205613A (zh) | 1999-01-20 |
| US6582391B2 (en) | 2003-06-24 |
| EP0917428A4 (en) | 2002-09-18 |
| NZ321417A (en) | 2000-03-27 |
| AU7474496A (en) | 1997-05-15 |
| AU706563B2 (en) | 1999-06-17 |
| BR9611248A (pt) | 1999-12-28 |
| US6472181B1 (en) | 2002-10-29 |
| NO326107B1 (no) | 2008-09-22 |
| WO1997015195A1 (en) | 1997-05-01 |
| US5965125A (en) | 1999-10-12 |
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