RU2196595C2 - Phytobalsam "vigor" and method of its preparation - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: phytobalsam includes vegetable raw material in the form of sweetflag rootstock, sweet dill fruits, yarrow herb, mint leaves, leuzea rootstock with roots, wild sage herb, linden flowers and oak bark, color, sugar and 40-% ethyl alcohol. Invention also deals with the method of balsam preparation. EFFECT: excluded side effects; wide range of treating-and-prophylactic action. 2 cl, 1 tbl

Description

 The invention relates to the field of medicine, namely the production of liquid medicines from plant materials.

 Recently, balms and tinctures made using plant materials, which have tonic and therapeutic properties, have been very popular. From literature data it is known that the most promising areas of application of phytobalms are diseases that occur against a background of depression, neurosis, acute and chronic stress, secondary immunological deficiency (for example, Tovstukha S. S. "Phytotherapy". K .: Health, 1990.- 544 pp. NI Shvets "Peculiarities of the course of some diseases of internal organs in conditions of increased intake of heavy metals in the body and the possibility of drug correction." Auth. Disd. MD - Kiev. - 1995).

The known composition for the balm "RIGA BLACK BALM" (collection "Recipes for alcoholic beverages and vodkas", Moscow, 1981, pp. 237-239), calculated on the preparation of 1000 gave balm, kg:
gentian (root) - 4.0
mountain arnica (flowers) - 1.6
wormwood (leaves and tops of the stem) - 3.0
ginger (rhizome) - 2.4
valerian medicinal (roots and rhizomes) - 2.0
curly mint (leaves) - 2.5
Melissa officinalis (leaves and tops of stems) - 2.0
calamus marsh (rhizomes), kg - 2.0
heart-shaped linden (flowers) - 1.6
winter oak (bark) - 1.6
black pepper (fruits) - 1.2
orange (dried peel) - 1.2
three-leaf watch (leaves) - 1.0
nutmeg - 1.0
St. John's wort (flowers and leaves) - 1.5
raspberries - 446
dried blueberries - 56
cognac with a strength of 40-42% vol. - 400
balsamic peruvian oil - 1.0
honey essence - 1.0
Kohler - 1300
65.8% sugar syrup - 345
Rectified ethyl alcohol of the highest purification and water - Based on a blend strength of 45%
This balm is black with a brown tint, the aroma is complex without highlighting the aroma of the individual ingredients, the taste is bitter with a slight aftertaste of burnt sugar. The common essential features with the claimed invention is the presence of the following components: wormwood, calamus marsh (rhizomes), mint (leaves), linden (flowers), oak (bark), three-leafed shift (leaves), color, sugar syrup 65.8% - rectified ethyl alcohol of the highest purification and water.

 Significant disadvantages of the RIGA BLACK balm is the very multicomponent composition and specific taste, which may not always appeal to the average consumer. In addition, this balm does not have pronounced preventive and therapeutic properties.

The known composition for the balm "MOSCOW" (collection "Recipes for alcoholic beverages and vodka", Moscow, 1981, pp. 248-249). The balm contains over 40 components, including those components that are common with the claimed invention, based on the preparation of 1000 gave balm, kg:
calamus marsh (root) - 1.0
safflower levzea - 2.0
lime color - 2.0
wormwood (leaves and tops of the stem) - 1.0
curly mint (leaves) - 1.8
three-leaf watch (leaves) - 1.5
oak bark - 1.5
fragrant dill (fruits) - 0.5
Kohler - 600
Rectified ethyl alcohol of the highest purification and water - Based on a blend strength of 45%
The balm has the following physicochemical characteristics: strength 45% vol., The content of extractives 14.5 g / 100 ml. Organoleptic indicators: color black with a brown tint; the taste is bitter and spicy; the smell is peculiar, complex, rounded without the smell of individual components.

 Significant disadvantages of MOSCOW balm is a very multicomponent composition using many expensive exotic components. In addition, this balm does not have pronounced preventive and therapeutic properties.

As a prototype for the largest number of coinciding essential features, the composition of the ingredients for Kupavna Balsam was selected (Russian patent 02117697, IPC ⁶ C 12 G 3/06, 1998). This composition has the following ratio of components (per 1000 gave balm):
calamus (rhizomes and roots) - 2.5-3.5
anise (fruits) - 0.8-1.2
fragrant dill (fruits) - 0.8-1.2
three-leaf watch (leaves) - 1.6-2.4
valerian (roots) - 1.6-2.4
clove (ovary of unblown flowers) - 1.2-1.8
oregano (tops of flowering stems) - 2.0-3.0
St. John's wort (flowers and leaves) - 2.2-2.8
calendula (flowers) - 1.7-2.3
safflower levzea (roots) - 1.5-2.5
juniper (pine cone) - 1.2-1.8
curly mint (leaves) - 2.2-2.8
black pepper (fruits) - 0.8-1.2
wormwood (leaves and tops of stems) - 2.5-3.5
pine buds - 1.2-1.8
black currant (fresh fruits) - 80-120
black currant (dried leaves) - 1.5-2.5
yarrow (tops of flowering stems) - 1.6-2.4
thyme (leaves and flowers) - 1.5-2.5
Eleutherococcus (root) - 1.5-2.5
Kohler - 290-340
water-alcohol liquid - The rest
Fresh fruits of currant can be replaced by dried in a reduced amount of 3.5 times. According to the description of the patent with rather high palatability, the balm has a healing effect on the respiratory and cardiovascular systems, activates the digestive and excretory systems, and improves metabolism in the body. With moderate consumption, the balm has an expanding effect on the vessels of the brain for a long time (up to 10-12 hours), thereby preventing headaches from the intoxicating effect of alcohol, especially during the period of sobering up. This preventive property of the balm prevents the emergence and development of a hangover syndrome and alcohol dependence. Along with this, the ability of the balm has a firming effect on the nervous system and for a long time to carry out a moderate tonic effect on the whole body. However, in specific examples of the invention there is no evidence of the achievement of the above actions on the human body. The common essential features with the claimed invention is the presence of the following components: calamus (rhizomes), fragrant dill (fruits), three-leafed shift (leaves), leuzea (roots), mint (leaves), wormwood (leaves), yarrow, color, ethyl alcohol Rectified higher purification and water.

 The reasons that impede the achievement of the expected result are the multicomponent composition (over 20 ingredients), which significantly affects the cost of the balm, as well as the lack of pronounced preventive and therapeutic properties.

Known methods for the preparation of balms (Recipe for alcoholic beverages and vodka. Derzharchoprom Ukraine, Kiev, 1994, pp. 213-238, 299), including the following stages:
- preparation of balm infusion from solid raw materials (usually of plant origin);
- cooking color (caramelized sugar);
- preparation of sugar syrup (if it is included in the formulation of the balm);
- the preparation of alcoholized juices and fruit drinks (if they are included in the balm recipe);
- blending (mixing the infusion of balm, color, sugar syrup, alcohol and water in the required ratio);
- filtering the blend and pouring into appropriate utensils.

 Known methods for producing balms differ among themselves not only in the qualitative and quantitative compositions of the components, but also in the parameters of the process for preparing the extract of balm from solid raw materials. So, for example, upon receipt of Yarilo balm (Russian patent 94032688, C 12 G 3/06, 1996), the roots of the plants are crushed, poured with water, boiled for 30-40 minutes, chopped herbs are added to the hot mixture with stirring withstand 10-12 hours. Natural honey, water-alcohol liquid are added to the mixture, they are left to stand for a day and the balm thus obtained is filtered. A significant disadvantage of this method is the low yield of balsam, a fairly significant part of the biologically active substances and natural honey remain adsorbed on the solid phase.

 As a prototype of the method of obtaining balm, the method of obtaining the balm prototype "Kupavna", described in Russian patent 02117697, C 12 G 3/06, 1998, was taken. According to this method, the calculated mass of plant material is filled with an aqueous-alcoholic liquid with a strength of 70% vol. (ratio 1:10), incubated for 10 days and the rare phase is drained (yield is 78% of the volume of liquid filled). Then, to obtain the second portion of the balsam infusion, 281 liters of aqueous-alcoholic liquid with a strength of 50% vol. Are poured, kept for 10 days and drained. The output of the infusion of the second discharge is 281 liters. Cooking color is produced by the usual known method and diluted with water to obtain a density of 1.35 kg / L. Blackcurrant fruit juice is prepared by double infusion of 100 kg of fresh fruits of blackcurrant with an aqueous-alcoholic liquid with a strength of 45% in a ratio of 1: 1 at the first discharge, and with a second discharge with an aqueous-alcoholic liquid with a strength of 30% in a ratio of 1: 0.7. The duration of infusion of each drain is 10 days. The total yield of fruit drink from mixing I and II plums is 206 liters with a strength of 20%. 190-240 l of blackcurrant fruit juice I and II of the plum, 290-350 kg of tint and 520-600 l of infusion of the first and second plum balm are added to the blending tank with the mixer. The blend is supplemented with a water-alcohol liquid up to a volume of 1000 dal with a 40% strength of the finished balm.

 Common essential features with the claimed method are the following stages: preparation of an infusion of balm; cooking color blending.

 The reasons that impede the expected result are the duration of the process, as well as the insufficiently high output of the balm.

 The basis of the invention is the task in the composition of the ingredients and the method of obtaining the balm by changing the qualitative and quantitative composition of the ingredients, as well as the parameters of the method of obtaining to increase the preventive and therapeutic properties without adverse pathological changes.

The problem is solved in that the composition of the ingredients of the phyto-balsam "Vigor", consisting of the following components: calamus (rhizomes), yarrow, mint (leaves), three-leafed watch (leaves), fragrant dill (fruits), wormwood (leaves), levzea ( roots), color, rectified ethyl alcohol of the highest purification and water, in accordance with the invention additionally contains the color of linden, oak bark and sugar in the following ratio of ingredients per 1000 gave phytobalm, kg:
calamus rhizomes - 5-8
yarrow grass - 6.2-9.8
linden flowers - 6.3-9.5
peppermint leaves - 1.6-3.8
the fruits of dill - 2.2-4.8
wormwood herb - 0.75-2.35
rhizomes with roots of the left-handed - 0.3-1.05
oak bark - 0.25-1.15
Kohler - 120-147
sugar - 120-147
softened drinking water and rectified ethyl alcohol - Per 1000 dal phytobalm
The problem is solved in that in the method of producing the phytobalm "Vigor", which includes weighing and grinding plant materials in the form of calamus rhizomes, fragrant dill, yarrow, mint leaves, rhizomes with left-handed roots, bitter wormwood grass, preparing balsam infusion, preparing color , the preparation of the balm by blending, in accordance with the invention, at the stage of preparing the infusion of the balm, linden flowers and oak bark are weighed into vegetable raw materials, weighed the required amount in the crushed plant material is loaded into the extractor, on the bottom of which a mesh covered with filter material is pre-laid, poured with an aqueous-alcoholic liquid, allowed to stand for 1-3 hours, the extract obtained is taken through the bottom drain of the extractor and returned to the extractor through the upper fitting of the extractor cover for 20-40 minutes, the operation of infusion and circulation is carried out another 1-3 times, prepare sugar syrup with a sugar content of 65.8% and blend infusion, color, sugar syrup, add refined w water, ethyl alcohol 96.2% solution, stirred and pushing. Infusion is carried out for 7 days.

For the preparation of phytobalm "Vigor" take the following ingredients:
- calamus rhizomes (State Pharmacopoeia XI, issue 2, Article 72);
- yarrow herb (State Pharmacopoeia XI, issue 2, Article 53);
- linden flowers (State Pharmacopoeia XI, issue 2, Article 12);
- peppermint leaves (State Pharmacopoeia XI, issue 2, Article 18);
- sheets of a three-leaf watch (State Pharmacopoeia XI, issue 2, Article 19);
- the fruits of fragrant dill (State Pharmacopoeia XI, issue 2, Article 29);
- wormwood grass (State Pharmacopoeia XI, issue 2, Article 44);
- rhizomes with roots of the leuzea (State Pharmacopoeia X, issue 2, Article 582);
- oak bark (State Pharmacopoeia XI, issue 2, Article 2);
- ethyl alcohol (State Pharmacopoeia XI, issue 2, Article 631);
- Refined granulated sugar in accordance with GOST 22-94;
- softened drinking water according to GOST 2874-82.

The manufacture of phyto-balm "Vigor" includes the following process steps:
- obtaining a water-alcohol extract of plant materials (infusion of phytobalm "Vigor");
- cooking color;
- preparation of sugar syrup;
- blending, settling and filtering.

 To obtain the infusion of Vigor phytobalm, the necessary quantities of calamus rhizomes, yarrow grass, linden flowers, peppermint leaves, three-leafed leaves of the herb, fragrant dill fruits, bitter wormwood grass, rhizomes with left-root roots, oak bark are weighed out and ground in a rotary knife mill. The crushed plant harvest is loaded into the extractor, on the bottom of which a mesh covered with filter material is preliminarily laid, and the prepared extractant (40% ethyl alcohol) is poured. Leave to insist for 1-3 hours. At the end of the infusion time, using the pump, the extract is taken through the lower drain of the extractor and returned to the extractor through the upper fitting of the extractor cap. The circulation operation is carried out for 20-40 minutes. The operation of insisting and circulation is carried out similarly to the above 2-3 times more. At the end of the infusion, the extract is pumped into the collection of infusion phytobalm "Vigor" using a pump.

 A sample is taken for a full analysis of the quality of the infusion of phytobalm "Vigor" according to the requirements of the temporary pharmacopoeial article VFS 42U 143 / 37-432-97. After analysis, the extract obtained (infusion of phyto-balsam "Vigor") is sent to the collection of extract. And the calculated volume of the extract is sent to the blending vat.

To prepare the color, sugar is weighed and loaded into a tinting boiler. Turn on the heating. For uniform heating of the mass of sugar periodically include a stirrer. At a temperature of 175-180 ^o C there is an intense caramelization of sugar for 15-20 minutes The heating is turned off and after 15-20 minutes with vigorous stirring, the purified water is sent in portions from the meter. Get a color with a density of 1.35 g / cm ³ . After cooling, the cooked color is pumped using a pump into a blending vat.

To prepare sugar syrup, purified water is loaded into the syrup boiler from the meter and heated to 60-70 ^o C, feeding steam into the boiler shirt. With continuous stirring, pour sugar in portions. The heating process for 35-40 minutes leads to the complete dissolution of sugar. Then the syrup is boiled 2 times for 20-25 minutes, the resulting foam is removed. Get sugar syrup with a sugar content of 65.8%. After cooling, the prepared syrup is pumped into the blending tank using a pump. Purified water is added to the blending vat with the infusion of the Vigor phytobalm, color, sugar syrup, 96.2% ethyl alcohol to obtain a blend strength of 40% vol. The prepared liquid is stirred for 20-30 minutes and left to settle for 7 days. At the end of the settling time, the Vigor phytobalm is filtered, using a pump it is sent to the collection of the finished product for pouring into the appropriate container.

 Vigor phytobalm contains essential oils, vitamins, organic acids, flavonoids, lactones, saponins, phytoncides, bitter glycosides, etc. Clinical trials of the phytobalm "Vigor" were conducted at the department of faculty therapy 1 of the National Medical University named after Bogomolets. Tests were conducted in open observations on 42 patients. For comparison, similar studies were conducted using the highly publicized Bitner Balm. The invention is further illustrated by the following examples of specific implementation.

Example 1. Prepare a composition of ingredients for balsam with the following ratios of components, in kilograms per 1000 gave finished products:
calamus rhizome - 8
yarrow grass - 6.2
linden flowers - 6.3
peppermint leaves - 3.8
three-leaf watch leaves - 0.85
the fruits of dill - 2.2
wormwood herb - 2.35
rhizome with roots of a leuzea - 0.3
oak bark - 1.15
The mixture is ground in a rotary knife mill.

 To obtain the infusion of Vigor phytobalm, the crushed and weighed mixture is loaded into the extractor, on the bottom of which a mesh is preliminarily laid, covered with filter material. The prepared extractant (aqueous-alcoholic liquid with a strength of 40% vol.) Is poured onto the raw materials in the extractor, left for 2 hours. Then, with the help of the pump, the aqueous-alcoholic liquid is taken through the lower discharge of the extractor and returned to the extractor through the upper fitting of the extractor cover. The circulation operation is carried out for 30 minutes. The operation of infusion and circulation is carried out similarly to the above 2 more times. At the end of the infusion, a sample is taken for analysis for compliance with the requirements of the temporary pharmacopoeial article VFS 42U 143 / 37-433-97. After analysis, the extract obtained (infusion of phyto-balsam "Vigor") is sent to the collection of extract. And the calculated volume of the extract (260 l) is sent to the blending vat.

To prepare the color, 137 kg of sugar is loaded into a tinting boiler. Turn on the heating. For uniform heating of the mass of sugar periodically include a stirrer. Full melting of sugar occurs at a temperature of 150-160 ^o C. At a temperature of 175-180 ^o C there is an intense caramelization of sugar. At this temperature, the molten sugar is stirred for 15-20 minutes. Then the heating of the tinting boiler is turned off, and after 15-20 minutes with vigorous stirring, purified water is fed in portions from the meter. The total volume of purified water is 55 l. Get 137 l of color with a density of 1.35 g / cm ³ . After cooling, the cooked color is pumped using a pump into a blending vat.

To prepare sugar syrup with a sugar content of 65.8%, 70 l of purified water are loaded from the meter into the syrup boiler and heated to 60-70 ^o C, feeding steam into the boiler shirt. With continuous stirring, 140 kg of sugar are poured in portions. The heating process for 35-40 minutes leads to the complete dissolution of sugar. Then the syrup is boiled 2 times for 20-25 minutes, the resulting foam is removed. After cooling, the prepared syrup is pumped into the blending tank using a pump. Purified water is added to the blending vat with Vigor phyto-balsam infusion, color, sugar syrup with stirring, ethyl alcohol 96.2% to obtain a blend strength of 40% vol. and mixed for 20-30 minutes The prepared mixture is left to settle for 7 days. At the end of the settling time, the Vigor phytobalm is filtered, with the help of a pump it is sent to the collection of the finished product for bottling in the appropriate container.

 Examples 2 and 3. The manufacture of the phytobalm "Vigor" was carried out analogously to example 1 except that the ratio of ingredients and process parameters were changed. The process parameters and the quantitative composition of the ingredients are shown in examples 2 and 3 of the table.

 Phytobalm has a dark brown color, a pleasant aromatic smell, pleasant taste. The results of clinical trials showed that the Vigor phytobalm has a tonic, antidepressant, anti-inflammatory, anti-allergic, immunomodelling, general strengthening effect on the body, is well tolerated by patients and does not cause pathological changes in laboratory parameters in the examined patients. The studies also found that the Vigor phytobalm can eliminate secondary immunological deficiency, enhance non-specific factors of the body’s defense, and remove various toxic substances from the body. Not a single side effect was noted as a result of using the Vigor phytobalm. According to the efficiency of use, the Vigor phytobalm on a conditional scale received an assessment of 18.6 points, and the Bitner balm - only 14.3 points with a maximum possible score of 21 points. Thus, in terms of overall performance indicators, Vigor phytobalm is a highly effective therapeutic and prophylactic agent of a general strengthening, immunomodulating, antitoxic, antidepressant effect. Phytobalm "Vigor" is also advisable to use in the form of compresses for diseases of the musculoskeletal system, as well as for chronic tonsillitis for gargling. The production of phyto-balm "Vigor" does not require sophisticated technological equipment, expensive exotic raw materials and can be implemented on standard equipment.

Claims (1)

1. Phytobalm, including calamus (rhizomes), yarrow (grass), mint (leaves), three-leafed shift (leaves), fragrant dill (fruits), bitter wormwood (grass), levsee (rhizomes with roots), color and 40% ethyl alcohol, characterized in that it additionally contains linden (flowers), oak (bark) and sugar in the following ratio of ingredients per 1000 gave phytobalm, kg:
Air (rhizomes) - 5.0 - 8.0
Yarrow (grass) - 6.2 - 9.8
Linden (flowers) - 6.3 - 9.5
Mint (leaves) - 1.6 - 3.8
Three-leaf watch (leaves) - 0.85 - 2.05
Aromatic dill (fruits) - 2.2 - 4.8
Wormwood (grass) - 0.75 - 2.35
Leuzea (rhizomes with roots) - 0.3 - 1.05
Oak (bark) - 0.25 - 1.15
Kohler - 120 - 147
Sugar - 120 - 147
40% Ethyl Alcohol - Per 1000 gave Phytobalm
2. A method of obtaining phytobalm, including weighing and grinding plant materials in the form of calamus rhizomes, aromatic dill, yarrow, mint leaves, rhizomes with roots of a left-handed, wormwood, linden flowers and oak bark, chopped plant material is loaded into an extractor, onto the bottom of which a mesh is pre-laid, covered with filter material, poured with aqueous-alcoholic liquid, left to infuse for 1-3 hours, the extract obtained is taken through the bottom drain of the extractor and returned to the extract through the upper fitting of the extractor cover for 20-40 minutes, the infusion and circulation operation is carried out 1-3 times, sugar syrup with a sugar content of 65.8% is prepared and balsam infusion, color, sugar syrup are blended, purified water and ethyl alcohol 96 are added , 2%, stirred, insisted for 7 days and filtered.

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