RU2166330C2 - Комбинация, содержащая антагонист рецептора ангиотензина ii и эпоксистероидный антагонист рецептора альдостерона - Google Patents
Комбинация, содержащая антагонист рецептора ангиотензина ii и эпоксистероидный антагонист рецептора альдостерона Download PDFInfo
- Publication number
- RU2166330C2 RU2166330C2 RU98100250/14A RU98100250A RU2166330C2 RU 2166330 C2 RU2166330 C2 RU 2166330C2 RU 98100250/14 A RU98100250/14 A RU 98100250/14A RU 98100250 A RU98100250 A RU 98100250A RU 2166330 C2 RU2166330 C2 RU 2166330C2
- Authority
- RU
- Russia
- Prior art keywords
- epoxy
- antagonist
- angiotensin
- hydroxy
- receptor antagonist
- Prior art date
Links
- 0 Cc1ccc(C2C=CC=C[C@]2C(N=N)=I*)cc1 Chemical compound Cc1ccc(C2C=CC=C[C@]2C(N=N)=I*)cc1 0.000 description 13
- WLUZFUMDNUZQOO-UHFFFAOYSA-N CC(c(cc1)ccc1-c1cnccc1C(N)=N)[n]1c(C(O)=O)c(-[n]2c(C(C(F)(F)F)=O)ccc2)nc1C Chemical compound CC(c(cc1)ccc1-c1cnccc1C(N)=N)[n]1c(C(O)=O)c(-[n]2c(C(C(F)(F)F)=O)ccc2)nc1C WLUZFUMDNUZQOO-UHFFFAOYSA-N 0.000 description 1
- CFRAFHOHHRPHMG-XDELDYFQSA-N CCCCC(N(Cc(cc1)ccc1-c(cccc1)c1C(C)=C)/C(/C=C(/Cc1ccc[s]1)\C(O)=O)=C(\C)/O)=C Chemical compound CCCCC(N(Cc(cc1)ccc1-c(cccc1)c1C(C)=C)/C(/C=C(/Cc1ccc[s]1)\C(O)=O)=C(\C)/O)=C CFRAFHOHHRPHMG-XDELDYFQSA-N 0.000 description 1
Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Organic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48645695A | 1995-06-07 | 1995-06-07 | |
| US08/486,456 | 1995-06-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU98100250A RU98100250A (ru) | 1999-09-27 |
| RU2166330C2 true RU2166330C2 (ru) | 2001-05-10 |
Family
ID=23931955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU98100250/14A RU2166330C2 (ru) | 1995-06-07 | 1996-06-05 | Комбинация, содержащая антагонист рецептора ангиотензина ii и эпоксистероидный антагонист рецептора альдостерона |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6653306B1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP0831910B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JPH11507627A (cg-RX-API-DMAC7.html) |
| KR (1) | KR100618466B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN1142793C (cg-RX-API-DMAC7.html) |
| AT (1) | ATE209047T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU725689B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR9609066A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2224079A1 (cg-RX-API-DMAC7.html) |
| CZ (1) | CZ297975B6 (cg-RX-API-DMAC7.html) |
| DE (1) | DE69617235T2 (cg-RX-API-DMAC7.html) |
| DK (1) | DK0831910T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2167571T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL122242A (cg-RX-API-DMAC7.html) |
| NO (1) | NO318184B1 (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ310730A (cg-RX-API-DMAC7.html) |
| PL (1) | PL185150B1 (cg-RX-API-DMAC7.html) |
| PT (1) | PT831910E (cg-RX-API-DMAC7.html) |
| RO (1) | RO118046B1 (cg-RX-API-DMAC7.html) |
| RU (1) | RU2166330C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO1996040257A1 (cg-RX-API-DMAC7.html) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2336876C2 (ru) * | 2002-05-29 | 2008-10-27 | Новартис Аг | Комбинация ингибитора дипептидилпептидазы iv (dpp iv) и сердечно-сосудистого вещества |
Families Citing this family (65)
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|---|---|---|---|---|
| CA2277018C (en) * | 1997-01-10 | 2006-10-03 | Merck & Co., Inc. | Use of angiotensin ii antagonists to treat symptomatic heart failure |
| US6201002B1 (en) | 1997-01-10 | 2001-03-13 | Merck & Co., Inc. | Method for reducing mortality with an angiotensin II antagonist |
| US6306826B1 (en) | 1997-06-04 | 2001-10-23 | The Regents Of The University Of California | Treatment of heart failure with growth hormone |
| HK1042252B (en) * | 1999-03-05 | 2004-04-23 | G.D. Searle Llc | Combination therapy of angiotensin converting enzyme inhibitor and epoxy-steroidal aldosterone antagonist for treatment of cardiovascular disease |
| US6211217B1 (en) | 1999-03-16 | 2001-04-03 | Novartis Ag | Method for reducing pericardial fibrosis and adhesion formation |
| US20030083342A1 (en) * | 2002-08-27 | 2003-05-01 | Steele Ronald Edward | Combination of organic compounds |
| JP2004501099A (ja) * | 2000-05-11 | 2004-01-15 | フアルマシア コーポレイション | アルドステロン頂点位相時の放出のためのアルドステロンアンタゴニスト組成物 |
| WO2001097805A2 (en) * | 2000-06-22 | 2001-12-27 | Novartis Ag | Solid valsartan pharmaceutical compositions |
| DE60127410T2 (de) * | 2000-07-27 | 2007-12-13 | Pharmacia Corp. | Kombinationstherapie mit epoxy-steroidalen aldosteronantagonisten und kalziumkanalblocker zur behandlung von kongestivem herzversagen |
| ES2269442T3 (es) * | 2000-07-27 | 2007-04-01 | Pharmacia Corporation | Terapia de combinacion de antagonista de aldosterona e inhibidor de ciclooxigenasa-2 para prevenir o tratar trastornos cardiovasculares relacionados con la inflamacion. |
| JP5082033B2 (ja) | 2001-12-21 | 2012-11-28 | エグゼリクシス パテント カンパニー エルエルシー | Lxrのモジュレーター |
| US7482366B2 (en) | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
| AU2003233946A1 (en) * | 2002-03-15 | 2003-09-29 | Novartis Ag | 4-(4-methylpiperazin-1-ylmethyl)-n-(4-methyl-3(4-pyridin-3-yl)pyrimidin-2-yl-amino)phenyl)-benzamide for treating ang ii-mediated diseases |
| CL2004000545A1 (es) * | 2003-03-18 | 2005-01-28 | Pharmacia Corp Sa Organizada B | Uso de un antagonista de los receptores de aldosterona y un antagonista de receptores de endotelina para el tratamiento o profilaxis de una condicion patologica relacionada con hipertension, disfuncion renal, insulinopatia y enfermedades cardiovascul |
| US20050153885A1 (en) * | 2003-10-08 | 2005-07-14 | Yun Anthony J. | Treatment of conditions through modulation of the autonomic nervous system |
| US20070123498A1 (en) * | 2003-10-17 | 2007-05-31 | Shetty Suraj S | Combination of organic compounds |
| US8226977B2 (en) | 2004-06-04 | 2012-07-24 | Teva Pharmaceutical Industries Ltd. | Pharmaceutical composition containing irbesartan |
| US8569277B2 (en) | 2004-08-11 | 2013-10-29 | Palo Alto Investors | Methods of treating a subject for a condition |
| WO2006068760A2 (en) | 2004-11-19 | 2006-06-29 | The Regents Of The University Of California | Anti-inflammatory pyrazolopyrimidines |
| CN101024643A (zh) * | 2006-02-20 | 2007-08-29 | 上海艾力斯医药科技有限公司 | 咪唑-5-羧酸类衍生物、制备方法及其应用 |
| US20080032960A1 (en) | 2006-04-04 | 2008-02-07 | Regents Of The University Of California | PI3 kinase antagonists |
| US20110160232A1 (en) | 2007-10-04 | 2011-06-30 | Pingda Ren | Certain chemical entities and therapeutic uses thereof |
| US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
| MX2010007418A (es) * | 2008-01-04 | 2010-11-12 | Intellikine Inc | Ciertas entidades quimicas, composiciones y metodos. |
| US8993580B2 (en) | 2008-03-14 | 2015-03-31 | Intellikine Llc | Benzothiazole kinase inhibitors and methods of use |
| US8637542B2 (en) | 2008-03-14 | 2014-01-28 | Intellikine, Inc. | Kinase inhibitors and methods of use |
| JP5788316B2 (ja) | 2008-07-08 | 2015-09-30 | インテリカイン, エルエルシー | キナーゼインヒビターおよび使用方法 |
| US20110224223A1 (en) | 2008-07-08 | 2011-09-15 | The Regents Of The University Of California, A California Corporation | MTOR Modulators and Uses Thereof |
| JP5731978B2 (ja) | 2008-09-26 | 2015-06-10 | インテリカイン, エルエルシー | 複素環キナーゼ阻害剤 |
| US8697709B2 (en) | 2008-10-16 | 2014-04-15 | The Regents Of The University Of California | Fused ring heteroaryl kinase inhibitors |
| US8476431B2 (en) | 2008-11-03 | 2013-07-02 | Itellikine LLC | Benzoxazole kinase inhibitors and methods of use |
| TWI468410B (zh) | 2009-01-30 | 2015-01-11 | Takeda Pharmaceutical | 稠環化合物及其用途 |
| EP2427195B1 (en) | 2009-05-07 | 2019-05-01 | Intellikine, LLC | Heterocyclic compounds and uses thereof |
| WO2011047384A2 (en) | 2009-10-16 | 2011-04-21 | The Regents Of The University Of California | Methods of inhibiting ire1 |
| WO2011146882A1 (en) | 2010-05-21 | 2011-11-24 | Intellikine, Inc. | Chemical compounds, compositions and methods for kinase modulation |
| JP2013545749A (ja) | 2010-11-10 | 2013-12-26 | インフィニティー ファーマシューティカルズ, インコーポレイテッド | 複素環化合物及びその使用 |
| EP2663309B1 (en) | 2011-01-10 | 2017-03-15 | Infinity Pharmaceuticals, Inc. | Processes for preparing isoquinolinones and solid forms of isoquinolinones |
| CN106619647A (zh) | 2011-02-23 | 2017-05-10 | 因特利凯有限责任公司 | 激酶抑制剂的组合及其用途 |
| WO2013012918A1 (en) | 2011-07-19 | 2013-01-24 | Infinity Pharmaceuticals Inc. | Heterocyclic compounds and uses thereof |
| EP2734520B1 (en) | 2011-07-19 | 2016-09-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| CA2846431A1 (en) | 2011-08-29 | 2013-03-07 | Infinity Pharmaceuticals Inc. | Heterocyclic compounds and uses thereof |
| WO2013077921A2 (en) | 2011-09-02 | 2013-05-30 | The Regents Of The University Of California | Substituted pyrazolo[3,4-d]pyrimidines and uses thereof |
| US8809372B2 (en) | 2011-09-30 | 2014-08-19 | Asana Biosciences, Llc | Pyridine derivatives |
| US9199975B2 (en) | 2011-09-30 | 2015-12-01 | Asana Biosciences, Llc | Biaryl imidazole derivatives for regulating CYP17 |
| US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
| WO2014052669A1 (en) | 2012-09-26 | 2014-04-03 | The Regents Of The University Of California | Modulation of ire1 |
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| US9481667B2 (en) | 2013-03-15 | 2016-11-01 | Infinity Pharmaceuticals, Inc. | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
| SG10201902074UA (en) | 2013-10-04 | 2019-04-29 | Infinity Pharmaceuticals Inc | Heterocyclic compounds and uses thereof |
| WO2015051241A1 (en) | 2013-10-04 | 2015-04-09 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| PT3119397T (pt) | 2014-03-19 | 2022-04-11 | Infinity Pharmaceuticals Inc | Compostos heterocíclicos para utilização no tratamento de distúrbios mediados por pi3k-gama |
| US20150320755A1 (en) | 2014-04-16 | 2015-11-12 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| WO2016054491A1 (en) | 2014-10-03 | 2016-04-07 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| KR102787845B1 (ko) | 2015-09-14 | 2025-03-31 | 트웰브 테라퓨틱스, 아이엔씨. | 이소퀴놀리논의 고체형, 그의 제조 방법, 이를 포함하는 조성물 및 이를 사용하는 방법 |
| US10759806B2 (en) | 2016-03-17 | 2020-09-01 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors |
| US10919914B2 (en) | 2016-06-08 | 2021-02-16 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| CN109640999A (zh) | 2016-06-24 | 2019-04-16 | 无限药品股份有限公司 | 组合疗法 |
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| WO2018002673A1 (en) | 2016-07-01 | 2018-01-04 | N4 Pharma Uk Limited | Novel formulations of angiotensin ii receptor antagonists |
| RS65963B1 (sr) | 2018-10-29 | 2024-10-31 | Myokardia Inc | Tetrahidropiran (thp)-supstituisana biciklična jedinjenja pirimidindiona |
| AU2019387370A1 (en) | 2018-11-30 | 2021-06-10 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5049565A (en) * | 1990-12-07 | 1991-09-17 | Merck & Co., Inc. | Microbial transformation process for preparing anti-hypertensive products |
| EP0481448A1 (en) * | 1990-10-16 | 1992-04-22 | E.R. SQUIBB & SONS, INC. | Dihydropyrimidine derivatives |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4559332A (en) * | 1983-04-13 | 1985-12-17 | Ciba Geigy Corporation | 20-Spiroxanes and analogues having an open ring E, processes for their manufacture, and pharmaceutical preparations thereof |
| US4880804A (en) * | 1988-01-07 | 1989-11-14 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking benzimidazoles |
| EP0586513A1 (en) * | 1991-05-10 | 1994-03-16 | Merck & Co. Inc. | Acidic aralkyl triazole derivatives active as angiotensin ii antagonists |
| US6008210A (en) * | 1992-04-21 | 1999-12-28 | Weber; Karl T. | Use of aldosterone antagonists to inhibit myocardial fibrosis |
| US5529992A (en) * | 1992-04-21 | 1996-06-25 | Curators Of The University Of Missouri | Method for inhibiting myocardial fibrosis by administering an aldosterone antagonist which suppresses aldoster one receptors |
| WO1994009778A1 (en) * | 1992-10-26 | 1994-05-11 | Merck & Co., Inc. | Combinations of angiotensin-ii receptor antagonists and diuretics |
| CA2125251C (en) * | 1993-06-07 | 2005-04-26 | Yoshiyuki Inada | A pharmaceutical composition for angiotensin ii-mediated diseases |
-
1996
- 1996-06-05 BR BR9609066A patent/BR9609066A/pt not_active Application Discontinuation
- 1996-06-05 AU AU61577/96A patent/AU725689B2/en not_active Ceased
- 1996-06-05 RO RO97-02272A patent/RO118046B1/ro unknown
- 1996-06-05 WO PCT/US1996/009335 patent/WO1996040257A1/en not_active Ceased
- 1996-06-05 CN CNB961961554A patent/CN1142793C/zh not_active Expired - Fee Related
- 1996-06-05 CN CNA2004100027960A patent/CN1522701A/zh active Pending
- 1996-06-05 KR KR1019970709029A patent/KR100618466B1/ko not_active Expired - Fee Related
- 1996-06-05 NZ NZ310730A patent/NZ310730A/xx unknown
- 1996-06-05 CZ CZ0385097A patent/CZ297975B6/cs not_active IP Right Cessation
- 1996-06-05 IL IL12224296A patent/IL122242A/en not_active IP Right Cessation
- 1996-06-05 CA CA002224079A patent/CA2224079A1/en not_active Abandoned
- 1996-06-05 ES ES96919170T patent/ES2167571T3/es not_active Expired - Lifetime
- 1996-06-05 PT PT96919170T patent/PT831910E/pt unknown
- 1996-06-05 JP JP9501678A patent/JPH11507627A/ja not_active Ceased
- 1996-06-05 PL PL96324001A patent/PL185150B1/pl not_active IP Right Cessation
- 1996-06-05 DK DK96919170T patent/DK0831910T3/da active
- 1996-06-05 EP EP96919170A patent/EP0831910B1/en not_active Expired - Lifetime
- 1996-06-05 AT AT96919170T patent/ATE209047T1/de not_active IP Right Cessation
- 1996-06-05 DE DE69617235T patent/DE69617235T2/de not_active Expired - Fee Related
- 1996-06-05 RU RU98100250/14A patent/RU2166330C2/ru not_active IP Right Cessation
-
1997
- 1997-01-09 US US08/781,786 patent/US6653306B1/en not_active Expired - Fee Related
-
2004
- 2004-11-23 NO NO19975741A patent/NO318184B1/no unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0481448A1 (en) * | 1990-10-16 | 1992-04-22 | E.R. SQUIBB & SONS, INC. | Dihydropyrimidine derivatives |
| US5049565A (en) * | 1990-12-07 | 1991-09-17 | Merck & Co., Inc. | Microbial transformation process for preparing anti-hypertensive products |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2336876C2 (ru) * | 2002-05-29 | 2008-10-27 | Новартис Аг | Комбинация ингибитора дипептидилпептидазы iv (dpp iv) и сердечно-сосудистого вещества |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2224079A1 (en) | 1996-12-19 |
| ATE209047T1 (de) | 2001-12-15 |
| CN1522701A (zh) | 2004-08-25 |
| RO118046B1 (ro) | 2003-01-30 |
| PL185150B1 (pl) | 2003-03-31 |
| DK0831910T3 (da) | 2002-05-21 |
| PT831910E (pt) | 2002-05-31 |
| NO975741L (no) | 1998-01-29 |
| US6653306B1 (en) | 2003-11-25 |
| KR100618466B1 (ko) | 2006-12-13 |
| JPH11507627A (ja) | 1999-07-06 |
| BR9609066A (pt) | 1999-01-26 |
| WO1996040257A1 (en) | 1996-12-19 |
| IL122242A (en) | 2001-07-24 |
| IL122242A0 (en) | 1998-04-05 |
| KR19990022548A (ko) | 1999-03-25 |
| PL324001A1 (en) | 1998-04-27 |
| EP0831910A1 (en) | 1998-04-01 |
| NO318184B1 (no) | 2005-02-14 |
| AU725689B2 (en) | 2000-10-19 |
| CN1192697A (zh) | 1998-09-09 |
| DE69617235D1 (de) | 2002-01-03 |
| CZ297975B6 (cs) | 2007-05-09 |
| EP0831910B1 (en) | 2001-11-21 |
| CN1142793C (zh) | 2004-03-24 |
| AU6157796A (en) | 1996-12-30 |
| NZ310730A (en) | 2001-01-26 |
| DE69617235T2 (de) | 2002-07-25 |
| CZ385097A3 (cs) | 1998-06-17 |
| NO975741D0 (no) | 1997-12-05 |
| ES2167571T3 (es) | 2002-05-16 |
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Effective date: 20090606 |