RU2130304C1 - Ointment for treatment of patients with sicknesses caused by herpes virus - Google Patents

Abstract

FIELD: medicine, virology, pharmacy. SUBSTANCE: invention proposes an ointment containing glycoseaminoglycans at concentration 0.1% isolated from human placenta. Ointment base has carboxymethylcellulose sodium salt (cross-linking agent), glycerol (plasticizer), Tween-80 (emulsifier), para-hydroxybenzoic acid methyl and propyl esters (preserving agent) and purified water taken at the definite ratio of components. Proposed ointment does not show pathological effect on skin and visceral organs, promotes effective healing skin damaged by herpetic rash for relative short time (below two weeks) and has no any contraindications for using. Ointment can be used for treatment of patients with viral sicknesses. EFFECT: enhanced effectiveness of an ointment. 3 ex

Description

 The invention relates to medicine, in particular, to the treatment of viral diseases.

 The widespread prevalence of diseases of viral etiology and the not always achievable effectiveness of their treatment suggest the need to develop new, more effective drugs.

 It is known that oxolin has antiviral activity, used for external use in the form of 0.25, 0.5, 1.2 and 3% ointments, riodoxol (0.25, 0.5 and 1% ointments), alpizarin (2 and 5% ointments), acyclovir (3 and 5% ointments) and other drugs, both synthetic and herbal [1]. Depending on the severity of the disease, the cure time for these drugs is 1 to 4 weeks. The disadvantages of these medicines include a number of contraindications: individual intolerance, pregnancy, impaired renal excretory function, hirsutism, etc.

The authors propose a new tool for the treatment of diseases caused by the herpes virus, which is an ointment containing glycosaminoglycans isolated from human placenta as an active substance, as well as other components in the following ratio (in%):
Glycosaminoglycans - 0.1
Sodium carboxymethyl cellulose (structurant) - 5.0
Glycerin (plasticizer) - 1.5
TWIN-80 (emulsifier) - 2.5
Para-hydroxybenzoic acid methyl ester (preservative) - 0.025
Para-hydroxybenzoic acid propyl ester (preservative) - 0.015
Purified Water - Else
All components of the ointment base are approved for use in pharmaceuticals [2].

 Glycosaminoglycans are linear heteropolysaccharides that are part of the main substance of the connective tissue of humans and animals [3]. The reparative properties of glycosaminoglycans are used in medical practice: honsurid for the treatment of burns; healon and provisc in ophthalmic surgery, placental extracts containing a significant amount of these substances to stimulate the reparative regeneration of epithelial and nervous tissue [4].

 1.0% ointment with glycosaminoglycans isolated from human placenta does not have a pathological effect on the skin and internal organs, has no contraindications for use, promotes the effective healing of skin affected by herpetic eruptions in a relatively short time (up to two weeks).

Example. Preparation of the ointment: sodium salt in 50 ml of purified water heated to 60-70 ^° C is placed in an evaporation cup and allowed to swell for 30-40 minutes, then the solution is heated in a water bath, thoroughly mixing; add all glycerin, TWIN-80 and preservatives. In the rest of the water, glycosaminoglycans are dissolved and both solutions are combined.

 The ointment thus obtained was used in a clinic.

 Example 1. Patient M., upon admission to the clinic, complained of constant burning pains in the abdominal wall and lumbosacral zone of the back on the right: rashes on the trunk and extremities with separate vesicles, in the pain zone a continuous inflamed surface with drainage blisters, as if burned.

 Sick 7 days. In the beginning, single rashes and pains appeared. Within 4 days, the pain quickly increased, and the rashes spread. Reception of analgesics did not give improvement.

Objectively: scattered herpetic eruptions of an erythematous edematous character were noted on the skin of the head, neck and chest. In the zone of segments D ₉ -L ₁ on the right, there were continuous hermetic confluent discharge rashes of herpes zoster, sharp swelling and hyperemia (Fig. 1).

Neurologically: cranial nerves are normal, there are no motor disorders. Hypesthesia in zone D ₂ -L ₁ on the right. Deep reflexes are uniformly lively, there are no pathological ones. From the internal organs there are no deviations from the norm. Blood pressure 130/80 mm Hg Blood and urine tests are normal.

 Diagnosis: herpes zoster, generalized.

 Treatment: the patient was applied an ointment dressing and all the rashes were smeared with glycosaminoglycan ointment. On the second day, new rashes were not noted, swelling and hyperemia decreased, fluid emptying from the blisters was observed. The treatment was performed 2 times a day until the disappearance of signs of the disease. After 10 days, healing began, and light pigmentation remained at the sites of the vesicles (Fig. 2).

Example 2. Patient N. on admission complained of severe pain, itching and rashes in the left half of the chest. The first signs of the disease appeared 3 days ago and were expressed in general malaise and chest pain. On the second day, rashes appeared and the temperature rose to 37.3 ^o C.

 Objectively: in the region of the left half of the back (D5-D8) herpetic eruptions of an erythematic-edematous nature are observed.

 Neurologically: cranial nerves are normal. There are no motor disorders or loss of sensitivity. Deep and superficial reflexes are alive, there are no pathological ones. From the internal organs pathology is not detected. Blood pressure 120/80 mm Hg, blood and urine tests are normal.

 Diagnosis: herpes zoster on the left (D5-D8).

 Treatment: ointment dressing with glycosaminoglycan ointment in zone D5-D8. Pain sensations decreased after 2 hours, on the second day, swelling and hyperemia disappeared, the vesicles became crusty. The treatment was carried out 2 times a day until the disappearance of signs of the disease. After 11 days, the skin became clean.

 Example 3. Patient K. was admitted with complaints of itching and mild pain in the area of rashes on the limbs and trunk. 2 days before the rashes noted a general malaise.

 Objectively: scattered rashes on the trunk and extremities in the form of papules on an edematous hyperemic basis.

 Neurologically: slight smoothing of the left nasolabial fold, decreased corneal reflexes. There are no motor disorders or loss of sensitivity. Deep and superficial reflexes are lively, uniform. There are no pathological reflexes. On the part of the internal organs, the phenomena of chronic bronchitis were observed. Blood pressure 110/80 mm RT. Art. Blood and urine tests are normal.

 Diagnosis: generalized herpes zoster.

 Treatment: one-time lubrication with glycosaminoglycan ointment eliminated pain and itching. A similar procedure, applied within 3 days, eliminated the rash. Full recovery came by the 12th day from the start of treatment.

Literature
1. Mashkovsky M.D. Medicines.- M.: Medicine, 1993. -T.1 - 2.

 2. Pharmacist Handbook. -M .: Medicine, 1981. -377 p.

 3. White A., Handler F., Smith E. et al. Fundamentals of biochemistry. -M: Mir, 1981. - 1878 p.

 4. Application of Japan N 62-129222.

Claims (1)

An ointment for the treatment of diseases caused by the herpes virus, characterized in that it contains glycosaminoglycans isolated from human placenta as the active substance, and the ointment base includes carboxymethyl cellulose sodium salt (structurant), glycerin (plasticizer), TWIN-80 (emulsifier), methyl and propyl esters of para-hydroxybenzoic acid (preservative) and purified water in the following ratio, wt.%:
Glycosaminoglycans - 0.1
Carboxymethyl Cellulose Sodium Salt - 5.0
Glycerin - 1.5
TWIN-80 - 2.5
Para-hydroxybenzoic acid methyl ester - 0.025
Para-hydroxybenzoic acid propyl ester - 0.015
Purified Water - Else

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