RU2120263C1 - Method for carrying out conservative treatment of burned eyes - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: method involves injecting 1% thiotriazoline solution 4 times a day into an injured eye in epibulbar administration mode and 0.5 ml once a day in parabulbar administration mode. EFFECT: enhanced effectiveness of treatment. 2 cl

Description

 The invention relates to medicine, namely to ophthalmology and can be used in the treatment of patients with burns of the eyeball.

 Known methods of treating eye burns / "Pamogenesis and treatment of eye burns" M., Medicine, 1973, S. 75-101, authors: Puchkovskaya N.A., Shulpina N.S., Nepomnyashchaya V.M. /, in which regenerative processes are stimulated by the use of drugs normalizing the vital activity of tissues, restoring metabolic processes - glucose, citral, riboflavin, ascorbic acid, B vitamins, oxygen, Ringer-Locke fluid, sea buckthorn and spermaceti oils.

 Treatment with such a quantity of drugs is difficult, expensive and does not guarantee complete restoration of the transparency of the cornea and visual functions due to the development of complications.

 A known method of treating eye burns with the use of inserts, according to the patents of the Russian Federation N 2018288 and 2017474, cl. A 61 F 9/00, with a composition having ion exchange properties.

 The use of inserts slows down the treatment process, since it takes time for the eyeball to adapt to the insert as a foreign body, it is painful in the initial stage and causes additional eye irritation.

 All this reduces the effectiveness of treatment.

 Known tool for the treatment of chemical burns of the eyes according to the patent of the Russian Federation N 2014812, class. A 61 F 9/00, consisting of a mixture of the sodium and hydrogen forms of the resin, polyvinyl alcohol, glycerol and aldehyde.

 This tool is also used in combination with liners, on the surface of which it is applied, and therefore it has the disadvantages of the above analogues.

 A known method of treating eye burns according to the patent of Russian Federation N 2008866, class. A 61 F 9/00, published March 15, 94, in which a drug is administered under the conjunctiva in the form of an enzyme obtained from hepatopancreas of king crab in a dose of 0.5-3 ml 1-3 times a day, for 1-2 days .

 This method is devoid of the disadvantages of the above analogues, we have adopted as a prototype, but obtaining the enzyme from heratopancreas of the Kamchatka crab is very expensive.

 The basis of the invention is the task of developing a method of conservative treatment of burns of the eyes, providing stimulation of regenerative processes in the cornea, reducing the number of complications, improving visual functions in patients with eye burns with minimal treatment costs.

 This goal is achieved by a conservative method of treating eye burns due to the fact that a 1% solution of thiotriazoline is used as a medicine, which is injected four times a day into the injured eye and is administered parabulbarly once a day.

 Thiotriazolin is a new drug registered by the Ministry of Health of Ukraine by order N 85 of 05.31.94, as a cardioprotective and hepatoprotective agent.

 Thiotriazoline has wound healing, antioxidant, membrane stabilizing, anti-ischemic, immunomodulatory effects, does not cause side effects and is non-toxic.

 The treatment of 57 patients with an eye burn was carried out as follows: from the moment the patient was admitted, along with antibacterial, anti-inflammatory drugs, 0.5 ml of a 1% solution of thiotriazoline was administered parabulbularly and four times a day in the form of drops. The course of treatment is 5-10 days, depending on the degree of burn.

 Example 1: Patient K., aged 30, was admitted for treatment with a diagnosis of thermal burn of the cornea and conjunctiva of the right eye of the 2nd degree. At admission: visual acuity OD = 0.2 n / a. Complaints of pain in the eye, profuse lacrimation, photophobia, blepharospasm, foreign body feeling. The eye is irritated, edema of the eyelids, palpebral fissure narrowed, the conjunctiva is swollen, pale, the surface is covered with fibrous exudate, along the vessels, streaky hemorrhages are visible. The cornea is rough, infiltrated, with multiple point erosion of the epithelium, its sensitivity is sharply reduced. Moisture of the anterior chamber slightly opalescent, moderate hyperemia of the vessels of the iris, smoothness of its pattern, sluggish reaction of the pupil to light.

 In the hospital, the patient was treated using a 1% solution of thiotriazolin, which was administered 2 drops four times a day in the lower conjunctival arch in combination with a single parabulbar injection of 0.5 ml of the drug daily.

 Four days later, the corneal epithelization was complete, the symptoms of inflammation of the membranes of the eye disappeared on the seventh day, a complete restoration of the sensitivity of the cornea was observed on the eighth day, on the ninth day the patient was discharged from the hospital. At discharge: visual acuity = 1.0. The cornea is transparent, shiny, specular, its sensitivity is restored.

 Example 2. Patient G., 39 years old, was admitted to the ophthalmic trauma unit with a diagnosis of a chemical burn of the conjunctiva of the 2nd degree and cornea of the 1st degree of the left eye.

 At admission: visual acuity OS = 0.4 n / a. Complaints of lacrimation, blepharospasm, photophobia, a feeling of a foreign body.

 Objectively: the eyelids are edematous, the palpebral fissure is narrowed, conjunctiva ischemia and chemosis, streaky hemorrhages along the vessels. Slight swelling of the corneal epithelium, in the optical zone erosion of 2 x 5 mm, the sensitivity of the cornea is reduced. In the hospital, the patient was treated with the inclusion of a 1% solution of thiotriazolin parabulbarno once a day and epibulbar four times a day. On the fourth day, visual acuity = 1.0, the eye is calm, the cornea is smooth, shiny, specular, its sensitivity is not impaired. The mild hyperimia of the conjunctiva is kept. The patient was discharged from the hospital on the 7th day.

 The advantage of the proposed method is that a new, in comparison with the prototype, cheap preparation is used, which has a pronounced regenerating effect on the cornea and conjunctiva of the eye without injuring them and does not have negative side effects in them.

 The application of the proposed method allows to ensure high efficiency in treating eye burns, to reduce the number of complications, to increase the number of patients with restored visual functions at minimal cost, which ultimately reduces the number of patients who went to primary disability after an eye burn.

 Analysis of patent and medical information confirms the novelty of the proposed method, therefore, by novelty, the proposed method meets the criteria of the invention.

 The proposed method is not obvious, since thiotriazolin is registered as a cardioprotective and hepatoprotective agent and the use of its solutions for the treatment of eye burns was not supposed. Therefore, according to this criterion, the claimed method meets the criteria of the invention.

 In terms of utility, this criterion is not required by the current provision, but the utility is obvious, since obtaining a solution of thiotriazoline is many times cheaper than obtaining the enzyme king crab.

Claims (2)

 1. A method of conservative treatment of eye burns by introducing a drug into the eye, characterized in that a solution of thiotriazoline administered epibulbar and parabulbar is used as a medicine.  2. The method according to claim 1, characterized in that they use a 1% solution of thiotriazoline, instilling it into the conjunctival cavity of the eye four times a day, 2-4 drops each and administering 0.5 ml parabulbarno once a day.