RU2140786C1 - Method of treatment of patient with shingles - Google Patents

Abstract

FIELD: medicine, dermatology. SUBSTANCE: invention relates to a method of treatment of patients with shingles (Herpes Zoster). Method involves applying an ointment containing 0.1% of a mixture of glycoseaminoglycans isolated from the human placenta on the skin region damaged by virus. The appearance of new rashes is stopped for the first 24 h after applying an ointment and recovery is accelerated by 7-10 days. EFFECT: enhanced effectiveness of treatment, absence of contraindications. 2 ex

Description

 The invention relates to medicine.

 Herpes Zoster is a serious disease of viral etiology. A pathological feature of the disease is damage to the spinal ganglion and hind root of the spinal cord, or homologous formations of the cranial nerves. The clinical picture is characterized by intense pain, after which bubble rashes appear on the skin, often accompanied by general infection symptoms [1].

 Various antiviral drugs are used intravenously, orally and topically for the treatment of herpes zoster: acyclovir, ganciclovir, helepin, megosin, gossypol, florenal, etc. The duration of treatment is on average 3-4 weeks. There are contraindications to almost all of the listed drugs: individual intolerance, pregnancy, increased blood coagulation, etc. [2].

Closest to the proposed invention is a method of treating shingles with application to human skin affected by the herpes virus [3], a solution of hyaluronic acid or its biocompatible salt having a viscosity of more than 0.4 Pa • s ^-1 .

 Hyaluronic acid and sulfated heteropolysaccharides of linear structure from the class of glycosaminoglycans (GAG) in the composition of proteoglycans are structural elements of the connective tissue of animals and humans [4]. The reparative properties of GAG or proteoglycans are used in medical practice: khonsurid - for the treatment of burns; Healon, Provisc - hyaluronic acid preparations used in ophthalmic surgery; placental extracts containing proteoglycans - to stimulate the regeneration of damaged epithelium and nerve cells [5].

 The authors propose a method for the treatment of herpes zoster, Herpes Zoster, which consists in applying an ointment containing as an active ingredient 0.1% glycosaminoglycans isolated from human placenta on the skin area affected by the herpetic virus.

 The difference of the proposed method for the treatment of herpes is the use as the active substance in the composition of the ointment instead of hyaluronic acid, the total GAG isolated from human placenta.

 For therapeutic purposes, GAG from the placenta is used, containing not more than 3% protein and not more than 1.5% nucleic acids.

 There are no contraindications to the use of ointments containing 0.1% GAG. In the concentration range from 0.1% to 1% GAG in the ointment does not have a pathological effect on the skin and internal organs of a person, do not cause side effects.

 The application of the proposed method of treatment Herpes Zoster in the first day prevents the appearance of new rashes, significantly reduces treatment time by an average of 7-10 days.

 Example: 2-5 g of an ointment containing 0.1% GAG is applied in a thin layer to a skin area affected by the herpes virus.

 Example 1. Patient M., upon admission to the clinic, complained of constant burning pains in the abdominal wall and lumbosacral zone of the back on the right; rashes on the trunk and extremities with separate vesicles, in the area of pain, with a continuous inflamed surface with drainage bubbles, as with a burn.

 Sick 7 days. In the beginning, single rashes and pains appeared. Within 4 days, the pain quickly increased, and the rashes spread. Reception of analgesics did not give improvement.

Objectively: scattered herpetic eruptions of an erythematous-edematous character were noted on the skin of the head, neck and chest. In the zone of segments D ₉ -L ₁ on the right, continuous confluent herpetic eruptions of herpes zoster, sharp swelling and hyperemia were observed (Fig. 1).

Neurologically: cranial nerves are normal, there are no motor disorders. Hypesthesia in zone D ₂ -L ₁ on the right. Deep reflexes are uniformly lively, there are no pathological ones. From the internal organs there are no deviations from the norm. Blood pressure 130/80 mm Hg Blood and urine tests are normal.

 Diagnosis: herpes zoster, generalized.

 Treatment: the patient was applied an ointment dressing and all the rashes were smeared with glycosaminoglycan ointment. On the second day, new rashes were not noted, swelling and hyperemia decreased, fluid emptying from the blisters was observed. The treatment was performed 2 times a day until the disappearance of signs of the disease. After 10 days, healing began, and light pigmentation remained at the sites of the vesicles (Fig. 2).

Example 2. Patient N. on admission complained of severe pain, itching and rashes in the left half of the chest. The first signs of the disease appeared 3 days ago and were expressed in general malaise and chest pain. On the second day, rashes appeared and the temperature rose to 37.3 ^o C.

 Objectively: in the region of the left half of the back (D5-D8) herpetic eruptions of an erythematic-edematous nature are observed.

 Neurologically: cranial nerves are normal. There are no motor disorders or loss of sensitivity. Deep and superficial reflexes are alive, there are no pathological ones. From the internal organs pathology is not detected. Blood pressure 120/80 mm RT. Art., blood and urine tests within normal limits.

 Diagnosis: herpes zoster on the left (D5-D8).

 Treatment: ointment dressing with glycosaminoglycan ointment in zone D5-D8. Pain sensations decreased after 2 hours, on the second day, swelling and hyperemia disappeared, the vesicles became crusty. The treatment was performed 2 times a day until the disappearance of signs of the disease. After 11 days, the skin became clean.

 Example 3. Patient K. was admitted with complaints of itching and mild pain in the area of rashes on the limbs and trunk. 2 days before the rashes noted a general malaise.

 Objectively: scattered rashes on the trunk and extremities in the form of papules on an edematous hyperemic basis.

 Neurologically: slight smoothing of the left nasolabial fold, decreased corneal reflexes. There are no motor disorders or loss of sensitivity. Deep and superficial reflexes are lively, uniform. There are no pathological reflexes. On the part of the internal organs, the phenomena of chronic bronchitis were observed. Blood pressure 110/80 mm RT. Art. Blood and urine tests are normal.

 Diagnosis: generalized herpes zoster.

 Treatment: one-time lubrication with glycosaminoglycan ointment eliminated pain and itching. A similar procedure, applied within 3 days, eliminated the rash. Full recovery came by the 12th day from the start of treatment.

Claims (1)

 A method of treating herpes zoster (Herpes Zoster), comprising applying a medicinal substance containing glycosaminoglycans to a skin area affected by the herpes virus, characterized in that they use 0.1% ointment containing total glycosaminoglycans isolated from human placenta.

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