RU2178699C1 - Method to treat herpetoviral infections including ozonotherapy - Google Patents

Abstract

FIELD: medicine, dermatology. SUBSTANCE: the method deals with a large-scale autohemoozonotherapy at 3-9 mcg/ml at 200-400 ml single injection volume up to pronounced signs of exacerbation. Then at the background of continuous large-scale autohemoozonotherapy antiviral preparations are injected. At local signs ozonotherapy is conducted as subcutaneous injections with ozone-oxygenous mixture along the periphery of affected area, application of "Ozonide" oil, irrigation with ozonized solution, subconjunctival injection of ozone-oxygenous mixture, subcutaneous injection of ozone-oxygenous mixture along the projection of affected nervous stems and sites where cerebrospinal and cranial nerves come out. EFFECT: decreased frequency of relapses; disease transition into latent phase. 5 cl

Description

 The invention relates to skin diseases and is intended for the treatment of herpes virus infections. The group of herpetic infections, which include diseases caused by herpes simplex viruses type I and II, herpes zoster virus, cytomegalovirus, Epstein-Barr virus, human herpes viruses of types 6, 7 and 8, has the widest distribution among the world's population. Herpetic viruses cause a variety of pathologies in humans, ranging from lesions of the skin and mucous membranes to generalized forms with damage to any organs and systems of a person. They can cause immune suppression, and some of them cause cancerous lesions.

 It is known that the cause of persistence and frequent exacerbation of herpetic infections are disorders in the human immune system. This is most often a decrease in the number and functional state of cytotoxic lymphocytes (CD8 +), natural killer cells, inhibition of interferon formation and production of specific antibodies by competent cells, as well as a decrease in phagocytic activity.

 Often this infection is considered as optional pathogenetic, the activity of which increases significantly when the body is weakened as a result of trauma, emotional overexcitation, medication, etc. All this should determine an integrated approach to treatment (A. L. Mashkeleyson "Treatment of skin diseases" M.: Medicine, 1990, p. 248).

 The treatment of herpes virus infections is one of the most difficult problems of medicine. Currently, their therapy uses drugs - nucleoside analogues (acyclovir, valtrex, famciclovir and several others), interferon preparations and interferonogenesis inducers, some immunomodulators. These methods are partially effective only during the period of exacerbation and cause a temporary effect, without translating the disease into prolonged remission, and do not lead to recovery.

 The closest analogue of the proposed method is a method of the same purpose, involving local treatment of areas of rashes on the skin by lubricating the affected area with ozonized oil with a peroxide number for ozonides 200-500 every 6 hours, which helps to resolve rashes (RU 2008898, 03/15/1994). It seems insufficient to use the ozonide-containing drug only locally, because, as you know, the manifestation of herpes virus infection reflects not only and not so much the local process, but to a greater extent general disorders associated with immune processes.

 Currently, for the treatment of various pathological conditions, ozone is used in various forms (solutions, ointments) and using various routes of administration (intravascular, topically, in the body cavity).

 Medical ozone, being a universal stimulant, triggering various intracellular biochemical processes of the body and participating in them, can act as an active immunomodulator. In addition, when applied topically, ozonated solutions and ozonated oil have a pronounced anti-inflammatory, analgesic, regenerating effect.

 The task of the invention was the development of an integrated approach in the treatment of herpes virus infection using medical ozone.

 The technical result of the invention is the transition from the acute phase of herpes virus infection to the stage of prolonged remission or complete recovery.

 The technical result is achieved due to the combined multilateral impact on the immune processes of the antiviral effect and the processes of the local effect of ozone therapy, supplemented with antiviral drugs.

 In the proposed method, the overall effect on the body is realized through a large autohemotherapy in order to stimulate antiviral immunity and relieve intoxication symptoms, supplemented by the use of antiviral drugs. The second aspect of the treatment of herpes virus infection is the reduction and elimination of local manifestations of the disease, for which, depending on the localization of the process, subcutaneous chipping with an ozone-oxygen mixture around the periphery of the rash zone or lubrication of the same zone with ozonide oil is used, the mucous membranes in the affected area are irrigated with an ozonized solution. subcutaneous administration of the ozone-oxygen mixture is carried out along the projection of the affected nerve trunks and exit points of the spinal and cranial nerves; carry out subconjunctival administration of an ozone-oxygen mixture with keratoconjunctivitis.

 We have selected the optimal doses and types of ozone therapy of general and local action for various types of process localization. However, in all cases with various clinical forms, the leading effect is the general effect of the immune and antiviral orientation on the part of ozone therapy as an immunocorrective effect and antiviral, supplemented by the effect of known antiviral drugs.

 The method is as follows.

100-200 ml of blood is taken from a patient with herpes virus infection from the cubital vein and placed in a special plastic bag - hemocon. At the same time, an ozone-oxygen mixture with an ozone concentration of 3 to 9 μg / ml is introduced into an equal volume (100-120 cm ³ ) with slow constant stirring of blood, anticoagulant and gas. Then, blood reinfusion is performed (at the rate of 60-90 drops in 1 min), i.e., the time of reinfusion of a given blood volume is within 20-25 minutes.

To control the speed of reinfusion, the hemocon bypass tube is slightly squeezed until a gas bubble of 0.5-1.0 cm ^{-3 is} obtained. The gas bubble should move towards the vein slowly. With an increased rate of reinfusion or with a sufficiently high concentration of ozone, the patient may notice numbness of the tip of the tongue and hands. In this case, it is necessary to lower the hemocon lower on the tripod, thereby slowing the speed of reinfusion.

The gas mixture of the desired concentration and volume is taken directly from the valve ("Multiossigen Medikal") into syringes with a capacity of 60 cm ³ , which have rubber tips on the piston and do not leak ozone, or indirectly first in a special plastic bag ("Medozon"), and then into the syringe.

 Large autohemotherapy is carried out in an amount of 10-12 procedures with an ozone concentration of 3 to 9 μg / ml, a volume of a single injection of 200-240 ml, 2-3 times a week until symptoms of exacerbation appear - redness with burning, itching, pain on the skin or mucous membranes, the appearance of herpetic vesicles. Then, without stopping the course of large autohemotherapy, they add antiherpetic drugs - nucleoside analogues (acyclovir, famciclovir, valtrex, etc.). Against the background of the course, antioxidants are prescribed.

 In the presence of herpes rashes on the skin, subcutaneous chipping of the zones of herpetic rashes is carried out - during the period of exacerbation against the background of a large autohemotherapy or during a relapse. From the first hours or on the first day of manifestations on the skin, chipping along the periphery of the zone of herpetic vesicles is carried out daily with an ozone concentration in the gas mixture of 3 to 20 μg / ml, a volume of 0.5 to 20 ml, depending on the area of the lesion, 1-3 days, or lubricate the affected area with ozonide oil.

 With herpetic keratitis or keratoconjunctivitis, subconjunctival administration of an ozone-oxygen mixture is performed 1-2 times a week, only 5-7 times at a concentration of 0.5-1 μg / ml, volume 0.3 ml.

 With herpetic eruptions on the vulva, vagina, cervix, daily flow irrigation sessions are carried out with ozonated solutions with an ozone concentration of 1-7 μg / ml in a volume of 300-400 ml. The procedure is carried out at a standard position of the patient on a gynecological chair. Using a gynecological mirror, a hollow plastic catheter is brought to the lesion site, through which an ozonized solution is supplied through an intravenous drip system from a glass or plastic bottle through an intravenous drip system. The number of procedures is 3-7.

 With herpetic stomatitis, rinsing of the oral cavity and pharynx is carried out with an ozonated solution of distilled water or an ozonized physiological solution with an ozone concentration of 1-7 μg / ml, 2-3 times a day, with a volume of 200-300 ml. The duration of treatment is 3-5 days until complete epithelization.

 When Herpes Zoster is affected, subcutaneous administration of the ozone-oxygen mixture is carried out along the projection of the affected nerve trunks of the exit points of the spinal and cranial nerves during the rash with the aim of rapid regeneration, analgesia against the background of a course of large autohemotherapy. Daily with an ozone concentration of 3 to 20 μg / ml (high concentrations for neuralgia), a volume of 10 to 100 ml, depending on the degree of damage.

Clinical examples
1. Patient T., 31 years old, outpatient card 71-99. Herpes simplex labialis (HSV type 1) suffers, in the last year frequent exacerbations - almost monthly. Addressed without exacerbation.

 A course of large autohemozoonoterium with an ozone concentration of 3-5 μg / ml with a frequency of 2 times a week and an antoxinate of 1 tablet 2 times a day was prescribed.

 After the 3rd procedure, the patient had a feeling of fullness on the upper lip, then redness and swelling. She began to apply topically ozonide oil 4 times a day and Valtrex 0.5 g 2 times a day for 10 days. On an outpatient basis, in the first two days of exacerbation above the border of the lip in the affected area, one injection of a subcutaneous ozone-oxygen mixture in a volume of 0.5 ml with an ozone concentration of 3 μg / ml was made.

 Against the background of treatment, characteristic herpetic vesicles did not appear, redness disappeared after 3 days. In total, 10 sessions of large autohemotherapy were performed.

 In the process of observation after a course of ozone therapy and valtrex, there is no recurrence of herpes within 16 months.

 2. Patient A., 28 years old, outpatient card 124-98.

 She complained of fatigue, periodic chills, subfibril temperature, sore throat, sweating, dizziness. These complaints within 6-7 months. An examination revealed an increase in the anterior and posterior cervical, axillary lymph nodes, and a liver of +1 cm. Blood lymphocytosis. In the immune status, a decrease in the number of natural killer cells, α and γ-interferons.

 An outpatient examination of blood and saliva revealed Epstein-Barr virus DNA.

 Diagnosed with a chronic Epstein-Barr viral infection.

 A course of large autohemozoonoterium with an ozone concentration of 3-5 μg / ml with a frequency of 2 times a week and an antoxinate of 1 tablet 2 times a day was prescribed. At the same time, intramuscularly every other day, reaferon of 3 million ME 15 was prescribed.

 Against the background of the course, the patient's health returned to normal, the lymph nodes were normal, and the size of the liver was normal.

 In the study of blood and saliva 1, 2, 3, 6 months after treatment, the Epstein-Barr virus DNA was not detected.

 Thus, the proposed method for the treatment of herpes virus infections with ozone therapy in combination with antiviral drugs allows you to get a good clinical effect, reduce the frequency of relapses, to achieve the transition of the disease to the latent phase.

Claims (5)

 1. A method for the treatment of herpes virus infections, including ozone therapy, characterized in that they carry out large autohemotherapy (BAT) in a dose of 3 to 9 μg / ml in a volume of a single injection of 200-240 ml until the symptoms of exacerbation, after which, against the background of continuing large autohemotherapy, antiviral drugs are administered.  2. The method according to p. 1, characterized in that in the presence of herpes rashes on the skin, an additional chipping is performed along the periphery of the rash zone with an ozone-oxygen mixture in a dose of 3-20 μg / ml with a volume of 0.5-20 ml or lubrication with ozonide oil .  3. The method according to p. 1, characterized in that in case of damage to the mucous membranes, they additionally irrigate the affected area with an ozonized solution with an ozone concentration of 1-7 μg / ml.  4. The method according to p. 1, characterized in that with herpetic keratitis or keratoconjunctivitis, an additional subconjunctival administration of an ozone-oxygen mixture in a single dose of 0.5-1 μg / ml in a volume of 0.3 ml is additionally carried out.  5. The method according to p. 1, characterized in that in case of infection caused by herpes zoster, an additional subcutaneous injection of the ozone-oxygen mixture is carried out along the projection of the nerve trunks and exit points of the spinal and cranial nerves in a dose of 3-20 μg / ml in a volume of 10 100 ml