RU2304429C2 - Ointment for treatment of degenerative-dystrophic diseases of locomotor system - Google Patents

Abstract

FIELD: medicine, pharmacy.

SUBSTANCE: invention relates to creature of ointment for external using. The proposed ointment used for treatment of degenerative-dystrophic diseases of locomotor system comprises vegetable as a fatty product, wax as a bee product, heparin as anticoagulant of direct effect, and glycerol, hydrocortisone and dimethylsulfoxide also. After applying ointment the method involves effect by ultrasound with frequency 88 MHz, power 0.4 Wt/cm² for 10-15 min. Treatment course is 10-15 procedures. Ointment has no adverse complications, it activates metabolic processes in joint region, improved microcirculation and recovers cartilage surface.

EFFECT: improved and valuable properties of ointment.

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Description

The invention relates to medicine, namely to compositions of ingredients that have a therapeutic purpose by external use on the human body.

Closest to the claimed ointment and selected as a prototype antiseptic agent (RF patent No. 1805952, IPC AK61/06, 1993) containing wax, vegetable oil, 15% aqueous solution of rivanol. in the following ratio of components, wt.%: wax 13-13, 15% aqueous solution of rivanol, 1.2-1.3, vegetable oil - the rest.

The disadvantage of ointment is the limited scope.

The technical result of the invention is aimed at expanding the functionality, namely, to accelerate the synthesis of glycosominoglycans and restore cartilage, by penetrating deep into the tissues.

The technical result of the invention is achieved in that the ointment for the treatment of degenerative diseases of the musculoskeletal system includes a bee product dissolved in a fat product - wax, vegetable oil is used as a fat product, direct-acting anticoagulant heparin, glycerin activates metabolic processes, hydrocortisone has an anti-inflammatory and anti-allergic effect, stabilizes the cell membrane, reduces capillary permeability and inhibits development inflammation. Dimethyl sulfoxide has an anti-inflammatory, analgesic effect, penetrates through the skin at a high speed, combines well with drugs in the following weight ratios: wax 13-15 g, heparin 5000-10000 units, hydrocortisone 125 mg, glycerol 10 mg, dimethyl sulfoxide 10 ml, vegetable oil - the rest.

Comparative analysis with the prototype showed that the claimed composition of the ointment differs from the known introduction of new components, namely: heparin, hydrocortisone, glycerol and dimethyl sulfoxide.

The ointment for the treatment of degenerative diseases of the musculoskeletal system is made as follows: the vegetable oil is brought to a boil in a steam bath, after which wax is added to it completely dissolved, and then filtered through a double sterile gauze layer. In a slightly cooled composition, a solution of heparin, hydrocortisone and glycerol in dimethyl sulfoxide is added. The resulting mass is stirred until a homogeneous mixture is formed.

The cooled ointment is applied with a sterile medical spatula in a thin layer on the required surface and is voiced by ultrasound.

The ointment is suitable for more than 2 years from the date of preparation when stored in a dark place at room temperature.

The therapeutic properties of the ointment are as follows.

Vegetable oil contains triglycerides and polyunsaturated fatty acids that promote tissue regeneration.

Wax, among other bee products used for ointments, has the least reactivity, while in the presence of triglycerides it is able to release oxidative oxygen into the wound, which promotes tissue regeneration.

Heparin improves, restores tissue microcirculation in most cases.

Hydrocortisone has a local anti-inflammatory effect, prevents the activation of phospholase A ₂ , stimulates the formation of its inhibitor, linomodulin and a direct effect on the membrane, disrupts the synthesis of PG and the release of macrophage chemotoxic factor, and inhibits the activation of tissue quinines. Reduces macrophage migration of lymphocytes, stopping the release of lysosomal enzymes. It inhibits hypersensitivity reactions, proliferative and exudative processes in the connective tissue, in the focus of inflammation.

Glycerin has a softening and at the same time astringent effect, has high hygroscopic, lubricating properties. When applied to the skin, it activates metabolic processes in it.

Dimethyl sulfoxide with high activity penetrates the skin, in most cases it is used in combination with other medicinal substances previously dissolved in it for better and deeper penetration into the tissues. It has antihistamines, m-anticholinergic and fibrinochitic properties.

Ointment activates metabolic processes in the joint area, improves microcirculation and restores the cartilage surface.

To enhance the permeability of the above ointments, we use ultrasound. Ultrasound therapy is considered to be one of the most common and highly effective methods of treating a wide variety of diseases. Ultrasound without significant absorption of the ointment penetrates the body tissues, has a pronounced analgesic, antispasmodic, anti-inflammatory and general tonic effect, stimulates blood and lymph circulation, regenerative processes. Under the influence of ultrasonic vibrations, the course of redox processes changes, complex protein complexes are more intensively depolymerized (cleaved) to ordinary organic molecules, and the action of a number of enzymes is activated. Under the influence of ultrasound, a conformational rearrangement of the membranes occurs. The consequence of this, as well as the decolymerizing effect and the capillary effect of ultrasound, is a change in the permeability of various membrane formations in the whole organism. An increase in the permeability of histohematological barriers has been proven with certainty.

We use ultrasound with a frequency of 800 MHz, continuous mode with a power of 0.4 W / cm ² , lasting 5-10 minutes on the joint area. The course of treatment is from 10 to 15 sessions.

The ointment is absolutely harmless.

Examples of specific performance of ointments at the boundary and average values of the content of the components are presented in the table.

The therapeutic effect of the ointment was tested in the entire range of changes in the quantitative content of the components.

The proposed ointment is more versatile, is widely used for degenerative diseases of the joints and spine, osteoarthritis, osteochondrosis, etc.

The ointment was tested on fifty patients with various lesions of the joint.

Example 1

Patient R. 48 years. He complained of pain in the knee joint. Pain at night. At present, he cannot walk to the fifth floor. Diagnosis: Deforming arthritis of the joint. Atrophy of the right knee joint. Treatment in a community hospital for about three weeks with no result. On the second or third day after treatment with this method, the patient stopped having pains, he began to easily climb the stairs (fifth floor). Got 10 treatment sessions, did not contact the hospital anymore.

Example 2

Patient C. 50 years. He complained of pain in the knee joints, especially on the right. Diagnosis: acute arthritis. He was treated in the clinic at the place of residence, no improvement was noted. On the third day after treatment, the joint pain disappeared. Took 12 treatments with a good effect.

Table Name of components The quantitative content of the masses Wax 13.0 g 14.0 g 15.0 g Heparin 5000 units 10,000 units 10,000 units Hydrocortisone 50 mg 100 mg 125 mg Glycerol 10.0 mg 10.0 mg 10.0 mg Dimethyl sulfoxide (C ₂ H ₆ O ₃ ) 10.0 mg 10.0 mg 10.0 mg Vegetable oil up to 100 up to 100 up to 100

Claims (1)

An ointment for the treatment of degenerative diseases of the musculoskeletal system containing wax, vegetable oil, characterized in that it additionally contains heparin, hydrocortisone, glycerin and dimethyl sulfoxide, with the following components, per 100 g of ointment: Wax 13-15 g Heparin 5000-10000 units. Hydrocortisone 125 mg Glycerol 10 mg Dimethyl sulfoxide 10 mg Vegetable oil Rest in this case, after applying the ointment, they are affected by ultrasound at a frequency of 800 MHz, with a power of 0.4 W / cm ² , for 10-15 minutes per course from 10 to 15 sessions.