RU2281084C1 - Ointment for treatment of scars - Google Patents

Abstract

FIELD: medicine, pharmacy.

SUBSTANCE: invention relates to ointment used in treatment of scars by external using on a patient body. Ointment for treatment of scars comprises wax, vegetable oil, heparin, lydaze, glycerol and dimethylsulfoxide in the following ratio of components per 100 g: wax, 13-15 g; heparin, 5000-10000 U; lydaze, 64-128 U; dimethylsulfoxide, 10-15 ml; glycerol, 10-15 ml, and vegetable oil, the balance. Invention provides enhancing effectiveness in treatment of patients and the absence of adverse complications.

EFFECT: improved, enhanced and valuable medicinal properties of ointment.

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Description

The invention relates to medicine, namely to compositions of ingredients that have a therapeutic purpose by external use on the human body.

Closest to the claimed ointment and selected as a prototype antiseptic agent (RF patent No. 1805952, IPC A 61 K 9/06, 1993) contains wax, vegetable oil, 15% aqueous solution of rivanol in the following ratio, wt.% Wax 13-13, 15% aqueous solution of rivanol 1.2-1.3, vegetable oil - the rest.

The disadvantage of this ointment is the limited scope of its application.

The technical result is aimed at expanding the functionality, namely, improving the ability to stretch scars, improving trophic tissue, preventing or reducing muscle atrophy and changes in joints and steam-articular tissues, as well as resorption of scars.

The technical result is achieved by the fact that the ointment for the treatment of scars includes a bee product dissolved in a fat product - wax, vegetable oil is used as a fat product, a direct-acting anticoagulant - heparin, glycerin activates metabolic processes, lidase has hyaluronidase activity, specifically breaks down the acid molecule muconolysaccharide - hyaluronic acid, is the main component of the interstitial substance of the connective tissue.

Dimethyl sulfoxide has an anti-inflammatory, analgesic effect, penetrates through the skin with high speed, combines well with medicinal substances in the following ratio of components: wax 13-15 g; heparin 5000-10000 units; lidase 64 units; dimethyl sulfoxide 10 ml; glycerin 10 mg; vegetable oil - the rest.

The drug reduces the viscosity of the interstitial substance and thereby helps to increase the permeability of tissues and facilitate the movement of fluid in interstitial spaces.

Comparative analysis with the prototype showed that the claimed composition of the ointment differs from the known introduction of new components, namely: heparin, lidase, dimethyl sulfoxide and glycerol.

An analysis of known ointments used for the same purposes showed that the combination of vegetable oil, wax, glycerin, lidase, heparin, dimethyl sulfoxide, in which the ingredients are soluble, were not found in practice both in terms of the combination and the ratio of ingredients.

Ointment is made as follows.

The vegetable oil is brought to a boil in a steam bath, after which wax is added to it until completely dissolved, and then after filtering through a double sterile gauze layer, a solution of heparin and glycerin is added. Lidase dissolved in dimethyl sulfoxide is added to the slightly cooled composition. The resulting mass is stirred until a homogeneous mixture is formed.

The cooled ointment is applied with a sterile medical spatula in a thin layer on the required surface and is voiced by ultrasound.

The ointment is suitable for more than 2 years from the date of preparation when stored in a dark place at room temperature.

The therapeutic properties of the ointment are as follows.

Vegetable oil contains triglycerides and polyunsaturated fatty acids that promote tissue regeneration.

Wax, among other bee products used for ointments, has the least reactivity, while in the presence of triglycerides it is able to release oxidative oxygen into the wound, which promotes tissue regeneration.

Heparin affects blood coagulation factors, inhibits the activity of plasma thromboplasty, inhibits the transition of prothrombin to thrombin and fibrinogen to fibrin, and reduces platelet aggregation. It activates the fibrinolytic properties of blood, lowers cholesterol and β-lipoproteins, has an immunosuppressive effect, improves, and restores tissue microcirculation in most cases.

Lidase has hyaluronidase activity, specifically cleaves a molecule of acid muconolysaccharide - hyaluronic acid, which is the main component of the interstitial substance of connective tissue. Reduces the viscosity of the interstitial substance and thereby contributes to an increase in the permeability of tissues and facilitate the movement of fluid in interstitial spaces.

Glycerin has a softening and at the same time astringent effect, has high hygroscopic, lubricating properties. When applied to the skin, it activates metabolic processes in it.

Dimethyl sulfoxide with high activity penetrates the skin, in most cases it is used in combination with other medicinal substances previously dissolved in it for better and deeper penetration. It has anti-inflammatory, analgesic, antimicrobial and weak antihistamines, slightly enhances the sensitivity of adrenoreceptors to adrenaline.

The ointment activates metabolic processes in the scar area, improves microcirculation, stretches the scar tissue, improves tissue trophism, prevents muscle atrophy, and also resolves scars.

To enhance the permeability of the above ointment, ultrasound is used. Ultrasound therapy is considered to be one of the most common and highly effective methods of treating a wide variety of diseases. Ultrasound without significant absorption of the ointment penetrates the body tissues, has a pronounced analgesic, antispasmodic, anti-inflammatory and general tonic effect, stimulates blood and lymph circulation, regenerative processes. Under the influence of ultrasonic vibrations, the course of redox processes changes, complex protein complexes are more rapidly depolymerized (cleaved) to ordinary organic molecules, and the action of a number of enzymes is activated. We use ultrasound with a frequency of 800 MHz, continuous mode, power 0.4 W / cm ² , lasting 10-15 minutes.

The ointment does not cause side effects and is absolutely harmless.

Examples of specific performance of ointments at the boundary and average values of the content of the components are presented in the table.

The therapeutic effect of the ointment was tested in the entire range of changes in the quantitative content of the components.

The ointment was tested on forty-six patients with various burns and postoperative scars.

Example 1

Patient O., 7 years old. Post-burn scars in the area of both thighs and the inner surfaces of both legs (burn 2-3 degrees). It was treated for 1.5 months. Discharged with rough scars. 2 weeks after treatment (ointment + ultrasound), the skin in the scar region became smooth, smooth, slightly hyperemic. The treatment went with a good result.

Example 2

Patient S., 22 years old, was operated on for an injury. A rough scar all over the neck, roughly stitched seams stand out. The operation was 2 years ago. It was treated all the time, using various ointments and methods, without dynamics. 12 days after treatment with the above method - a positive trend.

Example 3

Patient T. 38 years. Burn of the right hand with rough scars. Movement in the brush is limited. For 2.5 years, she was treated in the burn department without much improvement. 15 days after the start of treatment with ointment and ultrasound, the scars almost smoothed out, became softer, some scars resolved. The bone movement is almost restored (according to the patient - this is a miracle ointment).

Table Name of components Quantitative content Wax 13.0 g 14.0 g 15.0 g Heparin 5000 units 10,000 units 10,000 units Lidase 64 units 128 units 128 units Glycerol 10.0 mg 10.0 mg 10.0 mg Dimethyl sulfoxide 10.0 ml 10.0 ml 10.0 ml Vegetable oil up to 100 up to 100 up to 100

Claims (1)

An ointment for the treatment of scars containing wax, vegetable oil, characterized in that it additionally contains heparin, lidase, glycerin and dimethyl sulfoxide, with the following content of components per 100.0 g: Wax 13-15 g Heparin 5000-10000 units. Lidase 64-128 units Dimethyl sulfoxide 10-15 ml Glycerol 10-15 ml Vegetable oil Rest in this case, after applying the ointment, they are affected by ultrasound at a frequency of 800 MHz, with a power of 0.4 W / cm ² , for 10-15 minutes.